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Characterisation of the Novel HLA-A*32:187 Allele by Next-Generation Sequencing HLA-A*32:187等位基因的新一代测序研究
IF 4.1 4区 医学
HLA Pub Date : 2025-10-10 DOI: 10.1111/tan.70435
Grégory Gatouillat, Marcelle Tonye Libyh, Grégory Salez, Delphine Giusti, Bach Nga Pham
{"title":"Characterisation of the Novel HLA-A*32:187 Allele by Next-Generation Sequencing","authors":"Grégory Gatouillat,&nbsp;Marcelle Tonye Libyh,&nbsp;Grégory Salez,&nbsp;Delphine Giusti,&nbsp;Bach Nga Pham","doi":"10.1111/tan.70435","DOIUrl":"https://doi.org/10.1111/tan.70435","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*32:187</i> differs from <i>HLA-A*32:01:01:01</i> by one nucleotide substitution in codon 211 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Novel HLA-A Alleles in Individuals From India 印度人HLA-A等位基因的鉴定
IF 4.1 4区 医学
HLA Pub Date : 2025-10-07 DOI: 10.1111/tan.70427
Jyoti Rajak, Alfiya Firfire, Manisha Tambe, Selma Z. D'Silva
{"title":"Identification of Novel HLA-A Alleles in Individuals From India","authors":"Jyoti Rajak,&nbsp;Alfiya Firfire,&nbsp;Manisha Tambe,&nbsp;Selma Z. D'Silva","doi":"10.1111/tan.70427","DOIUrl":"10.1111/tan.70427","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel alleles <i>HLA-A*24:643</i>, -<i>A*24:02:01:145</i>, and -<i>A*24:07:05</i> were identified during routine HLA typing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Novel HLA-C Allele With a New Amino Acid Residue in the α-3 Domain, HLA-C*07:1216 α-3结构域新氨基酸残基HLA-C等位基因HLA-C*07:1216的鉴定
IF 4.1 4区 医学
HLA Pub Date : 2025-10-07 DOI: 10.1111/tan.70430
Judith Olleta, Maria Jesus Gil, Eva Bandres
{"title":"Identification of a Novel HLA-C Allele With a New Amino Acid Residue in the α-3 Domain, HLA-C*07:1216","authors":"Judith Olleta,&nbsp;Maria Jesus Gil,&nbsp;Eva Bandres","doi":"10.1111/tan.70430","DOIUrl":"10.1111/tan.70430","url":null,"abstract":"<div>\u0000 \u0000 <p>Characterisation of the novel HLA-C allele, <i>C*07:1216</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-DQB1*06:528 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual 中国人HLA-DQB1*06:528新等位基因的Sanger双脱氧核苷酸测序
IF 4.1 4区 医学
HLA Pub Date : 2025-10-07 DOI: 10.1111/tan.70432
Cheng-yan Gao, Tian-ju Hu, Zhi-cong Xie, Pei-pei Ding, Xiao-hong Cai
{"title":"The Novel HLA-DQB1*06:528 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual","authors":"Cheng-yan Gao,&nbsp;Tian-ju Hu,&nbsp;Zhi-cong Xie,&nbsp;Pei-pei Ding,&nbsp;Xiao-hong Cai","doi":"10.1111/tan.70432","DOIUrl":"10.1111/tan.70432","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*06:528</i> differs from <i>HLA-DQB1*06:09:01:01</i> by a single non-synonymous nucleotide change in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA Class I Allele, HLA-C*12:02:57, Identified by Next-Generation Sequencing in an Indian Individual 印度人HLA- I类等位基因HLA- c *12:02:57的新发现
IF 4.1 4区 医学
HLA Pub Date : 2025-10-06 DOI: 10.1111/tan.70431
Samir Agarwal, Shikha Kumari, Manu Bamal, Neha Bairagi, Sachin Rana
{"title":"The Novel HLA Class I Allele, HLA-C*12:02:57, Identified by Next-Generation Sequencing in an Indian Individual","authors":"Samir Agarwal,&nbsp;Shikha Kumari,&nbsp;Manu Bamal,&nbsp;Neha Bairagi,&nbsp;Sachin Rana","doi":"10.1111/tan.70431","DOIUrl":"10.1111/tan.70431","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele <i>HLA-C*12:02:57</i> differs from <i>HLA-C*12:02:02:01</i> by a one nucleotide change A &gt; T in exon 4 (CCA &gt; CCT).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the HLA-C*08:03:01:03 Allele in an Individual in a Kshatriya Family Kshatriya家族个体HLA-C*08:03:01:03等位基因的鉴定
IF 4.1 4区 医学
HLA Pub Date : 2025-10-03 DOI: 10.1111/tan.70421
Manisha Tambe, Jyoti Rajak, Alfiya Firfire, Selma Z. D'Silva
{"title":"Identification of the HLA-C*08:03:01:03 Allele in an Individual in a Kshatriya Family","authors":"Manisha Tambe,&nbsp;Jyoti Rajak,&nbsp;Alfiya Firfire,&nbsp;Selma Z. D'Silva","doi":"10.1111/tan.70421","DOIUrl":"10.1111/tan.70421","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-C*08:03:01:03</i> allele displays a polymorphism at position gDNA 1920 (C&gt;T) when compared to <i>HLA-C*08:03:01:02</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TinyHLAnet: A Light-Weight 3D Structure-Aware Architecture for Rapid and Explainable Identification of CD8+ T-Cell Antigens TinyHLAnet:用于CD8+ t细胞抗原快速和可解释鉴定的轻量级3D结构感知架构
IF 4.1 4区 医学
HLA Pub Date : 2025-10-03 DOI: 10.1111/tan.70410
Naren Chandran Sakthivel, Sumanta Mukherjee, Nagasuma Chandra
{"title":"TinyHLAnet: A Light-Weight 3D Structure-Aware Architecture for Rapid and Explainable Identification of CD8+ T-Cell Antigens","authors":"Naren Chandran Sakthivel,&nbsp;Sumanta Mukherjee,&nbsp;Nagasuma Chandra","doi":"10.1111/tan.70410","DOIUrl":"https://doi.org/10.1111/tan.70410","url":null,"abstract":"<div>\u0000 \u0000 <p>CD8+ T cell response is contingent on the surveillance and recognition of peptide antigens presented on HLA class I molecules. The highly polymorphic nature of the HLA loci combined with the vast cognate peptide space makes comprehensive experimental characterisation of the peptides presented by different individuals in different disease conditions intractable. Several computational methods for epitope prediction exist, but there is a necessity in the field for rapid, interpretable and personalised prediction of CD8+ T cell epitopes. We address this gap by developing a novel deep learning architecture, termed TinyHLAnet, that produces highly accurate and fast prediction of peptide-HLA (class I) complex formation. This architecture is developed using constraints derived from domain knowledge of contact formation in peptide-HLA (class I) complexes. Specifically, the estimation of binding affinity of the peptide-HLA complex is decomposed into subproblems relating to estimating the interaction strength of each intermolecular residue pair in the complex, which in itself is factorised into three different components based on knowledge of residue pair interactions. This compartmentalisation allows for the production of a model that uses a fraction of the parameters used by existing gold standard methods at no loss of prediction accuracy but provides much greater throughput. The TinyHLAnet prediction engine serves as a framework for several applications, with two examples shown here: TinyHLAnet-SCAN, for proteome-wide scanning of epitopes, and TinyHLAnet-ESCAPE, for prediction of likely immune escape mutants.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-C*08:294 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual 中国人新型HLA-C*08:294等位基因的Sanger双脱氧核苷酸测序
IF 4.1 4区 医学
HLA Pub Date : 2025-10-03 DOI: 10.1111/tan.70429
Cheng-yan Gao, Pei-pei Ding, Qiang Liu, Yan-ping Diao, Xiao-hong Cai
{"title":"The Novel HLA-C*08:294 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual","authors":"Cheng-yan Gao,&nbsp;Pei-pei Ding,&nbsp;Qiang Liu,&nbsp;Yan-ping Diao,&nbsp;Xiao-hong Cai","doi":"10.1111/tan.70429","DOIUrl":"https://doi.org/10.1111/tan.70429","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*08:294</i> allele differs from <i>HLA-C*08:01:01:01</i> by a single non-synonymous nucleotide change in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel Allele, HLA-B*50:01:01:14, in an Individual From North India 印度北部个体HLA-B*50:01:01:14等位基因的鉴定
IF 4.1 4区 医学
HLA Pub Date : 2025-10-02 DOI: 10.1111/tan.70425
Bhagyashri Karale, Manisha Tambe, Jyoti Rajak, Selma Zenia D'Silva
{"title":"Identification of the Novel Allele, HLA-B*50:01:01:14, in an Individual From North India","authors":"Bhagyashri Karale,&nbsp;Manisha Tambe,&nbsp;Jyoti Rajak,&nbsp;Selma Zenia D'Silva","doi":"10.1111/tan.70425","DOIUrl":"10.1111/tan.70425","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele <i>HLA-B*50:01:01:14</i> displays a single polymorphism in the 5′UTR when compared to <i>HLA-B*50:01:01:01</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Genomic Sequence of the HLA-A*02:453 Allele Characterised by Long-Range PCR, Cloning and Sequencing HLA-A*02:453等位基因的全基因组序列、克隆与测序
IF 4.1 4区 医学
HLA Pub Date : 2025-10-01 DOI: 10.1111/tan.70407
Wei Tian, LiXin Li
{"title":"Full Genomic Sequence of the HLA-A*02:453 Allele Characterised by Long-Range PCR, Cloning and Sequencing","authors":"Wei Tian,&nbsp;LiXin Li","doi":"10.1111/tan.70407","DOIUrl":"10.1111/tan.70407","url":null,"abstract":"<div>\u0000 \u0000 <p>The fully characterised sequence of <i>HLA-A*02:453</i> covers the 5′ and 3′ untranslated regions, all exons and introns.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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