{"title":"An Elderly Man with Epitheloid Angiosarcoma Presenting as Multiple Scalp Swellings.","authors":"Greeshma V Shetty, P N Girish, I Sandhya","doi":"10.4103/idoj.idoj_455_24","DOIUrl":"10.4103/idoj.idoj_455_24","url":null,"abstract":"","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"869-871"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thiamidol in Melasma in Patients of Skin of Color: A Preliminary Report of Efficacy and Safety.","authors":"Rashmi Sarkar, Anjali Sahu, Vibhu Mendiratta, Sonali Langar","doi":"10.4103/idoj.idoj_1170_24","DOIUrl":"10.4103/idoj.idoj_1170_24","url":null,"abstract":"<p><strong>Background: </strong>Melasma poses significant therapeutic challenges, especially in patients with skin of color, due to the increased risk of post-inflammatory hyperpigmentation. Thiamidol, a novel topical tyrosinase inhibitor, has demonstrated potential efficacy with a favorable safety profile in treating hyperpigmentation disorders.</p><p><strong>Objective: </strong>This case series evaluates the efficacy and safety of Thiamidol in women of skin of color with melasma.</p><p><strong>Patients and methods: </strong>Ten Indian women with Fitzpatrick skin types III-V and melasma applied 0.2% Thiamidol twice daily for 12 weeks. Outcomes were measured using the modified Melasma Area and Severity Index (mMASI) and patient satisfaction scores.</p><p><strong>Results: </strong>The average reduction in mMASI was 34.4%, with patient satisfaction averaging 62%. Reported adverse effects were minimal and self-limiting.</p><p><strong>Limitations: </strong>A small sample size and the lack of a control group limit generalizability of the results. Future research should explore thiamidol's efficacy in combination therapies and assess its long-term benefits.</p><p><strong>Conclusion: </strong>Thiamidol is a promising and well-tolerated treatment for melasma in patients with skin of color.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":"16 5","pages":"760-764"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermoscopy and Ultraviolet Reflectance Dermoscopy of Benign Lichenoid Keratosis Masquerading as Melanoma.","authors":"Aravind Baskar Murthy, Kallepu Rishika Sagar, Varshini Neelathalli Ramchandraiah, Murali Narasimhan","doi":"10.4103/idoj.idoj_1087_24","DOIUrl":"10.4103/idoj.idoj_1087_24","url":null,"abstract":"<p><strong>Abstract: </strong>Benign lichenoid keratosis (BLK), also known as lichen planus-like keratosis, is a benign cutaneous lesion of unknown etiology with overlapping clinical and dermoscopic features with malignant lesions. A 52-year-old female presented with a 10- years history of a single asymptomatic lesion on the left gluteal region not associated with loss of weight, loss of appetite, or other systemic symptoms. Clinical examination revealed a single well-defined violaceous to hyperpigmented plaque of approximately 4 cm × 3 cm in size, on the lateral aspect of the left gluteal region. Dermoscopic examination showed overlapping features of BLK and melanoma. Ultraviolet (UV)dermoscopy showed 'dermoscopic UV blink sign' and areas of blue, yellowish-green, and red fluorescence. Histopathological examination showed features suggestive of BLK with no cellular atypia. The patient was started on 5% imiquimod cream 5 days a week and advised to follow up. This case emphasizes the importance of clinical, dermoscopic, UV reflectance dermoscopic, and histopathological correlation in establishing the diagnosis of BLK masquerading as melanoma with regression, thus aiding in the avoidance of unnecessary surgeries.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"778-781"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inderpreet Kaur, Abhilasha Williams, M Joseph John, Emy Elzy Alexander
{"title":"Mucocutaneous Manifestations of Leukemias and Lymphomas: A Clinical Study from a Tertiary Care Center in North India.","authors":"Inderpreet Kaur, Abhilasha Williams, M Joseph John, Emy Elzy Alexander","doi":"10.4103/idoj.idoj_962_24","DOIUrl":"10.4103/idoj.idoj_962_24","url":null,"abstract":"<p><strong>Background: </strong>Mucocutaneous manifestations are common in hematological malignancies, but are generally misinterpreted. About two-thirds of the patients with hematological malignancies have mucocutaneous manifestations. Specific manifestations include leukemia cutis, leukemic vasculitis, and mucosal hyperplasia. Non-specific manifestations include reactive dermatoses, infective dermatoses, and miscellaneous manifestations. Mucocutaneous manifestations help in depicting the course and prognosis of hematological malignancies.</p><p><strong>Aim and objectives: </strong>To determine the frequency and pattern of mucocutaneous manifestations in patients with leukemia and lymphoma, and to determine the degree of correlation between various mucocutaneous manifestations and the types of leukemias and lymphomas.</p><p><strong>Patients and methods: </strong>This cross-sectional study was conducted in hematology and dermatology outpatient and inpatient departments in a tertiary care center in North India for 18 months. The study included 177 newly diagnosed leukemia and lymphoma patients who had not undergone chemotherapy.</p><p><strong>Results: </strong>Mucocutaneous manifestations were noted in 87.57% of patients, with specific manifestations in 5.08% (gingival hyperplasia = 3.39%, leukemic vasculitis = 1.13%, leukemia cutis = 0.56%) and non-specific manifestations in 87.01% (reactive dermatoses = 4.52%, infective dermatoses = 30.5%, miscellaneous = 76.27%). Acute myeloid leukemia (AML) showed the highest frequency (96.88%) of mucocutaneous involvement. AML was significantly associated with pallor ( P value <0.001), thrombocytopenic purpura ( P value <0.001), xerosis ( P value = 0.023), and bacterial infections ( P value = 0.028).</p><p><strong>Limitations: </strong>A small sample size and a cross-sectional design, that precluded the correlation between course of muco- cutaneous manifestations and disease progression.</p><p><strong>Conclusion: </strong>Mucocutaneous manifestations are common in acute leukemias, particularly myeloid lineage, due to bone-marrow suppression, immune dysregulation, and cutaneous spread. B-cell neoplasms show a higher propensity for skin involvement and paraneoplastic phenomena due to their aggressive nature compared to T-cell neoplasms.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"743-750"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plectin ( PLEC )-Related Intermediate Epidermolysis Bullosa Simplex without Extracutaneous Involvement with Response to Dapsone.","authors":"Anisha Biswal, Bikash Ranjan Kar, Rahul Mahajan, Liza Mohapatra, Anoop Kumar","doi":"10.4103/idoj.idoj_1064_24","DOIUrl":"10.4103/idoj.idoj_1064_24","url":null,"abstract":"<p><strong>Abstract: </strong>Plectinopathies, the spectrum of diseases caused by plectin gene ( PLEC ) mutations, have a wide range of manifestations, mostly extracutaneous, like pyloric atresia, muscular dystrophy, and cardiomyopathy, along with cutaneous tense blistering. Differently spliced exons give rise to various isoforms, which have definitive functions in different cell types and tissues. We report a case of a 14-year-old girl presenting with features of tense pruritic vesicles and bullae on extremities and trunk since childhood. She was diagnosed with intermediate epidermolysis bullosa simplex, having nonsense PLEC mutation at exon 1. The uniqueness of the case is the absence of extracutaneous manifestations and her dramatic response to dapsone.</p>","PeriodicalId":13335,"journal":{"name":"Indian Dermatology Online Journal","volume":" ","pages":"782-784"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}