HLA最新文献

{"title":"Detection of Novel HLA-C*07:1165, HLA-C*07:1166, HLA-C*07:02:161 Alleles and Confirmation of HLA-C*07:02:156","authors":"Maria Loginova,&nbsp;Julia Dudina,&nbsp;Igor Paramonov","doi":"10.1111/tan.70151","DOIUrl":"https://doi.org/10.1111/tan.70151","url":null,"abstract":"<div>\u0000 \u0000 <p>Novel HLA-C*07:1165, HLA-C*07:1166, HLA-C*07:02:161 alleles and confirmatory HLA-C*07:02:156 allele were detected during the HLA typing process.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HLA-B*39:01:01:31 Allele Identified by Next Generation Sequencing in an Asian Voluntary Bone Marrow Donor","authors":"Vasiliki Kitsiou,&nbsp;Theofilos Athanassiades,&nbsp;Diamanto Kouniaki,&nbsp;Panagiota Mantziou,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70180","DOIUrl":"https://doi.org/10.1111/tan.70180","url":null,"abstract":"<div>\u0000 \u0000 <p>The HLA-B*39:01:01:31 allele differs from HLA-B*39:01:01:03 by a single nucleotide substitution in intron 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Antigen and Allelic HLA Mismatches, and the Risk of Acute Rejection in Kidney Transplant Recipients","authors":"Ryan Gately,&nbsp;Anne Taverniti,&nbsp;Narelle Watson,&nbsp;Armando Teixeira-Pinto,&nbsp;Esther Ooi,&nbsp;Rowena Lalji,&nbsp;Ross Francis,&nbsp;Lucy Sullivan,&nbsp;William Mulley,&nbsp;Kate Wyburn,&nbsp;Scott Campbell,&nbsp;Carmel Hawley,&nbsp;Germaine Wong,&nbsp;Wai H. Lim","doi":"10.1111/tan.70163","DOIUrl":"https://doi.org/10.1111/tan.70163","url":null,"abstract":"<p>Deceased donor kidney allocation relies on HLA compatibility at the antigen level, as optimal matching reduces the risk of acute rejection. Whether HLA allele-level mismatches improve, the prediction of acute rejection after transplantation remains unclear. Using data from the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) from 2017 to 2020, HLA antigenic and allelic mismatches between recipients and deceased donors were calculated with imputation of two-field allelic equivalents undertaken where required. The discordance between antigen and allele mismatches was calculated, and oblique random survival forest models were used to predict acute rejection. Predictive performance of antigen (HLA-A, -B, -DRB1 and -DQB1), allele (HLA-A, -B, -DRB1 and -DQB1) and extended allele (HLA-A, -B, -C, -DRB1, -DQA1 and -DQB1) models was examined using concordance index and integrated Brier scores, with variable importance calculated using permutation-based methods. Among 2644 recipients followed for a median of 1.7 years, 521 recipients (20%) experienced acute rejection. Discordant numbers of antigenic and allelic mismatches occurred in 8%, 9%, 24% and 17% of HLA-A, -B, -DRB1 and -DQB1 loci, respectively. Predictive performances were similar across all models, with concordance indices of 0.62–0.63 and integrated Brier scores of 0.09. HLA-DRB1 and -DQB1 mismatches were the strongest predictors of acute rejection across models. In patients matched at the HLA-DRB1 or -DQB1 antigen, those with allelic mismatches had similar incidences of rejection compared to those without. Allelic-level assessment of HLA compatibility did not improve the prediction of acute rejection and may disadvantage certain recipients by reclassifying them into higher mismatch categories in allocation algorithms without providing clear clinical benefit.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the HLA-DQB1*06:02:49 Allele in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.70174","DOIUrl":"https://doi.org/10.1111/tan.70174","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide substitution at nucleotide 36 of <i>HLA-DQB1*06:02:01:01</i> results in a novel allele <i>HLA-DQB1*06:02:49</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-B*15:727 and HLA-C*04:01:01:194Q Alleles","authors":"Miguel Angel Moreno-Hidalgo,&nbsp;Raquel Alenda,&nbsp;Iris Vicente,&nbsp;Felix García-Sánchez,&nbsp;Antonio Balas","doi":"10.1111/tan.70177","DOIUrl":"https://doi.org/10.1111/tan.70177","url":null,"abstract":"<div>\u0000 \u0000 <p>Sequencing of the novel alleles HLA-B*15:727 and HLA-C*04:01:01:194Q.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Novel HLA-DQB1 Alleles Identified by Next Generation Sequencing","authors":"Anastasiia Ananeva,&nbsp;Gulnaz Akhmetshina,&nbsp;Liliya Aksenova,&nbsp;Anna V. Andryushkina,&nbsp;Elena Shagimardanova","doi":"10.1111/tan.70172","DOIUrl":"https://doi.org/10.1111/tan.70172","url":null,"abstract":"<div>\u0000 \u0000 <p>Three novel HLA alleles HLA-DQB1*03:01:60, -DQB1*03:526, and -DQB1*06:03:50 alleles detected during routine next generation sequencing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DRB1*14:268 Allele by Sequencing-Based Typing","authors":"Marine Cargou,&nbsp;Mamy Ralazamahaleo,&nbsp;Elodie Wojciechowski,&nbsp;Gwendaline Guidicelli,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70181","DOIUrl":"https://doi.org/10.1111/tan.70181","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DRB1*14:268 differs from HLA-DRB1*14:54:01:03 by one nucleotide substitution in codon 213 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a New HLA-DRB1 Allele in a Chinese Han Individual, HLA-DRB1*12:109","authors":"Liumei He,&nbsp;Hongyan Zou,&nbsp;Rong Tang","doi":"10.1111/tan.70128","DOIUrl":"https://doi.org/10.1111/tan.70128","url":null,"abstract":"<div>\u0000 \u0000 <p>The new <i>HLA-DRB1*12:109</i> allele differs from its most closely related allele <i>DRB1*12:02:01:04</i> in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-B*38:123 Allele With A Unique M-Leader Sequence","authors":"Mirzokhid Rakhmanov,&nbsp;Martin Bernheiden,&nbsp;Murielle Verboom,&nbsp;Michael Hallensleben,&nbsp;Florian Emmerich","doi":"10.1111/tan.70166","DOIUrl":"https://doi.org/10.1111/tan.70166","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-B*38:123 differs from HLA-B*38:01:01:01 by a single nucleotide substitution in codon -14 in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel Allele, HLA-C*06:395, in a Chinese Cord Blood Donor","authors":"Qimin Wu,&nbsp;Chen Chen,&nbsp;Wei Zhang,&nbsp;Sudan Tao,&nbsp;Faming Zhu","doi":"10.1111/tan.70167","DOIUrl":"https://doi.org/10.1111/tan.70167","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*06:395</i> differs from <i>HLA-C*06:02:01:01</i> by a single nucleotide substitution at position 520 G&gt;A.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}