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Characterisation of the Novel HLA-A*03:40:02 Allele by Next-Generation Sequencing 新HLA-A*03:40:02等位基因的新一代测序鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71031
Valery Cheranev, Irina Savvina, Denis Syrko, Olga Makhova, Maria Loginova
{"title":"Characterisation of the Novel HLA-A*03:40:02 Allele by Next-Generation Sequencing","authors":"Valery Cheranev,&nbsp;Irina Savvina,&nbsp;Denis Syrko,&nbsp;Olga Makhova,&nbsp;Maria Loginova","doi":"10.1111/tan.71031","DOIUrl":"10.1111/tan.71031","url":null,"abstract":"<div>\u0000 \u0000 <p>The new <i>HLA-A*03:40:02</i> allele showed single synonymous nucleotide difference compared to the <i>A*03:40:01</i> allele in Codon 163.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-C*03:04:119 Allele by Next-Generation Sequencing in a Chinese Cord Blood Donor 中国脐带血献血者HLA-C*03:04:119等位基因的新一代测序鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71003
Zhipan Wu, Qi Li, Chen Chen, Yanmin He, Faming Zhu
{"title":"Identification of the Novel HLA-C*03:04:119 Allele by Next-Generation Sequencing in a Chinese Cord Blood Donor","authors":"Zhipan Wu,&nbsp;Qi Li,&nbsp;Chen Chen,&nbsp;Yanmin He,&nbsp;Faming Zhu","doi":"10.1111/tan.71003","DOIUrl":"10.1111/tan.71003","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*03:04:119</i> shows one nucleotide substitution in exon 3 when compared to <i>HLA-C*03:04:01:01</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Non-Classical HLA Class I Molecule HLA-E in Health and Haematological Malignancies 非经典HLA I类分子HLA- e在健康和血液恶性肿瘤中的作用
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71026
Ekaterina Aleksandrovna Pashkina, Ivan Pavlovich Skachkov, Vladimir Aleksandrovich Kozlov
{"title":"The Role of the Non-Classical HLA Class I Molecule HLA-E in Health and Haematological Malignancies","authors":"Ekaterina Aleksandrovna Pashkina,&nbsp;Ivan Pavlovich Skachkov,&nbsp;Vladimir Aleksandrovich Kozlov","doi":"10.1111/tan.71026","DOIUrl":"https://doi.org/10.1111/tan.71026","url":null,"abstract":"<div>\u0000 \u0000 <p>The ability of the non-classical HLA Class I molecule HLA-E to both activate and suppress the immune response allows it to play an important role in both health and disease. Under normal conditions, HLA-E includes not only tolerance to self-antigens but also activating immune responses against intracellular pathogens and regulation of immune activation processes. Numerous studies confirm that increased HLA-E expression on tumour cells is associated with cancer progression. As a significant component of the tumour microenvironment, HLA-E facilitates tumour evasion from the immune response. By interacting with inhibitory receptors on immune cells, HLA-E can induce local immune suppression. However, there is also evidence for activation of the immune response by HLA-E. In this review, we summarise data on HLA-E expression in various cells and the role of this expression in regulating the immune response in health, solid tumours, and blood cancers.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description of the Novel HLA-C*05:01:87 Allele With Single Synonymous Substitution 单同义替换HLA-C*05:01:87等位基因的描述。
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71032
Valery Cheranev, Denis Syrko, Tabanakova Anastasia, Olga Makhova, Maria Loginova
{"title":"Description of the Novel HLA-C*05:01:87 Allele With Single Synonymous Substitution","authors":"Valery Cheranev,&nbsp;Denis Syrko,&nbsp;Tabanakova Anastasia,&nbsp;Olga Makhova,&nbsp;Maria Loginova","doi":"10.1111/tan.71032","DOIUrl":"10.1111/tan.71032","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-C*05:01:87</i> allele showed single nucleotide difference compared to the <i>HLA-C*05:01:01:01</i> allele in Codon 258.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DRB1*15:03:07 Allele by Next-Generation Sequencing 新HLA-DRB1*15:03:07等位基因的新一代测序分析
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71030
Elham Harfouch, Bénédicte Paré, Marilyne Gomes, Émilie Le Toriellec, Laure Croisille
{"title":"Characterisation of the Novel HLA-DRB1*15:03:07 Allele by Next-Generation Sequencing","authors":"Elham Harfouch,&nbsp;Bénédicte Paré,&nbsp;Marilyne Gomes,&nbsp;Émilie Le Toriellec,&nbsp;Laure Croisille","doi":"10.1111/tan.71030","DOIUrl":"10.1111/tan.71030","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB1*15:03:07</i> differs from <i>HLA-DRB1*15:03:01:01</i> by a single synonymous nucleotide substitution at position 318 of the cDNA.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-C*08:320 Allele in a Bone Marrow Donor 骨髓供者HLA-C*08:320等位基因的鉴定
IF 5 4区 医学
HLA Pub Date : 2026-09-30 DOI: 10.1111/tan.71033
Valery Cheranev, Irina Savvina, Varvara Kuznetsova, Olga Makhova, Maria Loginova
{"title":"Identification of the Novel HLA-C*08:320 Allele in a Bone Marrow Donor","authors":"Valery Cheranev,&nbsp;Irina Savvina,&nbsp;Varvara Kuznetsova,&nbsp;Olga Makhova,&nbsp;Maria Loginova","doi":"10.1111/tan.71033","DOIUrl":"10.1111/tan.71033","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-C*08:320</i> allele showed single nucleotide difference compared to the <i>HLA-C*08:02:01:01</i> allele in Codon 139.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of a Novel Variant Allele, HLA-DQA1*06:01:05, Identified in a Han Chinese Individual 汉人HLA-DQA1*06:01:05变异等位基因的特征分析
IF 5 4区 医学
HLA Pub Date : 2026-09-29 DOI: 10.1111/tan.71018
Liumei He, Zhanrou Quan, Hongyan Zou
{"title":"Characterisation of a Novel Variant Allele, HLA-DQA1*06:01:05, Identified in a Han Chinese Individual","authors":"Liumei He,&nbsp;Zhanrou Quan,&nbsp;Hongyan Zou","doi":"10.1111/tan.71018","DOIUrl":"https://doi.org/10.1111/tan.71018","url":null,"abstract":"<div>\u0000 \u0000 <p>The new <i>HLA-DQA1*06:01:05</i> allele differs from its most closely related allele <i>DQA1*06:01:01:02</i> in Exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DQB1*05:377 Allele by Sequencing-Based Typing 新型HLA-DQB1*05:37 77等位基因的分型分析
IF 5 4区 医学
HLA Pub Date : 2026-09-29 DOI: 10.1111/tan.70978
Intissar Dalhoumi, Elodie Wojciechowski, Océane Tenchon, Marine Cargou, Jonathan Visentin
{"title":"Characterisation of the Novel HLA-DQB1*05:377 Allele by Sequencing-Based Typing","authors":"Intissar Dalhoumi,&nbsp;Elodie Wojciechowski,&nbsp;Océane Tenchon,&nbsp;Marine Cargou,&nbsp;Jonathan Visentin","doi":"10.1111/tan.70978","DOIUrl":"https://doi.org/10.1111/tan.70978","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*05:377</i> differs from <i>HLA-DQB1*05:01:01:03</i> allele by a single non-synonymous substitution in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Confirmation of the HLA-DPB1*02:01:64 Allele characterised by an Exon 1 Substitution HLA-DPB1*02:01:64等位基因外显子1替换的证实
IF 5 4区 医学
HLA Pub Date : 2026-09-29 DOI: 10.1111/tan.71025
Zhan-Rou Quan, Jie Liu, Jia-Min Song, Bing-Na Yang, Hong-Yan Zou
{"title":"Confirmation of the HLA-DPB1*02:01:64 Allele characterised by an Exon 1 Substitution","authors":"Zhan-Rou Quan,&nbsp;Jie Liu,&nbsp;Jia-Min Song,&nbsp;Bing-Na Yang,&nbsp;Hong-Yan Zou","doi":"10.1111/tan.71025","DOIUrl":"https://doi.org/10.1111/tan.71025","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-DPB1*02:01:64</i> allele differs from <i>HLA-DPB1*02:01:02:01</i> by one nucleotide substitution in exon 1, and intronic changes.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Two Novel HLA-B Alleles by Next-Generation Sequencing: HLA-B*52:01:64 and HLA-B*07:561 新一代测序鉴定HLA-B*52:01:64和HLA-B*07:561等位基因
IF 5 4区 医学
HLA Pub Date : 2026-09-29 DOI: 10.1111/tan.71013
Sureka Rajendran, Sandeep Sivakumar, Kanaga Ganesan, Maniraj Ramalingam, Nagaraja M. Phani
{"title":"Identification of Two Novel HLA-B Alleles by Next-Generation Sequencing: HLA-B*52:01:64 and HLA-B*07:561","authors":"Sureka Rajendran,&nbsp;Sandeep Sivakumar,&nbsp;Kanaga Ganesan,&nbsp;Maniraj Ramalingam,&nbsp;Nagaraja M. Phani","doi":"10.1111/tan.71013","DOIUrl":"https://doi.org/10.1111/tan.71013","url":null,"abstract":"<div>\u0000 \u0000 <p>Two novel HLA-B alleles, <i>B*52:01:64</i> and <i>B*07:561</i> were identified during routine clinical HLA typing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"108 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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