IF 5.9 4区医学

HLA Pub Date : 2024-07-23 DOI: 10.1111/tan.15609

Katsushi Tanaka, Akira Meguro, Yu Hara, Lisa Endo, Ami Izawa, Suguru Muraoka, Ayami Kaneko, Kohei Somekawa, Momo Hirata, Yukiko Otsu, Hiromi Matsumoto, Ryo Nagasawa, Sosuke Kubo, Kota Murohashi, Ayako Aoki, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Hideaki Kato, Nobuaki Kobayashi, Ichiro Takeuchi, Atsushi Nakajima, Hidetoshi Inoko, Nobuhisa Mizuki, Takeshi Kaneko

{"title":"HLA-DQA1*01:03 and DQB1*06:01 are risk factors for severe COVID-19 pneumonia","authors":"Katsushi Tanaka, Akira Meguro, Yu Hara, Lisa Endo, Ami Izawa, Suguru Muraoka, Ayami Kaneko, Kohei Somekawa, Momo Hirata, Yukiko Otsu, Hiromi Matsumoto, Ryo Nagasawa, Sosuke Kubo, Kota Murohashi, Ayako Aoki, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Hideaki Kato, Nobuaki Kobayashi, Ichiro Takeuchi, Atsushi Nakajima, Hidetoshi Inoko, Nobuhisa Mizuki, Takeshi Kaneko","doi":"10.1111/tan.15609","DOIUrl":"10.1111/tan.15609","url":null,"abstract":"The clinical spectrum of COVID-19 includes a wide range of manifestations, from mild symptoms to severe pneumonia. HLA system plays a pivotal role in immune responses to infectious diseases. The purpose of our study was to investigate the association between HLA and COVID-19 severity in a Japanese population. The study included 209 Japanese COVID-19 patients aged ≥20 years. Saliva samples were collected and used to determine the HLA genotype by HLA imputation through genome-wide association analyses. The association between HLA genotype and COVID-19 severity was then evaluated. The allele frequency was compared between patients with respiratory failure (severe group: 91 cases) and those without respiratory failure (non-severe group: 118 cases), categorising the data into three time periods: pre-Omicron epidemic period, Omicron epidemic period, and total period of this study (from January 2021 to May 2023). In comparing the severe and non-severe groups, the frequencies of the HLA-DQA1*01:03 (35.1% vs. 10.5%, odds ratio [OR] = 4.57, corrected p [pc] = 0.041) and -DQB1*06:01 (32.4% vs. 7.9%, OR = 5.54, pc = 0.030) alleles were significantly higher in the severe group during the pre-Omicron epidemic period. During the Omicron epidemic period, HLA-DQB1*06 (32.4% vs. 7.9%, OR = 5.54, pc = 0.030) was significantly higher in the severe group. During total period of this study, HLA-DQA1*01:03 (30.2% vs. 14.4%, OR = 2.57, corrected pc = 0.0013) and -DQB1*06:01 (44.5% vs. 26.7%, OR = 2.20, pc = 0.013) alleles were significantly higher in the severe group. HLA-DQB1*06:01 and -DQA1*01:03 were in strong linkage disequilibrium with each other (r2 = 0.91) during total period of this study, indicating that these two alleles form a haplotype. The frequency of the HLA-DQA1*01:03–DQB1*06:01 in the severe group was significantly higher than in the non-severe group during pre-Omicron epidemic period (32.4% vs. 7.9%, OR = 5.59, pc = 0.00072), and total period of this study (28.6% vs. 13.1%, OR = 2.63, pc = 0.0013). During Omicron epidemic period, the haplotype did not demonstrate statistical significance, although the odds ratio indicated a value greater 1. Frequencies of the HLA-DQA1*01:03 and -DQB1*06:01 alleles were significantly higher in severe COVID-19 patients, suggesting that these alleles are risk factors for severe COVID-19 pneumonia in the Japanese population.","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nomenclature for factors of the HLA system, update April, May and June 2024 HLA 系统因子命名法，2024 年 4 月、5 月和 6 月更新。

IF 5.9 4区医学

HLA Pub Date : 2024-07-23 DOI: 10.1111/tan.15614

Steven G. E. Marsh

引用次数: 0

Optimisation of global stem cell donor recruitment based on analysis of unsuccessful donor searches 根据对不成功捐献者搜索的分析，优化全球干细胞捐献者招募工作。

IF 5.9 4区医学

HLA Pub Date : 2024-07-23 DOI: 10.1111/tan.15610

Jürgen Sauter, Stefanie N. Bernas, Denis Flaig, Jan A. Hofmann, Martin Maiers, Lydia Foeken, Julia Pingel, Alexander H. Schmidt

{"title":"Optimisation of global stem cell donor recruitment based on analysis of unsuccessful donor searches","authors":"Jürgen Sauter, Stefanie N. Bernas, Denis Flaig, Jan A. Hofmann, Martin Maiers, Lydia Foeken, Julia Pingel, Alexander H. Schmidt","doi":"10.1111/tan.15610","DOIUrl":"10.1111/tan.15610","url":null,"abstract":"Despite over 41 million registered potential volunteer stem cell donors worldwide, many patients in need of a transplant do not find an HLA-matched unrelated donor or cord blood units, with the respective odds differing significantly between various populations. In this study, we analysed data of 2205 unsuccessful real-life donor searches sent to the DKMS Registry to identify populations in which further donor recruitment would be associated with particularly large patient benefits. For that purpose, we estimated haplotype frequencies of 67 donor populations at various sample sizes and entered them into two different mathematical models. These models assessed patient benefits from population-specific donor recruitment, operationalised by the number of originally unsuccessful searches that may become successful due to new donors. Consistently, across the different mathematical models and sample sizes, we obtained several countries from East and Southeast Asia (Thailand, Vietnam, China, and the Philippines) and the population of Asians in the USA as countries/populations where donor recruitment activities would be particularly beneficial for patients. We also identified various countries in Southeast and Central Europe as possible target regions for donor recruitment with above-average patient benefits. The results presented are registry-specific in the sense that they were obtained by optimising unsuccessful searches that had been sent to the DKMS Registry. Therefore, it would be desirable to apply the presented methods to a global data set that includes all unsuccessful stem cell donor searches worldwide and uses population-specific haplotype frequencies based on all donors available in the WMDA Search & Match Service.","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the new allele HLA-A*24:632 in a Greek individual using next generation sequencing 利用新一代测序技术在一名希腊人身上鉴定出新的等位基因 HLA-A*24:632。

IF 5.9 4区医学

HLA Pub Date : 2024-07-23 DOI: 10.1111/tan.15622

Petros Mantzios, Theofilos Athanassiades, Panagiota Mantziou, Vasiliki Kitsiou, Alexandra Tsirogianni

引用次数: 0

Identification of the novel allele HLA-A*02:1144 in a Chinese platelet donor 在一名中国血小板捐献者体内鉴定出新型等位基因 HLA-A*02:1144。

IF 5.9 4区医学

HLA Pub Date : 2024-07-23 DOI: 10.1111/tan.15612

Yun-Ping Xu, Fan Yang, Wen-Xia Xia, Su-Qing Gao

引用次数: 0

The novel non-classical HLA-F*01:12 allele identified in a Brazilian individual 在一名巴西人身上发现的新型非典型 HLA-F*01:12 等位基因。