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Characterisation of the Novel HLA-B*18:247 Allele Using New Next-Generation Sequencing Methods 新型HLA-B*18:247等位基因的新一代测序方法
IF 5.9 4区 医学
HLA Pub Date : 2025-06-16 DOI: 10.1111/tan.70288
Printil Aho, Jean-Baptiste Baudey, Coralie Frassati, Agnès Basire, Pascal Pedini
{"title":"Characterisation of the Novel HLA-B*18:247 Allele Using New Next-Generation Sequencing Methods","authors":"Printil Aho,&nbsp;Jean-Baptiste Baudey,&nbsp;Coralie Frassati,&nbsp;Agnès Basire,&nbsp;Pascal Pedini","doi":"10.1111/tan.70288","DOIUrl":"https://doi.org/10.1111/tan.70288","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*18:247</i> differs from the <i>HLA-B*18:01:01:01</i> allele by one nucleotide substitution in codon 193 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-DQB1*06:03:56 Allele by Next-Generation Sequencing HLA-DQB1*06:03:56等位基因的新一代测序鉴定
IF 5.9 4区 医学
HLA Pub Date : 2025-06-13 DOI: 10.1111/tan.70283
Charlène Bouthemy, Jean Milhès, Nicolas Congy-Jolivet
{"title":"Identification of the Novel HLA-DQB1*06:03:56 Allele by Next-Generation Sequencing","authors":"Charlène Bouthemy,&nbsp;Jean Milhès,&nbsp;Nicolas Congy-Jolivet","doi":"10.1111/tan.70283","DOIUrl":"https://doi.org/10.1111/tan.70283","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DQB1*06:03:56 differs from HLA-DQB1*06:03:01 by one nucleotide substitution in codon 130 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Sequence of Five New Intronic Variants of HLA-DQB1*03 Characterised by Next-Generation Sequencing HLA-DQB1*03 5个新内含子变异的基因组序列
IF 5.9 4区 医学
HLA Pub Date : 2025-06-10 DOI: 10.1111/tan.70282
Luis Alberto Marin Rubio, Jesus Ontañon
{"title":"Genomic Sequence of Five New Intronic Variants of HLA-DQB1*03 Characterised by Next-Generation Sequencing","authors":"Luis Alberto Marin Rubio,&nbsp;Jesus Ontañon","doi":"10.1111/tan.70282","DOIUrl":"https://doi.org/10.1111/tan.70282","url":null,"abstract":"<div>\u0000 \u0000 <p>Genomic sequences of the HLA-DQB1*03:01:01:70, -DQB1*03:01:01:77, -DQB1*03:02:01:28, -DQB1*03:02:01:29, and -DQB1*03:03:02:19 alleles.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Novel HLA-DPA1 Alleles Identified in a Triple Negative Breast Cancer Patient From Brazil 在巴西三阴性乳腺癌患者中发现了两个新的HLA-DPA1等位基因
IF 5.9 4区 医学
HLA Pub Date : 2025-06-10 DOI: 10.1111/tan.70286
Vinícius N. Stelet, Christina Silva, Aline Diniz, Renata Binato, Eliana Abdelhay
{"title":"Two Novel HLA-DPA1 Alleles Identified in a Triple Negative Breast Cancer Patient From Brazil","authors":"Vinícius N. Stelet,&nbsp;Christina Silva,&nbsp;Aline Diniz,&nbsp;Renata Binato,&nbsp;Eliana Abdelhay","doi":"10.1111/tan.70286","DOIUrl":"https://doi.org/10.1111/tan.70286","url":null,"abstract":"<div>\u0000 \u0000 <p>Identification of the novel alleles HLA-DPA1*02:142 and HLA-DPA1*01:03:01:92.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-A*03:01:133 Allele by Next-Generation Sequencing in Brazil 新HLA-A*03:01:133等位基因在巴西的新一代测序分析
IF 5.9 4区 医学
HLA Pub Date : 2025-06-08 DOI: 10.1111/tan.70270
Isabella Fantini Molinari, Ana Paula Sokolowski de Lima, Fernanda Pelisson Massi, Bruna Karina Banin Hirata, Jeane Eliete Laguila Visentainer
{"title":"Characterisation of the Novel HLA-A*03:01:133 Allele by Next-Generation Sequencing in Brazil","authors":"Isabella Fantini Molinari,&nbsp;Ana Paula Sokolowski de Lima,&nbsp;Fernanda Pelisson Massi,&nbsp;Bruna Karina Banin Hirata,&nbsp;Jeane Eliete Laguila Visentainer","doi":"10.1111/tan.70270","DOIUrl":"https://doi.org/10.1111/tan.70270","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-A*03:01:133</i> allele differs from <i>A*03:01:01:01</i> by a change of C ➔ T in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrogation of Interfering Factors in ELISA Detecting Angiotensin Receptor Antibodies and Specificity Validation Using the Adsorption Elution Crossmatch (AXE) Technique ELISA检测血管紧张素受体抗体的干扰因素及吸附洗脱交叉匹配（AXE）技术特异性验证
IF 5.9 4区 医学
HLA Pub Date : 2025-06-08 DOI: 10.1111/tan.70268
Adak Karamafrooz, Julie Nguyen, Hong Ma, Dave Lowe, Michael Trinh, Rui Pei, Robert Carroll
{"title":"Interrogation of Interfering Factors in ELISA Detecting Angiotensin Receptor Antibodies and Specificity Validation Using the Adsorption Elution Crossmatch (AXE) Technique","authors":"Adak Karamafrooz,&nbsp;Julie Nguyen,&nbsp;Hong Ma,&nbsp;Dave Lowe,&nbsp;Michael Trinh,&nbsp;Rui Pei,&nbsp;Robert Carroll","doi":"10.1111/tan.70268","DOIUrl":"https://doi.org/10.1111/tan.70268","url":null,"abstract":"<p>Accurate detection of human leukocyte antigens (HLAs) and non-HLA antigens is critical for managing long-term allograft transplantation, particularly in the context of hyperacute, acute, and chronic allograft rejection. Recent studies have identified the role of non-HLA antibodies, such as those against Angiotensin II Type 1 receptor (AT<sub>1</sub>R) in transplant rejection. The enzyme-linked immunosorbent assay (ELISA) is the primary method for measuring AT<sub>1</sub>R-specific antibodies (AT<sub>1</sub>R-Ab), offering high specificity and reasonable sensitivity. Despite its widespread use in clinical settings, some reports have suggested that pre-treating the samples with latex beads can eliminate the detection signal in the CellTrend AT<sub>1</sub>R ELISA assay, potentially raising concerns over false reactivity in the assay. In this study, we demonstrate that the bovine serum albumin (BSA) present in the adsorb out beads (AOB) buffer, even at a dilution of 10<sup>−6</sup>, plays a key role in signal elimination in the CellTrend AT<sub>1</sub>R-Ab detection kit. Additionally, we evaluated the performance of the CellTrend kit and an in-house affinity-purified AT<sub>1</sub>R ELISA in detecting eluted AT<sub>1</sub>R-Abs from live cells using the adsorption crossmatch and elution (AXE) technique, which achieved a median elution efficiency of 30% when tested on the CellTrend ELISA platform. Our findings support that the CellTrend ELISA kit accurately detects anti-AT<sub>1</sub>R antibodies that bind to the active form of AT<sub>1</sub>R. However, serum treatments containing BSA interfere with the antibody–antigen capture interface, leading to signal suppression.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The HLA-DPB1*1469:01 Allele Identified by Next-Generation Sequencing HLA-DPB1*1469:01等位基因的新一代测序
IF 5.9 4区 医学
HLA Pub Date : 2025-06-07 DOI: 10.1111/tan.70277
He Zhao, Destinie Webster, Twyla Perace, Ahmed Mostafa
{"title":"The HLA-DPB1*1469:01 Allele Identified by Next-Generation Sequencing","authors":"He Zhao,&nbsp;Destinie Webster,&nbsp;Twyla Perace,&nbsp;Ahmed Mostafa","doi":"10.1111/tan.70277","DOIUrl":"https://doi.org/10.1111/tan.70277","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DPB1*1469:01 shows a non-synonymous mutation in codon 205 within Exon 4 compared with HLA-DPB1*25:01.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confirmation and Full-Length Sequence of the HLA-DQA1*05:82 Allele Using Next-Generation Sequencing HLA-DQA1*05:82等位基因的全序列分析
IF 5.9 4区 医学
HLA Pub Date : 2025-06-07 DOI: 10.1111/tan.70281
Zhan-Rou Quan, Jie Liu, Bing-Na Yang, Jia-Min Song, Hong-Yan Zou
{"title":"Confirmation and Full-Length Sequence of the HLA-DQA1*05:82 Allele Using Next-Generation Sequencing","authors":"Zhan-Rou Quan,&nbsp;Jie Liu,&nbsp;Bing-Na Yang,&nbsp;Jia-Min Song,&nbsp;Hong-Yan Zou","doi":"10.1111/tan.70281","DOIUrl":"https://doi.org/10.1111/tan.70281","url":null,"abstract":"<div>\u0000 \u0000 <p>We report a confirmatory HLA-DQA1*05:82 allele detected in a Chinese individual.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Full-Length Sequence of the HLA-DRB1*04:90 Allele Was Identified by PacBio Sequencing 采用PacBio测序技术鉴定HLA-DRB1*04:90等位基因的基因组全长序列
IF 5.9 4区 医学
HLA Pub Date : 2025-06-06 DOI: 10.1111/tan.70278
Bin Hu, Qi Yu, Li Liu, Zhihui Feng, Shutao Pang
{"title":"Genomic Full-Length Sequence of the HLA-DRB1*04:90 Allele Was Identified by PacBio Sequencing","authors":"Bin Hu,&nbsp;Qi Yu,&nbsp;Li Liu,&nbsp;Zhihui Feng,&nbsp;Shutao Pang","doi":"10.1111/tan.70278","DOIUrl":"https://doi.org/10.1111/tan.70278","url":null,"abstract":"<div>\u0000 \u0000 <p>The complete genomic sequence of <i>HLA-DRB1*04:90</i> was determined using a PacBio sequencing approach conducted in China.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DQB1*05:356 Allele by Sequencing-Based Typing 新型HLA-DQB1*05:356等位基因的分型分析
IF 5.9 4区 医学
HLA Pub Date : 2025-06-04 DOI: 10.1111/tan.70275
Vincent Elsermans, Marine Cargou, Thibault Pajot, Isabelle Top, Myriam Labalette
{"title":"Characterisation of the Novel HLA-DQB1*05:356 Allele by Sequencing-Based Typing","authors":"Vincent Elsermans,&nbsp;Marine Cargou,&nbsp;Thibault Pajot,&nbsp;Isabelle Top,&nbsp;Myriam Labalette","doi":"10.1111/tan.70275","DOIUrl":"https://doi.org/10.1111/tan.70275","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*05:356</i> differs from <i>HLA-DQB1*05:03:01:01</i> by one nucleotide substitution in codon 14 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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