Indian Journal of Gastroenterology最新文献

{"title":"Esophageal manometry in an infant.","authors":"Piyush Manoria, Roshan Chanchlani","doi":"10.1007/s12664-026-02004-5","DOIUrl":"https://doi.org/10.1007/s12664-026-02004-5","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron pill gastritis: An under recognised condition of therapeutic oral iron.","authors":"Srinu Deshidi, Gaurav Mahajan, Sreekanth Appasani","doi":"10.1007/s12664-026-02006-3","DOIUrl":"https://doi.org/10.1007/s12664-026-02006-3","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of endoscopic pre-aponeurotic repair of diastasis recti on gastroesophageal reflux symptoms: An observational retrospective study.","authors":"Salvatore Cuccomarino, Antonio Toscano, Ezequiel Mariano Palmisano, Derlin Marcio Juárez Muas, Marcel Caufriez, Antonella Nicotera, Luca Domenico Bonomo","doi":"10.1007/s12664-026-01995-5","DOIUrl":"https://doi.org/10.1007/s12664-026-01995-5","url":null,"abstract":"<p><strong>Background: </strong>Diastasis recti (DR) is a common condition, particularly in post-partum women, which may impair core function and alter intra-abdominal pressure (IAP). Gastro-esophageal reflux disease (GERD) is frequently associated with IAP imbalance, to which DR may be a contributing factor. This study aims to evaluate whether surgical correction of DR using pre-aponeurotic endoscopic repair (REPA) improves symptoms of GERD.</p><p><strong>Methods: </strong>Symptom changes were assessed in 115 REPA patients using a validated questionnaire (modified Italian GERD Health-Related Quality of Life, MI-GERD-HRQL) administered pre-operatively and post-operatively. All respondents had a body mass index (BMI) ≤ 25 and no other relevant gastrointestinal or systemic comorbidities.</p><p><strong>Results: </strong>This study showed a significant reduction in both prevalence and severity of GERD symptoms after surgery. The presence of reflux symptoms decreased from 75% pre-operatively to 50% post-operatively, p < 0.001. In particular, a significant reduction in prevalence was observed for heartburn after meals (28% vs. 57%), sensation of reflux (19% vs. 57%), reflux after meals (25% vs. 57%), heartburn (30% vs. 54%) and reflux when lying down (24% vs. 53%). Mean MI-GERD-HRQL score went from 16 (± 17) pre-operatively to 5 (± 10) post-operatively, p < 0.001. Mean scores for all symptoms examined showed a significant reduction in the post-operative period. Male sex, age ≥ 50 years and patients' geographical location (Italian sub-group) did not influence post-operative MI-GERD-HRQL score.</p><p><strong>Conclusions: </strong>Our findings suggest a possible mechanistic link between abdominal wall integrity and GERD. Epidemiological and prospective comparative studies are necessary to validate our results and provide a more precise understanding of the physiological impact of DR repair on GERD.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of trans-jugular intrahepatic portosystemic shunt in patient with liver cirrhosis with hepatorenal syndrome non-acute kidney injury and refractory ascites-A retrospective analysis.","authors":"Abhinandan Kumar, Amar Mukund, Omkar Rudra, Sushant Babbar, Ranjan Kumar Patel, Yashwant Patidar, Ankur Jindal, Shiv Kumar Sarin","doi":"10.1007/s12664-026-01977-7","DOIUrl":"https://doi.org/10.1007/s12664-026-01977-7","url":null,"abstract":"<p><strong>Background and aims: </strong>To evaluate the efficacy of trans-jugular intrahepatic portosystemic shunt (TIPS) in patients with liver cirrhosis with hepatorenal syndrome non-acute kidney injury (HRS-NAKI) and refractory ascites who are not candidates for liver transplantation.</p><p><strong>Methods: </strong>We retrospectively analyzed cirrhotic patients with refractory ascites and HRS-NAKI treated with TIPS (n = 35) and those receiving standard medical therapy alone (n = 134). Propensity score matching (1:1) was performed using age, sex, model for end-stage liver disease (MELD) score, Child-Turcotte-Pugh (CTP) score, serum bilirubin, serum creatinine, serum sodium and ascites severity, yielding 35 matched controls. Laboratory and clinical parameters at one, three and six months were recorded and comparisons were made between both groups using appropriate statistical tests.</p><p><strong>Results: </strong>At six months, TIPS patients demonstrated improvement in serum creatinine (1.72 ± 0.31 to 1.41 ± 0.28 mg/dL) and urea (78.6 ± 21.4 to 52.3 ± 18.9 mg/dL), while controls showed deterioration. Urinary sodium increased significantly after TIPS (14.0 ± 6.9 to 55.5 ± 25.0 mmol/L at three months, p = 0.001). Mean large-volume paracentesis frequency was lower in TIPS patients (0.52 vs. 1.16 per month, p = 0.002). Plasma renin activity declined after TIPS (13.9 ± 1.5 to 4.8 ± 1.2 ng/mL/h at six months). Hepatic encephalopathy occurred in 35.1%, liver failure in 5.7% and heart failure in 5.7%. Six-month mortality was 11.4% in the TIPS group and 20% in the control.</p><p><strong>Conclusion: </strong>TIPS improves renal function, neuro-hormonal activation and ascites control in patients with HRS-NAKI and refractory ascites who are not transplant candidates. However, it is associated with significant adverse events including hepatic encephalopathy, liver failure and cardiac decompensation. Larger prospective studies are required to identify patients who derive maximal benefit.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological approach and differentiation of Crohn's disease and gastrointestinal tuberculosis: Recommendations from the joint IAPM-ISG-CCFI Working Group.","authors":"Prasenjit Das, Puja Sakhuja, Aminder Singh, Arshdeep Singh, Sagir Akhtar, Saurabh Kedia, Vishal Sharma, Kim Vaiphei, Anna Pulimood, Roopa Rachel Paulose, Anuradha Sekaran, Sanjeev Vasudev Katti, Mala Banerjee, Ritambhra Nada, Nuzhat Hussain, Niraj Kumari, Rajni Yadav, Rajib Sarkar, Vatsala Misra, Vandana Midha, Uday C Ghoshal, Amit K Dutta, Rupa Banerjee, Devendra Desai, Ajay Kumar, Sandeep Nijhawan, Mathew Philip, Usha Dutta, Govind K Makharia, Siddhartha Datta Gupta, B S Ramakrishna, Ajit Sood, Vineet Ahuja","doi":"10.1007/s12664-026-01973-x","DOIUrl":"https://doi.org/10.1007/s12664-026-01973-x","url":null,"abstract":"<p><strong>Background: </strong>The most common causes for ulcero-stricturing diseases of the ileo-cecal region and colon in Southeast Asia are Crohn's disease (CD) and gastrointestinal tuberculosis (GI TB). Diagnosing these conditions is challenging because they share several clinical, endoscopic, radiological and histological features on mucosal biopsies. Therefore, there is a need to standardize the sampling, processing and interpretation of mucosal biopsies to aid clinical decision-making.</p><p><strong>Methods: </strong>Recognizing this challenge, core subject experts nominated by the Indian Association of Pathologists and Microbiologists (IAPM), the Indian Society of Gastroenterology (ISG) and the Colitis and Crohn's Foundation, India (CCFI), collaborated to formulate comprehensive recommendations for pathologists regarding optimal biopsy protocols, histological interpretation and reporting for differentiating CD from GI TB. A structured Delphi process was followed.</p><p><strong>Results: </strong>The recommendations from the core domain expert groups were based on discussions, brainstorming sessions and extensive literature reviews conducted over three virtual group meetings, multiple online voting sessions and one physical meeting involving all experts. This document is expected to standardize the practice of luminal gastroenterology by providing a ready reference for budding specialists and pathologists, thereby promoting uniformity in practice.</p><p><strong>Conclusion: </strong>These multi-society, evidence-based and practically applicable recommendations developed by core subject experts aim to promote uniformity and confidence in pathology reports, facilitate timely patient management and prevent complications arising from erroneous treatment.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of astrovirus-associated gastroenteritis among hospitalized pediatric patients in Asia: A systematic review and meta-analysis.","authors":"Bhavna Prajapati, Mudra Sikenis, Ashutosh Kumar Singh, Vishal Diwan, Uday Kumar Mandal, Surya Singh, Megha Katare Pandey, Karmveer Yadav, Rajnarayan R Tiwari, Pradyumna Kumar Mishra, Vikas Yadav, Ram Kumar Nema","doi":"10.1007/s12664-025-01951-9","DOIUrl":"https://doi.org/10.1007/s12664-025-01951-9","url":null,"abstract":"<p><strong>Background: </strong>Viral gastroenteritis is a significant public health concern in developing countries, primarily affecting children under five years. Human astrovirus (HAstV) is one of the key viral agents causing gastroenteritis. Despite the global recognition of HAstV as a causative agent of acute gastroenteritis, its impact on Asian populations, particularly among hospitalized children, is lacking. This systematic review and meta-analysis aimed at determining the prevalence of HAstV-associated acute gastroenteritis among hospitalized pediatric patients in Asia.</p><p><strong>Method: </strong>This systematic review and meta-analysis was conducted following PRISMA Guidelines and registered with PROSPERO (ID CRD42024519527). A comprehensive literature search was performed on PubMed, Web of Science and Scopus databases for studies published between January 2000 and December 2023. Keywords related to astrovirus, prevalence, pediatric populations and hospitalization in Asia were used. A pre-designed Excel sheet was used for data extraction and the Joanna Briggs Institute critical appraisal tool was used for quality assessment. Generalized Linear Mixed Models with logit transformation were used to calculate the effect sizes.</p><p><strong>Results: </strong>The analysis included 49 studies, encompassing data from various Asian countries. The pooled prevalence of HAstV in hospitalized pediatric patients due to acute gastroenteritis was 2.39%, highlighting the significant burden in Asia. Sub-group analysis revealed considerable difference in HAstV prevalence among Asian countries.</p><p><strong>Conclusions: </strong>This systematic review and meta-analysis summarizes the prevalence of HAstV among hospitalized pediatric patients in Asia, highlighting the need for country-specific strategies to improve surveillance and diagnostics.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of indomethacin and pancreatic duct stenting in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review and network meta-analysis.","authors":"Ahmed Gamal Elshaar, Ahmed Amir Samir, Ahmed Samy Elgammal, Roaa Abdulrhman Elaw, Effa Afif Zain, Omer Bin-Sahel, Nada Ramadan Kamh, Zahra Faried Farouq Serag, Mohamed Diab Ramadan, Magdy Mostafa Anber, Zainab Osama, Mohamed Elgohary, Hossam Tharwat Ali","doi":"10.1007/s12664-026-01974-w","DOIUrl":"https://doi.org/10.1007/s12664-026-01974-w","url":null,"abstract":"<p><strong>Background and aims: </strong>Endoscopic retrograde cholangiopancreatography (ERCP) has significant diagnostic and therapeutic roles in pancreaticobiliary disorders. Post-ERCP pancreatitis (PEP) is the most common adverse event that can be encountered and affects 1% to 9% of the average-risk group and 11% to 40% of the high-risk group. Several methods have been used to prevent PEP, including pancreatic duct (PD) stenting and pharmacological use, including indomethacin.</p><p><strong>Methods: </strong>We conducted a systematic review of PubMed (MEDLINE), Scopus and Web of Science (WOS) databases until November 1, 2024, using relevant keywords. Only randomized clinical trials (RCTs) were included. The network meta-analysis is reported using odds ratios (ORs) with 95% confidence intervals (CIs) with a significance level < 0.05. Rank probabilities were calculated using p-scores to rank treatments based on their effectiveness. All analyses were performed using R version 4.3.1 (2023-06-16 ucrt) with the netmeta package. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) assessment of the certainty of the evidence was performed.</p><p><strong>Results: </strong>Of 1828 references, total 31 RCTs with 9050 participants were included in this meta-analysis. Compared to placebo, indomethacin (OR = 0.50, 95% CI = 0.39-0.64, p < 0.001), PD stenting (OR = 0.33, 95% CI = 0.23-0.47, p < 0.001) and indomethacin combined with PD stenting (OR = 0.36, 95% CI = 0.18-0.73, p = 0.005) were effective in reducing PEP. Sub-group analysis of high-risk patients revealed similar results, indomethacin (OR = 0.43, 95% CI = 0.31-0.61, p < 0.001), PD stenting (OR = 0.32, 95% CI = 0.22-0.47, p < 0.001) and indomethacin combined with PD stenting (OR = 0.32, 95% CI = 0.14-0.72, p = 0.006). Notably, indomethacin did not show significant effects in mild, moderate or severe PEP. Notably, indomethacin showed significant benefit in the prevention of moderate-severe PEP only.</p><p><strong>Conclusions: </strong>The present network meta-analysis indicated that PD stenting seems to be the most effective in reducing PEP incidence among the examined treatments, particularly in high-risk patients, with inconsistent benefits of indomethacin in different PEP severities.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence augmented imaging of pancreatic fluid collections in acute pancreatitis.","authors":"Niharika Dutta, Samonee Ralmilay, Pankaj Gupta","doi":"10.1007/s12664-026-01979-5","DOIUrl":"https://doi.org/10.1007/s12664-026-01979-5","url":null,"abstract":"<p><p>Acute pancreatitis (AP) is a significant global health burden, with pancreatic fluid collections (PFCs) posing major diagnostic and therapeutic challenges. Distinguishing fluid-only pseudocysts from debris-containing walled-off necrosis is critical for management but is often difficult with conventional imaging. Contrast-enhanced computed tomography underestimates necrotic debris, while magnetic resonance imaging (MRI) is costly and time-consuming and endoscopic ultrasound is invasive. Artificial intelligence (AI), particularly deep learning and radiomics, is emerging as a powerful tool to overcome these limitations. AI algorithms can automate the segmentation of the pancreas and PFCs, provide objective quantification of necrotic debris and predict disease severity. Furthermore, AI-driven techniques can accelerate MRI acquisition times and potentially generate synthetic images, reducing scanner dependency. This review synthesizes AI's role in augmenting pancreatic imaging in PFC, covering its applications in segmentation and volumetry, image generation, outcome prediction and workflow optimization and discusses challenges and future directions for its clinical integration.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of circulatory microRNA-183_5p and 3651 in serum as novel potential diagnostic marker for gallbladder cancer.","authors":"Deepika Verma, Neelam Lohani, Joginder Kumar, Vivek Nayyar, Payal Gupta, S S Chauhan","doi":"10.1007/s12664-026-01967-9","DOIUrl":"https://doi.org/10.1007/s12664-026-01967-9","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder cancer (GBC) is the most common biliary tract malignancy and a leading cause for mortality in the Asian sub-continent. The low survival rate is attributed to current invasive diagnostic methods and late-stage disease detection. The aim of this study was to estimate the potential value of miR 183_5p and 3651 as diagnostic blood-based biomarkers in GBC patients.</p><p><strong>Methods: </strong>This single center observational study evaluates differential expression of miRNAs in GBC and normal gallbladder tissues via micro-array analysis. The level of selected oncogenic miRNAS were detected in 130 individuals comprising GBC patients, Gallbladder stone (GBS) and healthy controls by using qRT-PCR. The diagnostic value of miR-183-5p and 3651 in GBC was evaluated and compared with the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19.9 (CA 19.9).</p><p><strong>Results: </strong>As many as 45 differentially expressed microRNAs (p < 0.05) were determined, of which 23 were upregulated and 22 were down regulated. miR 183_5p (2.5-fold) and 3651 (5.6-fold) were significantly over expressed in GBC patients compared to controls (p < 0.05). The area under the curve (AUC) value of miR 183_5p and 3651 for GBC diagnosis was 0.684 and 0.752, respectively, which was more valuable than those including CEA (0.617) and CA19.9 (0.718).</p><p><strong>Conclusion: </strong>Study underscores ability of serum miRNAs 183_5p and 3651 as diagnostic biomarkers for early GBC detection.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Gender disparities in liver transplantation.","authors":"Rajalakshmi Govalan, Shikhar Singh, Pratima Sharma","doi":"10.1007/s12664-026-02003-6","DOIUrl":"https://doi.org/10.1007/s12664-026-02003-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}