利用PolyseqOne和Oxford Nanopore测序技术鉴定HLA-G*01:62等位基因

IF 5.9 4区医学 Q2 CELL BIOLOGY

HLA Pub Date : 2025-07-19 DOI:10.1111/tan.70295

Jianrong Chen, Guorong Liao, Runjun He, Jun Qian, Yuan Yao, YongGuang Liu

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引用次数: 0

摘要

HLA-G*01:62与HLA-G*01:04:01的不同之处在于外显子4密码子269的一个非同义核苷酸替换。

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Identification of a Novel HLA-G Allele, HLA-G*01:62, Using PolyseqOne and Oxford Nanopore Sequencing

HLA-G*01:62 differs from HLA-G*01:04:01 by one nonsynonymous nucleotide substitution in codon 269 in exon 4.

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.