HLA最新文献

{"title":"The Novel HLA-DRB1*12:113 Allele Was Identified by Next-Generation Sequencing","authors":"Min-Kyung So,&nbsp;Youn Keong Cho,&nbsp;Sori Lim,&nbsp;Jina Lee,&nbsp;Soo-Kyung Kim","doi":"10.1111/tan.70339","DOIUrl":"https://doi.org/10.1111/tan.70339","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB1*12:113</i> differs from <i>HLA-DRB1*12:01:01:14</i> at codon 95 (GTC&gt;ATC) and codon 191 (CGG&gt;TGG).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Identification of the HLA-B*27:277 Allele in Individuals of European Descent and Native American Descent”","authors":"","doi":"10.1111/tan.70331","DOIUrl":"https://doi.org/10.1111/tan.70331","url":null,"abstract":"<p> <span>S. Al Agbar</span>, <span>K. De Koning</span>, <span>A. Sharma</span>, <span>D. Beaune</span>, and <span>A. M. E. Sidahmed</span>, “ <span>Identification of the HLA-B*27:277 Allele in Individuals of European Descent and Native American Descent</span>,” <i>HLA</i> <span>105</span>, no. <span>6</span> (<span>2025</span>): e70287, https://doi.org/10.1111/tan.70287.</p><p>In the author byline, the author's order was incorrect.</p><p>The incorrect list of authors reads:</p><p>David Beaune, Arpit Sharma, Kathryn De Koning, Abubaker M. E. Sidahmed, Sabina Al Agbar.</p><p>The correct list of authors should be:</p><p>Sabina Al Agbar, Kathryn De Koning, Arpit Sharma, David Beaune, Abubaker M. E. Sidahmed.</p><p>We apologise for this error.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor HLA Class I Evolutionary Divergence and Late Allograft Rejection After Liver Transplantation in Children: An Emulated Target Trial","authors":"Jérôme Dumortier,&nbsp;Sarah Hamada,&nbsp;Emma Wischlen,&nbsp;Céline Mandier,&nbsp;Noémie Laverdure,&nbsp;Olivier Boillot,&nbsp;Ilias Kounis,&nbsp;Vincent Allain,&nbsp;Valérie Hervieu,&nbsp;Sophie Collardeau-Frachon,&nbsp;Valérie Dubois,&nbsp;Cyrille Feray","doi":"10.1111/tan.70320","DOIUrl":"https://doi.org/10.1111/tan.70320","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA evolutionary divergence (HED), a continuous metric quantifying the differences between each amino acid of two homologous HLA alleles, reflects the importance of the immunopeptidome presented to T lymphocytes. It has been associated with rejection after liver transplantation. This retrospective cohort study aimed to analyse the potential effect of donor or recipient HED on liver transplant rejection in a new series of patients transplanted during childhood and followed in adulthood. The study included 120 children who had been transplanted between 1991 and 2010 and were followed by routine biopsies and histological evaluations with a median of 14.1 years post-LT. Liver biopsies were performed routinely 1, 5, 10 and 20 years after transplantation and in the event of liver dysfunction. HED was calculated using the physicochemical Grantham distance for donor and recipient Class I (HLA-A, -B, -C) and Class II (HLA-DRB1, -DQB1) alleles. The influence of HED on rejection was analysed using inverse probability weighting (IPW) and target trial emulation using the g method. Based on the IPW score, donor HED class I was correlated with the occurrence of late (&gt; 90 days) rejection (HR, 1.19, 95% CI: 1.01–1.40) independently of HLA mismatches, donor age and initial induction. The emulated target trial confirmed that donor HED Class I has a causal effect on liver graft rejection and this relationship was observed long-term.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DPA1*02:113 Allele Using Next-Generation Sequencing","authors":"Junhyup Song,&nbsp;Jongseon Park,&nbsp;Sunmi Jung,&nbsp;Jina Lee,&nbsp;Younhee Park","doi":"10.1111/tan.70334","DOIUrl":"https://doi.org/10.1111/tan.70334","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-DPA1*02:113</i> allele differs from the <i>HLA-DPA1*02:02:02:01</i> allele by a single nucleotide at codon-3 in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DQA1*03:60 Allele Using Next-Generation Sequencing","authors":"Jiyeon Kim,&nbsp;Jongseon Park,&nbsp;Sunmi Jung,&nbsp;Jina Lee,&nbsp;Younhee Park","doi":"10.1111/tan.70335","DOIUrl":"https://doi.org/10.1111/tan.70335","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-DQA1*03:60</i> allele differs from the <i>HLA-DQA1*03:02:01:01</i> allele by a single nucleotide at codon 161 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate Effects of SNPs on Environmental Streptococcal Mastitis Evaluated With an NGS-Based Association Study Using Targeted Resequencing in the Bovine MHC Region","authors":"Fumihiro Nagata,&nbsp;Chieh-Wen Lo,&nbsp;Susumu Saito,&nbsp;Ryosuke Matsuura,&nbsp;Sonoko Watanuki,&nbsp;Kazuyoshi Hosomichi,&nbsp;Shinji Sasaki,&nbsp;Ryusaku Kawata,&nbsp;Hiroyuki Shimizu,&nbsp;Takahiro Sone,&nbsp;Haruna Yamazaki,&nbsp;Ayuha Niwano,&nbsp;Kazuhiro Kawai,&nbsp;Tetsuya Mizutani,&nbsp;Yasunobu Matsumoto,&nbsp;Shin-nosuke Takeshima,&nbsp;Yoko Aida","doi":"10.1111/tan.70333","DOIUrl":"https://doi.org/10.1111/tan.70333","url":null,"abstract":"<p>Mastitis is an inflammatory reaction caused by bacterial infection of the teat, and a relationship between its onset and cattle major histocompatibility complex (<i>BoLA</i>) region has been reported. However, no comprehensive genetic analysis of mastitis caused by environmental streptococci has been reported. Here, we resequenced the <i>BoLA</i> region using a hybridisation capture target next-generation sequencing (NGS) method to identify disease susceptibility markers mapped to the <i>BoLA</i> region in environmental streptococcal mastitis. This study examined 75 cows with mastitis caused by environmental streptococci selected from 1641 cows with mastitis and 222 healthy cows without mastitis in Japan. Targeted sequences obtained from MiSeq NGS were aligned to the bovine reference genome (ARS-UCD1.2/bosTau9), and 2,920,355 variants were detected within the <i>BoLA</i> region of the 297 Holstein cattle. In an association study using 2264 variants after quality control, the top 20 variants with the lowest <i>P</i> values were selected and assigned to the 18 surrounding candidate genes, and a gene network analysis of these genes resulted in the narrowing down of five candidate genes <i>POU5F1</i>, <i>IER3</i>, <i>GNL1</i>, <i>ABCF1,</i> and <i>PRR3</i>. Multivariate effect analysis of all 6 SNPs associated with these 5 genes revealed that they were significantly correlated with mastitis, indicating that they were useful for classification of mastitis-resistant and mastitis-susceptible cattle. This is the first report to identify SNPs associated with environmental streptococcal mastitis with an NGS-based association study using targeted resequencing in the <i>BoLA</i> region, and understanding host factors may provide important clues for mastitis control.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DRB1*12:110 Allele Using Next-Generation Sequencing","authors":"Junhyup Song,&nbsp;Jongseon Park,&nbsp;Sunmi Jung,&nbsp;Jina Lee,&nbsp;Younhee Park","doi":"10.1111/tan.70332","DOIUrl":"https://doi.org/10.1111/tan.70332","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-DRB1*12:110</i> allele differs from the <i>HLA-DRB1*12:01:01:05</i> allele by a single nucleotide at codon 179 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirteen Novel HLA Class I Alleles Identified in a Brazilian Population Using NGS-Based Typing","authors":"Adalberto Socorro da Silva,&nbsp;Anaregina de Sousa Araujo,&nbsp;Rubens de Sousa Santana,&nbsp;Semiramis Jamil Hadad do Monte","doi":"10.1111/tan.70306","DOIUrl":"https://doi.org/10.1111/tan.70306","url":null,"abstract":"<div>\u0000 \u0000 <p>Eight nonsynonymous and five synonymous HLA class I variants identified in admixed Brazilian individuals.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Roberto Tosi (1938–2024)","authors":"Doriana Fruci,&nbsp;Rosa Sorrentino","doi":"10.1111/tan.70300","DOIUrl":"https://doi.org/10.1111/tan.70300","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-C*14:168 Allele by Two Different Sequencing-Based Typing Techniques","authors":"Magali Devriese,&nbsp;Anne-Flore Le Collonnier,&nbsp;Melchior Le Mene,&nbsp;Jean-Luc Taupin","doi":"10.1111/tan.70316","DOIUrl":"https://doi.org/10.1111/tan.70316","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel HLA-C*14:168 allele differs from HLA-C*14:02:01:02 by three nucleotides in exon 7.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}