HLA最新文献

{"title":"Comment on ‘Replacements at Structural or Functional Dimorphisms 103, 109 and 167 Distinguish HLA Class I Serologically Defined Antigens’","authors":"Alberto Cardoso Martins Lima, Maria Gerbase-DeLima, Isaú Henrique Noronha, Renato de Marco","doi":"10.1111/tan.71052","DOIUrl":"https://doi.org/10.1111/tan.71052","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel MICA*298 Allele by Oxford Nanopore Sequencing in an Indian Individual","authors":"Disha Agarwal,&nbsp;Gaurav Sharma,&nbsp;Aruna Rakha,&nbsp;Alka Khadwal,&nbsp;Pankaj Malhotra","doi":"10.1111/tan.71056","DOIUrl":"10.1111/tan.71056","url":null,"abstract":"<div>\u0000 \u0000 <p>We identified the novel <i>MICA*298</i> allele by Oxford Nanopore sequencing in an individual from India.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a Distinct HLA-DRB1*15:02–DQB1*03:01 Haplotype in a Transplant Pair","authors":"Sheerin A. Alandejani,&nbsp;Nada Saleh,&nbsp;Abdullah Alshubaili,&nbsp;Hanan Anazi,&nbsp;Ali H. Hajeer","doi":"10.1111/tan.71009","DOIUrl":"10.1111/tan.71009","url":null,"abstract":"<div>\u0000 \u0000 <p>Linkage disequilibrium (LD) plays a foundational role in understanding the genetic structure of human populations, offering crucial information about their demographic history, population structure and evolution. In this study, we identified a distinct HLA haplotype in a kidney transplant pair of Indonesian ancestry using high-resolution next-generation sequencing (NGS) during evaluation in Saudi Arabia. The HLA typing was performed using the One Lambda AllType NGS 11 Loci Amplification kit (One Lambda, USA). The donor and recipient, as siblings, were found to share the same infrequently documented haplotype <i>A*24:07~C*07:04~B*18:01~DRB5*01:08N~DRB1*15:02~DQA1*06:01~DQB1*03:01~DPA1*02:02</i>~<i>DPB1*02:02:01G</i>. This haplotype represents a <i>DRB1*15:02</i>~<i>DQB1*03:01</i> association that appears to be distinctive to Southeast Asian populations.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-C*07:997 Allele Using Third-Generation HLA-Targeted Sequencing Technology","authors":"Yuanyuan Jing,&nbsp;Dongmei Li,&nbsp;Caifeng Long,&nbsp;Yujie Wen,&nbsp;Yanjun Jia","doi":"10.1111/tan.71050","DOIUrl":"10.1111/tan.71050","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-C*07:997</i> allele differs from <i>HLA-C*07:02:01:01</i> by one nucleotide substitution in codon 128 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Comparative Evaluation of a Saudi cPRA Calculator for Transplant Sensitisation Assessment","authors":"Nada M. Saleh,&nbsp;Sheerin A. Alandejani,&nbsp;Faisal Abdullah Al Mofeez,&nbsp;Alanoud Alhussain,&nbsp;Hanan Anazi,&nbsp;Ali Hajeer","doi":"10.1111/tan.70992","DOIUrl":"10.1111/tan.70992","url":null,"abstract":"<div>\u0000 \u0000 <p>Calculated panel reactive antibody (cPRA) is widely used to estimate the proportion of donors against whom a transplant candidate has unacceptable HLA specificities. Because cPRA is derived from donor HLA frequencies, estimates generated using externally derived donor datasets may not fully reflect local donor compatibility in populations with distinct immunogenetic backgrounds. We developed and comparatively evaluated a Saudi cPRA calculator based on observed HLA phenotypes from 675 local living donors. A total of 250 unacceptable antigen profiles were analysed and entered into the Saudi calculator and three established international systems: Eurotransplant Reference Laboratory (ETRL), Canadian cPRA, and United States Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) calculators. System-specific nomenclature harmonisation was performed where required. The cPRA distributions showed a broadly similar shape across the calculators, with mean values of 32.33% for Saudi cPRA, 31.31% for ETRL, 32.30% for Canadian cPRA, and 32.56% for OPTN/UNOS. However, individual profiles showed larger inter-calculator differences in some cases. Spearman correlation coefficients demonstrated strong concordance between Saudi cPRA and ETRL, Canadian, and OPTN/UNOS estimates (<i>ρ</i> = 0.9450, 0.9474, and 0.9560, respectively; all <i>p</i> &lt; 0.001). Bland–Altman analysis showed minimal mean bias across comparisons, although limits of agreement were relatively wide and maximum absolute differences reached 46–48 percentage points in selected profiles. These findings indicate that the Saudi cPRA calculator performs comparably to established international systems at the cohort level, while highlighting meaningful individual-level variation. A locally calibrated Saudi cPRA framework may support more context-specific sensitisation assessment, although further evaluation using larger donor reference datasets and clinically linked transplant outcomes is needed.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Characterisation of a Novel HLA-DPB1*1985:01 Allele by Long-Read Sequencing","authors":"Yaxin Fan,&nbsp;Suning Bai,&nbsp;Wenqian Song","doi":"10.1111/tan.71042","DOIUrl":"10.1111/tan.71042","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPB1*1985:01</i> differs from <i>HLA-DPB1*41:01:01:02</i> by a single nonsynonymous substitution in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-G*01:01:39 Allele Using PolyseqOne Sequencing","authors":"Xia Zhao,&nbsp;Musheng Shen,&nbsp;Jia Shen,&nbsp;Shunyong Chen","doi":"10.1111/tan.71047","DOIUrl":"10.1111/tan.71047","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-G*01:01:39</i> differs from <i>HLA-G*01:01:05</i> by a single synonymous nucleotide substitution (T&gt;A) at codon 107 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of the Novel KIR2DL1*00406 Allele Identified in a Chinese Han Individual","authors":"Yunan Li,&nbsp;Quanfu Zhang,&nbsp;Jianxin Zhen,&nbsp;Chuying Wang","doi":"10.1111/tan.71046","DOIUrl":"10.1111/tan.71046","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>KIR2DL1*00406</i> allele differs from the closest allele <i>KIR2DL1*00401</i> by a single synonymous mutation.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel MICA*296 Allele in a Chinese Cord Blood Donor","authors":"Wei Wang,&nbsp;Chen Chen,&nbsp;Ying Li,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.71040","DOIUrl":"10.1111/tan.71040","url":null,"abstract":"<div>\u0000 \u0000 <p><i>MICA*296</i> differs from <i>MICA*008:01:01</i> by a single nonsynonymous nucleotide substitution in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DQB1*02:85:02 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Vincent Elsermans,&nbsp;Isabelle Top,&nbsp;Marine Cargou,&nbsp;Jonathan Visentin","doi":"10.1111/tan.71044","DOIUrl":"10.1111/tan.71044","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*02:85:02</i> differs from <i>HLA-DQB1*02:85:01</i> by one single synonymous substitution in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}