Human Cell最新文献_第2页

A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe 可异种移植的恶性蜕皮间皮瘤细胞系--D-Meso-Sonobe

IF 4.3 3区生物学

Human Cell Pub Date : 2024-04-10 DOI: 10.1007/s13577-024-01063-0

Yuki Hanamatsu, Chiemi Saigo, Hiroshi Sonobe, Tamotsu Takeuchi

引用次数: 0

The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs 运动对表观遗传修饰的影响：关注 DNA 甲基化、组蛋白修饰和非编码 RNA

IF 4.3 3区生物学

Human Cell Pub Date : 2024-04-08 DOI: 10.1007/s13577-024-01057-y

Junxiong Zhang, Zhongxin Tian, Chao Qin, Mohammad Reza Momeni

引用次数: 0

Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA 建立 PIK3CB 而非 PIK3CA 突变的人类卵巢透明细胞癌细胞系

IF 4.3 3区生物学

Human Cell Pub Date : 2024-04-04 DOI: 10.1007/s13577-024-01058-x

Hitomi Hoshino, Daisuke Inoue, Akiko Shinagawa, Hisato Yoshida, Shohei Shigeto, Kazuyuki Matsuda, Tomoya O. Akama, Yoshio Yoshida, Motohiro Kobayashi

{"title":"Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA","authors":"Hitomi Hoshino, Daisuke Inoue, Akiko Shinagawa, Hisato Yoshida, Shohei Shigeto, Kazuyuki Matsuda, Tomoya O. Akama, Yoshio Yoshida, Motohiro Kobayashi","doi":"10.1007/s13577-024-01058-x","DOIUrl":"https://doi.org/10.1007/s13577-024-01058-x","url":null,"abstract":"A human ovarian clear cell carcinoma cell line was established from a 46-year-old Japanese woman. That line, designated MTC-22, has proliferated continuously for over 6 months in conventional RPMI 1640 medium supplemented with 10% foetal bovine serum and has been passaged over 50 times. MTC-22 doubling-time is ~ 18 h, which is much shorter than most ovarian clear cell carcinoma lines reported to date. Morphologically, MTC-22 cells exhibit polygonal shapes and proliferate to form a monolayer in a jigsaw puzzle-like arrangement without contact inhibition. Ultrastructurally, cells exhibit numerous intracytoplasmic glycogen granules and well-developed mitochondria. G-band karyotype analysis indicated that cells have a complex karyotype close to tetraploid. We observed that the expression pattern of a series of ovarian carcinoma-related molecules in MTC-22 cells was identical to that seen in the patient’s tumour tissue. Notably, MTC-22 cells, and the patient’s carcinoma tissue, expressed low-sulphated keratan sulphate recognised by R-10G and 294-1B1 monoclonal antibodies, a hallmark of non-mucinous ovarian carcinoma, and particularly of clear cell ovarian carcinoma. Moreover, characteristic point mutations—one in ARID1A, which encodes the AT-rich interaction domain containing protein 1A, and the other in PIK3CB, which encodes the catalytic subunit of phosphoinositide 3-kinase—were seen in the patient’s tumour tissue and retained in MTC-22 cells. Collectively, these findings indicate that MTC-22 cells could serve as a valuable tool for investigating the pathophysiology of ovarian clear cell carcinoma, particularly that harbouring PIK3CB mutations, and for developing and validating new diagnostic and therapeutic approaches to this life-threatening malignancy.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line 新型侵袭性人类皮肤鳞状细胞癌细胞系 HCB-541 的建立与分子特征描述

IF 4.3 3区生物学

Human Cell Pub Date : 2024-04-03 DOI: 10.1007/s13577-024-01054-1

{"title":"Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line","authors":"","doi":"10.1007/s13577-024-01054-1","DOIUrl":"https://doi.org/10.1007/s13577-024-01054-1","url":null,"abstract":"<h3>Abstract</h3> Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer that can result in significant morbidity, although it is usually well-managed and rarely metastasizes. However, the lack of commercially available cSCC cell lines hinders our understanding of this disease. This study aims to establish and characterize a new metastatic cSCC cell line derived from a Brazilian patient. A tumor biopsy was taken from a metastatic cSCC patient, immortalized, and named HCB-541 after several passages. The cytokeratin expression profile, karyotypic alterations, mutational analysis, mRNA and protein differential expression, tumorigenic capacity in xenograft models, and drug sensitivity were analyzed. The HCB-541 cell line showed a doubling time between 20 and 30 h and high tumorigenic capacity in the xenograft mouse model. The HCB-541 cell line showed hypodiploid and hypotetraploidy populations. We found pathogenic mutations in TP53 p.(Arg248Leu), HRAS (Gln61His) and TERT promoter (C228T) and high-level microsatellite instability (MSI-H) in both tumor and cell line. We observed 37 cancer-related genes differentially expressed when compared with HACAT control cells. The HCB-541 cells exhibited high phosphorylated levels of EGFR, AXL, Tie, FGFR, and ROR2, and high sensitivity to cisplatin, carboplatin, and EGFR inhibitors. Our study successfully established HCB-541, a new cSCC cell line that could be useful as a valuable biological model for understanding the biology and therapy of metastatic skin cancer.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"71 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome 二磷酸法尼基合成酶对 RAC1/MAPK/ERK 信号通路的调节作用可调控多囊卵巢综合征中颗粒细胞的增殖

IF 4.3 3区生物学

Human Cell Pub Date : 2024-03-29 DOI: 10.1007/s13577-024-01050-5

{"title":"Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome","authors":"","doi":"10.1007/s13577-024-01050-5","DOIUrl":"https://doi.org/10.1007/s13577-024-01050-5","url":null,"abstract":"<h3>Abstract</h3> Polycystic ovary syndrome (PCOS) is a complex gynaecological endocrine disease that occurs in women of childbearing age. The pathogenesis of PCOS is still unclear and further exploration is needed. Here, proteomic analysis indicated that the expression of farnesyl diphosphate synthase (FDPS) protein in ovarian tissue of PCOS mice was significantly decreased. The purpose of this study is to investigate the relationship between potential biomarkers of PCOS and granulosa cells (GCs) function. The mechanisms by which FDPS affected the proliferation of granulosa cells were also explored both in vitro and in vivo. We found that knockdown of FDPS inhibited the proliferation of KGN (human ovarian granulosa cell line), while overexpression of FDPS had the opposite effect. FDPS activated Rac1 (Rac Family Small GTPase 1) activity and regulated MAPK/ERK signalling pathway, which affecting the proliferation of KGN cells significantly. In addition, treatment with the adeno-associated virus (AAV)-FDPS reverses the dehydroepiandrosterone (DHEA)-induced PCOS-phenotype in mice. Our data indicated that FDPS could regulate the proliferation of ovarian GCs by modulating MAPK/ERK (mitogen-activated protein kinase/extracellular regulated protein kinases) pathway via activating Rac1 activity. These findings suggest that FDPS could be of great value for the regulation of ovarian granulosa cell function and the treatment of PCOS.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"45 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis 通过抑制活化的 p38 MAPK 介导的神经元凋亡，补偿性上调 MT2A 可缓解神经源性间歇性跛行

IF 4.3 3区生物学

Human Cell Pub Date : 2024-03-28 DOI: 10.1007/s13577-024-01043-4

Chenggang Wang, Zhanchao Wang, Ying Zi, Xuejian Dan, Jiahui Xu, Jingwei Zhao, Wei Xu, Zhourui Wu, Wei Liu, Bin Ma

{"title":"Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis","authors":"Chenggang Wang, Zhanchao Wang, Ying Zi, Xuejian Dan, Jiahui Xu, Jingwei Zhao, Wei Xu, Zhourui Wu, Wei Liu, Bin Ma","doi":"10.1007/s13577-024-01043-4","DOIUrl":"https://doi.org/10.1007/s13577-024-01043-4","url":null,"abstract":"Neurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal apoptosis. To explore the novel therapeutic target of NIC treatment, we constructed the rat model of NIC by cauda equina compression (CEC) method and collected dorsal root ganglion (DRG) tissues, a region responsible for sensory and motor function, for mRNA sequencing. Bioinformatic analysis of mRNA sequencing indicated that upregulated metallothionein 2A (MT2A), an apoptosis-regulating gene belonging to the metallothionein family, might participate in NIC progression. Activated p38 MAPK mediated motor dysfunction following LSS and it was also found in DRG tissues of rats with NIC. Therefore, we supposed that MT2A might affect NIC progression by regulating p38 MAPK pathway. Then the rat model of NIC was used to explore the exact role of MT2A. Rats at day 7 post-CEC exhibited poorer motor function and had two-fold MT2A expression in DRG tissues compared with rats with sham operation. Co-localization analysis showed that MT2A was highly expressed in neurons, but not in microglia or astrocytes. Subsequently, neurons isolated from DRG tissues of rats were exposed to hypoxia condition (3% O2, 92% N2, 5% CO2) to induce cell damage. Gain of MT2A function in neurons was performed by lentivirus-mediated overexpression. MT2A overexpression inhibited apoptosis by inactivating p38 MAPK in hypoxia-exposed neurons. Our findings indicated that high MT2A expression was related to NIC progression, and MT2A overexpression protected against NIC through inhibiting activated p38 MAPK-mediated neuronal apoptosis in DRG tissues.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"193 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140314271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cardiac microenvironment in cardiovascular diseases: implications for therapy 心脏微环境在心血管疾病中的作用：对治疗的影响

IF 4.3 3区生物学

Human Cell Pub Date : 2024-03-18 DOI: 10.1007/s13577-024-01052-3

Jiayu Yao, Yuejun Chen, Yuqing Huang, Xiaoou Sun, Xingjuan Shi

{"title":"The role of cardiac microenvironment in cardiovascular diseases: implications for therapy","authors":"Jiayu Yao, Yuejun Chen, Yuqing Huang, Xiaoou Sun, Xingjuan Shi","doi":"10.1007/s13577-024-01052-3","DOIUrl":"https://doi.org/10.1007/s13577-024-01052-3","url":null,"abstract":"Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death worldwide. The heart is a complicated organ composed of multicellular types, including cardiomyocytes, fibroblasts, endothelial cells, vascular smooth muscle cells, and immune cells. Cellular specialization and complex interplay between different cell types are crucial for the cardiac tissue homeostasis and coordinated function of the heart. Mounting studies have demonstrated that dysfunctional cells and disordered cardiac microenvironment are closely associated with the pathogenesis of various cardiovascular diseases. In this paper, we discuss the composition and the homeostasis of cardiac tissues, and focus on the role of cardiac environment and underlying molecular mechanisms in various cardiovascular diseases. Besides, we elucidate the novel treatment for cardiovascular diseases, including stem cell therapy and targeted therapy. Clarification of these issues may provide novel insights into the prevention and potential targets for cardiovascular diseases.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"7 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140147854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1 两种新型骨巨细胞瘤患者衍生细胞系的建立和特征描述：NCC-GCTB8-C1和NCC-GCTB9-C1

IF 4.3 3区生物学

Human Cell Pub Date : 2024-03-11 DOI: 10.1007/s13577-024-01042-5

Yuki Adachi, Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Julia Osaki, Takuya Ono, Shuhei Iwata, Taro Akiyama, Ryuto Tsuchiya, Yu Toda, Shin Ishihara, Koichi Ogura, Eisuke Kobayashi, Naoki Kojima, Akihiko Yoshida, Hideki Yokoo, Akira Kawai, Tadashi Kondo

{"title":"Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1","authors":"Yuki Adachi, Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Julia Osaki, Takuya Ono, Shuhei Iwata, Taro Akiyama, Ryuto Tsuchiya, Yu Toda, Shin Ishihara, Koichi Ogura, Eisuke Kobayashi, Naoki Kojima, Akihiko Yoshida, Hideki Yokoo, Akira Kawai, Tadashi Kondo","doi":"10.1007/s13577-024-01042-5","DOIUrl":"https://doi.org/10.1007/s13577-024-01042-5","url":null,"abstract":"Giant cell tumor of bone (GCTB) is a rare osteolytic bone tumor consisting of mononuclear stromal cells, macrophages, and osteoclast-like giant cells. Although GCTB predominantly exhibits benign behavior, the tumor carries a significant risk of high local recurrence. Furthermore, GCTB can occasionally undergo malignant transformation and distal metastasis, making it potentially fatal. The standard treatment is complete surgical resection; nonetheless, an optimal treatment strategy for advanced GCTB remains unestablished, necessitating expanded preclinical research to identify appropriate therapeutic options. However, only one GCTB cell line is publicly available from a cell bank for research use worldwide. The present study reports the establishment of two novel cell lines, NCC-GCTB8-C1 and NCC-GCTB9-C1, derived from the primary tumor tissues of two patients with GCTB. Both cell lines maintained the hallmark mutation in the H3-3A gene, which is associated with tumor formation and development in GCTB. Characterization of these cell lines revealed their steady growth, spheroid-formation capability, and invasive traits. Potential therapeutic agents were identified via extensive drug screening of the two cell lines and seven previously established GCTB cell lines. Among the 214 antitumor agents tested, romidepsin, a histone deacetylase inhibitor, and mitoxantrone, a topoisomerase inhibitor, were identified as potential therapeutic agents against GCTB. Conclusively, the establishment of NCC-GCTB8-C1 and NCC-GCTB9-C1 provides novel and crucial resources that are expected to advance GCTB research and potentially revolutionize treatment strategies.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"37 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140098137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new lymphedema treatment using pyro-drive jet injection 利用热驱动喷射注射治疗淋巴水肿的新方法

IF 4.3 3区生物学

Human Cell Pub Date : 2024-01-14 DOI: 10.1007/s13577-023-01021-2

Megumi Nishiyama, Yuko Sakaguchi, Sayuri Morito, Kei Nagase, Takehisa Sakumoto, Kunihiko Yamashita, Mariko Hashiguchi, Makoto Fukuda, Shuji Toda, Shigehisa Aoki

{"title":"A new lymphedema treatment using pyro-drive jet injection","authors":"Megumi Nishiyama, Yuko Sakaguchi, Sayuri Morito, Kei Nagase, Takehisa Sakumoto, Kunihiko Yamashita, Mariko Hashiguchi, Makoto Fukuda, Shuji Toda, Shigehisa Aoki","doi":"10.1007/s13577-023-01021-2","DOIUrl":"https://doi.org/10.1007/s13577-023-01021-2","url":null,"abstract":"Lymphedema, resulting from impaired lymphatic drainage, causes inflammation, fibrosis and tissue damage leading to symptoms such as limb swelling and restricted mobility. Despite various treatments under exploration, no standard effective therapy exists. Here a novel technique using the pyro-drive jet injection (PJI) was used to create artificial clefts between collagen fibers, which facilitated the removal of excess interstitial fluid. The PJI was used to deliver a mixture of lactated Ringer’s solution and air into the tail of animals with secondary skin edema. Edema levels were assessed using micro-CT scanning. Histopathological changes and neovascularization were evaluated on the injury-induced regenerative tissue. Regarding tissue remodeling, we focused on connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF)-C. PJI markedly diminished soft tissue volume in the experimental lymphedema animals compared to the non-injected counterparts. The PJI groups exhibited a significantly reduced proportion of inflammatory granulation tissue and an enhanced density of lymphatic vessels and α-smooth muscle actin (αSMA)-positive small vessels in the fibrous granulation tissue compared to the controls. In addition, PJI curtailed the prevalence of CTGF- and VEGF-C-positive cells in regenerative tissue. In a lymphedema animal model, PJI notably ameliorated interstitial edema, promoted lymphatic vessel growth, and bolstered αSMA-positive capillaries in fibrous granulation tissue. PJI’s minimal tissue impact post-lymph node dissection indicates significant potential as an early, standard preventative measure. Easily applied in general clinics without requiring specialized training, it offers a cost-effective and highly versatile solution to the management of lymphedema.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"5 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl4-caused murine liver fibrosis in vivo miR-3074/BMP7 轴调节体外 TGF-β 引起的肝星状细胞活化和体内 CCl4 引起的小鼠肝纤维化

IF 4.3 3区生物学

Human Cell Pub Date : 2024-01-14 DOI: 10.1007/s13577-023-01017-y

Bingjie Liu, Xia Xie, Xin Yang, Chengyun Dou, Haibo Tang, Jing Liu

{"title":"The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl4-caused murine liver fibrosis in vivo","authors":"Bingjie Liu, Xia Xie, Xin Yang, Chengyun Dou, Haibo Tang, Jing Liu","doi":"10.1007/s13577-023-01017-y","DOIUrl":"https://doi.org/10.1007/s13577-023-01017-y","url":null,"abstract":"Continuously progressive hepatic fibrosis might cause chronic liver diseases, resulting in hepatic failure. The activation of hepatic stellate cells (HSCs) residing in the liver might induce and influence hepatic fibrosis. In the present study, microRNA 3074 (miR-3074) was found increased within transforming growth factorβ (TGF-β)-activated HSCs and enriched within the TGF-β signaling. In activated HSCs by TGF-β, miR-3074 overexpression aggravated TGF-β-induced fibrotic changes, whereas miR-3074 inhibition exerted opposite effects. miR-3074 directly targeted bone morphogenetic protein 7 (BMP7) and inhibited BMP7 expression. Under TGF-β induction, overexpressed BMP7 notably attenuated the promotive roles of miR-3074 overexpression in TGF-β-activated HSCs. Within carbon tetrachloride (CCl4)-caused liver fibrosis murine model, miR-3074 agomir administration promoted, while LV-BMP7 administration alleviated CCl4-induced fibrotic changes; LV-BMP7 significantly attenuated the effects of miR-3074 agomir. Lastly, mmu-miR-3074 also targeted mouse BMP7 and inhibited mouse BMP7 expression. In conclusion, the miR-3074/BMP7 axis regulates TGF-β-caused activation of HSCs in vitro and CCl4-caused murine liver fibrosis in vivo. BMP7-mediated Smad1/5/8 activation might be involved.","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"211 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0