HLA最新文献 - Book学术

Identification of the Novel HLA-DPB1*19:01:02 Allele by Next-Generation Sequencing HLA-DPB1*19:01:02等位基因的新一代测序鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70289

Chen Chen, Fang Wang, Wenwen Pi, Wei Zhang, Faming Zhu

引用次数: 0

Characterisation of the Novel KIR2DL3*038 Allele by Next Generation Sequencing 新型KIR2DL3*038等位基因的下一代测序研究

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70297

Velizar Shivarov, Angelina Mladenova, Ilina Micheva, Milena Ivanova

引用次数: 0

Identification of the Novel HLA-C*01:257N Allele by Next-Generation Sequencing 新HLA-C*01:25 . 7n等位基因的新一代测序鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70290

Qi Li, Wenwen Pi, Ying Li, Wei Zhang, Faming Zhu

引用次数: 0

The Novel HLA-DRB1*11:341 Allele Identified in a Brazilian Bone Marrow Donor 在巴西骨髓供者中鉴定出新的HLA-DRB1* 11:31 1等位基因

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70298

Isabella Fantini Molinari, Fernanda Pelisson Massi, Bruna Karina Banin Hirata, Larissa Danielle Bahls Pinto, Jeane Eliete Laguila Visentainer

引用次数: 0

Characterisation of Three Novel HLA-DQB1*02 Alleles, DQB1*02:02:32, DQB1*02:251N and DQB1*02:256 HLA-DQB1*02、DQB1*02:02:32、DQB1*02:251N和DQB1*02:256等位基因的鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70292

Raquel Alenda, Miguel Angel Moreno-Hidalgo, Iris Vicente, Felix García-Sánchez, Antonio Balas

引用次数: 0

Identification of Genetic Variations in HLA Region for Kidney Functions 肾脏功能HLA区域遗传变异的鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70284

Wan-Hsuan Chou, Chun-Yu Wei, Min-Rou Lin, Che-Mai Chang, Stephen B. Gruber, Mai-Szu Wu, Wei-Chiao Chang

{"title":"Identification of Genetic Variations in HLA Region for Kidney Functions","authors":"Wan-Hsuan Chou, Chun-Yu Wei, Min-Rou Lin, Che-Mai Chang, Stephen B. Gruber, Mai-Szu Wu, Wei-Chiao Chang","doi":"10.1111/tan.70284","DOIUrl":"https://doi.org/10.1111/tan.70284","url":null,"abstract":"<div>\u0000 \u0000 HLA allelic polymorphisms are associated with a variety of kidney-related traits in different populations. Although Taiwanese-specific genetic variants associated with kidney function have been reported, the role of HLA alleles is unclear. In this study, the association between eGFR and genetic variations in the HLA region was explored in a cohort of 59,448 Taiwanese subjects. A total of 448 genetic variations in the HLA region are significantly associated with eGFR. HLA-C*03 is associated with decreased eGFR, while HLA-DQA1*03, HLA-DQB1*03:03 and HLA-DQB1*03:03:02 demonstrated protective effects. Moreover, amino acid changes on HLA-C and HLA-DRB1 are significantly associated with eGFR. Finally, the eGFR-associated single nucleotide variations (SNVs) and insertions and deletions (indels) are enriched in the HLA-DQB1 gene. After conditional analysis, we identified two independent signals, including rs2853941, rs3830060. In summary, this study highlights the role of HLA-C, HLA-DQA1, HLA-DQB1 and HLA-DRB1 variations in kidney function in the Taiwan Han Chinese population.\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Swine Xenografts Share Few Predicted Indirectly Recognisable SLA-Derived Epitopes With HLA-Derived Epitopes From Human Kidney Grafts 猪异种移植物与人肾移植物的hla衍生表位几乎没有预测的可间接识别的sla衍生表位

IF 5.9 4区医学

HLA Pub Date : 2025-06-21 DOI: 10.1111/tan.70291

Benedict M. Matern, Eric Spierings, Emma Peereboom, Matt Tector, Joseph Tector, Massimo Mangiola, Robert A. Montgomery, Matthias Niemann

{"title":"Swine Xenografts Share Few Predicted Indirectly Recognisable SLA-Derived Epitopes With HLA-Derived Epitopes From Human Kidney Grafts","authors":"Benedict M. Matern, Eric Spierings, Emma Peereboom, Matt Tector, Joseph Tector, Massimo Mangiola, Robert A. Montgomery, Matthias Niemann","doi":"10.1111/tan.70291","DOIUrl":"https://doi.org/10.1111/tan.70291","url":null,"abstract":"Swine-derived kidneys are a promising alternative organ source for transplantation, but compatibility in the major histocompatibility complex remains an immunological barrier. Furthermore, in repeat transplantations, CD4+ memory T cells can lead to a more rapid immune response against repeated exposure to the same antigens. Several studies have shown that HLA and SLA proteins share overlapping B cell epitopes due to structural or electrostatic similarities, but the role of overlapping T cell epitopes has not been fully explored. This study aims to computationally analyse the potential risk of memory T cell activation in subsequent human-after-swine and swine-after-human transplantation by evaluating shared T cell epitopes between the two graft sources. We show that while HLA and SLA demonstrate striking structural similarities, their linear protein sequences are very distinct, which translates to disparate HLA- and SLA-derived peptidomes and T cell epitopes. By applying the PIRCHE-II Tmem analysis to a simulated panel of recipients receiving repeat transplantations from a human kidney and from a swine xenograft, we observed a median of 1 shared T cell epitope in the cross-species context, compared to a median of 17 shared between two human-derived kidneys. This suggests that a swine xenograft exposes a low risk of T cell memory against a later human donor, and that xenotransplantation may provide an opportunity to receive a graft for highly HLA-sensitised recipients.","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Novel HLA-DPB1*1156:01:02 Allele was Identified by Next-Generation Sequencing 新一代测序鉴定HLA-DPB1*1156:01:02等位基因

IF 5.9 4区医学

HLA Pub Date : 2025-06-19 DOI: 10.1111/tan.70280

Chen Chen, Nanying Chen, Qi Li, Wei Zhang, Faming Zhu

引用次数: 0

Belimumab to Aid Pre-Transplant Immunological Risk-Stratification by Uncovering Broader HLA-Specific Memory B-Cell Profiles Belimumab通过揭示更广泛的hla特异性记忆b细胞谱来帮助移植前免疫风险分层

IF 5.9 4区医学

HLA Pub Date : 2025-06-16 DOI: 10.1111/tan.70285

Dennis A. J. van den Broek, Gonca E. Karahan, Soufian Meziyerh, Yvonne de Vaal, Kim H. Bakker, Geert W. Haasnoot, Joris I. Rotmans, Y. K. Onno Teng, Cees van Kooten, Sebastiaan Heidt, Dave L. Roelen, Aiko P. J. de Vries

{"title":"Belimumab to Aid Pre-Transplant Immunological Risk-Stratification by Uncovering Broader HLA-Specific Memory B-Cell Profiles","authors":"Dennis A. J. van den Broek, Gonca E. Karahan, Soufian Meziyerh, Yvonne de Vaal, Kim H. Bakker, Geert W. Haasnoot, Joris I. Rotmans, Y. K. Onno Teng, Cees van Kooten, Sebastiaan Heidt, Dave L. Roelen, Aiko P. J. de Vries","doi":"10.1111/tan.70285","DOIUrl":"https://doi.org/10.1111/tan.70285","url":null,"abstract":"Highly sensitised kidney transplant candidates face substantial barriers to transplantation due to limited donor compatibility. Delisting unacceptable antigens with detectable HLA-specific antibodies can improve transplant access. It is, however, challenging to determine which specificities are safe to delist. Assessment of circulating HLA-specific memory B-cells may support risk stratification. However, current methodologies are limited by the predominant localisation of memory B-cells in secondary lymphoid organs and thus by potential false negativity. BAFF inhibitors, such as belimumab, mobilise memory B-cells into the circulation, which could reduce false-negative evaluations and improve pretransplant risk stratification. We administered off-label treatment with 200 mg of subcutaneous belimumab weekly for 4 weeks to seven highly sensitised patients with limited allocation probability. The clinical aim was to safely increase allocation probability by selectively delisting unacceptable HLA-specificities without detectable B-cell memory. HLA-specific memory B-cell profiles were assessed before and after treatment, revealing significantly broader HLA-specific memory B-cell profiles after belimumab in addition to a significant increase of HLA-antibody MFI in the eluate of stimulated memory B-cells. This strategy may pave the way for a new paradigm in pretransplant immunological risk-stratification, allowing improved assessment of HLA-specific memory B-cell profiles, which could potentially limit the risk of memory responses.","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the HLA-B*27:277 Allele in Individuals of European Descent and Native American Descent 欧洲血统和美洲原住民血统个体HLA-B*27:277等位基因的鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-16 DOI: 10.1111/tan.70287

David Beaune, Arpit Sharma, Kathryn De Koning, Abubaker M. E. Sidahmed, Sabina Al Agbar

引用次数: 0