Immunohematology最新文献_第2页

Hemolysis due to anti-IH in a patient with beta-thalassemia and Mycoplasma pneumoniae infection. 地中海贫血和肺炎支原体感染患者抗ih引起的溶血。

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-018

Jennifer N Chousal, Forough Sargolzaeiaval, Tridu R Huynh, Mitchell Zhao, Karen Rodberg, Patricia M Kopko, Srila Gopal, Elizabeth S Allen

{"title":"Hemolysis due to anti-IH in a patient with beta-thalassemia and Mycoplasma pneumoniae infection.","authors":"Jennifer N Chousal, Forough Sargolzaeiaval, Tridu R Huynh, Mitchell Zhao, Karen Rodberg, Patricia M Kopko, Srila Gopal, Elizabeth S Allen","doi":"10.2478/immunohematology-2024-018","DOIUrl":"10.2478/immunohematology-2024-018","url":null,"abstract":"Anti-IH is a common cold agglutinin that is typically clinically insignificant. We present a case that resulted in hemolysis. A 32-year-old male patient with transfusion-independent beta-thalassemia intermedia presented with symptomatic anemia. His blood sample typed as group B, D+ and demonstrated multiple alloantibodies and cold autoantibodies. He was transfused uneventfully, but re-presented 10 days later with recurrent, worsening anemia. At this time, transfusion of group O, phenotype-matched red blood cells (RBCs) resulted in an acute hemolytic reaction. While anemia was initially attributed to drug-mediated bone marrow toxicit y and subsequently to a delayed hemolytic reaction, further evaluation revealed Mycoplasma pneumoniae infection and a cold agglutinin (anti-IH specificity), indicating a likely autoimmune-mediated anemia due to an infectious etiology. Subsequent transfusion of 2 group B, phenotype-matched RBC units using a blood warmer was uneventful. Anti-IH is only rarely associated with hemolytic transfusion reactions, which may be exacerbated when transfusing group O RBC units to group B patients. M. pneumoniae infection likely led to cold agglutinin-mediated hemolysis of endogenous and transfused RBCs. The patient was successfully managed with intravenous immunoglobulin, steroids, rituximab, erythropoietin, hydroxyurea, and amoxicillin clavulanate/azithromycin. This case illustrates the importance of infectious disease evaluation in patients with unexplained anemia, the potential clinical significance of autoanti-IH, and the value of providing type-specific RBC units in these circumstances.","PeriodicalId":13357,"journal":{"name":"Immunohematology","volume":"40 4","pages":"139-144"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anti-G evaluations in D- pregnant women determine the need for Rh immune globulin prophylaxis: report of two illustrative cases. D孕妇的抗g评价确定是否需要Rh免疫球蛋白预防：两个说明性病例的报告。

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-019

Soumya Jaladi, Wenjing Cao, Daniel R Meinecke, Patricia A Ruegsegger, John Weiss, Janine Rhoades, Joseph Connor

{"title":"Anti-G evaluations in D- pregnant women determine the need for Rh immune globulin prophylaxis: report of two illustrative cases.","authors":"Soumya Jaladi, Wenjing Cao, Daniel R Meinecke, Patricia A Ruegsegger, John Weiss, Janine Rhoades, Joseph Connor","doi":"10.2478/immunohematology-2024-019","DOIUrl":"10.2478/immunohematology-2024-019","url":null,"abstract":"Distinguishing anti-D, anti- C, and anti-G specificities is particularly essential in antenatal cases to ensure proper patient management. The clinical management as well as Rh immune globulin (RhIG) prophylaxis depend on the accurate identification of these distinct antibodies. D- pregnant women with anti-G, but without anti-D, in their serum need RhIG prophylaxis at 28 weeks of gestation, at delivery if the infant is D+, and when clinically indicated to prevent the formation of anti-D and potential hemolytic disease of the fetus and newborn (HDFN). We present two cases in which determining the antibody specificities determined the course of the patient's treatment. In one case, a 30-year-old, gravida-1, para-0 woman with blood group A, D- and with no previous RhIG administration had the presence of anti-D, -C, and -G in her plasma. Because she had already been alloimmunized and developed anti-D, RhIG prophylaxis was not necessary. In another case, a 37-year-old, gravida-2, para-1 woman with blood group A, D- and no prior RhIG administration had anti-C and anti-G in her plasma. Because she was not sensitized to D, she needed RhIG prophylaxis. In conclusion, pregnant women can develop anti-C and/or anti-G in the absence of anti-D. Therefore, studies should be conducted to differentiate anti-D, -C, and -G in pregnant women who are presumptively identified as having anti-D and anti-C when their medical history (RhIG prophylactic therapy) suggests that anti-D may not actually be present. In the absence of anti-D, pregnant women should receive prophylaxis with RhIG to prevent alloimmunization to D. For pregnant women who are already sensitized to D, RhIG prophylaxis is not needed.","PeriodicalId":13357,"journal":{"name":"Immunohematology","volume":"40 4","pages":"145-148"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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To contributors to the 2024 issues. 致2024期杂志的撰稿人。

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-023

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Contents. 内容。

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-017

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To contributors to the 2024 issues. 致2024期杂志的撰稿人。

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-023

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A case of assisted reproductive technology-induced maternal alloimmunization: an emerging sensitizing factor to consider? 1例辅助生殖技术诱导的母体同种异体免疫：一个需要考虑的新致敏因素？

Immunohematology Pub Date : 2024-12-31 Print Date: 2024-12-01 DOI: 10.2478/immunohematology-2024-020

Deepti Sachan, Varnisha Thiyagarajan, Deepthi Krishna G

{"title":"A case of assisted reproductive technology-induced maternal alloimmunization: an emerging sensitizing factor to consider?","authors":"Deepti Sachan, Varnisha Thiyagarajan, Deepthi Krishna G","doi":"10.2478/immunohematology-2024-020","DOIUrl":"10.2478/immunohematology-2024-020","url":null,"abstract":"Red blood cell (RBC) alloimmunization can occur because of exposure to various sensitizing factors and poses a constant threat in transfusion. Assisted reproductive technology (ART) involves manipulation of sperm, ova, or embryos in vitro with the goal of producing a pregnancy. We present an interesting case of ART-induced maternal alloimmunization (AIMA) due to anti-c in a woman carrying a twin pregnancy. A 35-year-old primigravida, whose blood sample typed as group B, D+ and showed anti-c in her plasma, delivered twins by cesarean section. The spouse's blood group was also B, D+. The blood groups of twins I and II were confirmed to be B, D+ and AB, D+, respectively. The RBCs of twin I were c+, but those of twin II and the spouse were c-. On enquiry, history of ART with donor sperm insemination was noted. Because there were no previous sensitizations, antigenic inheritance from the sperm donor to twin I could be the possible sensitizing factor for maternal alloimmunization. To the best of our knowledge, this case is the first report of ART-induced maternal RBC alloimmunization in the literature. History of ART exposures should be documented, and appropriate RBC phenotyping of the parent as well as potential ART donors will help in timely detection or prevention of hemolytic disease of the fetus and newborn or other AIMA-related complications.","PeriodicalId":13357,"journal":{"name":"Immunohematology","volume":"40 4","pages":"149-152"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The American Rare Donor Program: 25 years supporting rare blood needs. 美国稀有捐献者计划：25 年来为稀有血液需求提供支持。

Immunohematology Pub Date : 2024-10-04 Print Date: 2024-09-01 DOI: 10.2478/immunohematology-2024-015

Margaret A Keller, Sandra T Nance, Joan Maurer, Victoria Kavitsky, Shraddha P Babariya

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Contents. 内容

Immunohematology Pub Date : 2024-10-04 eCollection Date: 2024-09-01 DOI: 10.2478/immunohematology-2024-012

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Mixed-field ABO front typing as an early sign of disease recurrence in ABO-matched stem cell transplantation. ABO 混合场前分型是 ABO 配型干细胞移植中疾病复发的早期征兆。

Immunohematology Pub Date : 2024-10-04 Print Date: 2024-09-01 DOI: 10.2478/immunohematology-2024-013

Nalan Yurtsever, Edward S Lee, Lisa Pinatti, Bhushan Shah, Christopher A Tormey, Alexa J Siddon

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A challenging case of hemolytic disease of the fetus and newborn (HDFN) due to anti-Ku in a K₀ (Kell_null) mother. 一名 K0（Kellnull）母亲因抗 Ku 而导致胎儿和新生儿溶血病（HDFN）的棘手病例。

Immunohematology Pub Date : 2024-10-04 Print Date: 2024-09-01 DOI: 10.2478/immunohematology-2024-016

Siti A Wan Mohd Hasni, Nor H Ahmad, Muniswaran Ganeshan, Soon L Yong, Pei P Tan, Rahimah Abdul Wahab, Rozi H Musa, Gunaseelan Muniandi, Ambika Nakulan, Afifah Hassan

{"title":"A challenging case of hemolytic disease of the fetus and newborn (HDFN) due to anti-Ku in a K0 (Kellnull) mother.","authors":"Siti A Wan Mohd Hasni, Nor H Ahmad, Muniswaran Ganeshan, Soon L Yong, Pei P Tan, Rahimah Abdul Wahab, Rozi H Musa, Gunaseelan Muniandi, Ambika Nakulan, Afifah Hassan","doi":"10.2478/immunohematology-2024-016","DOIUrl":"10.2478/immunohematology-2024-016","url":null,"abstract":"Hemolytic disease of the fetus and newborn (HDFN) due to an antibody in the Kell blood group system can be associated with severe fetal anemia. This case report details the challenges of managing a Kellnull mother with anti-Ku that affected her fetus/newborn. A gravida 4 para 3 woman at term underwent an emergency lower caesarean section because of fetal distress. The baby was intubated because of low oxygen saturation. An urgent request for a hematology workup showed severe anemia and erythroblastosis fetalis. Unfortunately, no compatible blood was found, and the baby died. The case was referred to the National Blood Centre, and anti-Ku was confirmed in a sample sent from the mother. When she presented with her fifth pregnancy, meticulous planning was used to manage this pregnancy. Her family screening revealed one brother with a matching phenotype. Three blood donations were planned for the brother-for freezing, for intrauterine transfusion, and for standby during delivery. Serial anti-Ku titrations of maternal samples were performed, and the fetus was monitored for anemia through middle cerebral artery Doppler scans. Although the anti-Ku titers reached as high as 1024, fetal anemia was never diagnosed. The neonate was delivered safely but was diagnosed with severe pathologic jaundice and anemia secondary to HDFN and congenital pneumonia. The baby was transfused with K0 packed red blood cells and later discharged to home.","PeriodicalId":13357,"journal":{"name":"Immunohematology","volume":"40 3","pages":"122-127"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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