Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-28 eCollection Date: 2023-09-01 DOI:10.1515/hmbci-2022-0103

Mai S Sater, Dhuha M B AlDehaini, Zainab Hasan Abdulla Malalla, Muhalab E Ali, Hayder Ahmed Giha

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引用次数: 2

Abstract

Objectives: Type 2 diabetes (T2D) is known to be associated with chronic inflammation, but the inflammatory regulators/markers are not exactly defined and the link between them remains undetermined. The objective of this study is to identify these markers by testing traditional (IL6 & IL8) and non-traditional (TREM1 & uPAR) inflammatory markers.

Methods: Data and blood samples were obtained from 114 T2D and 74 non-diabetic Kuwaiti subjects attending health facilities in Kuwait. Chemical analyzers were used to measure glycemic and lipid profiles, while ELISA was used to measure plasma levels of insulin and several inflammatory markers.

Results: Showed that the IL-6 and TREM1 were significantly higher in T2D compared to non-diabetic controls, and the uPAR level was borderline higher in T2D but significantly correlated with IL-6 levels. Unexpectedly, IL8 was significantly below normal in T2D and IL6/IL8 ratio was significantly higher in T2D patients. Unlike other tested markers, uPAR was in addition strongly correlated with insulin levels and HOMA-IR index.

Conclusions: Raised levels of IL6, TREMI, IL6/IL8 ratio, and the strong positive correlation of plasma levels of uPAR with IL-6, insulin, and HOMA-IR index, are reliable spectators of chronic inflammation in T2D patients. The reduced level of IL-8 in T2D was a peculiar observation that needs further explanation. Finally, the consequences and impact of the sustained rise of these inflammatory regulators in diabetic tissues need to be meticulously explored.

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血浆IL-6、TREM1、uPAR和IL6/IL8生物标志物的增加进一步见证了2型糖尿病的慢性炎症。

目的：已知2型糖尿病（T2D）与慢性炎症有关，但炎症调节因子/标志物尚未确切定义，它们之间的联系尚不确定。本研究的目的是通过测试传统（IL6和IL8）和非传统（TREM1和uPAR）炎症标记物来鉴定这些标记物。方法：从科威特卫生机构的114名T2D和74名非糖尿病科威特受试者中获得数据和血液样本。化学分析仪用于测量血糖和脂质状况，而ELISA用于测量血浆胰岛素和几种炎症标志物的水平。结果：与非糖尿病对照组相比，T2D患者的IL-6和TREM1显著升高，uPAR水平在T2D患者中处于临界水平，但与IL-6水平显著相关。出乎意料的是，T2D患者的IL8明显低于正常水平，而T2D患者IL6/IL8的比例明显更高。与其他测试的标志物不同，uPAR与胰岛素水平和HOMA-IR指数密切相关。结论：IL6、TREMI、IL6/IL8比值的升高，以及血浆uPAR水平与IL-6、胰岛素和HOMA-IR指数的强正相关，是T2D患者慢性炎症的可靠观察者。T2D患者的IL-8水平降低是一个特殊的观察结果，需要进一步解释。最后，这些炎症调节因子在糖尿病组织中持续升高的后果和影响需要仔细研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.