Immune Network最新文献_第2页

Germinal Center Response to mRNA Vaccination and Impact of Immunological Imprinting on Subsequent Vaccination. 生殖中心对 mRNA 疫苗接种的反应以及免疫印迹对后续疫苗接种的影响。

IF 4.3 4区医学

Immune Network Pub Date : 2024-06-25 eCollection Date: 2024-08-01 DOI: 10.4110/in.2024.24.e28

Wooseob Kim

{"title":"Germinal Center Response to mRNA Vaccination and Impact of Immunological Imprinting on Subsequent Vaccination.","authors":"Wooseob Kim","doi":"10.4110/in.2024.24.e28","DOIUrl":"10.4110/in.2024.24.e28","url":null,"abstract":"Vaccines are the most effective intervention currently available, offering protective immunity against targeted pathogens. The emergence of the coronavirus disease 2019 pandemic has prompted rapid development and deployment of lipid nanoparticle encapsulated, mRNA-based vaccines. While these vaccines have demonstrated remarkable immunogenicity, concerns persist regarding their ability to confer durable protective immunity to continuously evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. This review focuses on human B cell responses induced by SARS-CoV-2 mRNA vaccination, with particular emphasis on the crucial role of germinal center reactions in shaping enduring protective immunity. Additionally, we explored observations of immunological imprinting and dynamics of recalled pre-existing immunity following variants of concern-based booster vaccination. Insights from this review contribute to comprehensive understanding B cell responses to mRNA vaccination in humans, thereby refining vaccination strategies for optimal and sustained protection against evolving coronavirus variants.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 4","pages":"e28"},"PeriodicalIF":4.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells. 重组人 IL-32θ 可诱导人单核细胞极化为 M1 样巨噬细胞。

IF 4.3 4区医学

Immune Network Pub Date : 2024-06-24 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e27

Hyo-Min Park, Jae-Young Park, Na-Yeon Kim, Hyemoon Kim, Hong-Gyum Kim, Dong-Ju Son, Jin Tae Hong, Do-Young Yoon

{"title":"Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells.","authors":"Hyo-Min Park, Jae-Young Park, Na-Yeon Kim, Hyemoon Kim, Hong-Gyum Kim, Dong-Ju Son, Jin Tae Hong, Do-Young Yoon","doi":"10.4110/in.2024.24.e27","DOIUrl":"10.4110/in.2024.24.e27","url":null,"abstract":"The tumor microenvironment (TME) is formed by several immune cells. Notably, tumor-associated macrophages (TAMs) are existed in the TME that induce angiogenesis, metastasis, and proliferation of cancer cells. Recently, a point-mutated variant of IL-32θ was discovered in breast cancer tissues, which suppressed migration and proliferation through intracellular pathways. Although the relationship between cancer and IL-32 has been previously studied, the effects of IL-32θ on TAMs remain elusive. Recombinant human IL-32θ (rhIL-32θ) was generated using an Escherichia coli expression system. To induce M0 macrophage polarization, THP-1 cells were stimulated with PMA. After PMA treatment, the cells were cultured with IL-4 and IL-13, or rhIL-32θ. The mRNA level of M1 macrophage markers (IL-1β, TNFα, inducible nitric oxide synthase) were increased by rhIL-32θ in M0 macrophages. On the other hand, the M2 macrophage markers (CCL17, CCL22, TGFβ, CD206) were decreased by rhIL-32θ in M2 macrophages. rhIL-32θ induced nuclear translocation of the NF-κB via regulation of the MAPK (p38) pathway. In conclusion, point-mutated rhIL-32θ induced the polarization to M1-like macrophages through the MAPK (p38) and NF-κB (p65/p50) pathways.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 3","pages":"e27"},"PeriodicalIF":4.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management. 探索髓系衍生抑制细胞糖酵解调节在免疫疗法和疾病管理方面的潜力

IF 4.3 4区医学

Immune Network Pub Date : 2024-06-24 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e26

Jisu Kim, Jee Yeon Choi, Hyeyoung Min, Kwang Woo Hwang

{"title":"Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management.","authors":"Jisu Kim, Jee Yeon Choi, Hyeyoung Min, Kwang Woo Hwang","doi":"10.4110/in.2024.24.e26","DOIUrl":"10.4110/in.2024.24.e26","url":null,"abstract":"Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 3","pages":"e26"},"PeriodicalIF":4.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c⁺ B Cells Induced by TLR9 in Lupus. 线粒体活性和 CXCR4 协同促进红斑狼疮中由 TLR9 诱导的 CD11c+ B 细胞的分化

IF 4.3 4区医学

Immune Network Pub Date : 2024-06-19 eCollection Date: 2024-08-01 DOI: 10.4110/in.2024.24.e25

Sung Hoon Jang, Joo Sung Shim, Jieun Kim, Eun Gyeol Shin, Jong Hwi Yoon, Lucy Eunju Lee, Ho-Keun Kwon, Jason Jungsik Song

{"title":"Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c+ B Cells Induced by TLR9 in Lupus.","authors":"Sung Hoon Jang, Joo Sung Shim, Jieun Kim, Eun Gyeol Shin, Jong Hwi Yoon, Lucy Eunju Lee, Ho-Keun Kwon, Jason Jungsik Song","doi":"10.4110/in.2024.24.e25","DOIUrl":"10.4110/in.2024.24.e25","url":null,"abstract":"Lupus is characterized by the autoantibodies against nuclear Ags, underscoring the importance of identifying the B cell subsets driving autoimmunity. Our research focused on the mitochondrial activity and CXCR4 expression in CD11c+ B cells from lupus patients after ex vivo stimulation with a TLR9 agonist, CpG-oligodeoxyribonucleotide (ODN). We also evaluated the response of CD11c+ B cells in ODN-injected mice. Post-ex vivo ODN stimulation, we observed an increase in the proportion of CD11chi cells, with elevated mitochondrial activity and CXCR4 expression in CD11c+ B cells from lupus patients. In vivo experiments showed similar patterns, with TLR9 stimulation enhancing mitochondrial and CXCR4 activities in CD11chi B cells, leading to the generation of anti-dsDNA plasmablasts. The CXCR4 inhibitor AMD3100 and the mitochondrial complex I inhibitor IM156 significantly reduced the proportion of CD11c+ B cells and autoreactive plasmablasts. These results underscore the pivotal roles of mitochondria and CXCR4 in the production of autoreactive plasmablasts.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 4","pages":"e25"},"PeriodicalIF":4.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement C5a Receptor Signaling in Macrophages Enhances Trained Immunity Through mTOR Pathway Activation. 巨噬细胞中的补体 C5a 受体信号通过激活 mTOR 途径增强训练有素的免疫力

IF 4.3 4区医学

Immune Network Pub Date : 2024-06-05 eCollection Date: 2024-08-01 DOI: 10.4110/in.2024.24.e24

Eun-Hyeon Shim, Sae-Hae Kim, Doo-Jin Kim, Yong-Suk Jang

引用次数: 0

Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue. 炎症脂肪组织中的中性粒细胞迁移是由 VLA-6 介导的

IF 4.3 4区医学

Immune Network Pub Date : 2024-05-31 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e23

Hyunseo Lim, Young Ho Choe, Jaeho Lee, Gi Eun Kim, Jin Won Hyun, Young-Min Hyun

引用次数: 0

Erratum: Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin. 更正：K284-6111抑制几丁质酶-3-样-1可通过抑制乳铁蛋白减轻特应性皮肤炎症。

IF 4.3 4区医学

Immune Network Pub Date : 2024-05-29 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e22

Seong Hee Jeon, Yong Sun Lee, In Jun Yeo, Hee Pom Lee, Jaesuk Yoon, Dong Ju Son, Sang-Bae Han, Jin Tae Hong

引用次数: 0

IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance. 免疫细胞中的 IL-1 受体动力学：协调免疫精确性和平衡。

IF 4.3 4区医学

Immune Network Pub Date : 2024-05-29 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e21

Dong Hyun Kim, Won-Woo Lee

{"title":"IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance.","authors":"Dong Hyun Kim, Won-Woo Lee","doi":"10.4110/in.2024.24.e21","DOIUrl":"10.4110/in.2024.24.e21","url":null,"abstract":"IL-1, a pleiotropic cytokine with profound effects on various cell types, particularly immune cells, plays a pivotal role in immune responses. The proinflammatory nature of IL-1 necessitates stringent control mechanisms of IL-1-mediated signaling at multiple levels, encompassing transcriptional and translational regulation, precursor processing, as well as the involvement of a receptor accessory protein, a decoy receptor, and a receptor antagonist. In T-cell immunity, IL-1 signaling is crucial during both the priming and effector phases of immune reactions. The fine-tuning of IL-1 signaling hinges upon two distinct receptor types; the functional IL-1 receptor (IL-1R) 1 and the decoy IL-1R2, accompanied by ancillary molecules such as the IL-1R accessory protein (IL-1R3) and IL-1R antagonist. IL-1R1 signaling by IL-1β is critical for the differentiation, expansion, and survival of Th17 cells, essential for defense against extracellular bacteria or fungi, yet implicated in autoimmune disease pathogenesis. Recent investigations emphasize the physiological importance of IL-1R2 expression, particularly in its capacity to modulate IL-1-dependent responses within Tregs. The precise regulation of IL-1R signaling is indispensable for orchestrating appropriate immune responses, as unchecked IL-1 signaling has been implicated in inflammatory disorders, including Th17-mediated autoimmunity. This review provides a thorough exploration of the IL-1R signaling complex and its pivotal roles in immune regulation. Additionally, it highlights recent advancements elucidating the mechanisms governing the expression of IL-1R1 and IL-1R2, underscoring their contributions to fine-tuning IL-1 signaling. Finally, the review briefly touches upon therapeutic strategies targeting IL-1R signaling, with potential clinical applications.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 3","pages":"e21"},"PeriodicalIF":4.3,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis). 肺部疾病对神经系统健康的影响（肺-脑轴）。

IF 4.3 4区医学

Immune Network Pub Date : 2024-05-29 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e20

Hongryeol Park, Chan Hee Lee

引用次数: 0

Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines. 流感病毒衍生的 CD8 T 细胞表位：开发通用流感疫苗的意义。

IF 4.3 4区医学

Immune Network Pub Date : 2024-05-07 eCollection Date: 2024-06-01 DOI: 10.4110/in.2024.24.e19

Sang-Hyun Kim, Erica Españo, Bill Thaddeus Padasas, Ju-Ho Son, Jihee Oh, Richard J Webby, Young-Ran Lee, Chan-Su Park, Jeong-Ki Kim

{"title":"Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines.","authors":"Sang-Hyun Kim, Erica Españo, Bill Thaddeus Padasas, Ju-Ho Son, Jihee Oh, Richard J Webby, Young-Ran Lee, Chan-Su Park, Jeong-Ki Kim","doi":"10.4110/in.2024.24.e19","DOIUrl":"10.4110/in.2024.24.e19","url":null,"abstract":"The influenza virus poses a global health burden. Currently, an annual vaccine is used to reduce influenza virus-associated morbidity and mortality. Most influenza vaccines have been developed to elicit neutralizing Abs against influenza virus. These Abs primarily target immunodominant epitopes derived from hemagglutinin (HA) or neuraminidase (NA) of the influenza virus incorporated in vaccines. However, HA and NA are highly variable proteins that are prone to antigenic changes, which can reduce vaccine efficacy. Therefore, it is essential to develop universal vaccines that target immunodominant epitopes derived from conserved regions of the influenza virus, enabling cross-protection among different virus variants. The internal proteins of the influenza virus serve as ideal targets for universal vaccines. These internal proteins are presented by MHC class I molecules on Ag-presenting cells, such as dendritic cells, and recognized by CD8 T cells, which elicit CD8 T cell responses, reducing the likelihood of disease and influenza viral spread by inducing virus-infected cell apoptosis. In this review, we highlight the importance of CD8 T cell-mediated immunity against influenza viruses and that of viral epitopes for developing CD8 T cell-based influenza vaccines.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"24 3","pages":"e19"},"PeriodicalIF":4.3,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0