Ying Zhou, Xiaofeng Song, Miaomiao Yuan, Yongli Li
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引用次数: 0
Abstract
This research examines the complex roles of IL-6 in the context of cancer, including its action on tumor cells and tumor microenvironment via modulation of immune, stroma cells, and endothelial cells. IL-6 mediates its tumor-supportive action mainly via traditional and trans-signaling, with tumor growth, immune evasion, and survival of tumor cells being its consequences. Elevated circulating levels of IL-6 correlate with more advanced disease and enhanced resistance against treatment, highlighting its importance as a target for treatment. Existing treatment modalities include anti-IL-6 and anti-IL-6 receptor monoclonal antibodies, with small molecule JAK1/2 and STAT3 downstream targets. The complex and redundant mechanisms of IL-6, however, challenge treatment efficacy. This review contextualizes the novel advancements in IL-6 target therapies and discusses combinatorial approaches under investigation to circumvent resistance and improve clinical outcomes.
期刊介绍：
Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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