HLA最新文献

{"title":"Extended Characterisation of the Coding Sequence of the HLA-A*02:97:01 Allele by Next and Third-Generation Sequencing","authors":"Romain Ferru-Clément,&nbsp;Perrine Augustin,&nbsp;Pauline Jamain,&nbsp;Isabelle Jollet","doi":"10.1111/tan.70708","DOIUrl":"10.1111/tan.70708","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*02:97:01</i> differs from <i>HLA-A*02:01:01:01</i> by a single nucleotide substitution in codon 232 within exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-B*58:162 Allele by Next-Generation Sequencing","authors":"Zechang Shi,&nbsp;Bin Xi,&nbsp;Jianing Yuan,&nbsp;Mingrui Huo","doi":"10.1111/tan.70711","DOIUrl":"10.1111/tan.70711","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*58:162</i> differs from <i>HLA-B*58:01:01:01</i> by one non-synonymous nucleotide change in codon 66 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-A*30:238 Allele by Next-Generation Sequencing","authors":"Jianing Yuan,&nbsp;Bin Xi,&nbsp;Zechang Shi,&nbsp;Mingrui Huo","doi":"10.1111/tan.70720","DOIUrl":"10.1111/tan.70720","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*30:238</i> has a single nonsynonymous nucleotide substitution at position 335 G&gt;T when compared to the <i>A*30:01:01:01</i> allele.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of the Novel HLA-B*40:636N Allele in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.70705","DOIUrl":"10.1111/tan.70705","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide substitution in codon −18 of <i>HLA-B*40:01:02:01</i> results in a novel null allele, <i>HLA-B*40:636N</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Phenotype List String Grammar for Enhanced Protein and Antigen Reporting in the Immunogenetic Context","authors":"Steven J. Mack,&nbsp;Nicholas K. Brown,&nbsp;Loren Gragert,&nbsp;Jan A. Hofmann,&nbsp;William Lemieux,&nbsp;Benedict M. Matern,&nbsp;Kazutoyo Osoegawa,&nbsp;Jürgen Sauter,&nbsp;Martin Maiers,&nbsp;Eric Spierings","doi":"10.1111/tan.70693","DOIUrl":"10.1111/tan.70693","url":null,"abstract":"<p>Standardised data representation is fundamental to the integrity, interoperability and reproducibility of immunogenetics and histocompatibility testing. While well-established standards such as the genotype list (GL) String, histoimmunogenetics markup language (HML) and minimum information for reporting next-generation sequence genotyping exist for encoding HLA genotyping results, no equivalent syntax currently exists for describing phenotype- or antigen-level information that underlies antibody testing and immunological risk assessment. We introduce the <i>phenotype list</i> (PL) <i>String</i> grammar and the <i>phenotype list string code</i> (PLSC) syntax, structured, machine-readable grammars designed to represent antigen- and protein-level data across three contexts: (1) the HLA phenotype composition of assay reagents, (2) test results derived from those reagents and (3) clinical interpretations of HLA antibody specificities. PL String extends the hierarchical logic of the GL String grammar, while adapting a subset of GL String delimiters and rules to describe ambiguity, heterodimeric relationships and phenotypic composition. PL String incorporates explicit namespace definitions (e.g., World Health Organization HLA Nomenclature Committee for Factors of the HLA System, Organ Procurement and Transplantation Network, Eurotransplant and NMDP) to ensure traceability and compatibility with existing regulatory and operational frameworks. By harmonising how HLA phenotypic and antibody data are encoded, PL Strings enable automated data exchange between laboratories, registries and information systems, reducing transcription errors and improving computational interpretation. This new grammar establishes a foundation for interoperable representation of serologic and functional HLA data, facilitating reproducible research and enhancing clinical decision support in transplantation and immunogenetics. Technical specifications for PL Strings and PLSCs are available at plstring.org.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-A*02:1040:02 Allele by Next-Generation Sequencing","authors":"Zeying Du,&nbsp;Ma. Easter April Sudario,&nbsp;Aubrey E. Nicks,&nbsp;Charles D. Williams,&nbsp;Mohamed Elrefaei","doi":"10.1111/tan.70704","DOIUrl":"10.1111/tan.70704","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*02:1040:02</i> differs from <i>HLA-A*02:01:01:01</i> by a single nucleotide substitution in codon 283 (CCC&gt;TCC) in exon 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-DRB1*16:80 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual","authors":"Xiao-hang Huang,&nbsp;Tian-ju Hu,&nbsp;Rui-peng Lu,&nbsp;Pei-pei Ding,&nbsp;Xiao-dong Wang","doi":"10.1111/tan.70596","DOIUrl":"10.1111/tan.70596","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB1*16:80</i> differs from <i>HLA-DRB1*16:02:01:01</i> by a single non-synonymous nucleotide change in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel HLA-A Allele, HLA-A*24:672, Identified by Next Generation Sequencing","authors":"Bilkay Basturk,&nbsp;Miray Kavuzlu,&nbsp;Bircan Zengel","doi":"10.1111/tan.70702","DOIUrl":"10.1111/tan.70702","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*24:672</i> differs from <i>HLA-A*24:424</i> allele by one nucleotide substitution in codon 73 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirmation of the HLA-DQB1*02:147 Allele","authors":"Mariana Guimarães Barbosa de Medeiros,&nbsp;Rafael Formenton Cita,&nbsp;Fernanda Pelisson Massi,&nbsp;Bruna Karina Banin Hirata,&nbsp;Larissa Danielle Bahls Pinto","doi":"10.1111/tan.70706","DOIUrl":"10.1111/tan.70706","url":null,"abstract":"<div>\u0000 \u0000 <p>We confirmed the <i>HLA-DQB1*02:147</i> allele and determined its complete genomic sequence.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DQB1 Allele, DQB1*02:02:01:28Q, With a Mutation in the Intron 3 Donor Splice Site","authors":"Hua Zhu,&nbsp;Terrence K. Robinson Jr,&nbsp;Eric D. Garabiles,&nbsp;Mohamed Elrefaei,&nbsp;Zeying Du","doi":"10.1111/tan.70703","DOIUrl":"10.1111/tan.70703","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-DQB1*02:02:01:28Q</i> shows a point mutation in the intron 3 splice site.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"107 4","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}