Indian Journal of Gastroenterology最新文献

{"title":"Role of fecal calprotectin to differentiate between treatment-naive intestinal tuberculosis and Crohn's disease: A pilot study.","authors":"Sayan Malakar, Uday C Ghoshal, Umair Samshul Hoda, Srikant Kothalkar, Vishwas Kapoor, Gourav Jyoti Borah, Piyush Mishra","doi":"10.1007/s12664-025-01812-5","DOIUrl":"https://doi.org/10.1007/s12664-025-01812-5","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal stromal tumors: Clinicopathological features and outcome-Real-world experience.","authors":"Suriya Nedunchezhian, Vikas Pemmada, Divija Sharma, Athish Shetty, Shiran Shetty, Balaji Musunuri, Jegan Mohan S, Ganesh Bhat","doi":"10.1007/s12664-025-01800-9","DOIUrl":"https://doi.org/10.1007/s12664-025-01800-9","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal stromal tumors (GISTs) are rare neoplasms with diverse clinical profiles and treatment outcomes. This study aims to evaluate the clinical characteristics, treatment modalities and survival outcomes of patients with GISTs treated at a tertiary care hospital in India.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 51 patients with GISTs. Data collected included tumor location, gender, presenting complaints, staging, pathological data, National Institutes of Health (NIH) risk category, treatment offered and outcome. Statistical analyses were performed using SPSS Statistics version 23. Descriptive statistics were used to summarize data and significance was determined with p-values < 0.05.</p><p><strong>Results: </strong>Total 51 patients of GIST were included in this study. Mean age of presentation was 54.38 ± 13.2 and 61% (31/51) patients were male. In this study, most common site of involvement was the small bowel (25/51), followed by stomach (24/51). Most common presenting feature was  pain in abdomen (59% 30/51), followed by gastrointestinal bleed. At diagnosis, localized disease was present in a majority of patients and metastasis was present in only 10% (5/51) of cases. Among non-metastatic disease, spindle cell morphology was predominant (71.7%) and in metastatic disease; mixed cell morphology was more common (60%). Mitotic activity (0.034) and CD34 positivity (p = 0.046) were significantly associated with metastasis. According to NIH risk classification, 33% were low risk, 27% intermediate risk and 39% high risk. Imatinib was given to 75% of patients, while 25% received no drug therapy.</p><p><strong>Conclusion: </strong>GISTs predominantly affect proximal bowel and metastatic disease is very uncommon. Surgical resection with adjuvant tyrosine kinase inhibitor in selected patient is the main treatment with good survival rate. CD34 positivity and mitotic activity was significantly associated with metastasis, indicating its potential as a marker for predicting metastatic spread.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic median arcuate ligament release: Outcomes of 59 cases.","authors":"Fahri Yetişir, Oguzhan Özdemir, Ömer Kurt, Ramazan Tiken, Osman Yüksel","doi":"10.1007/s12664-025-01825-0","DOIUrl":"https://doi.org/10.1007/s12664-025-01825-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided portal venous thrombolysis: A promising avenue.","authors":"Venkatesh Vaithiyam, Lalit Chandra Kummetha, Ravi Teja Reddy, Ujjwal Sonika, Ashok Dalal, Ajay Kumar, Sanjeev Sachdeva, Siddharth Srivastava","doi":"10.1007/s12664-025-01807-2","DOIUrl":"https://doi.org/10.1007/s12664-025-01807-2","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices for endoscopic management of achalasia cardia: A multicenter survey across tertiary care centers in India.","authors":"Zaheer Nabi, Shubra Mishra, Pradev Inavolu, D Nageshwar Reddy","doi":"10.1007/s12664-025-01818-z","DOIUrl":"https://doi.org/10.1007/s12664-025-01818-z","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endo-histologic outcomes in patients with ulcerative colitis responding to tofacitinib.","authors":"Arshdeep Singh, Arshia Bhardwaj, Devanshi Jain, Riya Sharma, Dharmatma Singh, Ramit Mahajan, Kirandeep Kaur, Aminder Singh, Vikram Narang, Harpreet Kaur, Manavjot Singh, Pritish Gupta, Tanisha Sehgal, Vandana Midha, Ajit Sood","doi":"10.1007/s12664-025-01779-3","DOIUrl":"https://doi.org/10.1007/s12664-025-01779-3","url":null,"abstract":"<p><strong>Background: </strong>The therapeutic target for ulcerative colitis (UC) has shifted towards deeper disease control. The real-world data on efficacy of tofacitinib in inducing histologic remission (HR) remains limited. We evaluated the real-world efficacy of tofacitinib in achieving endoscopic remission (ER) and HR.</p><p><strong>Methods: </strong>A prospective observational cohort study was conducted from January 2022 to June 2024. Adult patients with moderate-to-severe UC (Mayo score ≥ 6, endoscopic subscore ≥ 2) who responded to tofacitinib induction by week 16 were included. Paired endoscopic and histologic assessments were performed at baseline and week 48. Endoscopic disease activity was graded using the Mayo endoscopic score (MES), while histologic activity was evaluated using the Nancy index (NI). The primary outcome was combined endoscopic-histologic remission (EHR), defined as MES of 0 and a NI of 0, at week 48. The key secondary outcomes included ER, HR, histologic endoscopic mucosal improvement (HEMI) and endoscopic improvement histologic remission (EIHR).</p><p><strong>Results: </strong>Total 86 patients who received tofacitinib induction therapy were evaluated. Nine non-responders at 16 weeks were excluded and 77 patients (median age 37 years, 38 [49%] females) were analyzed. At week eight, clinical response and remission were achieved in 66 (85.7%) and 37 (48.1%) patients, respectively. At week 48, 57 (74.02%) patients maintained clinical response. Median MES and NI were 1 (IQR 0-3) and 3 (IQR 0-3), respectively. Combined EHR was achieved in 22 (28.6%) patients, while ER and HR were observed in 30 (38.9%) and 29 (37.6%) patients, respectively. HEMI was noted in 32 (41.6%) patients, while EIHR was seen in 27 (35.1%) patients. No significant predictors of ER, HR or combined EHR were identified. No serious adverse effects were reported.</p><p><strong>Conclusions: </strong>Tofacitinib is effective in achieving combined EHR, ER and HR. These findings support the potential for histologic healing as a therapeutic target for UC in real world.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute-on-chronic liver failure-Prime time for unity.","authors":"James Fung","doi":"10.1007/s12664-025-01798-0","DOIUrl":"10.1007/s12664-025-01798-0","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and manometry characteristics of patients with motor dysphagia.","authors":"Mayank Jain","doi":"10.1007/s12664-025-01810-7","DOIUrl":"10.1007/s12664-025-01810-7","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary lipoarabinomannan for gastrointestinal tuberculosis: Another tool in the kit.","authors":"Julajak Limsrivilai","doi":"10.1007/s12664-025-01795-3","DOIUrl":"https://doi.org/10.1007/s12664-025-01795-3","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vonoprazan in Helicobacter pylori treatment regimens in India: Dawn of a New Era.","authors":"Anuraag Jena, Usha Dutta","doi":"10.1007/s12664-025-01790-8","DOIUrl":"https://doi.org/10.1007/s12664-025-01790-8","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}