Immune Network最新文献_第8页

Aromatic Amino Acid Metabolites: Molecular Messengers Bridging Immune-Microbiota Communication. 芳香氨基酸代谢物：连接免疫-微生物群通讯的分子信使。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-14 eCollection Date: 2025-02-01 DOI: 10.4110/in.2025.25.e10

Hyun-Ki Shin, Ye-Ji Bang

{"title":"Aromatic Amino Acid Metabolites: Molecular Messengers Bridging Immune-Microbiota Communication.","authors":"Hyun-Ki Shin, Ye-Ji Bang","doi":"10.4110/in.2025.25.e10","DOIUrl":"10.4110/in.2025.25.e10","url":null,"abstract":"Aromatic amino acid (AAA) metabolites, derived from tryptophan, phenylalanine, and tyrosine through coordinated host and microbial metabolism, have emerged as critical modulators of immune function. We examine the complex journey of AAAs from dietary intake through intestinal absorption and metabolic transformation, highlighting the crucial role of host-microbe metabolic networks in generating diverse immunomodulatory compounds. This review provides a unique integrative perspective by mapping the molecular mechanisms through which these metabolites orchestrate immune responses. Through detailed analysis of metabolite-receptor and metabolite-transporter interactions, we reveal how specific molecular recognition drives cell type-specific immune responses. Our comprehensive examination of signaling networks-from membrane receptor engagement to nuclear receptor activation to post-translational modifications- demonstrates how the same metabolite can elicit distinct functional outcomes in different immune cell populations. The context-dependent nature of these molecular interactions presents both challenges and opportunities for therapeutic development, particularly in inflammatory conditions where metabolite signaling pathways are dysregulated. Understanding the complexity of these regulatory networks and remaining knowledge gaps is fundamental for advancing metabolite-based therapeutic strategies in immune-mediated disorders.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 1","pages":"e10"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling. 干扰素驱动的代谢重编程和肿瘤微环境重塑。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-12 eCollection Date: 2025-02-01 DOI: 10.4110/in.2025.25.e8

Tzu-Hsuan Chang, Ping-Chih Ho

引用次数: 0

Molecular Biology and Functions of T Follicular Helper Cells in Cancer and Immunotherapy. T滤泡辅助细胞在肿瘤和免疫治疗中的分子生物学和功能。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-11 eCollection Date: 2025-04-01 DOI: 10.4110/in.2025.25.e7

Mengyuan Xin, Antuo Wang, Minghao Ji, Jingru Wu, Bin Jiang, Mo Shi, Liang Song, Zhongwei Xin

引用次数: 0

Regulation of Ferroptosis in Cancer and Immune Cells. 铁下垂在肿瘤和免疫细胞中的调控作用。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-11 eCollection Date: 2025-02-01 DOI: 10.4110/in.2025.25.e6

Naeyoon Jang, Il-Kyu Kim, Dawoon Jung, Yeonseok Chung, Yun Pyo Kang

引用次数: 0

Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3. 抗几丁质酶-3样1抗体通过抑制MMP3抗关节炎的作用。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-07 eCollection Date: 2025-04-01 DOI: 10.4110/in.2025.25.e5

Dae Hwan Kim, Ji Eun Yu, Dong Hun Lee, Min Ji Kim, Seong Hee Jeon, Jaesuk Yun, Dong Ju Son, Bongcheol Kim, Yoon Ji Yong, Young-Soo Lim, Tae Hun Kim, Azizi Mohammad Khalid, Sang-Bae Han, Yong Sun Lee, Jin Tae Hong

{"title":"Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3.","authors":"Dae Hwan Kim, Ji Eun Yu, Dong Hun Lee, Min Ji Kim, Seong Hee Jeon, Jaesuk Yun, Dong Ju Son, Bongcheol Kim, Yoon Ji Yong, Young-Soo Lim, Tae Hun Kim, Azizi Mohammad Khalid, Sang-Bae Han, Yong Sun Lee, Jin Tae Hong","doi":"10.4110/in.2025.25.e5","DOIUrl":"https://doi.org/10.4110/in.2025.25.e5","url":null,"abstract":"Chitinase-3-like 1 (CHI3L1) is a key factor in regulating inflammatory processes and development of rheumatoid arthritis (RA) since is highly produced by synoviocytes and macrophages in the development RA. Collagen-induced arthritis (CIA) model is the most widely used because its pathogenesis is similar to human RA. Thus, we aimed to investigate if anti-CHI3L1 antibody could reduce RA development in the CIA model. To induce CIA, DBA1/J mice were immunized with a type II bovine collagen emulsion in complete Freund's adjuvant, and boosted type II bovine collagen. THP-1 and MH7A cells were used for pro-inflammation responses. Anti-CHI3L1 Ab treatment reduced the RA clinical score and paw thickness of mice. Inflammation-induced matrix metalloproteinase 3 (MMP3) expression was reduced by inhibiting CHI3L1, and MMP3 knockdown suppressed the expression of RA-related inflammatory cytokines in LPS-treated THP-1 and MH7A cells. Our findings suggest that anti-CHI3L1 Ab showed significant anti-arthritic effects by inhibiting MMP3 expression.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 2","pages":"e5"},"PeriodicalIF":4.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease. 先天淋巴样细胞组织特异性代谢重编程及其对疾病的影响。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-07 eCollection Date: 2025-02-01 DOI: 10.4110/in.2025.25.e3

Jongho Ham, Wooseok Yang, Hye Young Kim

{"title":"Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease.","authors":"Jongho Ham, Wooseok Yang, Hye Young Kim","doi":"10.4110/in.2025.25.e3","DOIUrl":"10.4110/in.2025.25.e3","url":null,"abstract":"Recent advances have highlighted the crucial role of metabolic reprogramming in shaping the functions of innate lymphoid cells (ILCs), which are vital for tissue immunity and homeostasis. As tissue-resident cells, ILCs dynamically respond to local environmental cues, with tissue-derived metabolites such as short-chain fatty acids and amino acids directly modulating their effector functions. The metabolic states of ILC subsets-ILC1, ILC2, and ILC3-are closely linked to their ability to produce cytokines, sustain survival, and drive proliferation. This review provides a comprehensive analysis of how key metabolic pathways, including glycolysis, oxidative phosphorylation, and fatty acid oxidation, influence ILC activation and function. Furthermore, we explore the complex interactions between these metabolic pathways and tissue-specific metabolites, which can shape ILC-mediated immune responses in health and disease. Understanding these interactions reveals new insights into the pathogenesis of conditions such as asthma, inflammatory bowel disease, and cancer. A deeper understanding of these mechanisms may not only advance our knowledge of disease pathogenesis but also lead to the development of novel therapeutic strategies targeting metabolic pathways in ILCs to treat tissue-specific immune disorders.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 1","pages":"e3"},"PeriodicalIF":4.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4⁺ T Cells. 轻度COVID-19患者表现出低功能的SARS-CoV-2膜蛋白反应性CD4+ T细胞。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-07 eCollection Date: 2025-04-01 DOI: 10.4110/in.2025.25.e4

A-Reum Kim, June-Young Koh, Min-Seok Rha, Jae Hyung Jung, Jae-Hoon Ko, Hee Kyoung Choi, Ji Hoon Jeon, Hyeri Seok, Dae Won Park, Kyong Ran Peck, Jun Yong Choi, Su-Hyung Park, Won Suk Choi, Hye Won Jeong, Eui-Cheol Shin

{"title":"Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4+ T Cells.","authors":"A-Reum Kim, June-Young Koh, Min-Seok Rha, Jae Hyung Jung, Jae-Hoon Ko, Hee Kyoung Choi, Ji Hoon Jeon, Hyeri Seok, Dae Won Park, Kyong Ran Peck, Jun Yong Choi, Su-Hyung Park, Won Suk Choi, Hye Won Jeong, Eui-Cheol Shin","doi":"10.4110/in.2025.25.e4","DOIUrl":"https://doi.org/10.4110/in.2025.25.e4","url":null,"abstract":"Herein, we found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-unexposed individuals exhibited an increased frequency of CD4+ T cells against SARS-CoV-2 membrane (M) protein, suggesting that SARS-CoV-2 M-reactive cells may be primed by previous infection with common cold coronaviruses (CCCoVs). We confirmed that CCCoV M-reactive CD4+ T cells cross-recognize SARS-CoV-2 M in unexposed individuals. Among coronavirus disease 2019 (COVID-19) convalescents and unexposed individuals, SARS-CoV-2 M-reactive CD4+ T cells exhibited significantly lower functional avidity than CD4+ T cells reactive to other viruses. Importantly, convalescents from mild COVID-19 had SARS-CoV-2 M-reactive CD4+ T cells with significantly lower functional avidity than convalescents from severe COVID-19. The current data suggest that pre-existing CCCoV M-specific memory CD4+ T cells may contribute to controlling SARS-CoV-2 infection by cross-reactivity, leading to mild disease but leaving memory cells with low functional avidity to SARS-CoV-2 M due to incomplete homology. These data provide indirect evidence that pre-existing cross-reactive CD4+ T cells contribute to protection from severe COVID-19.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 2","pages":"e4"},"PeriodicalIF":4.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial Fluid as a Crucial Component of the Joint Microenvironment in Rheumatoid Arthritis. 滑液是类风湿关节炎关节微环境的重要组成部分。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-05 eCollection Date: 2025-04-01 DOI: 10.4110/in.2025.25.e2

Shukhrat Khudaiberdievich Ziyadullaev, Shavkat Shukhratovich Khudaiberdiev, Tamara Uktamovna Aripova, Salvatore Chirumbolo, Zaynitdin Saifitdinovich Kamalov, Geir Bjørklund, Jasur Alimdjanovich Rizaev, Eleonora Negmatovna Tashkenbaeva, Obid Abdurakhmanovich Khamidov, Usmon Bobonazarovich Gaffarov

{"title":"Synovial Fluid as a Crucial Component of the Joint Microenvironment in Rheumatoid Arthritis.","authors":"Shukhrat Khudaiberdievich Ziyadullaev, Shavkat Shukhratovich Khudaiberdiev, Tamara Uktamovna Aripova, Salvatore Chirumbolo, Zaynitdin Saifitdinovich Kamalov, Geir Bjørklund, Jasur Alimdjanovich Rizaev, Eleonora Negmatovna Tashkenbaeva, Obid Abdurakhmanovich Khamidov, Usmon Bobonazarovich Gaffarov","doi":"10.4110/in.2025.25.e2","DOIUrl":"https://doi.org/10.4110/in.2025.25.e2","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease closely associated with synovial tissue proliferation, pannus formation in small joints such as the hands, wrists, and feet, cartilage destruction, and systemic complications such as pulmonary, cardiovascular, neurological, and skeletal muscle lesions, glucocorticoid-induced osteoporosis and infections. The importance of confirming the diagnosis and determining local activity is given to the study of synovial fluid. A deep understanding of the pathological process in the joint in RA, characterized by changes in autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies, has now been achieved, although much remains to be explored. This article provides an updated overview of the pathogenesis of RA, revealing even more therapeutic targets for the intra-articular pathological process.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 2","pages":"e2"},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells. 芳烃受体在成体干细胞自我更新、分化和免疫调节中的作用。

IF 4.3 4区医学

Immune Network Pub Date : 2025-02-05 eCollection Date: 2025-04-01 DOI: 10.4110/in.2025.25.e1

Myeong-Seong Seo, Jiyeon Baek, Myung-Shin Jeon

{"title":"Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells.","authors":"Myeong-Seong Seo, Jiyeon Baek, Myung-Shin Jeon","doi":"10.4110/in.2025.25.e1","DOIUrl":"https://doi.org/10.4110/in.2025.25.e1","url":null,"abstract":"Adult stem cells are a rare population of undifferentiated cells present in almost all body tissues. Depending on their location, stem cells can differentiate into various tissue types, primarily contributing to maintenance, repair, and immune system regulation. Stem cell therapies have significant potential in regenerative medicine and treatment of inflammatory diseases. However, many factors must be considered for successful clinical commercialization, including enhancing therapeutic potential, ensuring product differentiation, and optimizing the manufacturing process for large-scale production. The development of sophisticated regulatory mechanisms may enhance therapeutic applications. The aryl hydrocarbon receptor (AhR) is expressed in all adult stem cells, and its activation and function are tightly regulated. Understanding the role and regulation of AhR is crucial for developing effective stem cell therapies. This review examines the role of the AhR in regulating the fundamental characteristics of adult stem cells, which may contribute to advancing adult stem cell therapies.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 2","pages":"e1"},"PeriodicalIF":4.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways. 鞘甲磷胆碱通过调控Smad3、STAT5和β-Catenin通路促进Th9细胞分化。

IF 4.3 4区医学

Immune Network Pub Date : 2024-12-26 eCollection Date: 2024-12-01 DOI: 10.4110/in.2024.24.e45

Ji Cheol Kim, Wonseok Hu, Mingyu Lee, Geon Ho Bae, Ji Ye Park, Suh Yeon Lee, Yu Sun Jeong, Byunghyun Park, Joon Seong Park, Brian A Zabel, Yong-Soo Bae, Yoe-Sik Bae

{"title":"Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways.","authors":"Ji Cheol Kim, Wonseok Hu, Mingyu Lee, Geon Ho Bae, Ji Ye Park, Suh Yeon Lee, Yu Sun Jeong, Byunghyun Park, Joon Seong Park, Brian A Zabel, Yong-Soo Bae, Yoe-Sik Bae","doi":"10.4110/in.2024.24.e45","DOIUrl":"10.4110/in.2024.24.e45","url":null,"abstract":"Sphingosylphosphorylcholine (SPC) is one of sphingomyelin-derived sphingolipids. SPC levels are increased in ascitic fluids of ovarian cancer patients and stratum corneum of atopic dermatitis (AD) patients. SPC has antitumor activity against several cancer cells by reducing proliferation and migration and increasing apoptosis in vitro. SPC can also cause scratching, potentially exacerbating symptoms of AD. However, the role of SPC in modulating immune responses, particularly in the differentiation of Th9 cells, which carry the most powerful antitumor activity among CD4+ T cells, has yet to be investigated. In this study, we found that SPC is another inducer of Th9 cell differentiation by replicating TGF-β. SPC upregulated Smad3, STAT5, and β-catenin signaling pathways. Increased Smad3 and STAT5 signaling pathways by SPC promoted the differentiation of Th9 cells and increased β-catenin signaling pathway resulted in a less-exhausted, memory-like phenotype of Th9 cells. Increased Smad3, STAT5 and β-catenin signaling pathways by SPC were mediated by increased mitochondrial ROS. These results suggest that SPC is an important endogenous inducer of Th9 cell differentiation and may be one of the targets for treating Th9-related diseases, and that enhancing Th9 differentiation by SPC may be helpful in adoptive T cell therapy for cancer treatment.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 6","pages":"e45"},"PeriodicalIF":4.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0