HLA最新文献

{"title":"Sequencing of the Novel HLA-DPB1*1762:01 Allele in a Spanish Individual","authors":"J. Gonzalo Ocejo-Vinyals,&nbsp;Nerea Mota-Pérez,&nbsp;Carolina Castro-Hernández,&nbsp;María Toriello,&nbsp;Antonio Balas","doi":"10.1111/tan.70195","DOIUrl":"https://doi.org/10.1111/tan.70195","url":null,"abstract":"<div>\u0000 \u0000 <p>Description of the novel HLA-DPB1*1762:01 allele.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-A*01:01:01:121 Allele by Next Generation Sequencing","authors":"Vasiliki Kitsiou,&nbsp;Theofilos Athanassiades,&nbsp;Panagiota Mantziou,&nbsp;Diamanto Kouniaki,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70196","DOIUrl":"https://doi.org/10.1111/tan.70196","url":null,"abstract":"<div>\u0000 \u0000 <p>The HLA-A*01:01:01:121 allele differs from HLA-A*01:01:01:01 by a single nucleotide substitution in intron 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-B*38:125 Allele by Next-Generation Sequencing","authors":"Zeying Du,&nbsp;Totiana A. Ussery,&nbsp;Eric D. Garabiles,&nbsp;Jessie D. Dzion,&nbsp;Mohamed Elrefaei","doi":"10.1111/tan.70192","DOIUrl":"https://doi.org/10.1111/tan.70192","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*38:125</i> differs from <i>HLA-B*38:02:01:01</i> by one nucleotide substitution in codon 248 (GTG&gt;ATG) in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of the HLA-A*02:924 Allele, a Variant of A*02:07:01:01, in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.70193","DOIUrl":"https://doi.org/10.1111/tan.70193","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide mutation in exon 4 of <i>HLA-A*02:07:01:01</i> results in the novel allele, <i>HLA-A*02:924.</i></p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DQA1*05:01:21 Allele by Next-Generation Sequencing","authors":"Zeying Du,&nbsp;Totiana A. Ussery,&nbsp;Jasmine R. Kendrick,&nbsp;Charles D. Williams,&nbsp;Mohamed Elrefaei","doi":"10.1111/tan.70191","DOIUrl":"https://doi.org/10.1111/tan.70191","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQA1*05:01:21</i> differs from <i>HLA-DQA1*05:01:01:02</i> by one nucleotide substitution in codon 198 (TGC &gt; TGT) in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully Phased Population-Prevalent East African Cattle BoLA-I Alleles Determined Using PacBio HiFi Long-Read Sequencing Represent Five Novel Specificities With Distinctive Peptide Binding Potential","authors":"Isaiah Obara,&nbsp;Andreotti Sandro,&nbsp;Khawla Elati,&nbsp;Timothy Conneley,&nbsp;Morten Nielsen,&nbsp;Naftaly Githaka,&nbsp;Anne Nanteza,&nbsp;Richard Bishop,&nbsp;Ard Nijhof","doi":"10.1111/tan.70183","DOIUrl":"https://doi.org/10.1111/tan.70183","url":null,"abstract":"<p>Due to factors such as lower biosecurity, greater wildlife/farm animal interfaces, and environmental challenges, cattle in sub-Saharan Africa are exposed to more diverse and intensive bacterial, viral and protozoan pathogen challenges than cattle in Europe and other high-income regions of the world. Classical class I genes of the major histocompatibility complex (MHC) contribute to protection from diseases caused by these pathogens by refining a huge pool of potential pathogen-derived peptide ligands into a smaller ensemble for presentation to CD8+ T cells. Knowledge of population-prevalent MHC alleles is therefore critical for evidence-based approaches to vaccine design and improved understanding of pathogen resistance. Whereas variation in MHC molecules is understood in most detail for European <i>Bos taurus</i>, the alleles expressed by Africa's cattle remain poorly defined. We have leveraged recent improvements in the accuracy of PacBio high-fidelity (HiFi) circular consensus sequencing (CCS) and adapted stringent sequence filtering algorithms to identify hundreds of as yet uncharacterised fully phased BoLA-I alleles from multiple populations of African taurine (Ankole) and indicine (Zebu) cattle in East Africa. The analysis highlights a convergence of population-prevalent class I MHC allelic repertoires in taurine and indicine cattle, likely due to the similar pathogen-driven selective pressures. Our analysis of the anchor residue accommodating pockets of these prevalent alleles revealed extremely high levels of polymorphism, which contrast with Holstein alleles that exhibit a more limited repertoire of MHC specificity-determining pocket residues, potentially constraining the breadth of peptide presentation. However, in the context of considerable sequence and physicochemical variation in the pocket-forming residues, it was possible to discern overlaps in the predicted peptide binding spectrum. Interrogation of potential differences in peptide binding specificities with European <i>B. taurus</i> alleles revealed that the fully phased African cattle class I MHC alleles represent five novel specificities. We envisage that this novel finding will find broad application in assessing potentially achievable vaccination coverages of future pathogen-encoded vaccine candidates against important intracellular pathogens. One aim of future research should be to leverage recent improvements in the sensitivity of mass spectrometry combined with immunoprecipitation of peptides bound to African cattle MHC to search directly for T-cell epitopes in the context of the inferred ‘supertype’ diversity.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel Allele HLA-A*26:01:80 Was Identified in a Chinese Individual","authors":"Zhipan Wu,&nbsp;Ji He,&nbsp;Wei Zhang,&nbsp;Yanmin He,&nbsp;Faming Zhu","doi":"10.1111/tan.70187","DOIUrl":"https://doi.org/10.1111/tan.70187","url":null,"abstract":"<div>\u0000 \u0000 <p>The sequence of HLA-A*26:01:80 differs from HLA-A*26:01:01 by one single nucleotide substitution.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification of 56 Novel HLA Alleles in Hong Kong Chinese Individuals in 2024","authors":"Alan L. M. Li,&nbsp;Stephen K. F. Cheung,&nbsp;Albert J. E. French,&nbsp;Johnathan A. M. Lucas,&nbsp;Thomas R. Turner,&nbsp;Charlotte A. Cambridge,&nbsp;Neema P. Mayor,&nbsp;Steven G. E. Marsh,&nbsp;Patrick W. K. Chu,&nbsp;Kitty K. M. Lau,&nbsp;Gillian Ng,&nbsp;C. K. Lee,&nbsp;Janette S. Y. Kwok","doi":"10.1111/tan.70188","DOIUrl":"https://doi.org/10.1111/tan.70188","url":null,"abstract":"<div>\u0000 \u0000 <p>We report here 56 novel HLA alleles identified in Hong Kong Chinese individuals. They have been submitted and officially named by the World Health Organization Nomenclature Committee for Factors of the HLA System in the year 2024.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-C Allele, HLA-C*03:595, was Identified by Sequence-Based Typing","authors":"Chen Luo,&nbsp;Xin Ji,&nbsp;Jue Wang","doi":"10.1111/tan.70179","DOIUrl":"https://doi.org/10.1111/tan.70179","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-C*03:595</i> allele was identified in an individual from the Sichuan province of China.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-B*49:01:01:23 Allele by Sequencing-Based Typing","authors":"Sheerin A. Alandejani,&nbsp;Aishah Alanzi,&nbsp;Abdullah Alshubaili,&nbsp;Mohammed Alzahrani,&nbsp;Hanan Anazi","doi":"10.1111/tan.70022","DOIUrl":"https://doi.org/10.1111/tan.70022","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel HLA-B*49:01:01:23 allele differs from HLA-B*49:01:01:01 allele by single nucleotide polymorphism in the 3′UTR.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}