Immune Network最新文献_第2页

Selective Enrichment of Non-Canonical Vγ9-Jγ2 TRG Clonotypes in Clear Cell Renal Cell Carcinoma With Shorter CDR3 Loops. 非典型Vγ9-Jγ2 TRG克隆型在具有较短CDR3环的透明细胞肾细胞癌中的选择性富集

IF 5.9 4区医学

Immune Network Pub Date : 2026-06-02 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e25

Won Joon Oh, Seong Il Seo, H K Imashi Chamathka, Jae-Hyun Park, Tae Jin Kim

引用次数: 0

Decoding Immune Regulation: From Genetic Variation to Mechanism Through Single-Cell Genomics. 解码免疫调节：从遗传变异到单细胞基因组学机制。

IF 5.9 4区医学

Immune Network Pub Date : 2026-05-27 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e24

Jung Hee Koh, Chun Jimmie Ye

{"title":"Decoding Immune Regulation: From Genetic Variation to Mechanism Through Single-Cell Genomics.","authors":"Jung Hee Koh, Chun Jimmie Ye","doi":"10.4110/in.2026.26.e24","DOIUrl":"10.4110/in.2026.26.e24","url":null,"abstract":"Immune cell states are not fixed. Rather, they emerge from dynamic transcriptional programs shaped by genetic variation, cellular context, and gene regulatory networks (GRNs). Single-cell and multi-omic technologies now enable population-scale immune profiling across molecular layers, revealing that cell-to-cell transcriptional variability is a functional feature that diversifies immune responses. Distribution-aware and tensor-based analytical frameworks capture this variability beyond mean expression, resolving coordinated gene programs across cell types, individuals, and conditions. Integrating human genetics with single-cell genomics demonstrates that genetic effects on gene expression, splicing, and chromatin accessibility are highly dependent on cell type, activation state, and differentiation trajectory. These variant-level signals converge on GRNs in which key transcription factors orchestrate context-dependent immune programs. High-throughput perturbation screens enable scalable functional validation of these networks, linking genetic variation to cellular function. Together, these integrative approaches translate molecular discoveries into clinical applications, from patient stratification to therapeutic target prioritization. Emerging spatial multi-omics and in situ perturbation screens further resolve neighbor-dependent regulation within intact tissue niches, offering a path from variant to mechanism to clinical translation.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 3","pages":"e24"},"PeriodicalIF":5.9,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention. 呼吸微生物组在衰老中的重塑：免疫衰老和治疗干预的意义。

IF 5.9 4区医学

Immune Network Pub Date : 2026-05-22 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e23

Seong-Mook Jung, Wonkeon Sunwoo, Young Min Son

{"title":"Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention.","authors":"Seong-Mook Jung, Wonkeon Sunwoo, Young Min Son","doi":"10.4110/in.2026.26.e23","DOIUrl":"10.4110/in.2026.26.e23","url":null,"abstract":"Aging involves progressive declines in lung structure and immune function, increasing the incidence and severity of respiratory diseases and reducing vaccine responsiveness. Meanwhile, the respiratory tract harbors a dynamic microbial ecosystem that contributes to immune homeostasis and colonization resistance. Growing evidence indicates that aging disrupts this host-microbe balance within the respiratory tract; however, the mechanisms and therapeutic implications remain incompletely integrated. This review summarizes age-related remodeling of the respiratory microbiome. Beyond compositional shifts, aging alters microbial functions, including metabolic output and resilience to perturbation, exhibiting downstream effects on epithelial barriers, mucus clearance, and immune priming. Furthermore, as the microbiome-immune axis is modifiable, microbiome-targeted therapies represent key opportunities to restore respiratory homeostasis during aging. These interventions, combined with senescence- and cytokine-directed immunomodulation and vaccine optimization using adjuvants and mucosal immune-informed designs, may reduce infection burden and chronic lung disease progression in older populations. Together, this review highlights that a deeper understanding of age-related respiratory microbiome remodeling and its interplay with immunosenescence will be essential for the rational design of microbiome-informed therapies.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 3","pages":"e23"},"PeriodicalIF":5.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Induction of Neutrophilic Inflammatory Programs by Staphylococcus aureus and Cigarette Smoke in Airway Epithelial Cells. 金黄色葡萄球菌和香烟烟雾对气道上皮细胞中性粒细胞炎症的协同诱导。

IF 5.9 4区医学

Immune Network Pub Date : 2026-05-13 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e21

Ha-Kyeong Won, Jiwon Lee, Jae Won Yun, Kyung Eun Park, Ji-Hyang Lee, You Sook Cho, Sang Heon Cho, Kian Fan Chung, Claus Bachert, Jun-Pyo Choi, Woo-Jung Song

{"title":"Synergistic Induction of Neutrophilic Inflammatory Programs by Staphylococcus aureus and Cigarette Smoke in Airway Epithelial Cells.","authors":"Ha-Kyeong Won, Jiwon Lee, Jae Won Yun, Kyung Eun Park, Ji-Hyang Lee, You Sook Cho, Sang Heon Cho, Kian Fan Chung, Claus Bachert, Jun-Pyo Choi, Woo-Jung Song","doi":"10.4110/in.2026.26.e21","DOIUrl":"10.4110/in.2026.26.e21","url":null,"abstract":"Staphylococcus aureus (SA) colonization and cigarette smoking are both implicated in the pathogenesis of chronic airway disease, yet their combined effects on epithelial responses remain unclear. We investigated transcriptomic changes in human bronchial epithelial cells (BEAS-2B) following co-exposure to SA and cigarette smoke extract (CSE). RNA sequencing revealed that combined SA+CSE co-exposure was associated with a marked increase in differentially expressed genes, compared with single exposures. Functional enrichment and network analyses identified significant activation of pathways related to neutrophil migration, extracellular matrix remodeling, and inflammatory cascades, including TNF and IL-17 signaling. Key hub genes, notably CCL20, CXCL1, CXCL8, and IL-24, showed marked synergistic upregulation, which was validated by quantitative RT-PCR. These findings suggest that SA and cigarette smoke co-exposure is associated with a transcriptomic profile suggestive of neutrophilic inflammation. The involvement of IL-24 and IL-17 signaling suggests potential pathways linking bacterial colonization and smoking to airway inflammation and remodeling.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 3","pages":"e21"},"PeriodicalIF":5.9,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgE Production Beyond Classical T-Cell Help. IgE生产超越经典t细胞的帮助。

IF 5.9 4区医学

Immune Network Pub Date : 2026-05-13 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e22

Boryeong Jo, Jaechul Lim

{"title":"IgE Production Beyond Classical T-Cell Help.","authors":"Boryeong Jo, Jaechul Lim","doi":"10.4110/in.2026.26.e22","DOIUrl":"10.4110/in.2026.26.e22","url":null,"abstract":"IgE plays a central role in allergic diseases by binding to specific allergens and triggering the release of inflammatory mediators from mast cells and basophils. Conventionally, allergen-specific IgE is generated by T-cell-dependent mechanisms in which IL-4-producing CD4+ T helper cells, including Th2 cells and T follicular helper cells, orchestrate B cell class switch recombination to IgE. However, elevated IgE levels are also observed in diverse contexts, including primary immunodeficiencies and inflammatory conditions, where allergen involvement is less clear, suggesting the existence of additional pathways for IgE biogenesis. Supporting this notion, recent studies have identified alternative routes in which innate immune cells such as basophils or group 2 innate lymphoid cells provide bystander IL-4 to drive the production of IgE. In this review, we provide a comprehensive overview of IgE production pathways and examine how they operate across physiological and pathological conditions. Recognizing this mechanistic diversity will deepen our understanding of IgE biology beyond its role in allergy, highlighting its multifaceted contributions to barrier defense, protective immunity, and the pathogenesis of various inflammatory disorders.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 3","pages":"e22"},"PeriodicalIF":5.9,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Bacterial Contractile Injection Systems for Ag Delivery and CD8⁺ T Cell Activation. 用于银递送和CD8+ T细胞活化的可编程细菌收缩注射系统。

IF 5.9 4区医学

Immune Network Pub Date : 2026-04-13 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e20

Jeong-Yun Hwang, Sang-Hyun Kim, Jeong-Ki Kim, Soohwan Oh

引用次数: 0

Intranasal Delivery of an RSV A2-Derived Pre-F VLP Vaccine Induces Robust Mucosal and Systemic Immunity Against RSV B Strain Without Enhanced Disease. 鼻内递送RSV a2衍生的前f VLP疫苗可诱导对RSV B株的强大粘膜和全身免疫，而不会增强疾病

IF 5.9 4区医学

Immune Network Pub Date : 2026-04-13 eCollection Date: 2026-06-01 DOI: 10.4110/in.2026.26.e19

Arun Meas, Young Hun Kim, Su Jeong Leem, Karmina Barrogoa, Hyun Bo Sim, Jong-Jin Kim, Young-Tae Lee, Eun-Ju Ko, Ki-Hye Kim, Sang-Moo Kang, Hye Suk Hwang

{"title":"Intranasal Delivery of an RSV A2-Derived Pre-F VLP Vaccine Induces Robust Mucosal and Systemic Immunity Against RSV B Strain Without Enhanced Disease.","authors":"Arun Meas, Young Hun Kim, Su Jeong Leem, Karmina Barrogoa, Hyun Bo Sim, Jong-Jin Kim, Young-Tae Lee, Eun-Ju Ko, Ki-Hye Kim, Sang-Moo Kang, Hye Suk Hwang","doi":"10.4110/in.2026.26.e19","DOIUrl":"10.4110/in.2026.26.e19","url":null,"abstract":"Respiratory syncytial virus (RSV) is a contagious pathogen that infects respiratory epithelial cells and causes serious lower respiratory diseases in young children and the elderly. In this study, we evaluated the cross-protective efficacy of intranasally administered virus-like particles (VLPs) expressing the prefusion (pre-F) conformation of the RSV A2 fusion protein against RSV B challenge. The VLPs displayed higher reactivity against pre-F site Ø-specific mAbs, compared to the formalin-inactivated RSV vaccines. Intranasally administered pre-F VLPs vaccine induced a Th1-biased immune response in both local and systemic compartments. In the systemic compartment, it elicited a high IgG2a/IgG1 ratio in sera and strong IFN-γ production by splenic cells, reflecting a robust Th1-type systemic immune activation. It promoted significantly increased IgA levels in bronchoalveolar lavage fluid and lung tissues. Furthermore, no significant histopathological lesions were observed in the lungs of RSV A2-derived pre-F VLPs immunized mice compared to FI-RSV vaccinated mice. These results highlight the relevance of intranasal RSV A2-based pre-F VLP immunization in eliciting cross-protection against RSV B while minimizing the risk of vaccine-associated enhanced respiratory disease (VERD). Therefore, RSV A2-derived pre-F VLPs can be a potential safe and effective nasal vaccine candidate against RSV B infection by inducing Th1-skewed immune responses and reducing the risk of VERD.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 3","pages":"e19"},"PeriodicalIF":5.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Perineural Drainage: Revisiting the Olfactory Nerve as an Active Immunological Interface During Neuroinflammation. 超越神经周围引流：在神经炎症期间作为主动免疫界面的嗅神经的重访。

IF 5.9 4区医学

Immune Network Pub Date : 2026-03-27 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e18

Hyun-Min Choi, Min-Ji Cho, Seung-Jun Yoo, Je-Min Choi

引用次数: 0

Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway. 香烟烟雾通过激活IL-33/ st2依赖通路诱导肺巨噬细胞的促炎反应

IF 5.9 4区医学

Immune Network Pub Date : 2026-03-23 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e17

Yujin Kim, Yosep Mo, Ji-Young Bang, Jihyun Kim, In-Gu Lee, Hye Young Kim, Hye-Ryun Kang

{"title":"Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway.","authors":"Yujin Kim, Yosep Mo, Ji-Young Bang, Jihyun Kim, In-Gu Lee, Hye Young Kim, Hye-Ryun Kang","doi":"10.4110/in.2026.26.e17","DOIUrl":"10.4110/in.2026.26.e17","url":null,"abstract":"Cigarette smoke broadly affects the immune system, but the mechanisms by which it disrupts lung innate immunity and impairs macrophage-mediated homeostasis in healthy individuals remain unclear. This study investigates airway inflammation induced by chronic cigarette smoke extract (CSE) exposure by profiling pulmonary macrophages. CSE was generated by bubbling smoke from ten Marlboro cigarettes into 10 ml PBS to obtain 100% CSE, and C57BL/6 mice received 10% CSE intranasally 3 times per week for 4 wk. Chronic CSE exposure induced neutrophilic airway inflammation and augmented pulmonary Th17 and Th1 responses. Among macrophage subsets, CSE exposure promoted the expansion of CD11c+CD11b- alveolar macrophages (AMs) and upregulated IL-17A across macrophage subsets in lung tissue. In the lung, epithelial-derived IL-33 was significantly increased and was associated with enhanced IL-33/ST2 axis activity in IL-17A+ macrophages. In AMs, sequential CSE and IL-33 stimulation significantly increased ST2 expression and an IL-33/ST2-mediated pro-inflammatory response marked by elevated IL-6. Moreover, CSE exposure reprogrammed AMs with enhanced MAPK and NF-κB signaling. Notably, IL-33-stimulated macrophages after CSE exposure skewed naive CD4+ T cells toward Th17 differentiation. These findings suggest that CSE-activated, IL-33/ST2-driven pro-inflammatory macrophages drive neutrophilic inflammation and Th17 skewing, linking innate and adaptive immune responses in airway inflammation.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 2","pages":"e17"},"PeriodicalIF":5.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinant Japanese Encephalitis Virus Envelope Antigen Presented on CoPoP Liposomes Elicits Cellular Immunity and Protects Mice From Lethal Challenge. 在CoPoP脂质体上表达的重组乙型脑炎病毒包膜抗原可诱导细胞免疫并保护小鼠免受致命攻击。

IF 5.9 4区医学

Immune Network Pub Date : 2026-03-13 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e16

Seung Yong Kim, In Ryeong Jung, Hyojung Park, Jin Ouk Choi, Sang Hyeon Kim, Jimin Pak, Jinil Kim, Cheoljun Choi, Seung Yeon Kwon, Kiho Jeong, Nari Kim, Jiseon Kim, Ki Taek Nam, Dae Gwin Jeong, Doo Hee Shim, Jae Myun Lee, Ji-Man Kang, Soo Seok Hwang, June-Yong Lee

{"title":"Recombinant Japanese Encephalitis Virus Envelope Antigen Presented on CoPoP Liposomes Elicits Cellular Immunity and Protects Mice From Lethal Challenge.","authors":"Seung Yong Kim, In Ryeong Jung, Hyojung Park, Jin Ouk Choi, Sang Hyeon Kim, Jimin Pak, Jinil Kim, Cheoljun Choi, Seung Yeon Kwon, Kiho Jeong, Nari Kim, Jiseon Kim, Ki Taek Nam, Dae Gwin Jeong, Doo Hee Shim, Jae Myun Lee, Ji-Man Kang, Soo Seok Hwang, June-Yong Lee","doi":"10.4110/in.2026.26.e16","DOIUrl":"10.4110/in.2026.26.e16","url":null,"abstract":"Japanese encephalitis virus (JEV) causes severe encephalitis in endemic regions, and vaccination remains the primary preventive measure. To develop subunit vaccines that enhance cellular immunity, we produced a soluble His-tagged recombinant JEV envelope (rJEV-E) ectodomain and particularized it on cobalt porphyrin-phospholipid (CoPoP) immunogenic liposomes containing an monophosphoryl lipid A-related TLR4 agonist, with or without Quillaja saponaria saponin fraction 21 (QS-21). CoPoP-mediated particleization enabled stable antigen display and, when combined with QS-21 (rJEV-E/ECLSQ), elicited Th1-biased CD4+ and CD8+ T-cell IFN-γ responses alongside functional neutralizing Abs. In a stringent intracerebral lethal challenge model, rJEV-E/ECLSQ conferred robust protection despite moderate 50% plaque reduction neutralization test titers. JEV-specific IgG responses were sustained for at least one year, with recallable cellular immunity upon late boosting. These findings demonstrate that CoPoP-based particleization enables qualitative modulation of vaccine-induced immunity while maintaining effective protection in a stringent challenge setting.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 2","pages":"e16"},"PeriodicalIF":5.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0