Snehal Lunge, Anshu Baghel, Vaibhav B Patil, Vidyadhar R Sardesai
{"title":"Unmasking the Hidden Risk: Urticaria and Angioedema with Direct Oral Anticoagulants.","authors":"Snehal Lunge, Anshu Baghel, Vaibhav B Patil, Vidyadhar R Sardesai","doi":"10.4103/idoj.idoj_1280_25","DOIUrl":"10.4103/idoj.idoj_1280_25","url":null,"abstract":"<p><strong>Abstract: </strong>Direct oral anticoagulants (DOACs), such as rivaroxaban and dabigatran, are widely used for thromboembolic conditions. While bleeding is the most well-recognized adverse effect, rare cutaneous hypersensitivity reactions, such as urticaria and angioedema, are increasingly reported. We describe a case series of nine patients who developed cutaneous hypersensitivity reactions to DOACs. All patients developed symptoms within 1-10 days of DOAC initiation. Rivaroxaban was associated with angioedema and urticaria, whereas dabigatran was limited to urticaria. All reactions resolved after drug discontinuation and symptomatic treatment. Dermatologic adverse effects of DOACs, although uncommon, warrant heightened clinical suspicion. A limitation of this study is the small sample size and absence of rechallenge confirmation of hypersensitivity. Management should be individualized. Increased awareness among dermatologists and physicians is crucial for timely management and pharmacovigilance.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"693-695"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Sneha, Seema Jain, Deepika Pandhi, Shukla Das, Sumita Halder
{"title":"Comparative Efficacy of Terbinafine, Itraconazole, and Griseofulvin in Treatment of Steroid-Modified Tinea.","authors":"K Sneha, Seema Jain, Deepika Pandhi, Shukla Das, Sumita Halder","doi":"10.4103/idoj.idoj_1126_25","DOIUrl":"10.4103/idoj.idoj_1126_25","url":null,"abstract":"<p><strong>Background: </strong>Steroid-modified tinea or tinea incognito has emerged as a significant challenge in India due to the widespread misuse of topical corticosteroids, leading to chronic, treatment-resistant dermatophytosis.</p><p><strong>Aim and objectives: </strong>This study was performed to compare the efficacy and safety of antifungal drugs: oral terbinafine, itraconazole, and griseofulvin in the treatment of steroid-modified tinea. In addition, patient awareness about steroid misuse and consequent impact on quality of life were also assessed.</p><p><strong>Patients and methods: </strong>A total of 90 potassium hydroxide (KOH)-positive patients ( ≥18 years) with tinea corporis, cruris, or faciei, having a history of prior topical steroid use, were randomly assigned to receive terbinafine (250 mg twice a day), itraconazole (100 mg twice a day), or griseofulvin (500 mg twice a day) for eight weeks ( n = 30 each). Clinical severity scores, cure rates, dermatology life quality index (DLQI) scores, steroid misuse patterns, and any adverse drug reactions reported were recorded for each patient.</p><p><strong>Results: </strong>The group treated with itraconazole showed highest cure rate (70%) at eight weeks, followed by terbinafine (36.7%) and griseofulvin (26.7%) ( P = 0.529). Clinical severity scores reduced significantly in all three groups by the end of eight weeks (within-group comparison P = 0.001). DLQI scores improved most with itraconazole ( P = 0.003). Regarding a prior history of steroid use in the study population, the misuse of clobetasol propionate was seen in 46.7-76.7%, with 90-100% of patients being unaware of steroid content or its side effects.</p><p><strong>Limitations: </strong>Limited sample size may have limited statistical ability to detect significant cure rates. Despite intention-to-treat analysis, loss of follow-up may introduce bias. Baseline differences in gender and comorbidities among the study groups may have confounded the observed outcomes. Additionally, the lack of blinding may have influenced outcome assessment.</p><p><strong>Conclusion: </strong>Itraconazole appears to be the most effective for steroid-modified tinea, with superior clinical and quality-of-life outcomes. Steroid misuse, driven by pharmacist recommendations, underscores the need for public health interventions.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"675-682"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148827913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Ultrasonography in the Diagnosis and Treatment of Hidradenitis Suppurativa: A Narrative Review.","authors":"Apoorva Sharma, Hridya Karakkattil, Anindita Sinha, Nikita Verma, Sunil Dogra","doi":"10.4103/idoj.idoj_716_25","DOIUrl":"10.4103/idoj.idoj_716_25","url":null,"abstract":"<p><strong>Abstract: </strong>Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disorder that predominantly affects the axillae, anogenital, and inguinal regions in the form of recurrent painful, suppurative abscesses, nodules, and fistulae. The major challenge in the management of HS lies not only in the difficulty of early diagnosis but also in the initial treatment decisions, which heavily rely on the stage of the disease. Multiple studies in the literature have concluded that clinical examination significantly underestimates the severity of HS, thus impacting treatment choices and the course of the disease. Ultrasonography (USG) is becoming a valuable aid in assessing disease extent and guiding treatment decisions in HS. For this review, the PubMed database was searched using 'USG,' 'ultrasound,' 'ultrasonography,' and 'hidradenitis suppurativa' as the keywords in the title with no date limits. The utility of USG in HS reported in the literature was evaluated by reviewing each abstract. The current review emphasizes the emerging usefulness of USG in HS, both in the diagnosis and treatment of disease.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"17 5","pages":"639-647"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}