Indian Journal of Endocrinology and Metabolism最新文献

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Clinical Profile and Treatment Outcomes in Patient with Acromegaly Using 14th Acromegaly Consensus Criteria. 肢端肥大症患者的临床概况和治疗结果采用第14肢端肥大症共识标准。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_522_24
Jyoti Sharma, Rajeev Kasaliwal, Puneet Shivnani, Utkarsh Balani, Payal Bargujar, Pankaj Gupta, Bhawani S Sharma, Vineet Mishra, Akash Mishra, Surendra K Sharma
{"title":"Clinical Profile and Treatment Outcomes in Patient with Acromegaly Using 14<sup>th</sup> Acromegaly Consensus Criteria.","authors":"Jyoti Sharma, Rajeev Kasaliwal, Puneet Shivnani, Utkarsh Balani, Payal Bargujar, Pankaj Gupta, Bhawani S Sharma, Vineet Mishra, Akash Mishra, Surendra K Sharma","doi":"10.4103/ijem.ijem_522_24","DOIUrl":"10.4103/ijem.ijem_522_24","url":null,"abstract":"<p><strong>Introduction: </strong>Acromegaly is a chronic systemic disease characterized by excessive secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). This study reviews our experience with endoscopic transsphenoidal surgery (TSS) in acromegaly patients, focusing on remission rates according to the 2023 consensus criteria.</p><p><strong>Methods: </strong>We conducted a hospital based, retrospective study involving 42 patients diagnosed with acromegaly who underwent endoscopic TSS, between January 2020 and June 2024. Clinical and hormonal profiles, comorbidities and outcome data were analysed. Remission was defined as age-adjusted IGF-1 levels 3 months post-surgery.</p><p><strong>Results: </strong>Mean age at diagnosis was 36.43 ± 10.70 years. The two most frequent presenting symptoms were headache (64.28%) and visual deficits (47.61%). Common comorbidities included diabetes mellitus (23.8%) and hypertension (28.57%). Pre-operative hormonal evaluation revealed secondary hypogonadism in 41.66% of patients, followed by hypothyroidism (23.81%) and cortisol deficiency (21.43%). Biochemical remission was achieved in 18 out of 42 patients (42.85%), including all five patients with microadenomas and 35.13% of those with macroadenomas. Although Knosp grade, maximum tumour diameter and pre-operative post glucose growth hormone levels showed significant associations in univariate analyses, these associations were not significant after adjustment. On multivariate analysis, post-operative day 2 GH levels (≤2.75 ng/ml) emerged as a significant predictor of remission.</p><p><strong>Conclusions: </strong>This study provides the comprehensive review of clinical presentations and outcomes of patients with acromegaly based on the latest acromegaly consensus guidelines. Notably, a post-operative day 2 GH less than 2.75 ng/ml emerged as a significant predictor of outcome.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the Emotional, Social and Ethical Aspects of Premature Ovarian Insufficiency (POI): A Personal Narrative. 解决卵巢功能不全(POI)的情感,社会和伦理方面:个人叙述。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_332_24
Hiya Boro
{"title":"Addressing the Emotional, Social and Ethical Aspects of Premature Ovarian Insufficiency (POI): A Personal Narrative.","authors":"Hiya Boro","doi":"10.4103/ijem.ijem_332_24","DOIUrl":"10.4103/ijem.ijem_332_24","url":null,"abstract":"<p><p>Premature Ovarian Insufficiency (POI) poses complex medical, emotional and ethical challenges, especially in conservative societies like India. This narrative highlights an endocrinologist's experience in managing a young woman with POI, emphasizing the profound emotional distress and societal implications, particularly regarding subfertility and an impending marriage. The case explores the nuanced approach required to deliver this life-altering diagnosis with empathy, address the patient's and family's emotional needs, and offer psychological support alongside fertility options and hormone replacement therapy. Ethical considerations, including patient autonomy, confidentiality, and the delicate decision of disclosing the diagnosis to a prospective groom, are also examined. The narrative underscores the importance of cultural sensitivity and the endocrinologist's role in mitigating societal stigma. It illustrates the broader responsibilities of healthcare providers, who must navigate these multifaceted challenges with compassion, providing medical care and emotional and ethical guidance to help patients and their families cope with the impact of POI.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"168-169"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Complications Post Parathyroidectomy: A Systematic Review. 甲状旁腺切除术后心脏并发症:系统回顾。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_312_24
Arun K R Pande, Ashish Jhaa, Navneet Tripathi, Arvind Kanchan
{"title":"Cardiac Complications Post Parathyroidectomy: A Systematic Review.","authors":"Arun K R Pande, Ashish Jhaa, Navneet Tripathi, Arvind Kanchan","doi":"10.4103/ijem.ijem_312_24","DOIUrl":"10.4103/ijem.ijem_312_24","url":null,"abstract":"<p><p>Parathyroidectomy (PTX) treats hyperparathyroidism, but it can lead to significant cardiac complications. This systematic review analyses the incidence, types, risk factors, pathophysiological mechanisms, and management strategies of cardiac complications following PTX. Following PRISMA guidelines, a systematic search of PubMed and Europe PMC up to May 2024 included 62 studies. Cardiac complications identified included early and delayed reversible cardiac failure, tachyarrhythmias (such as atrial fibrillation and ventricular tachyarrhythmia), chest pain, myocardial infarction mimic, hypotension, and other two rare complications. Rapid calcium level changes and thyrotoxicosis post-surgery were the significant contributors to the complications. Vigilant monitoring and management are essential for favourable outcomes post-PTX. Comprehensive preoperative evaluation, meticulous intraoperative monitoring, and tailored postoperative care are crucial. Further research is needed to refine management protocols and improve patient safety.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"142-152"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Reconstitution Inflammatory Syndrome Following Remission of Cushing's Syndrome and Review of Literature. 库欣综合征缓解后的免疫重建炎性综合征及文献回顾。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_291_24
Mintu M Baruah, Umanath Adhikari, Trupti Prasad, Biona D Konsam, Liza Das, Aman Sharma, Sanjay K Bhadada, Rama Walia
{"title":"Immune Reconstitution Inflammatory Syndrome Following Remission of Cushing's Syndrome and Review of Literature.","authors":"Mintu M Baruah, Umanath Adhikari, Trupti Prasad, Biona D Konsam, Liza Das, Aman Sharma, Sanjay K Bhadada, Rama Walia","doi":"10.4103/ijem.ijem_291_24","DOIUrl":"10.4103/ijem.ijem_291_24","url":null,"abstract":"<p><p>The current study aims to report cases of immune reconstitution inflammatory syndrome (IRIS) following Cushing's syndrome (CS) treatment and elucidate various presentations of IRIS and its management. A single-centre study was conducted in individuals with endogenous CS who presented with immune reconstitution inflammatory syndrome after CS remission. A literature review was also conducted to describe the previous reporting of IRIS. Nine cases from the author's centre were identified. Out of 9 cases, one case was ectopic CS, who presented with CNS vasculitis following excision of the primary lesion. Other 8 cases were Cushing's disease (CD) presented with diverse IRIS manifestations in the form of thyroiditis, oculomotor neuritis, extraocular muscle palsy, episcleritis, bell's palsy, rheumatoid arthritis (RA) and Charcot neuroarthropathy, with the time of presentation from less than 1 month till 24 months. The most common IRIS described in the literature is thyroid dysfunction, and the time of presentation of IRIS is variable from less than one month to 5 years. Immune reconstitution inflammatory syndrome is a unique and rare post-operative complication after CS remission, affecting various organ systems due to rebound immunity.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"153-159"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balanodynia.
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_531_24
Sanjay Kalra, Atul Dhingra, Nitin Kapoor
{"title":"Balanodynia.","authors":"Sanjay Kalra, Atul Dhingra, Nitin Kapoor","doi":"10.4103/ijem.ijem_531_24","DOIUrl":"10.4103/ijem.ijem_531_24","url":null,"abstract":"","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Realisation of Remission of Diabetes Using Pharmacotherapy (DiaRem-1). 利用药物治疗实现糖尿病缓解(DiaRem-1)。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_356_24
Anand Sudhayakumar, Durairaj Arjunan, Shobhit Bhansali, Harish Bhujade, Sanjay K Bhadada, Sunita Malhotra, Rama Walia
{"title":"Realisation of Remission of Diabetes Using Pharmacotherapy (DiaRem-1).","authors":"Anand Sudhayakumar, Durairaj Arjunan, Shobhit Bhansali, Harish Bhujade, Sanjay K Bhadada, Sunita Malhotra, Rama Walia","doi":"10.4103/ijem.ijem_356_24","DOIUrl":"10.4103/ijem.ijem_356_24","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes mellitus has traditionally been considered a lifelong disease, with treatment focused on glycaemic control and complication prevention. Emerging evidence suggests that targeting glucolipotoxicity and insulin resistance may restore beta-cell function, potentially leading to remission. This study aimed to evaluate the feasibility of achieving diabetes remission through pharmacotherapy by promoting weight loss and maintaining strict glycaemic control over a 3-month period.</p><p><strong>Methods: </strong>This is a single-centre, open-label, randomised controlled trial conducted at a tertiary care center in India, with adult subjects with type 2 diabetes mellitus <5 years duration and HbA1c <8.5% randomised to an intervention arm using liraglutide, dapagliflozin and metformin, and a control arm using vildagliptin, glimepiride and metformin. The subjects were treated for 3 months followed by an off-treatment period for 3 months to assess for remission of diabetes.</p><p><strong>Results: </strong>Two hundred thirty-six subjects were assessed for eligibility and 29 subjects underwent randomisation. Fourteen subjects were randomised to the intervention arm and 15 subjects were randomised to the control arm. Twenty-three of the 29 recruited subjects completed the trial. At the end of the off-treatment period, nine patients (31.04%) were in remission, with 4 out of 14 patients (28.57%) in the intervention arm and 5 out of 15 patients (33.33%) in the control arm maintaining HbA1c less than 6.5% without any treatment. No baseline clinical or biochemical parameters were found to be reliable predictors of remission.</p><p><strong>Conclusion: </strong>This trial provides evidence that pharmacotherapy targeting tight glycaemic control on an outpatient basis is effective in achieving diabetes remission.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"217-223"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic and Genotypic Spectrum of Indian Patients with Hypophosphatasia. 印度低磷血症患者的表型和基因型谱。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_378_24
Melkunte S Dhananjaya, S Thrupti, Hamsa V Reddy, Anusha Nadig, Kenchappa S Adarsh, Swati Jadhav, Parvathy Lalitha, Sandhya Nair, Shaila Bhattacharyya, Anurag Lila, Vijaya Sarathi
{"title":"Phenotypic and Genotypic Spectrum of Indian Patients with Hypophosphatasia.","authors":"Melkunte S Dhananjaya, S Thrupti, Hamsa V Reddy, Anusha Nadig, Kenchappa S Adarsh, Swati Jadhav, Parvathy Lalitha, Sandhya Nair, Shaila Bhattacharyya, Anurag Lila, Vijaya Sarathi","doi":"10.4103/ijem.ijem_378_24","DOIUrl":"10.4103/ijem.ijem_378_24","url":null,"abstract":"<p><strong>Introduction: </strong>Hypophosphatasia (HPP) is a rare disorder, with only two genetically proven cases reported from India. Here, We report five Indian patients with genetically proven hypophosphatasia and describe their clinical, biochemical, and genetic profiles.</p><p><strong>Methods: </strong>The study included patients with genetically proven hypophosphatasia managed at different healthcare centers in South India. The participants' case records were reviewed, and relevant phenotypic and genotypic information was collected and analyzed.</p><p><strong>Results: </strong>Case 1 presented at 4 months of age for failure to thrive, found to have persistent hypercalcemia for which she received bisphosphonate therapy. A low alkaline phosphatase was recognized later. Case 2 presented during adolescence with bilateral genu valgus and delayed dentition with classical tongue-like translucencies on radiology and low alkaline phosphatase. Genetic evaluation in cases 1 and 2 revealed compound heterozygous variants in the <i>ALPL</i> gene. Case 1 received asfotase alfa with remarkable improvement in growth. Case 3 presented with multiple vertebral fractures at 33 years of age whereas cases 4 (42 years) and 5 (63 years) presented with musculoskeletal pains with delayed diagnosis for 8 and 13 years, respectively. Cases 3-5 had heterozygous variants in the <i>ALPL</i> gene.</p><p><strong>Conclusions: </strong>In the largest case series of hypophosphatasia from India, we report five cases of hypophosphatasia with two novel variants. Our study emphasizes the need to increase awareness regarding the disease to improve its early diagnosis and also, the need to form strategies to reduce the challenges in obtaining enzyme replacement therapy for hypophosphatasia in India.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"188-194"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining Liver Fibrosis Risk Assessment in Indians with Type 2 Diabetes: New FIB-4 Score Cutoff for Optimizing Sequential Assessment with Transient Elastography. 重新定义印度2型糖尿病患者肝纤维化风险评估:新的FIB-4评分临界值用于优化瞬时弹性成像的序贯评估。
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_457_24
Rajat Deb, Soumik Goswami, Nilanjan Sengupta, Arjun Baidya, Vibhu R Khare, Joydip Datta, Mousumi Das, Debes Ray
{"title":"Redefining Liver Fibrosis Risk Assessment in Indians with Type 2 Diabetes: New FIB-4 Score Cutoff for Optimizing Sequential Assessment with Transient Elastography.","authors":"Rajat Deb, Soumik Goswami, Nilanjan Sengupta, Arjun Baidya, Vibhu R Khare, Joydip Datta, Mousumi Das, Debes Ray","doi":"10.4103/ijem.ijem_457_24","DOIUrl":"10.4103/ijem.ijem_457_24","url":null,"abstract":"<p><strong>Introduction: </strong>Liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly related to hepatic and extrahepatic outcomes. Clinically Significant Liver Fibrosis (CSLF) screening using FIB-4 score is mandated in all T2D patients. The existing FIB-4 cutoff of 1.3 is derived from Western studies and could differ for Indians. Hence, we aimed to determine the FIB-4 cutoff to rule out Transient Elastography (TE) proven CSLF among Indians with T2D.</p><p><strong>Methods: </strong>551 individuals with T2D underwent laboratory tests for FIB-4 calculation and transient elastography (TE) to detect CSLF defined as Liver Stiffness Measurement (LSM) ≥ 8kPa. The Receiver Operative Characteristic (ROC) curve was used to determine the optimum cutoff value of FIB4 to rule out CSLF.</p><p><strong>Results: </strong>129 (23.4%) of 551 T2D patients in our cohort had CSLF. We found that a FIB-4 of 1.5 rules out CSLF with a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Diagnostic Accuracy (DA) of 82.9%, 79.9%, 55.7%, 93.8%, and 80.6%, respectively, compared with a FIB4 of 1.3 which has values of 91.5%, 67.3%, 46.1%, 96.2%, and 72.9%, respectively.</p><p><strong>Conclusion: </strong>A FIB-4 cutoff of 1.5 rather than 1.3 is suggested for Indian subjects with T2DM and needs to be validated in further large multicenter prospective studies, preferably with histopathology as the gold standard.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"237-241"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occurrence and Predictors of Diabetes Distress in Adult Patients with Type 2 Diabetes from North India. 印度北部成年2型糖尿病患者糖尿病窘迫的发生及预测因素
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_170_24
Joshita Gupta, Deepak Khandelwal, Lovely Gupta, Deep Dutta, Suresh Mittal, Ritesh Khandelwal, Sachin Chittawar
{"title":"Occurrence and Predictors of Diabetes Distress in Adult Patients with Type 2 Diabetes from North India.","authors":"Joshita Gupta, Deepak Khandelwal, Lovely Gupta, Deep Dutta, Suresh Mittal, Ritesh Khandelwal, Sachin Chittawar","doi":"10.4103/ijem.ijem_170_24","DOIUrl":"10.4103/ijem.ijem_170_24","url":null,"abstract":"<p><strong>Introduction: </strong>There is limited data regarding the prevalence and predictors of diabetes distress in Indians with type 2 diabetes (T2D). The study aimed to determine the occurrence and predictors of diabetes distress in adult persons with T2D.</p><p><strong>Methods: </strong>In a cross-sectional study, persons with T2D on pharmacotherapy for at least 1 year were evaluated. They were administered three questionnaires namely- Diabetes Distress Scale-17, Patient Health Questionnaire-9, and Morisky Medication Adherence Scale-8. Clinically meaningful data regarding diabetes complications, anthropometry, and biochemical parameters were recorded.</p><p><strong>Results: </strong>Two hundred persons completed the study (mean age 57 ± 9.89 years, 59% males). Overall 140 (70%) of the patients had diabetes distress (mean DDS score ≥2). Clinically significant diabetes distress (CSDD) that requires a physician's attention (mean DDS score ≥3) was seen in 75 (37.50%) of the study participants. The mean HbA1c was significantly higher in participants with CSDD (10.24 ± 2.01 vs. 7.85 ± 1.14; <i>P</i> = <0.001). Both microvascular [retinopathy (28% vs. 5.60%; <i>P</i> ≤ 0.001), neuropathy (28% vs. 0%; <i>P</i> ≤ 0.001), nephropathy (32% vs. 6.40%; <i>P</i> ≤ 0.001)] and macrovascular (CAD 24% vs. 4.80%; <i>P</i> ≤ 0.001) and (CVA 6.67% vs. 1.60%; <i>P</i> = 0.059) complications were significantly correlated with CSDD. Medication adherence was significantly lower in patients with CSDD (p=<0.001). An increased number of insulin injections increased BMI and HbA1c, and the presence of nephropathy were independent predictors of CSDD.</p><p><strong>Conclusion: </strong>Diabetes distress is a common co-morbid condition in persons with T2D. CSDD had a significant correlation with poor glycaemic control, higher BMI, presence of nephropathy, and higher number of insulin injections.</p>","PeriodicalId":13353,"journal":{"name":"Indian Journal of Endocrinology and Metabolism","volume":"29 2","pages":"202-208"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Diabetes and Pre-Diabetes among Adults in the Western Province of Sri Lanka. 斯里兰卡西部省成人糖尿病和糖尿病前期患病率
Indian Journal of Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.4103/ijem.ijem_383_24
Prasad Katulanda, Desha R Fernando, Upul Senarath, Sembakutti Samita, Gaya W Katulanda, Vithanage P Wickramasinghe, Eranga Wijewickrama
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