HLA最新文献

{"title":"Characterisation of the Novel HLA-DPA1*01:03:64 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Marco Andreani,&nbsp;Marine Cargou,&nbsp;Mamy Ralazamahaleo,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70973","DOIUrl":"10.1111/tan.70973","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPA1*01:03:64</i> differs from <i>HLA-DPA1*01:03:01:05</i> by one synonymous nucleotide substitution in codon 20 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-C*16:01:53 Allele by Next-Generation Sequencing","authors":"Delphine Giusti,&nbsp;Grégory Salez,&nbsp;Thierry Tabary,&nbsp;Marcelle Tonye Libyh,&nbsp;Grégory Gatouillat","doi":"10.1111/tan.70989","DOIUrl":"10.1111/tan.70989","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*16:01:53</i> differs from <i>HLA-C*16:01:01:01</i> by one nucleotide substitution in codon 130 of exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the MICA*045:01:04 and MICA*004:01:22 Alleles in Haematopoietic Stem Cell Donors From India","authors":"Disha Agarwal,&nbsp;Gaurav Sharma,&nbsp;Alka Khadwal,&nbsp;Pankaj Malhotra","doi":"10.1111/tan.70983","DOIUrl":"10.1111/tan.70983","url":null,"abstract":"<div>\u0000 \u0000 <p><i>MICA*045:01:04</i> and <i>MICA*004:01:22</i> alleles were identified in Haematopoietic stem cell donors from India.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-C*16:240 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Vincent Elsermans,&nbsp;Marine Cargou,&nbsp;Oceane Tenchon,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70984","DOIUrl":"10.1111/tan.70984","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*16:240</i> differs from <i>HLA-C*16:01:01:01</i> by one nucleotide substitution in codon 276 in exon 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DRB1*16:86 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Marco Andreani,&nbsp;Marine Cargou,&nbsp;Elodie Wojciechowski,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70994","DOIUrl":"10.1111/tan.70994","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB1*16:86</i> differs from <i>HLA-DRB1*16:01:01:03</i> by one nucleotide substitution in codon 205 in Exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA Diversity of Over 500,000 Individuals on the DATRI Register Across 18 Regions in India","authors":"Michaela Agapiou,&nbsp;Nezih Cereb,&nbsp;Claudia Rutt,&nbsp;Steven G. E. Marsh,&nbsp;James Robinson","doi":"10.1111/tan.70908","DOIUrl":"10.1111/tan.70908","url":null,"abstract":"<p>Registries of unrelated stem cell donors can use HLA haplotype frequencies to aid in registry management. DATRI is India's largest registry with over 550,000 donors, with donors in 35 of India's 36 states and union territories. A geographical based analysis on HLA haplotype frequencies has not previously been carried out with an Indian dataset of this size. To balance granularity and accuracy in estimating 5-locus haplotype frequencies for HLA-A, -C, -B, -DRB1 and -DQB1, we grouped donors into 18 regions with a minimum population size of 2000 donors. We identified the most frequent haplotype as <i>A*33:03-ARD~C*07:01-ARD~B*44:03-ARD~DRB1*07:01-ARD~DQB1*02:01-ARD</i> in Odisha (6.09%), which was also the most frequent haplotype in nine other regions. Assigning the most likely diplotypes to donors, there were a total of 57,959 haplotypes and just 202 (0.3%) of those were present in all 18 regions. HLA-B had the greatest number of alleles across the whole dataset (559) and HLA-DQB1 the least (167). However, HLA-C displayed the most inter-region diversity with only 6.7% of HLA-C alleles present in all regions (average 9.5%). We clustered the regions, using Nei's standard genetic distance, and these correlated with geography; however, three regions (North India, Kerala, and the Gujarat area) did not fit into any cluster. These regions each had one or more distinctive haplotypes that were very frequent (≥ 0.5%) in that region alone. Additionally, the Gujarat area had the lowest diversity metrics. These data can be used to inform the management of registries and contribute to our understanding of HLA diversity globally.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-B*55:01:37 Allele by Next Generation Sequencing","authors":"Julien Lion,&nbsp;Myriam Dollerschell,&nbsp;Sylvie Desmons,&nbsp;Judith Desoutter,&nbsp;Nicolas Guillaume","doi":"10.1111/tan.70988","DOIUrl":"10.1111/tan.70988","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*55:01:37</i> differs from the <i>HLA-B*55:01:01:01</i> allele by one nucleotide at position 2260 in exon 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DPB1*1965:01 Allele Using PacBio Sequencing Technology","authors":"Xiaohua Liang,&nbsp;Suning Bai,&nbsp;Wanzhen Yu","doi":"10.1111/tan.70938","DOIUrl":"https://doi.org/10.1111/tan.70938","url":null,"abstract":"<div>\u0000 \u0000 <p>Compared with <i>HLA-DPB1*13:01:01:01</i>, <i>HLA-DPB1*1965:01</i> has a nucleotide substitution in Exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Fetal HLA Heterozygosity in Preeclampsia: Insights From a Large Multi-Ancestry Pregnancy Cohort","authors":"Chang Cao,&nbsp;Matthew Maher,&nbsp;Jie Hu,&nbsp;Brendan J. Keating,&nbsp;Richard M. Burwick,&nbsp;S. Ananth Karumanchi,&nbsp;G. Larry Maxwell,&nbsp;Camille E. Powe,&nbsp;Thomas F. McElrath,&nbsp;David E. Cantonwine,&nbsp;Norma Serrano,&nbsp;Claudia Colmenares,&nbsp;Juan P. Casas,&nbsp;Richa Saxena,&nbsp;Kathryn J. Gray","doi":"10.1111/tan.70970","DOIUrl":"https://doi.org/10.1111/tan.70970","url":null,"abstract":"<div>\u0000 \u0000 <p>Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity, with immune dysregulation at the maternal–fetal interface central to its pathogenesis. The highly polymorphic HLA region mediates maternal immune tolerance of the semi-allogeneic fetus, yet the contribution of HLA diversity to PE risk remains poorly defined. Whether the HLA heterozygote advantage observed in other immune disorders is relevant to PE has not been systematically evaluated. Using data from the multi-ancestry TOPMed Boston–Colombia Collaborative for Adverse Pregnancy Outcomes (<i>n</i> = 12,790; 4770 PE, 8020 controls; 10,808 maternal, 1982 fetal, including 1848 pairs), we evaluated associations between heterozygosity across eight classical HLA loci and PE and four sub-phenotypes, adjusting for genetic ancestry. HLA heterozygosity was common across most loci (&gt; 80%). No individual maternal HLA locus was associated with overall PE; however, heterozygosity across Class I loci showed a protective effect in preterm PE (OR = 0.81, 95% CI: 0.68–0.97), with a similar pattern for HLA-A heterozygosity (OR = 0.78, 95% CI: 0.64–0.97). In contrast, fetal heterozygosity at HLA-DQB1 was nominally associated with increased risk of PE (OR = 1.36, 95% CI: 1.03–1.80) and preterm PE (OR = 1.73, 95% CI: 1.13–2.74). No individual maternal or fetal HLA alleles were associated with PE. Maternal–fetal mismatch analysis demonstrated locus-specific associations with preterm PE, including increased risk with HLA-DQA1 mismatch and reduced risk with HLA-C mismatch. These findings highlight distinct maternal and fetal immunogenetic contributions to PE risk and underscore the importance of considering HLA diversity—rather than individual alleles alone—in studies of PE aetiology.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome Address","authors":"","doi":"10.1111/tan.70886","DOIUrl":"https://doi.org/10.1111/tan.70886","url":null,"abstract":"<p>Dear Colleagues,</p><p>On behalf of the German Society for Immunogenetics (Deutsche Gesellschaft für Immungenetik, DGI) and the Scientific and Local Organising Committees, we are delighted to welcome all participants to the 33rd Annual DGI Conference, taking place from 16th to 18th September at the University Hospital Erlangen, Bavaria, Germany.</p><p>The scientific programme focuses on HLA genetics and the role of HLA antigens in modulating immune responses in solid organ and hematopoietic stem cell transplantation, as well as on fundamental aspects of HLA biology and nomenclature. It also highlights recent clinical advances in immunotherapy and histocompatibility, including novel diagnostic and therapeutic approaches, as well as developments in quality management.</p><p>The plenary sessions feature presentations on organ preservation, post-transplant patient monitoring, and the future direction of the Eurotransplant Reference Laboratory, as presented by its newly appointed director. The programme also includes lectures on platelet antibodies, the influence of the microbiome on graft-versus-host disease (GvHD), donor chimerism monitoring, and early relapse detection. Additional sessions will address non-classical HLA genes, evolutionary aspects of immunogenetics, and computational approaches to HLA data analysis. Further topics include quality management, external proficiency testing, delisting and desensitization, the diagnosis of antibody-mediated rejection (ABMR), and emerging therapeutic strategies following organ transplantation.</p><p>In addition to numerous scientific abstract presentations, the conference offers two educational sessions specifically designed for medical laboratory technicians—a forum and a workshop—as well as a dedicated training session on xenotransplantation, virtual crossmatching, and the future of the lymphocytotoxicity test.</p><p>This year, the DGI will present several prestigious awards. Honorary Membership will be conferred upon Wolfgang Mayr of the Medical University of Vienna in recognition of his outstanding contributions to the field. Further awards include the Next Generation Award for outstanding young scientists, awards for medical laboratory technicians and information technology, as well as prizes for the Best Abstract and Best Poster.</p><p>The Annual DGI Conference aims to showcase the latest scientific developments in immunogenetics while fostering discussion on future challenges and opportunities in the field. We hope that this year's meeting will provide valuable scientific insights, stimulate inspiring discussions, and offer many opportunities for professional exchange. We wish all participants a successful, enjoyable, and rewarding conference.</p><p><b>Bernd Spriewald</b>  President of the DGI and Conference President</p><p><b>Markus Luber</b>   Conference President</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 S1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}