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The New HLA-B*38:114 Allele Characterised by Two Different Sequencing-Based Typing Techniques
IF 5.9 4区 医学
HLA Pub Date : 2025-03-03 DOI: 10.1111/tan.70113
Thomas Morel, Michaël Pérès, Sandra Clément, Alice Aarnink, Adèle Dhuyser
{"title":"The New HLA-B*38:114 Allele Characterised by Two Different Sequencing-Based Typing Techniques","authors":"Thomas Morel,&nbsp;Michaël Pérès,&nbsp;Sandra Clément,&nbsp;Alice Aarnink,&nbsp;Adèle Dhuyser","doi":"10.1111/tan.70113","DOIUrl":"https://doi.org/10.1111/tan.70113","url":null,"abstract":"<div>\u0000 \u0000 <p>The new allele <i>HLA-B*38:114</i> differs from <i>HLA-B*38:32</i> by three nucleotide substitutions in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-C*02:231 Allele
IF 5.9 4区 医学
HLA Pub Date : 2025-03-03 DOI: 10.1111/tan.70108
F. Ingrassia, A. Pecoraro, I. Aiello, R. Fedele, V. Cappuzzo
{"title":"Characterisation of the Novel HLA-C*02:231 Allele","authors":"F. Ingrassia,&nbsp;A. Pecoraro,&nbsp;I. Aiello,&nbsp;R. Fedele,&nbsp;V. Cappuzzo","doi":"10.1111/tan.70108","DOIUrl":"https://doi.org/10.1111/tan.70108","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*02:231 differs from C*02:02:02:79 by a single non-synonymous nucleotide change in codon 124 (ATC&gt;GTC).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-B*56:102 Allele by Next-Generation Sequencing
IF 5.9 4区 医学
HLA Pub Date : 2025-02-26 DOI: 10.1111/tan.70116
Xavier Fournel, Margot Lepage, Isabelle Favre-Victoire, Philippe Moskovtchenko, Valérie Dubois
{"title":"Identification of the Novel HLA-B*56:102 Allele by Next-Generation Sequencing","authors":"Xavier Fournel,&nbsp;Margot Lepage,&nbsp;Isabelle Favre-Victoire,&nbsp;Philippe Moskovtchenko,&nbsp;Valérie Dubois","doi":"10.1111/tan.70116","DOIUrl":"https://doi.org/10.1111/tan.70116","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-B*56:102 differs from HLA-B*56:01:01:02 by one nucleotide substitution at codon 240 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description of the Novel Allele HLA-C*03:702, Identified in a Bone Marrow Donor
IF 5.9 4区 医学
HLA Pub Date : 2025-02-26 DOI: 10.1111/tan.70106
Valery Cheranev, Tatiana Jankevich, Olga Makhova, Maria Loginova, Andrey Goltsov
{"title":"Description of the Novel Allele HLA-C*03:702, Identified in a Bone Marrow Donor","authors":"Valery Cheranev,&nbsp;Tatiana Jankevich,&nbsp;Olga Makhova,&nbsp;Maria Loginova,&nbsp;Andrey Goltsov","doi":"10.1111/tan.70106","DOIUrl":"https://doi.org/10.1111/tan.70106","url":null,"abstract":"<div>\u0000 \u0000 <p>The new HLA-C*03:702 allele showed one non-synonymous nucleotide difference compared to the HLA-C*03:04:01:01 allele in codon 258.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two Novel HLA-B Alleles With Coding Change in Key Exons, HLA-B*27:282 and HLA-B*40:593
IF 5.9 4区 医学
HLA Pub Date : 2025-02-26 DOI: 10.1111/tan.70101
Maria Loginova, Igor Paramonov
{"title":"Two Novel HLA-B Alleles With Coding Change in Key Exons, HLA-B*27:282 and HLA-B*40:593","authors":"Maria Loginova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70101","DOIUrl":"https://doi.org/10.1111/tan.70101","url":null,"abstract":"<div>\u0000 \u0000 <p>Two novel HLA alleles, HLA-B*27:282 and HLA-B*40:593, were detected using next generation sequencing technology.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of HLA Polymorphism on Immune Response to SARS-CoV-2 Vaccination Within an Infection-Naïve, Vulnerable Population With End-Stage Renal Disease
IF 5.9 4区 医学
HLA Pub Date : 2025-02-24 DOI: 10.1111/tan.70076
Fiona Erskine, Katrina Spensley, Maria Prendecki, Eva Santos, Arthi Anand, Danny Altmann, Michelle Willicombe
{"title":"The Effect of HLA Polymorphism on Immune Response to SARS-CoV-2 Vaccination Within an Infection-Naïve, Vulnerable Population With End-Stage Renal Disease","authors":"Fiona Erskine,&nbsp;Katrina Spensley,&nbsp;Maria Prendecki,&nbsp;Eva Santos,&nbsp;Arthi Anand,&nbsp;Danny Altmann,&nbsp;Michelle Willicombe","doi":"10.1111/tan.70076","DOIUrl":"https://doi.org/10.1111/tan.70076","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA genes exhibit a high degree of polymorphism, contributing to genetic variability known to influence immune responses to infection. Here we investigate associations between HLA polymorphism and serological and T-lymphocyte responses to the BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines within a population receiving maintenance haemodialysis (HD) for End-Stage Renal Disease (ESRD). Our primary objective was to identify HLA alleles associated with diminished serological and T-cellular responsiveness to vaccination. As a secondary objective, the associations between HLA type and COVID-19 disease outcomes were investigated using an independent ESRD cohort (<i>n</i> = 327). This aimed to determine if the alleles associated with poor vaccine response were also linked to unfavourable infection outcomes. In the main study, serum from 225 SARS-CoV-2 infection-naïve patients was HLA-typed using high-resolution Next Generation Sequencing, and serological titres were analysed for the presence of SARS-CoV-2 spike glycoprotein-specific antibodies after two doses of vaccination. A subset of patients (<i>n</i> = 33) was also tested for a T-lymphocyte response. Overall, 89% (<i>n</i> = 200) of patients seroconverted, but only 18% (<i>n</i> = 6) of the cellular response subgroup had a positive T-lymphocyte response. The HLA class II alleles DPB1*104:01, DRB1*04:03 and DRB1*14:04 and HLA class I alleles B*08:01 and B*18:01 were found to significantly correlate with seronegativity, and DQB1*06:01 correlated with serological responsiveness. We were unable to analyse the effect of HLA on disease outcome and T-lymphocyte response due to sample size limitations. Our results suggest pathways for further research and begin to elucidate the relationship between HLA polymorphism and immune responses in the vulnerable ESRD population.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept
IF 5.9 4区 医学
HLA Pub Date : 2025-02-24 DOI: 10.1111/tan.70057
Guillermo Giovambattista, Arisa Kawamura, Akane Ishida, Yukine Murakawa, Kazuyoshi Hosomichi, Fumihiro Nagata, Yoko Aida, Shin-nosuke Takeshima
{"title":"Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept","authors":"Guillermo Giovambattista,&nbsp;Arisa Kawamura,&nbsp;Akane Ishida,&nbsp;Yukine Murakawa,&nbsp;Kazuyoshi Hosomichi,&nbsp;Fumihiro Nagata,&nbsp;Yoko Aida,&nbsp;Shin-nosuke Takeshima","doi":"10.1111/tan.70057","DOIUrl":"https://doi.org/10.1111/tan.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>The bovine leukocyte antigen (BoLA) comprises four regions that contain a high density of polymorphic genes and frequently show gene copy number variations (CNV). Therefore, genotyping <i>BoLA</i> using genome-wide resequencing is difficult. This study aimed to develop four probe sets for resequencing of the <i>BoLA</i> region using a hybridization capture target next–generation sequencing (NGS) method. This proof of concept showed and discussed the several applications of the used strategy. DNAs from nine Japanese Black cows and one Holstein cow were genotyped for <i>BoLA-DRB3</i> using PCR sequence-based typing (SBT). DNA libraries were constructed using the KAPA HyperPlus Kit, and <i>BoLA</i> DNA sequences were enriched using the SeqCap EZ kit and four custom-made probes. Based on preliminary results, the probe set BoLA2 was selected for further analysis. This analysis resulted in a mean coverage of 90.8% with an average depth of 108 reads. A total of 113,646 SNPs and 17,995 indels were detected, several of which have previously been described in the dbSNP database. This allowed the genotyping of class II genes, including <i>BoLA-DRB3</i>. A comparison between target resequencing and PCR-SBT assays did not show conflicts between the <i>BoLA-DRB3</i> genotyping results. CNV analysis based on read number inferred that the <i>BoLA-DQA1</i>, <i>BoLA-DQA2</i>, <i>BoLA-DQA5</i>, and <i>BoLA-DQB</i> genes would be present in the homozygous or heterozygous states or absent, allowing for the definition of four class II and three class I haplotypes. In addition, CNV of non-classical class I genes were also observed. In conclusion, results show that approach used in this study is a cost–effective strategy for sequencing large samples for many research purposes.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor in Response to Paper “Peptide Sharing Between CMV and Mismatched HLA Class I Peptides Promotes Early T- Cell-Mediated Rejection After Kidney Transplantation”
IF 5.9 4区 医学
HLA Pub Date : 2025-02-24 DOI: 10.1111/tan.70090
Jip Jonker, Jan Stephan F. Sanders, Laura B. Bungener, Coretta van Leer-Buter, TransplantLines Investigators, Stephan J. L. Bakker
{"title":"Letter to the Editor in Response to Paper “Peptide Sharing Between CMV and Mismatched HLA Class I Peptides Promotes Early T- Cell-Mediated Rejection After Kidney Transplantation”","authors":"Jip Jonker,&nbsp;Jan Stephan F. Sanders,&nbsp;Laura B. Bungener,&nbsp;Coretta van Leer-Buter,&nbsp;TransplantLines Investigators,&nbsp;Stephan J. L. Bakker","doi":"10.1111/tan.70090","DOIUrl":"https://doi.org/10.1111/tan.70090","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DQA1*05:05:24 Allele by Next Generation Sequencing
IF 5.9 4区 医学
HLA Pub Date : 2025-02-24 DOI: 10.1111/tan.70095
Julien Lion, Cecilia Da Costa, Nicolas Guillaume, Judith Desoutter
{"title":"Characterisation of the Novel HLA-DQA1*05:05:24 Allele by Next Generation Sequencing","authors":"Julien Lion,&nbsp;Cecilia Da Costa,&nbsp;Nicolas Guillaume,&nbsp;Judith Desoutter","doi":"10.1111/tan.70095","DOIUrl":"https://doi.org/10.1111/tan.70095","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DQA1*05:05:24 differs from HLA-DQA1*05:05:01 by one synonymous nucleotide in codon 27 in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of the Novel HLA-C*07:1145N Allele, First Identified in a Brazilian Individual
IF 5.9 4区 医学
HLA Pub Date : 2025-02-24 DOI: 10.1111/tan.70094
Jonathan Pinto, Angela Santos, Romulo Vianna, Luís Cristóvão Porto, Danielle Secco
{"title":"Discovery of the Novel HLA-C*07:1145N Allele, First Identified in a Brazilian Individual","authors":"Jonathan Pinto,&nbsp;Angela Santos,&nbsp;Romulo Vianna,&nbsp;Luís Cristóvão Porto,&nbsp;Danielle Secco","doi":"10.1111/tan.70094","DOIUrl":"https://doi.org/10.1111/tan.70094","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-C*07:1145N</i> allele was first described in a potential bone marrow donor from Brazil.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 2","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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