Hormone Molecular Biology and Clinical Investigation最新文献_第9页

Population status of selenium in Colombia and associated factors: a cross-sectional study. 哥伦比亚人口的硒状况及相关因素：一项横断面研究。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-27 eCollection Date: 2023-06-01 DOI: 10.1515/hmbci-2022-0047

Hernando Vargas-Uricoechea, Beatriz Bastidas, María V Pinzón

引用次数: 0

The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation. x射线照射下抗阻训练对雄性大鼠性激素水平和精子质量的影响。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0086

Mohammadreza Bayatiani, Fatemeh Seif, Shiva Molavi, Zahra Ansari, Mohammad Parastesh

{"title":"The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation.","authors":"Mohammadreza Bayatiani, Fatemeh Seif, Shiva Molavi, Zahra Ansari, Mohammad Parastesh","doi":"10.1515/hmbci-2021-0086","DOIUrl":"https://doi.org/10.1515/hmbci-2021-0086","url":null,"abstract":"Objectives: The present study aims to investigate the effects of resistance training on sex hormones and sperm parameters in male rats under X-ray.Methods: In this experimental study, 24 Sprague Dawley rats (200-250 g) were randomly assigned into four groups: healthy control, irradiated control, healthy training and irradiated training. Irradiation was induced at a dose of 4 Gy on the whole body. The resistance training protocol was performed for 10 weeks. Finally, blood serum was used to assess FSH, LH and testosterone and sperm quality. Data were analyzed using ANOVA and Tukey's post hoc test.Results: The results showed that radiation significantly reduced serum levels of LH (p=0.42), FSH (p=0.001) and testosterone (p=0.28) between radiation control and healthy control groups. Also, no significant difference was observed between serum levels of LH (p=0.135) and testosterone (p=0.419) in radiation resistance training and the healthy control groups. In addition, significant differences were observed between radiation resistance training and radiation control groups in sperm parameters such as sperm count (p=0.02) and progressively motile sperm (p=0.031).Conclusions: It seems that short-term resistance training can improve sperm parameters, including sperm count and sperm motility through increasing serum levels testosterone and LH in male rat under X-ray.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"441-447"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial. 直肠黄体酮对早产胎膜早破孕妇产妇和新生儿结局的疗效:一项三盲随机临床试验

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0103

Shohre Vosoogh, Marzieh Zanganeh, Behnaz Gonabadi

{"title":"Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial.","authors":"Shohre Vosoogh, Marzieh Zanganeh, Behnaz Gonabadi","doi":"10.1515/hmbci-2021-0103","DOIUrl":"https://doi.org/10.1515/hmbci-2021-0103","url":null,"abstract":"Objectives: This study was conducted to evaluate the efficacy of rectal progesterone suppositories on pregnancy outcomes of pregnant women diagnosed with PPROM at the gestational age of 26-34 weeks, as well as on maternal and neonatal outcomes.Methods: This is a double-blind, randomized clinical trial in pregnant women with PROM with gestational age of 26-24 weeks, conducted between February 2020 and December 2020 in Sayyad Shirazi Hospital, Gorgan, Iran.Results: According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.Conclusions: According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"463-468"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10422890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus. 促肾上腺皮质激素(ACTH)水平与皮肤粘膜性天疱疮患者肾上腺缺乏的关系。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0097

Mohammadreza Salehi, Zabihollah Shahmoradi, Seyed Mohammad Razavi, Iraj Lali, Elham Faghihian

{"title":"Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus.","authors":"Mohammadreza Salehi, Zabihollah Shahmoradi, Seyed Mohammad Razavi, Iraj Lali, Elham Faghihian","doi":"10.1515/hmbci-2021-0097","DOIUrl":"https://doi.org/10.1515/hmbci-2021-0097","url":null,"abstract":"Objectives: This study aimed to evaluate the level of adrenocorticotropic hormone (ACTH) and adrenal insufficiency in patients with mucocutaneous pemphigus lesions who use oral corticosteroids.Methods: This descriptive-analytical study was performed on 54 patients (48.44 ± 12.74 years) with mucocutaneous pemphigus in 2019. Those patients taken corticosteroids in different doses and way. At first, collected patients information including age, sex, type of pemphigus, duration of use, patient dosage, duration of corticosteroid administration, and method of administration were collected daily. Adrenal gland function was measured by evaluating ACTH levels. Data were analyzed by using Pearson correlation coefficient and t-test.Results: Our study showed that 37 cases (68.5%) had normal ACTH average hormone level (7.3-63.3 mL/pg), 11 cases (20.4%) were lower levels (<7.2 mL/pg), and 6 cases (11.1%) were higher levels (63.3 > mL/pg). Wo observed no significant relationship between ACTH and duration of corticosteroids usage (p=0.207).Conclusions: Taking a maintenance dose of between 12.5 and 25 mg daily does not usually lead to adrenal insufficiency. The present study showed that the lower the daily dose of corticosteroids, the lower the likelihood of adrenal insufficiency.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"437-440"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10455332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esketamine-A quick-acting novel antidepressant without the disadvantages of ketamine. 艾氯胺酮-一种新型快速抗抑郁药，没有氯胺酮的缺点。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0099

Sheikh Shoib, Madhulika Kotra, Sana Javed, Vinh-Son Nguyen, Barikar C Malathesh

引用次数: 1

Ovarian tissue cryopreservation in Malaysia: a case series. 马来西亚卵巢组织冷冻保存:一个案例系列。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0096

Norazilah Mat Jin, Siti Maisarah Ahmad, Ahmad Mohd Faizal, Abdul Kadir Bin Abdul Karim, Muhammad Azrai Abu

{"title":"Ovarian tissue cryopreservation in Malaysia: a case series.","authors":"Norazilah Mat Jin, Siti Maisarah Ahmad, Ahmad Mohd Faizal, Abdul Kadir Bin Abdul Karim, Muhammad Azrai Abu","doi":"10.1515/hmbci-2021-0096","DOIUrl":"https://doi.org/10.1515/hmbci-2021-0096","url":null,"abstract":"Objectives: We aim to discuss the hematological cancer cases that opted for ovarian tissue cryopreservation (OTC) as fertility preservation before the gonadotoxic chemotherapy agent.Case presentation: The ovarian tissue cryopreservation (OTC) was started in August 2020 in our center. Up to now, there were four cases have been performed and included in this report. The ovarian tissue cortex was cryopreserved with cryoprotectant using Kitazato™ (Tokyo, Japan) media and fit in the closed system devices. A total of four post-OTC patients were included. The mean age was 24 years old, whereas the mean serum AMH level was 30.43 pmol/L. Most of them were diagnosed with lymphoma, except one was leukemia. All of them received additional GnRH analog following OTC as a chemoprotective agent before cancer treatment. Currently, they are recovering well and on regular follow-up with the hematological department.Conclusions: Although The OTC is an ultimate option for prepubertal girls, it can be proposed as a good strategy for adult cancer women who could not delay cancer therapy.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"469-474"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis. 肝硬化患者α -1-抗胰蛋白酶表型频率的研究。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2022-0001

Mehdi Afsharinasab, Amir Hossein Akbari, Vahid Mirzaei, Mehdi Mahmoodi, Mohammad Reza Hajizadeh, Jamal Amri, Alireza Khoshdel

{"title":"The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis.","authors":"Mehdi Afsharinasab, Amir Hossein Akbari, Vahid Mirzaei, Mehdi Mahmoodi, Mohammad Reza Hajizadeh, Jamal Amri, Alireza Khoshdel","doi":"10.1515/hmbci-2022-0001","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0001","url":null,"abstract":"Objectives: Alpha-1-antitrypsin (AAT) has different phenotypes. Evidence suggests that the abundance of each of these phenotypes may be associated with a disease. The purpose of this study was to evaluate the frequency of AAT phenotypes in patients with liver cirrhosis as well as in healthy individuals.Methods: In this study, 42 patients with liver cirrhosis were selected. The results of the previous research done by the researcher on healthy individuals were used to construct the control group. After obtaining informed consent, 5 mL of fasting venous blood sample was taken, and phenotypes were analyzed by isoelectric focusing. Data were analyzed using Chi-square and Fisher's exact tests at a significant level of 0.05.Results: The results of this study indicated that all 42 healthy subjects had an MM allele (100%). However, among 42 patients, 35 (83.3%) had an MM allele, 5 (11.9%) had an MS allele, and 2 (4.8%) had MZ allele. The difference between the two groups was significant (p=0.02). There was no difference between men and women in the allele type (p=0.557).Conclusions: This study revealed that MS and MZ alleles were observed only in patients with liver cirrhosis, and none of these alleles were found in healthy subjects. Therefore, MS and MZ alleles can be further investigated as risk factors for liver cirrhosis.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"397-403"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae. 神经和心脏生物标志物对COVID-19后遗症患者预后的价值综述

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2022-0015

Madhusudhan Umesh, Vidya Singaravelu, Vandana Daulatabad, Prafull Kamble, Anish Singhal, Nitin Ashok John, Jyoti John

{"title":"An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae.","authors":"Madhusudhan Umesh, Vidya Singaravelu, Vandana Daulatabad, Prafull Kamble, Anish Singhal, Nitin Ashok John, Jyoti John","doi":"10.1515/hmbci-2022-0015","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0015","url":null,"abstract":"Many studies conducted after the pandemic period revealed that, while COVID-19 primarily injured the lungs, it also affects other organs in the form of cardiovascular complications, metabolic derangements, renal damage, and so on. Although we know that inflammatory cascades, complement activation, and pro-inflammatory cytokines are all involved in vasculitic processes that cause organ damage, we do not know the exact mechanism of complications such as acute respiratory distress syndrome (ARDS), cardiovascular ischemia, deep vein thrombosis, pulmonary thromboembolism, and brain injuries (embolism) that are frequently observed in COVID 19. The currently available biomarkers do not predict the severity of the aforementioned complications. As a result, more specific biomarkers such as serum calcium binding protein (S100B), glial fibrillary acid protein (GFAP), myelin basic protein (MBP), neuron-specific enolase (NSE), hs-TNI, (highly sensitive cardiac troponin) - HBDH, (Hydroxybutyrate Dehydrogenase), CK-MB (creatine kinase myocardial band), ST2 (suppression of tumorigenicity 2) are in need for early detection & improved clinical outcome.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"475-484"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10420988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3- independent GPx1 expression in the heart of mice with endometriosis. 二甲双胍通过AMPK/SIRT1/PGC-1α/SIRT3独立的GPx1表达在子宫内膜异位症小鼠心脏中的抗氧化作用。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2022-0039

Rodrigo Felgueiras, Ana C Neto, Adriana R Rodrigues, Alexandra M Gouveia, Henrique Almeida, Delminda Neves

{"title":"Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3- independent GPx1 expression in the heart of mice with endometriosis.","authors":"Rodrigo Felgueiras, Ana C Neto, Adriana R Rodrigues, Alexandra M Gouveia, Henrique Almeida, Delminda Neves","doi":"10.1515/hmbci-2022-0039","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0039","url":null,"abstract":"Objectives: Endometriosis is a gynecological disease associated with an imbalance between oxidative species production and anti-oxidative defenses. In women, endometriosis has been reported to associate with increased incidence of cardiovascular events. As such, this study aimed to analyze the oxidation-responsive AMPK/SIRT1/PGC-1α/SIRT3 pathway in the heart of a mouse model of endometriosis. The effect of metformin, an insulin-sensitizing and anti-oxidative drug with already shown positive results in endometriotic tissue was studied.Methods: Thirty-six female B6CBA/F1 mice were divided into 4 groups (Control-C, Surgery-induced Endometriosis and Metformin-EM (50 mg/kg/day orally administrated for 3 months), Endometriosis-E and Metformin-M). Immunofluorescent labelling of SIRT1 and SIRT3 was performed in the heart tissue. Assessment of expression of AMPKα, SIRT1, PGC-1α, SIRT3, SOD2, and GPx1 was performed by Western Blotting. The quantification of microRNA(miR)-34a, miR-195, miR-217, miR-155 and miR-421, involved in the regulation of expression of SIRT1 and SIRT3, was performed by Real-Time PCR.Results: Data showed an increase in phospho-AMPKα and in GPx1 expression in the EM group when compared to the C group, but not in the total AMPK, SIRT1, PGC-1α, SIRT3 and SOD2, suggesting a GPx1 expression increase independently of the AMPK/SIRT1/PGC-1α/SIRT3 pathway. MicroRNAs, excepting miR-217, showed a consistent trend of increase in the M group.Conclusions: Our study showed that endometriosis does not significantly affect the expression of the components of the AMPK/SIRT1/PGC-1α/SIRT3 pathway in the heart. However, it indicates that an oxidative condition underlying endometriosis is required for metformin to evidence an increment in the expression of the anti-oxidative enzyme GPx1.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"405-414"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet. 高强度间歇训练对高脂高糖饮食大鼠血清和脂肪组织血管素水平的影响。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI: 10.1515/hmbci-2021-0107

Ali Delpisheh, Alireza Safarzade

{"title":"The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet.","authors":"Ali Delpisheh, Alireza Safarzade","doi":"10.1515/hmbci-2021-0107","DOIUrl":"https://doi.org/10.1515/hmbci-2021-0107","url":null,"abstract":"Background: Vaspin is an adipocytokine with insulin-sensitizing and anti-inflammatory traits.Objectives: The purpose of this study was to evaluate the effect of high-intensity interval training (HIIT) on serum, visceral and subcutaneous adipose tissue vaspin levels in rats exposed to a diet high in fat and sugar (HFS).Materials and methods: Thirty-two male Wistar rats were randomly divided into HFS and standard diet (SD) groups. After 12 weeks, each group was divided into sedentary and HIIT groups. HIIT program was performed 3 times/week for 8 weeks. Retroperitoneal adipose tissue, inguinal adipose tissue and serum were collected to analyze vaspin levels. Also, serum glucose and insulin levels, insulin resistance index (HOMA-IR) and retroperitoneal and inguinal fat weights were measured.Results: HFS significantly increased weight gain, weight of inguinal (p=0.001) and retroperitoneal fat depots (p<0.001), serum glucose levels (p<0.001) and HOMA-IR (p<0.001). The HIIT was able to decline weight gain and fat mass (p<0.05) but did not affect inguinal and retroperitoneal fat depots' vaspin levels. Eight weeks' HIIT significantly increased serum vaspin (p=0.002) and decreased insulin (p=0.001) levels only in rats fed with SD.Conclusions: Although the HIIT program can cause significantly reducing effects on weight gain and fat depots' weights, it does not effect on circulating and fat depots' vaspin levels in rats fed an HFS.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":"43 4","pages":"449-453"},"PeriodicalIF":1.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0