HLA最新文献

{"title":"Identification of the novel HLA-DRB3*02:209 allele by next-generation sequencing","authors":"Jong Kwon Lee,&nbsp;Sookyeon Lee,&nbsp;Jun Woo Park,&nbsp;Sori Lim,&nbsp;Eun-Suk Kang","doi":"10.1111/tan.15630","DOIUrl":"10.1111/tan.15630","url":null,"abstract":"<p><i>HLA-DRB3*02:209</i> is identical to <i>HLA-DRB3*02:02:01:01</i> except for a single nucleotide substitution in exon 4.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the novel HLA-B*51:413 allele by next-generation sequencing in a Chinese Han individual","authors":"Qinqin Pan,&nbsp;Xiao Ma,&nbsp;Yajie You,&nbsp;Ying Li,&nbsp;Xiaoyu Zhou","doi":"10.1111/tan.15617","DOIUrl":"10.1111/tan.15617","url":null,"abstract":"<p>The novel allele <i>HLA-B*51:413</i> differs from <i>HLA-B*51:92:02</i> by one nucleotide substitution in exon 3.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the novel HLA-A*33:01:21 allele, first identified in a Brazilian individual","authors":"Mayara Cunha,&nbsp;Gabriela Andrade,&nbsp;Romulo Vianna,&nbsp;Luís Cristóvão Porto,&nbsp;Danielle Secco","doi":"10.1111/tan.15618","DOIUrl":"10.1111/tan.15618","url":null,"abstract":"<p>The novel <i>HLA-A*33:01:21</i> allele, first described in a potential bone marrow donor from Brazil.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes”","authors":"","doi":"10.1111/tan.15615","DOIUrl":"10.1111/tan.15615","url":null,"abstract":"<p>\u0000 <span>Pollock, NR</span>, <span>Farias, TDJ</span>, <span>Kichula, KM</span>, et al. <span>The 18th International HLA &amp; Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes</span>. <i>HLA.</i> <span>2024</span>; <span>103</span>(<span>6</span>):e15568. doi:10.1111/tan.15568\u0000 </p><p>In the article, the Abstract section was inadvertently removed. The Abstract should read:</p><p><b>Abstract</b></p><p>A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the <i>MHC</i> genomic region. This collection proved invaluable for assay development in the histocompatibility and immunogenetics field, for generating the human reference genome, and furthered our understanding of <i>MHC</i> diversity. Defined by their <i>HLA-A, -B, -C</i> and <i>-DRB1</i> alleles, the combined frequency of the haplotypes from these individuals is ~20% in Europe. Thus, a significant proportion of <i>MHC</i> haplotypes, both common and rare throughout the world, and including many associated with disease, are not yet represented. In this workshop component, we are collecting the next generation of <i>MHC</i>-homozygous samples, to expand, diversify and modernize this critical community resource that has been foundational to the field. We asked laboratories worldwide to identify samples homozygous through all <i>HLA class I</i> and/or <i>HLA class II</i> genes, or through whole-genome SNP genotyping or sequencing, to have extensive homozygosity tracts within the <i>MHC</i> region. The focus is non-Europeans or those having <i>HLA</i> haplotypes less common in Europeans. Through this effort, we have obtained samples from 537 individuals representing 294 distinct haplotypes, as determined by their <i>HLA class I</i> and <i>II</i> alleles, and an additional 50 haplotypes distinct in <i>HLA class I</i> or <i>II</i> alleles. Although we have expanded the diversity, many populations remain underrepresented, particularly from Africa, and we encourage further participation. The data will serve as a resource for investigators seeking to characterise variation across the <i>MHC</i> genomic region for disease and population studies.</p><p>The abstract has been added to the online version.</p><p>We apologize for this error.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the novel HLA-B*27:276 allele by next-generation sequencing","authors":"Galluccio Tiziana,&nbsp;Giustiniani Paola,&nbsp;Guagnano Annalisa,&nbsp;Basi Francesca,&nbsp;Andreani Marco","doi":"10.1111/tan.15605","DOIUrl":"10.1111/tan.15605","url":null,"abstract":"<p>The novel <i>HLA-B*27:276</i> allele differs from <i>HLA-B*27:05:02:05</i> by one nucleotide substitution in exon 1.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the novel HLA-DQA1*05:112 allele by sequencing-based typing","authors":"Lucie Blandin,&nbsp;Jonathan Visentin,&nbsp;Elodie Wojciechowski,&nbsp;Richard Lemal,&nbsp;Paul Rouzaire","doi":"10.1111/tan.15621","DOIUrl":"10.1111/tan.15621","url":null,"abstract":"<p><i>HLA-DQA1*05:112</i> differs from <i>HLA-DQA1*05:05:01:01</i> by one nucleotide substitution in codon −7 in exon 1.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the novel HLA-DRB1*04:379N allele by sequencing-based typing","authors":"Lucie Blandin,&nbsp;Mamy Ralazamahaleo,&nbsp;Gwendaline Guidicelli,&nbsp;Paul Rouzaire,&nbsp;Richard Lemal","doi":"10.1111/tan.15623","DOIUrl":"10.1111/tan.15623","url":null,"abstract":"<p><i>HLA-DRB1*04:379N</i> differs from <i>HLA-DRB1*04:01:01:01</i> by one nucleotide substitution in codon 4 in exon 1.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allosensitisation in NHP results in cross-reactive anti-SLA antibodies not detected by a lymphocyte-based flow cytometry crossmatch","authors":"Joseph M. Ladowski,&nbsp;Henry Chapman,&nbsp;Isabel DeLaura,&nbsp;Imran J. Anwar,&nbsp;Janghoon Yoon,&nbsp;Zheng Chen,&nbsp;Adella Clark,&nbsp;DongFeng Chen,&nbsp;Stuart Knechtle,&nbsp;Annette Jackson,&nbsp;Bruce Rogers,&nbsp;Jean Kwun","doi":"10.1111/tan.15599","DOIUrl":"10.1111/tan.15599","url":null,"abstract":"<p>Xenotransplantation is a potential option for individuals for whom an acceptable human allograft is unavailable. Individuals with broadly reactive HLA antibodies due to prior exposure to foreign HLA are potential candidates for a clinical xenotransplant trial. It remains controversial if allosensitisation results in the development of cross-reactive antibodies against SLA. This may require increased histocompatibility scrutiny for highly sensitised individuals prior to enrollment in a clinical trial. Serum samples were obtained from non-human primates sensitised via serial skin transplantation from maximally MHC-mismatched donor, as reported. Sera from pre- and post-allosensitisation timepoints were assessed in a flow crossmatch (FXM) for IgM and IgG binding to pig splenocytes with or without red blood cell adsorption. Xenoreactive antibodies were eluted from pig splenocytes and screened on a single antigen HLA bead assay. A MHC Matchmaker algorithm was developed to predict potential conserved amino acid motifs among the pig, NHP, and human. Our sensitised NHP model was used to demonstrate that allosensitisation does not result in an appreciable difference in xenoreactive antibody binding in a cell-based FXM. However, antibody elution and screening on single antigen HLA beads suggest the existence of potential cross-reactive antibodies against SLA. The cross-reactive IgG after allosensitisation were predicted by comparing the recipient Mamu alleles against its previous allograft donor Mamu alleles and the donor pig SLA alleles. Our study suggests that allosensitisation could elevate cross-reactive antibodies, but a more sensitive assay than a cell-based FXM is required to detect them. The MHC Matchmaker algorithm was developed as a potential tool to help determine amino acid motif conservation and reactivity pattern.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-B*51:197: A composite product of interlocus recombination of B*51:01:01:01 and C*01:02:01:01","authors":"Niels Kouprie,&nbsp;Laura B. Bungener,&nbsp;Annechien J. A. Lambeck,&nbsp;Bart-Jan Kroesen,&nbsp;Bouke G. Hepkema","doi":"10.1111/tan.15606","DOIUrl":"10.1111/tan.15606","url":null,"abstract":"<p>The <i>HLA-B*51:197</i> allele is generated from the interlocus recombination of both <i>HLA-B*51:01:01:01</i> and <i>HLA-C*01:02:01:01</i> alleles.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the novel HLA-A*11:01:117 allele by next-generation sequencing","authors":"Yizhen He,&nbsp;Qi Li,&nbsp;Fang Wang,&nbsp;Chen Chen,&nbsp;Faming Zhu","doi":"10.1111/tan.15608","DOIUrl":"10.1111/tan.15608","url":null,"abstract":"<p><i>HLA-A*11:01:117</i> differs from <i>HLA-A*11:01:01:01</i> by a single nucleotide substitution at position 780 A&gt;G.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}