HLA最新文献

{"title":"The Novel HLA-DQB1*03:568 Allele Identified in a Canadian Family","authors":"He Zhao,&nbsp;Destinie Webster,&nbsp;Twyla Pearce,&nbsp;Ahmed Mostafa","doi":"10.1111/tan.70178","DOIUrl":"https://doi.org/10.1111/tan.70178","url":null,"abstract":"<div>\u0000 \u0000 <p>Identification of the novel HLA-DQB1*03:568 allele that differs from HLA-DQB1*03:03:02:01 by a non-synonymous mutation within exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The New HLA-DRB1*11:343 Allele Encoding for A Distinctive Peptide-Binding Domain","authors":"Mirzokhid Rakhmanov,&nbsp;Martin Bernheiden,&nbsp;Murielle Verboom,&nbsp;Michael Hallensleben,&nbsp;Florian Emmerich","doi":"10.1111/tan.70175","DOIUrl":"https://doi.org/10.1111/tan.70175","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DRB1*11:343 differs from HLA-DRB1*11:03:01 by a single nucleotide substitution in codon 12 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-Β Allele, HLA-B*18:05:01:03, Identified by Next-Generation Sequencing in a Greek Individual","authors":"Theofilos Athanassiades,&nbsp;Petros Mantzios,&nbsp;Vasiliki Kitsiou,&nbsp;Diamanto Kouniaki,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70189","DOIUrl":"https://doi.org/10.1111/tan.70189","url":null,"abstract":"<div>\u0000 \u0000 <p>The HLA-B*18:05:01:03 allele differs from HLA-B*18:05:01:02 by a single-nucleotide substitution in Intron 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Novel HLA-C Alleles Identified in Unrelated Bone Marrow Volunteers","authors":"Maria Loginova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70150","DOIUrl":"https://doi.org/10.1111/tan.70150","url":null,"abstract":"<div>\u0000 \u0000 <p>Five novel HLA-C alleles have been identified using full next-generation sequencing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-C*07:1173 Allele by Sequencing-Based Typing","authors":"Marine Cargou,&nbsp;Vincent Elsermans,&nbsp;Isabelle Top,&nbsp;Gwendaline Guidicelli,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70186","DOIUrl":"https://doi.org/10.1111/tan.70186","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*07:1173 differs from HLA-C*07:02:01:03 by one nucleotide substitution in codon 96 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Genomic Sequence of the HLA-A*24:85 Allele Identified by Long-Range PCR, Cloning and Sequencing","authors":"Wei Tian,&nbsp;LiXin Li","doi":"10.1111/tan.70176","DOIUrl":"https://doi.org/10.1111/tan.70176","url":null,"abstract":"<div>\u0000 \u0000 <p>The full-length sequence of HLA-A*24:85 covers the 5′-untranslated region (UTR), all introns and exons and the 3′ UTR.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DQA1*01:170 by Sequencing-Based Typing","authors":"Marine Cargou,&nbsp;Marco Andreani,&nbsp;Antonio Giuseppe Bianculli,&nbsp;Mamy Ralazamahaleo,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70185","DOIUrl":"https://doi.org/10.1111/tan.70185","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DQA1*01:170 differs from HLA-DQA1*01:03:01:02 by one nucleotide substitution in codon 183 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allele and Haplotype Frequencies of 17 HLA-Related Loci in Shenzhen Chinese Population by Next-Generation Sequencing","authors":"Jie Liu,&nbsp;Zhan-Rou Quan,&nbsp;Tian-Hui Zhu,&nbsp;Yan-Ping Zhong,&nbsp;Ren-Hui Jiang,&nbsp;Bing-Na Yang,&nbsp;Yin-Ming Zhang,&nbsp;Jia-Min Song,&nbsp;Hong-Yan Zou,&nbsp;Zhi-Hui Deng","doi":"10.1111/tan.70148","DOIUrl":"https://doi.org/10.1111/tan.70148","url":null,"abstract":"<div>\u0000 \u0000 <p>Although the allele and haplotype frequencies of 11 HLA loci (<i>HLA-A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1</i> and <i>DPB1</i>) have been reported in different populations, rare studies have simultaneously assessed the allele distributions of non-classical HLA class I genes (HLA-E/F/G/H) and MICA/MICB together with the 11 classical HLA loci, or further analysed the haplotype frequencies covering the 17 loci. The present study aims to investigate the allele diversity and haplotype frequencies of 17 HLA-related loci including HLA genes and <i>MICA/MICB</i> simultaneously using a hybrid capture (HC)-based NGS method. A total of 358 HLA alleles including 177 class I and 137 class II alleles, as well as 29 <i>MICA</i> and 15 <i>MICB</i> alleles were identified in this project. The most frequent alleles at each locus were <i>A*11:01</i> (29.10%), <i>B*40:01</i> (14.46%), <i>C*01:02</i> (19.90%), <i>DRB1*09:01</i> (15.61%), <i>DQB1*03:01</i> (18.48%), <i>DPB1*05:01</i> (40.13%), <i>DQA1*01:02</i> (22.58%), <i>DPA1*02:02</i> (55.27%), <i>DRB3*02:02</i> (65.95%), <i>DRB4*01:03</i> (95.20%), <i>DRB5*01:01</i> (75.97%), <i>E*01:03</i> (62.63%), <i>F*01:01</i> (97.07%), <i>G*01:01</i> (70.74%), <i>H*01:01</i> (35.87%), <i>MICA*010:01</i> (19.90%) and <i>MICB*005:02</i> (57.53%), respectively. The haplotype frequencies for different combinations of HLA loci were estimated and linkage disequilibrium (LD) between alleles for all pairs of neighbouring loci were calculated. The most frequent haplotype covering 17 loci was <i>F*01:01-G*01:01-H*01:01-A*02:07-E*01:03-C*01:02-B*46:01-MICA*010:01-MICB*005:02-DRB4*01:03-DRB1*09:01-DQA1*03:02-DQB1*03:03-DPA1*02:02-DPB1*05:01</i> with a frequency of 3.18%. This is the first study on allelic polymorphism, haplotype inference and LD covering 17 HLA-related loci simultaneously in the Shenzhen Chinese population. These results will extend our knowledge of the allelic diversity of the HLA complex and provide population genetics data for transplantation and HLA-associated disease studies.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five New Alleles of HLA-A Identified by Next-Generation Sequencing","authors":"Maria Loginova,&nbsp;Olga Makhova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70152","DOIUrl":"https://doi.org/10.1111/tan.70152","url":null,"abstract":"<div>\u0000 \u0000 <p>Genomic sequence of HLA-A*01:475, -A*01:476Q, -A*11:482, -A*25:93 and -A*68:91:02 alleles in Russian individuals.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Novel HLA-C*07:1165, HLA-C*07:1166, HLA-C*07:02:161 Alleles and Confirmation of HLA-C*07:02:156","authors":"Maria Loginova,&nbsp;Julia Dudina,&nbsp;Igor Paramonov","doi":"10.1111/tan.70151","DOIUrl":"https://doi.org/10.1111/tan.70151","url":null,"abstract":"<div>\u0000 \u0000 <p>Novel HLA-C*07:1165, HLA-C*07:1166, HLA-C*07:02:161 alleles and confirmatory HLA-C*07:02:156 allele were detected during the HLA typing process.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}