Indian Journal of Gastroenterology最新文献

{"title":"Long-term outcomes and quality of life after surgical repair of benign biliary stricture following bile duct injury during cholecystectomy.","authors":"Peeyush Varshney, Vinay K Kapoor","doi":"10.1007/s12664-025-01874-5","DOIUrl":"10.1007/s12664-025-01874-5","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"804-807"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral semaglutide for weight loss and liver fibrosis in overweight and obesity: A randomized controlled trial.","authors":"Anudeep Katrevula, Rakesh Kalapala, Siddhant Agrawal, Nitin Jagtap, Pratik Chhabra, Anand V Kulkarni, Chandhana Merugu, Goutham Reddy Katukuri, Nageshwar Reddy Duvvur","doi":"10.1007/s12664-025-01856-7","DOIUrl":"10.1007/s12664-025-01856-7","url":null,"abstract":"<p><strong>Background and objectives: </strong>Obesity is a leading risk factor for fatty liver disease and weight loss has been shown to improve liver parameters. This study evaluates the efficacy of oral semaglutide for weight loss in individuals with overweight or obesity, excluding those with diabetes mellitus.</p><p><strong>Methods: </strong>A randomized, open-label, controlled trial was conducted at the Asian Institute of Gastroenterology, Hyderabad, from June 2022 to December 2023. Adults (≥ 18 years) with a body mass index (BMI) ≥ 30 or ≥ 27 with comorbidities (pre-diabetes, hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease) were randomized into two groups. Both groups received counselling on a reduced-calorie diet and increased physical activity. Group 1 also received oral semaglutide, starting at 3 mg/day and titrated to 14 mg/day over two to four weeks. The objectives were to assess the effects of semaglutide on weight loss, non-invasive markers of liver fibrosis and cardiometabolic parameters. (ClinicalTrials.gov ID: NCT05442450).</p><p><strong>Results: </strong>Total 116 participants (58 per group) completed the study. At 28 weeks, the mean percentage weight reduction was -10.47% (SD 5.3) in the Semaglutide group vs. -2.4% (SD 4.5) in the control group (p < 0.001). Semaglutide treatment significantly improved alanine aminotransferase (ALT) (serum glutamic-pyruvic transaminase [SGPT]) levels, along with reductions in the aspartate aminotransferase to platelet ratio index (APRI) score, liver fat content and liver stiffness. However, NFS (NAFLD fibrosis score) and FIB-4 (fibrosis-4 index) did not show significant reductions. Improvements in BMI, waist circumference, HbA1c, fasting insulin and C-reactive protein (CRP) were significantly greater with semaglutide (p < 0.001). Total fat mass decreased by 7.3 kg vs. 1.74 kg (p < 0.0001) in controls, while visceral fat ratings dropped by 3.67 vs. 0.6 (p < 0.0001).</p><p><strong>Conclusions: </strong>In adults with overweight or obesity without diabetes, oral semaglutide, combined with dietary and lifestyle modifications, led to significant and clinically meaningful weight loss and metabolic improvements compared to lifestyle modifications alone.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"872-883"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and quality of life after repair of benign biliary stricture of post-cholecystectomy bile duct injury.","authors":"Jyoti Kharel, Thakur Deen Yadav, Rajesh Gupta, Harjeet Singh","doi":"10.1007/s12664-025-01832-1","DOIUrl":"10.1007/s12664-025-01832-1","url":null,"abstract":"<p><strong>Introduction: </strong>Bile duct injury (BDI) is a potentially devastating complication of cholecystectomy. Although the repair may be successful, patients often experience a decline in their quality of life (QoL). However, there is a paucity of data regarding the factors influencing long-term outcomes and QOL in these patients.</p><p><strong>Methods: </strong>Patients who underwent benign biliary stricture (BBS) repair with at least three years of follow-up were assessed for inclusion in the study. Long-term outcomes were assessed with MacDonald Grading. QOL assessed using the SF-36 questionnaire, with a control group of patients who had uncomplicated laparoscopic cholecystectomy (LC).</p><p><strong>Results: </strong>Of 156 patients screened, 41 were included in the study, with a median follow-up duration of five (IQR 4.8) years. Successful long-term outcomes with MacDonald outcome grade A were observed in 28 (68.3%) patients, 12 (29.2%) patients had grade B and one (2.4%) had grade-D outcomes. External biliary fistula at the time of repair had grade-D outcome in one patient (14.2%) and grades B and A in three (42.9%) patients each. The higher strictures (types IV and V) were associated with higher MacDonald grade-B outcomes compared to types I-III strictures (7 [53.8%] vs. 5 [17.9%]) , whereas lower strictures were more likely to have grade-A outcomes as compared to higher strictures (22 [78.6%] vs. 6 [46.2%] [p = 0.044]). Patients with BDI repair reported significantly lower scores in all eight SF-36 domains compared to controls (p < 0.05).</p><p><strong>Conclusion: </strong>The long-term outcomes of delayed BBS repair are favorable in high-volume center. Despite the acceptable post operative clinical outcomes, the long-term QOL remains compromised after BBS repairs.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"864-871"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution anorectal manometry in chronic constipation-Defining dysfunction beyond diagnosis.","authors":"Rajesh Sainani","doi":"10.1007/s12664-025-01865-6","DOIUrl":"10.1007/s12664-025-01865-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"813-815"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous rupture of hepatic hydatid cyst into the right portal vein-A rare entity.","authors":"Archita Mahajan, Mansi Verma, Sumala Kapila","doi":"10.1007/s12664-024-01706-y","DOIUrl":"10.1007/s12664-024-01706-y","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"968-969"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of gastric candidiasis in a patient with cirrhosis.","authors":"Kunwar Ashish Singh, Lipika Lipi, Narendra Singh Choudhary","doi":"10.1007/s12664-024-01691-2","DOIUrl":"10.1007/s12664-024-01691-2","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"963-965"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corkscrew esophagus due to type-3 achalasia: A rare combination.","authors":"Sanjeev Sachdeva, Ravi Teja Reddy, Rahul Chittem, Venkatesh Vaithiyam","doi":"10.1007/s12664-024-01716-w","DOIUrl":"10.1007/s12664-024-01716-w","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"970-971"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices for endoscopic management of achalasia cardia: A multicenter survey across tertiary care centers in India.","authors":"Zaheer Nabi, Shubra Mishra, Pradev Inavolu, D Nageshwar Reddy","doi":"10.1007/s12664-025-01818-z","DOIUrl":"10.1007/s12664-025-01818-z","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"929-931"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the burden and trends of pancreatitis in India from 1990-2021: An analysis of the global burden of disease database.","authors":"H Shafeeq Ahmed","doi":"10.1007/s12664-025-01869-2","DOIUrl":"10.1007/s12664-025-01869-2","url":null,"abstract":"<p><strong>Background and aim: </strong>Pancreatitis poses a growing health concern globally, yet its burden in India has not been comprehensively assessed over time. This study aimed to quantify the national and sub-national trends in incidence, prevalence, mortality and disability burden of pancreatitis in India from 1990 to 2021, using Global Burden of Disease (GBD) 2021 data.</p><p><strong>Methods: </strong>Data on six core indicators: incidence, prevalence, deaths, disability-adjusted life years (DALYs), years of life lost (YLLs) and years lived with disability (YLDs) were extracted from the GBD database. Age-standardized rates (ASRs) per 100,000 population were analyzed across 31 Indian states and union territories. Trends were evaluated by age, sex and region.</p><p><strong>Results: </strong>From 1990 to 2021, incident cases rose from 229,614 (95% UI: 190,053-274,618) to 523,074 (95% UI: 435,284-625,178) and prevalence rose from 249,067 (95% UI: 169,900-342,317) to 547,618 (95% UI: 369,410-750,696). The age-standardized incidence rate increased modestly from 32.78 (95% UI: 27.25-38.72) to 36.76 (95% UI: 30.52-43.44), while the prevalence rate rose from 37.83 (95% UI: 25.53-51.76) to 39.70 (95% UI: 26.84-54.45). The ASR for deaths declined from 2.24 (95% UI: 1.57-3.12) to 1.71 (95% UI: 1.27-2.25) and the DALY rate from 77.69 (95% UI: 57.42-111.80) to 56.82 (95% UI: 43.50-73.46). Male ASRs remained consistently higher than female. Higher Socio-Demographic Index (SDI) states showed increased YLDs and reduced premature mortality.</p><p><strong>Conclusion: </strong>The pancreatitis burden in India has increased substantially, with notable regional and sex-based differences. These findings point out the need for early diagnosis, targeted interventions in high-burden states and improved outpatient care to manage chronic morbidity.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"898-909"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Asian-Pacific consensus on small intestinal bacterial overgrowth in gastrointestinal disorders: An initiative of the Indian Neurogastroenterology and Motility Association\".","authors":"S Dhanya Dedeepya, Vaishali Goel, Nivedita Nikhil Desai","doi":"10.1007/s12664-025-01932-y","DOIUrl":"10.1007/s12664-025-01932-y","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"937-938"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}