HLA最新文献 - Book学术

Effect of angiotensin II type 1 receptor antibodies on graft function and survival in paediatric kidney transplant recipients 血管紧张素 II 1 型受体抗体对小儿肾移植受者移植物功能和存活率的影响。

IF 5.9 4区医学

HLA Pub Date : 2024-09-09 DOI: 10.1111/tan.15649

R. F. Kermond, S. Kim, F. Mackie, D. Hahn, R. P. Carroll, A. Sharma, A. M. Durkan

{"title":"Effect of angiotensin II type 1 receptor antibodies on graft function and survival in paediatric kidney transplant recipients","authors":"R. F. Kermond, S. Kim, F. Mackie, D. Hahn, R. P. Carroll, A. Sharma, A. M. Durkan","doi":"10.1111/tan.15649","DOIUrl":"10.1111/tan.15649","url":null,"abstract":"HLA donor specific antibodies (DSA) are implicated in antibody-mediated rejection (AMR), graft dysfunction and failure in kidney transplant (KT) recipients. Non-HLA antibodies including angiotensin II type 1 receptor (AT1R) may also play a role in AMR, impact graft function and survival. Data is limited in paediatric KT cohorts. We aimed to assess the prevalence and effect of pre-transplant AT1R antibodies on rejection, graft function and survival in paediatric KT recipients. This was a retrospective cohort study conducted across two paediatric centres including KT recipients with a pre-transplant AT1R antibody level. Outcomes included rejection, de novo DSA formation, graft function, failure, proteinuria and hypertension. Of 71 individuals, 72% recorded a positive pre-transplant AT1R Ab level (≥17 U/mL). Over a median follow-up of 4.7 years, AT1R Ab positivity demonstrated a trend towards increased risk of rejection however was not statistically significant (HR 3.45, 95% CI 0.97–12.35, p-value 0.06). Sensitivity analysis with AT1R Ab levels of ≥25 U/mL (HR 2.05 95% CI 0.78–5.39, p-value 0.14) and ≥40 U/mL (HR 1.32, CI 95% 0.55–3.17, p-value 0.53) validated this. De novo DSA formation occurred more frequently with AT1R Ab positivity (41% vs. 20%, p-value 0.9). AT1R Ab was not associated with hypertension, proteinuria, graft failure or dysfunction. In conclusion, this cohort study demonstrated a high prevalence of pre-transplant AT1R Ab positivity (72%). AT1R Ab positivity demonstrated a trend towards increased risk of rejection and de novo DSA formation however did not meet statistical significance. There was no association between AT1R Ab and hypertension, proteinuria, graft failure or dysfunction.","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterisation of the novel KIR2DL1*00308 allele identified in a Chinese Han individual 在一名中国汉族个体中发现的新型 KIR2DL1*00308 等位基因的特征。

IF 5.9 4区医学

HLA Pub Date : 2024-09-09 DOI: 10.1111/tan.15680

Renhui Jiang, Yunan Li, Jianxin Zhen, Zhihui Deng

引用次数: 0

Refining cPRA calculation to improve HLA compatibility assessment in organ transplantation: A detailed picture of the Paris waiting list 完善 cPRA 计算，改进器官移植中的 HLA 相容性评估：巴黎候选名单的详细情况

IF 5.9 4区医学

HLA Pub Date : 2024-09-09 DOI: 10.1111/tan.15675

Cédric Usureau, Romain Lhotte, Valentin Clichet, Alexandre Foroutan, Magali Devriese, Jean-Luc Taupin

{"title":"Refining cPRA calculation to improve HLA compatibility assessment in organ transplantation: A detailed picture of the Paris waiting list","authors":"Cédric Usureau, Romain Lhotte, Valentin Clichet, Alexandre Foroutan, Magali Devriese, Jean-Luc Taupin","doi":"10.1111/tan.15675","DOIUrl":"10.1111/tan.15675","url":null,"abstract":"The determination of panel reactive antibodies (cPRA) scores plays a critical role in assessing the immunological compatibility between organ transplant recipients and potential donors. Traditional cPRA methods focus on a limited number of HLA loci using physical cytotoxicity tests. However, advancements such as the Luminex single antigen (LSA) assay, which uses mean fluorescence intensity (MFI) of individualised HLA antigens for antibody evaluation, provide a foundation for a more precise assessment. We developed cPRAdictor, a novel cPRA calculation tool using a large series of HLA-type individuals in France with NGS. cPRAdictor was applied to a cohort of 5962 kidney transplant candidates in Paris. We analysed how extending the range of HLA specificities could affect cPRA values. Implementing cPRAdictor revealed and allowed quantification of the significant discrepancies in cPRA values that appeared when HLA loci C and DP, and antigen-specific antibodies were taken into account. Notably, over 43% of the immunised transplant candidates showed an increase in calculated cPRA values when considering C/DP loci and antigen-specific antibodies, negatively impacting their eligibility and prioritisation in the transplantation programme. These findings highlight the necessity of revisiting cPRA calculation methodologies to include a broader spectrum of immunological data, as more exhaustive and precise information regarding anti-HLA antibodies in patients' sera and donor and recipient HLA typing are available prospectively. This will strongly improve both accuracy and equity at the organ allocation step, especially for highly sensitised candidates for whom organ offers are very limited in number.","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of nine novel HLA alleles by next-generation sequencing in individuals from India 通过下一代测序在印度个体中鉴定出九种新型 HLA 等位基因。

IF 5.9 4区医学

HLA Pub Date : 2024-09-05 DOI: 10.1111/tan.15676

S. Archita, P. S. Shruthi, A. Deepika, K. Manpreet, P. I. Megha

引用次数: 0

The novel HLA class I allele HLA-C*07:02:81 differs from HLA-C*07:02:01:01 by a synonymous mutation 新型 HLA I 类等位基因 HLA-C*07:02:81 与 HLA-C*07:02:01:01 存在同义突变。

IF 5.9 4区医学

HLA Pub Date : 2024-09-05 DOI: 10.1111/tan.15672

Chia-Ling Chang, Chun-Ying Lin

引用次数: 0

Seven new HLA alleles characterised by next-generation sequencing 通过下一代测序鉴定七种新的 HLA 等位基因。