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Characterisation of the Novel HLA-DPB1*1933:01 Allele by Sequencing-Based Typing 新型HLA-DPB1*1933:01等位基因的测序分型分析
IF 5 4区 医学
HLA Pub Date : 2026-10-02 DOI: 10.1111/tan.71043
Intissar Dalhoumi, Vincent Elsermans, Marine Cargou, Elodie Wojciechowski, Jonathan Visentin
{"title":"Characterisation of the Novel HLA-DPB1*1933:01 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Vincent Elsermans,&nbsp;Marine Cargou,&nbsp;Elodie Wojciechowski,&nbsp;Jonathan Visentin","doi":"10.1111/tan.71043","DOIUrl":"10.1111/tan.71043","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPB1*1933:01</i> differs from <i>HLA-DPB1*03:01:01:01</i> by a single non-synonymous change in Exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-B*27:313 Allele by Sequencing-Based Typing 新型HLA-B*27:313等位基因的测序分型鉴定
IF 5 4区 医学
HLA Pub Date : 2026-10-02 DOI: 10.1111/tan.71037
Intissar Dalhoumi, Vincent Elsermans, Marine Cargou, Elodie Wojciechowski, Jonathan Visentin
{"title":"Characterisation of the Novel HLA-B*27:313 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Vincent Elsermans,&nbsp;Marine Cargou,&nbsp;Elodie Wojciechowski,&nbsp;Jonathan Visentin","doi":"10.1111/tan.71037","DOIUrl":"10.1111/tan.71037","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*27:313</i> differs from <i>HLA-B*27:05:02:05</i> by a single non-synonymous change in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-A*02:1128 Was Identified in a Chinese Individual. 新HLA-A*02:11 . 128在中国个体中的鉴定。
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.71016
Wenwen Pi, Yizhen He, Fang Wang, Wei Zhang, Faming Zhu
{"title":"The Novel HLA-A*02:1128 Was Identified in a Chinese Individual.","authors":"Wenwen Pi, Yizhen He, Fang Wang, Wei Zhang, Faming Zhu","doi":"10.1111/tan.71016","DOIUrl":"10.1111/tan.71016","url":null,"abstract":"<p><p>HLA-A*02:1128 differs from the HLA-A*02:07:01:01 allele by one nucleotide substitution in the Exon 4.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":"e71016"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel MICA*293N Allele in a Chinese Individual 中国人MICA*293N新等位基因的鉴定
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.71045
Wei Wang, Lina Dong, Yizhen He, Wei Zhang, Faming Zhu
{"title":"Identification of the Novel MICA*293N Allele in a Chinese Individual","authors":"Wei Wang,&nbsp;Lina Dong,&nbsp;Yizhen He,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.71045","DOIUrl":"10.1111/tan.71045","url":null,"abstract":"<div>\u0000 \u0000 <p><i>MICA*293N</i> differs from <i>MICA*019:01:01</i> by one single nucleotide substitution in Exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Resolution HLA Class I Genotyping Using G-Seq Platform-Based Nanopore Long-Read Sequencing Integrated With the HLATyper Pipeline. 基于G-Seq平台的纳米孔长读测序与HLATyper管道集成的高分辨率HLA I类基因分型
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.71051
Hong-Hong He, Run-Yu Xu, Qiu-Lei Zhong, Yan Yu, Ming-Yuan Wang, Miao He, Long-Hai Tang
{"title":"High-Resolution HLA Class I Genotyping Using G-Seq Platform-Based Nanopore Long-Read Sequencing Integrated With the HLATyper Pipeline.","authors":"Hong-Hong He, Run-Yu Xu, Qiu-Lei Zhong, Yan Yu, Ming-Yuan Wang, Miao He, Long-Hai Tang","doi":"10.1111/tan.71051","DOIUrl":"https://doi.org/10.1111/tan.71051","url":null,"abstract":"<p><p>This study evaluated the performance and clinical applicability of a novel third-generation sequencing (TGS) strategy for high-resolution HLA class I genotyping, employing nanopore long-read sequencing combined with a dedicated analytical workflow, HLATyper. A total of 49 clinical samples were analysed in parallel using conventional PCR-based sequence-based typing (PCR-SBT) and a TGS-based approach on the G-seq500 platform with the in-house-developed HLATyper pipeline. Genotyping results for HLA-A, -B and -C loci were compared between the two methods with respect to concordance, typing resolution and the ability to resolve ambiguous allele assignments. Ambiguity rates between the two methods were evaluated using Fisher's exact test. Complete concordance was observed between PCR-SBT and the TGS method at the two-field level across all samples. Ambiguous allele assignments were detected in 63.27% (31/49) of cases using PCR-SBT, whereas the TGS strategy produced a single, unambiguous genotype for every sample (p < 0.0001). Furthermore, TGS enabled assignment of four-field typing through comprehensive sequence alignment and successfully resolved ambiguities and exonic coverage gaps inherent to short-read approaches. G-seq500 platform-based nanopore long-read sequencing combined with the HLATyper analytical pipeline enables high-resolution, unambiguous and comprehensive HLA class I genotyping. This integrated strategy represents a valuable complementary approach for clinical applications requiring precise HLA matching, such as transplantation and platelet transfusion support.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":"e71051"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Fine-Mapping of HLA Effects in Oral and Non-Oral Lichen Planus". 对“HLA在口腔和非口腔扁平苔藓中的作用精细制图”的修正。
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.70969
{"title":"Correction to \"Fine-Mapping of HLA Effects in Oral and Non-Oral Lichen Planus\".","authors":"","doi":"10.1111/tan.70969","DOIUrl":"10.1111/tan.70969","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":"e70969"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description of the Novel HLA-C*06:414 Allele in a Bone Marrow Donor 骨髓供者HLA-C*06:41 14等位基因的描述
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.71035
Valery Cheranev, Irina Savvina, Varvara Kuznetsova, Olga Makhova, Maria Loginova
{"title":"Description of the Novel HLA-C*06:414 Allele in a Bone Marrow Donor","authors":"Valery Cheranev,&nbsp;Irina Savvina,&nbsp;Varvara Kuznetsova,&nbsp;Olga Makhova,&nbsp;Maria Loginova","doi":"10.1111/tan.71035","DOIUrl":"10.1111/tan.71035","url":null,"abstract":"<div>\u0000 \u0000 <p>The new <i>HLA-C*06:414</i> allele showed single nucleotide difference in codon 218 compared to the <i>HLA-C*06:02:01:01</i> allele.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Characterisation of the Novel HLA-A*30:272 Allele Identified by Third-Generation Sequencing. HLA-A*30:272等位基因的第三代测序分析
IF 5 4区 医学
HLA Pub Date : 2026-10-01 DOI: 10.1111/tan.71054
Guangjie Wang, Suning Bai, Wenqian Song, Bing Li
{"title":"Molecular Characterisation of the Novel HLA-A*30:272 Allele Identified by Third-Generation Sequencing.","authors":"Guangjie Wang, Suning Bai, Wenqian Song, Bing Li","doi":"10.1111/tan.71054","DOIUrl":"https://doi.org/10.1111/tan.71054","url":null,"abstract":"<p><p>The novel HLA-A*30:272 allele differs from HLA-A*30:01:01:01 by a missense mutation in exon 5.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":"e71054"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel Allele HLA-A*30:263 by Next-Generation Sequencing 新等位基因HLA-A*30:263的新一代测序分析。
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71036
Elham Harfouch, Marilyne Gomes, Xavier Chamillard, Émilie Letoriellec, Laure Croisille
{"title":"Characterisation of the Novel Allele HLA-A*30:263 by Next-Generation Sequencing","authors":"Elham Harfouch,&nbsp;Marilyne Gomes,&nbsp;Xavier Chamillard,&nbsp;Émilie Letoriellec,&nbsp;Laure Croisille","doi":"10.1111/tan.71036","DOIUrl":"10.1111/tan.71036","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*30:263</i> differs from <i>HLA-A*30:01:01:01</i> by a single nucleotide substitution at position 20 of the cDNA, in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel KIR2DL1*070 Allele Identified in a Chinese Han Individual 中国汉族KIR2DL1*070等位基因的鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71041
Manru Zhang, Zhihui Deng
{"title":"Characterisation of the Novel KIR2DL1*070 Allele Identified in a Chinese Han Individual","authors":"Manru Zhang,&nbsp;Zhihui Deng","doi":"10.1111/tan.71041","DOIUrl":"10.1111/tan.71041","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>KIR2DL1*070</i> allele differs from the closest allele <i>KIR2DL1*00401</i> by a single missense mutation in Exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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