HLA最新文献

{"title":"Identification of the Novel HLA-DQB1*04:95 Allele Using Next-Generation Sequencing in a Chinese Cord Blood Donor","authors":"Nanying Chen,&nbsp;Lina Dong,&nbsp;Fang Wang,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.70260","DOIUrl":"https://doi.org/10.1111/tan.70260","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1</i>*04:95 shows one single-nucleotide substitution at position 431 A&gt;G in Exon 3 compared with <i>HLA-DQB1</i>*04:01:01:01.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel MICA*002:01:30 Allele in a Haematopoietic Stem Cell Donor From India","authors":"Gaurav Sharma,&nbsp;Disha Agarwal,&nbsp;Alka Khadwal,&nbsp;Pankaj Malhotra","doi":"10.1111/tan.70237","DOIUrl":"https://doi.org/10.1111/tan.70237","url":null,"abstract":"<div>\u0000 \u0000 <p>MICA*002:01:30 differs from MICA*002:01:03 by a transition of C &gt; T at position 3678 in intron 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-C*04:538 Allele by Third-Generation Sequencing","authors":"Chiara Biagini,&nbsp;Silvia Fornaciari,&nbsp;Roberta Lamanna,&nbsp;Veronica De Gregorio,&nbsp;Michele Curcio","doi":"10.1111/tan.70256","DOIUrl":"https://doi.org/10.1111/tan.70256","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*04:538 differs from HLA-C*04:01:01:01 by a single nucleotide polymorphism in exon 1, codon −13.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated HLA-DRB1 and HLA-DQB1 Mismatches Without Preformed DSA Affect Graft Survival, Rejection and DSA Development: A Multicenter Analysis","authors":"D. A. J. van den Broek,&nbsp;S. Meziyerh,&nbsp;D. van der Helm,&nbsp;J. C. van den Born,&nbsp;J. S. F. Sanders,&nbsp;B. G. Hepkema,&nbsp;J. van de Wetering,&nbsp;J. A. Kal van Gestel,&nbsp;J. Kers,&nbsp;C. van Kooten,&nbsp;J. I. Rotmans,&nbsp;A. P. J. de Vries,&nbsp;D. L. Roelen","doi":"10.1111/tan.70264","DOIUrl":"https://doi.org/10.1111/tan.70264","url":null,"abstract":"<p>Repeat transplantations represent up to 20% of all kidney transplants. Whereas repeat transplantations in the presence of circulating donor-specific HLA-antibodies are generally avoided, the risk of repeated HLA-mismatches (RMM) without detectable antibodies remains debated. This multicenter study evaluated the hazard of RMM, stratified by HLA-class, on transplant outcomes in the absence of preformed donor-specific antibodies. We included repeat kidney transplant recipients from January 2009 onward with available HLA typing for HLA-A, -B, -C, -DRB1, -DRB3/4/5 and -DQB1 from current and previous donors. RMM were defined at the split serological antigen level, excluding patients with only HLA-DP or HLA-DRB3/4/5 RMM. Patients were included if: (a) preformed donor-specific HLA-antibodies (DSA) had never been detected and (b) this was confirmed by Luminex assays within 6 months pre-transplantation. A competing risk model, adjusting for demographic factors and total HLA-mismatch load while accounting for death as a competing risk, showed that HLA-DRB1 and/or HLA-DQB1 RMM significantly increased the risk of graft loss within 1 year post-transplant (HR 3.75 [95% CI 1.51–9.34], <i>p</i> = 0.004). Cox proportional hazard models further linked these HLA-class II RMM to higher risks of biopsy-proven rejection (HR 1.98 [95% CI 1.04–3.76], <i>p</i> = 0.037) and DSA development (HR 9.89 [95% CI 1.92–50.99], <i>p</i> = 0.006), while no significant risks were observed for HLA-class I RMM. Sensitivity analyses in patients screened for pretransplant DSA via single antigen bead assays, those with similar immunosuppression, and those with allelic RMM further confirmed these findings. These results suggest that avoiding HLA-DRB1 and HLA-DQB1 RMM, when feasible, may improve transplant outcomes.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Five New and Confirmation of Three HLA-C Alleles","authors":"Maria Loginova,&nbsp;Daria Smirnova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70258","DOIUrl":"https://doi.org/10.1111/tan.70258","url":null,"abstract":"<div>\u0000 \u0000 <p>Identification of the <i>HLA-C*01:287, HLA-C*03:710, HLA-C*04:543, HLA-C*08:304</i> and <i>HLA-C*16:228</i> alleles and confirmation of <i>HLA-C*02:249, HLA-C*04:532</i> and <i>HLA-C*03:693</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-E Allele, HLA-E*01:01:46, Identified in a Chinese Individual","authors":"Yizhen He,&nbsp;Lina Dong,&nbsp;Fang Wang,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.70254","DOIUrl":"https://doi.org/10.1111/tan.70254","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-E*01:01:46 differs from HLA-E*01:01:01:01 by a single nucleotide substitution at position 12 A&gt;C.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomenclature for Factors of the HLA System, Update January, February, and March 2025","authors":"Steven G. E. Marsh","doi":"10.1111/tan.70203","DOIUrl":"https://doi.org/10.1111/tan.70203","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-B Allele HLA-B*13:01:01:12 in Two Individuals From South India","authors":"Mamidi Neeraja,&nbsp;Neerudi Raj Kumar,&nbsp;Vadde Srikanth","doi":"10.1111/tan.70261","DOIUrl":"https://doi.org/10.1111/tan.70261","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide change (C→T) in intron 1 of HLA-B*<i>13:01:01:01</i> results in the novel HLA allele HLA-B*<i>13:01:01:12.</i></p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-C*07:1088 Allele Characterised by Two Different Sequencing-Based Typing Techniques","authors":"Michaël Pérès,&nbsp;Adèle Dhuyser,&nbsp;Thomas Morel,&nbsp;Sandra Clément,&nbsp;Alice Aarnink","doi":"10.1111/tan.70103","DOIUrl":"https://doi.org/10.1111/tan.70103","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele <i>HLA-C*07:1088</i> differs from <i>HLAC*07:01:01:01</i> by one non-synonymous nucleotide substitution in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the HLA-DPB1*104:01:08 Allele by Sequencing-Based Typing","authors":"Marine Cargou,&nbsp;Vincent Elsermans,&nbsp;Isabelle Top,&nbsp;Intissar Dalhoumi,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70245","DOIUrl":"https://doi.org/10.1111/tan.70245","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DPB1*104:01:08 differs from HLA-DPB1*104:01:01:04 by one nucleotide substitution in codon 199 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}