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33rd Annual Conference of the German Society for Immunogenetics (Deutsche Gesellschaft für Immungenetik-DGI), from September 16th to 18th 2026 in Erlangen, Bavaria, Germany 第33届德国免疫遗传学学会（Deutsche Gesellschaft fr Immungenetik - DGI）年会摘要，2026年9月16日至18日，巴伐利亚州埃尔兰根。
IF 5 4区 医学
HLA Pub Date : 2026-09-10 DOI: 10.1111/tan.70874
{"title":"33rd Annual Conference of the German Society for Immunogenetics (Deutsche Gesellschaft für Immungenetik-DGI), from September 16th to 18th 2026 in Erlangen, Bavaria, Germany","authors":"","doi":"10.1111/tan.70874","DOIUrl":"10.1111/tan.70874","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 S1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Confirmation of HLA-A*02:94N By Next-Generation Sequencing HLA-A*02:94N基因的新一代测序证实
IF 5 4区 医学
HLA Pub Date : 2026-09-10 DOI: 10.1111/tan.70968
Jarret Merschman, Justin Kreuter, Kevin Millard, Laurie Wakefield, Manish J. Gandhi
{"title":"Genomic Confirmation of HLA-A*02:94N By Next-Generation Sequencing","authors":"Jarret Merschman,&nbsp;Justin Kreuter,&nbsp;Kevin Millard,&nbsp;Laurie Wakefield,&nbsp;Manish J. Gandhi","doi":"10.1111/tan.70968","DOIUrl":"10.1111/tan.70968","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-A*02:94N</i> allele is characterised by a nonsense mutation in codon 89 in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the HLA-DQB1*03:626 Allele in Two Individuals in a Western Indian Family 西印度一个家族中HLA-DQB1*03:626等位基因的鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-08 DOI: 10.1111/tan.70971
Bansi Parsaniya, Vaishali Patil, Milind Chanekar, Sanjay Gohil, Kirti Chadha
{"title":"Identification of the HLA-DQB1*03:626 Allele in Two Individuals in a Western Indian Family","authors":"Bansi Parsaniya,&nbsp;Vaishali Patil,&nbsp;Milind Chanekar,&nbsp;Sanjay Gohil,&nbsp;Kirti Chadha","doi":"10.1111/tan.70971","DOIUrl":"10.1111/tan.70971","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*03:626</i> differs from <i>DQB1*03:02:01:01</i> by one nucleotide change in gDNA at position 1795 in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-Generation Sequencing-Based High-Resolution Typing of HLA-A, -B, -C and HPA Genes in Jilin Province: Building a Platelet Donor Database and Identifying Novel Alleles 基于新一代测序的吉林省HLA-A、-B、-C和HPA基因高分辨率分型：血小板供体数据库的建立和新等位基因的鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-08 DOI: 10.1111/tan.70851
Yu Han, Hong Yuan, Fan Yang, Lingling Liu, Tingting Nie, Ruiqing Ju, Rixin Bai, Jianghong Yu, Pengli Wang, Lixin Jiao, Xuesong Zhang, Li Yan, Mei Di
{"title":"Next-Generation Sequencing-Based High-Resolution Typing of HLA-A, -B, -C and HPA Genes in Jilin Province: Building a Platelet Donor Database and Identifying Novel Alleles","authors":"Yu Han,&nbsp;Hong Yuan,&nbsp;Fan Yang,&nbsp;Lingling Liu,&nbsp;Tingting Nie,&nbsp;Ruiqing Ju,&nbsp;Rixin Bai,&nbsp;Jianghong Yu,&nbsp;Pengli Wang,&nbsp;Lixin Jiao,&nbsp;Xuesong Zhang,&nbsp;Li Yan,&nbsp;Mei Di","doi":"10.1111/tan.70851","DOIUrl":"10.1111/tan.70851","url":null,"abstract":"<div>\u0000 \u0000 <p>To systematically analyse HLA-A, -B and -C and human platelet antigen (HPA) genotypes of platelet donors in Jilin Province using next-generation sequencing (NGS) technology, a comprehensive donor database was established. Additionally, potential novel alleles were identified, providing a scientific basis for enhancing the safety of clinical blood transfusions. DNA fragments from 200 platelet donor samples in Jilin Province were amplified using locus-specific primers. Comprehensive sequencing of HLA and HPA genes was performed via NGS. Bioinformatics analysis was employed to process genotyping results and screen for novel genetic variants. Newly discovered alleles were validated by Sanger sequencing to ensure accuracy and reliability. HLA genotyping achieved three-field allele resolution, revealing the highest-frequency alleles are as follows: <i>HLA-A*11:01:01</i>, <i>HLA-B*13:02:01</i>, <i>HLA-C*01:02:01</i> and <i>C*03:04:01</i>. A novel allele <i>B*49:91</i> (mutation: E2 24T&gt;C) was identified. For the HPA systems (HPA-1, -2, -3, -5, -6, -15, -21), high heterozygosity was observed in HPA-3 and HPA-15, while no bb homozygosity was detected in HPA-1, -2, -5, -6 or -21. The application of NGS in constructing a platelet HLA/HPA gene database enables high-resolution genotyping, laying a critical foundation for precise platelet matching. This significantly reduces the risk of platelet transfusion refractoriness (PTR) and facilitates the discovery of novel allelic variants. The database provides essential theoretical and practical guidance for future donor screening and personalised transfusion strategies.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-A*03:541 Allele by Next-Generation Sequencing 新HLA-A*03:541等位基因的新一代测序研究
IF 5 4区 医学
HLA Pub Date : 2026-09-04 DOI: 10.1111/tan.70967
Elham Harfouch, Marilyne Gomes, Aicha Hamdaoui, Meriem Merabet, Xavier. Chamillard
{"title":"Characterisation of the Novel HLA-A*03:541 Allele by Next-Generation Sequencing","authors":"Elham Harfouch,&nbsp;Marilyne Gomes,&nbsp;Aicha Hamdaoui,&nbsp;Meriem Merabet,&nbsp;Xavier. Chamillard","doi":"10.1111/tan.70967","DOIUrl":"10.1111/tan.70967","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*03:541</i> differs from <i>HLA-A*03:01:01:01</i> by a single nucleotide substitution at position 728 of the cDNA in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-A*02:1229 Allele Was Identified by Next-Generation Sequencing 新一代测序技术鉴定HLA-A*02:12 . 29等位基因
IF 5 4区 医学
HLA Pub Date : 2026-09-03 DOI: 10.1111/tan.70964
Ying Li, Chen Chen, Fang Wang, Wei Zhang, Faming Zhu
{"title":"The Novel HLA-A*02:1229 Allele Was Identified by Next-Generation Sequencing","authors":"Ying Li,&nbsp;Chen Chen,&nbsp;Fang Wang,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.70964","DOIUrl":"10.1111/tan.70964","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-A*02:1229</i> differs from <i>HLA-A*02:07:01:01</i> by a single nucleotide substitution at position 1014 T&gt;A.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-A*02:1205 and HLA-A*02:07:27 Alleles by Next-Generation Sequencing HLA-A* 02:20 05和HLA-A*02:07:27等位基因的新一代测序分析
IF 5 4区 医学
HLA Pub Date : 2026-09-03 DOI: 10.1111/tan.70962
Ying Li, Fang Wang, Wenwen Pi, Wei Zhang, Faming Zhu
{"title":"Characterisation of the Novel HLA-A*02:1205 and HLA-A*02:07:27 Alleles by Next-Generation Sequencing","authors":"Ying Li,&nbsp;Fang Wang,&nbsp;Wenwen Pi,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.70962","DOIUrl":"10.1111/tan.70962","url":null,"abstract":"<div>\u0000 \u0000 <p>Compared with <i>HLA-A*02:07:01:01</i>, the alleles <i>HLA-A*02:1205</i> and <i>HLA-A*02:07:27</i> each show one nucleotide substitution, respectively.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DRB3*02:240 Allele by Sequencing-Based Typing 新型HLA-DRB3*02:240等位基因的测序分型研究
IF 5 4区 医学
HLA Pub Date : 2026-09-03 DOI: 10.1111/tan.70963
Intissar Dalhoumi, Marco Andreani, Marine Cargou, Gwendaline Guidicelli, Jonathan Visentin
{"title":"Characterisation of the Novel HLA-DRB3*02:240 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Marco Andreani,&nbsp;Marine Cargou,&nbsp;Gwendaline Guidicelli,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70963","DOIUrl":"10.1111/tan.70963","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB3*02:240</i> differs from <i>HLA-DRB3*02:20</i> by one nucleotide substitution in codon 74 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Exonic Variant MICB*075 Was Identified in an Individual From Maharashtra, India 一个新的外显子变异MICB*075在印度马哈拉施特拉邦的个体中被发现。
IF 5 4区 医学
HLA Pub Date : 2026-09-02 DOI: 10.1111/tan.70965
Manisha Tambe, Alfiya Firfire, Selma Z. D'Silva
{"title":"A Novel Exonic Variant MICB*075 Was Identified in an Individual From Maharashtra, India","authors":"Manisha Tambe,&nbsp;Alfiya Firfire,&nbsp;Selma Z. D'Silva","doi":"10.1111/tan.70965","DOIUrl":"10.1111/tan.70965","url":null,"abstract":"<div>\u0000 \u0000 <p><i>MICB*075</i> differs from <i>MICB*004:01:11</i> by a single nucleotide substitution in codon 6 within exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DPB1*1979:01 Allele by Next Generation Sequencing. 新HLA-DPB1*1979:01等位基因的下一代测序鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-01 DOI: 10.1111/tan.70975
Julien Lion, Myriam Dollerschell, Sylvie Larivière, Judith Desoutter, Nicolas Guillaume
{"title":"Characterisation of the Novel HLA-DPB1*1979:01 Allele by Next Generation Sequencing.","authors":"Julien Lion, Myriam Dollerschell, Sylvie Larivière, Judith Desoutter, Nicolas Guillaume","doi":"10.1111/tan.70975","DOIUrl":"10.1111/tan.70975","url":null,"abstract":"<p><p>HLA-DPB1*1979:01 differs from the HLA-DPB1*01:01:01:01 allele by one nucleotide at position 4672 in exon 2.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 3","pages":"e70975"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148967867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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