{"title":"Characterisation of the Novel HLA-A*32:187 Allele by Next-Generation Sequencing","authors":"Grégory Gatouillat, Marcelle Tonye Libyh, Grégory Salez, Delphine Giusti, Bach Nga Pham","doi":"10.1111/tan.70435","DOIUrl":"https://doi.org/10.1111/tan.70435","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*32:187</i> differs from <i>HLA-A*32:01:01:01</i> by one nucleotide substitution in codon 211 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jyoti Rajak, Alfiya Firfire, Manisha Tambe, Selma Z. D'Silva
{"title":"Identification of Novel HLA-A Alleles in Individuals From India","authors":"Jyoti Rajak, Alfiya Firfire, Manisha Tambe, Selma Z. D'Silva","doi":"10.1111/tan.70427","DOIUrl":"10.1111/tan.70427","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel alleles <i>HLA-A*24:643</i>, -<i>A*24:02:01:145</i>, and -<i>A*24:07:05</i> were identified during routine HLA typing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of a Novel HLA-C Allele With a New Amino Acid Residue in the α-3 Domain, HLA-C*07:1216","authors":"Judith Olleta, Maria Jesus Gil, Eva Bandres","doi":"10.1111/tan.70430","DOIUrl":"10.1111/tan.70430","url":null,"abstract":"<div>\u0000 \u0000 <p>Characterisation of the novel HLA-C allele, <i>C*07:1216</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng-yan Gao, Tian-ju Hu, Zhi-cong Xie, Pei-pei Ding, Xiao-hong Cai
{"title":"The Novel HLA-DQB1*06:528 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual","authors":"Cheng-yan Gao, Tian-ju Hu, Zhi-cong Xie, Pei-pei Ding, Xiao-hong Cai","doi":"10.1111/tan.70432","DOIUrl":"10.1111/tan.70432","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*06:528</i> differs from <i>HLA-DQB1*06:09:01:01</i> by a single non-synonymous nucleotide change in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samir Agarwal, Shikha Kumari, Manu Bamal, Neha Bairagi, Sachin Rana
{"title":"The Novel HLA Class I Allele, HLA-C*12:02:57, Identified by Next-Generation Sequencing in an Indian Individual","authors":"Samir Agarwal, Shikha Kumari, Manu Bamal, Neha Bairagi, Sachin Rana","doi":"10.1111/tan.70431","DOIUrl":"10.1111/tan.70431","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele <i>HLA-C*12:02:57</i> differs from <i>HLA-C*12:02:02:01</i> by a one nucleotide change A > T in exon 4 (CCA > CCT).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manisha Tambe, Jyoti Rajak, Alfiya Firfire, Selma Z. D'Silva
{"title":"Identification of the HLA-C*08:03:01:03 Allele in an Individual in a Kshatriya Family","authors":"Manisha Tambe, Jyoti Rajak, Alfiya Firfire, Selma Z. D'Silva","doi":"10.1111/tan.70421","DOIUrl":"10.1111/tan.70421","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-C*08:03:01:03</i> allele displays a polymorphism at position gDNA 1920 (C>T) when compared to <i>HLA-C*08:03:01:02</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TinyHLAnet: A Light-Weight 3D Structure-Aware Architecture for Rapid and Explainable Identification of CD8+ T-Cell Antigens","authors":"Naren Chandran Sakthivel, Sumanta Mukherjee, Nagasuma Chandra","doi":"10.1111/tan.70410","DOIUrl":"https://doi.org/10.1111/tan.70410","url":null,"abstract":"<div>\u0000 \u0000 <p>CD8+ T cell response is contingent on the surveillance and recognition of peptide antigens presented on HLA class I molecules. The highly polymorphic nature of the HLA loci combined with the vast cognate peptide space makes comprehensive experimental characterisation of the peptides presented by different individuals in different disease conditions intractable. Several computational methods for epitope prediction exist, but there is a necessity in the field for rapid, interpretable and personalised prediction of CD8+ T cell epitopes. We address this gap by developing a novel deep learning architecture, termed TinyHLAnet, that produces highly accurate and fast prediction of peptide-HLA (class I) complex formation. This architecture is developed using constraints derived from domain knowledge of contact formation in peptide-HLA (class I) complexes. Specifically, the estimation of binding affinity of the peptide-HLA complex is decomposed into subproblems relating to estimating the interaction strength of each intermolecular residue pair in the complex, which in itself is factorised into three different components based on knowledge of residue pair interactions. This compartmentalisation allows for the production of a model that uses a fraction of the parameters used by existing gold standard methods at no loss of prediction accuracy but provides much greater throughput. The TinyHLAnet prediction engine serves as a framework for several applications, with two examples shown here: TinyHLAnet-SCAN, for proteome-wide scanning of epitopes, and TinyHLAnet-ESCAPE, for prediction of likely immune escape mutants.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng-yan Gao, Pei-pei Ding, Qiang Liu, Yan-ping Diao, Xiao-hong Cai
{"title":"The Novel HLA-C*08:294 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual","authors":"Cheng-yan Gao, Pei-pei Ding, Qiang Liu, Yan-ping Diao, Xiao-hong Cai","doi":"10.1111/tan.70429","DOIUrl":"https://doi.org/10.1111/tan.70429","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*08:294</i> allele differs from <i>HLA-C*08:01:01:01</i> by a single non-synonymous nucleotide change in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of the Novel Allele, HLA-B*50:01:01:14, in an Individual From North India","authors":"Bhagyashri Karale, Manisha Tambe, Jyoti Rajak, Selma Zenia D'Silva","doi":"10.1111/tan.70425","DOIUrl":"10.1111/tan.70425","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele <i>HLA-B*50:01:01:14</i> displays a single polymorphism in the 5′UTR when compared to <i>HLA-B*50:01:01:01</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Full Genomic Sequence of the HLA-A*02:453 Allele Characterised by Long-Range PCR, Cloning and Sequencing","authors":"Wei Tian, LiXin Li","doi":"10.1111/tan.70407","DOIUrl":"10.1111/tan.70407","url":null,"abstract":"<div>\u0000 \u0000 <p>The fully characterised sequence of <i>HLA-A*02:453</i> covers the 5′ and 3′ untranslated regions, all exons and introns.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}