IF 5.9 4区医学

HLA Pub Date : 2025-07-02 DOI: 10.1111/tan.70313

He Zhao, Destinie Webster, Twyla Perace, Ahmed Mostafa

引用次数: 0

Investigations of HLA-F and HLA-G 3′UTR Polymorphisms in Preeclampsia and Fetal Growth Restriction Indicate a Possible Role of HLA-F-HLA-G Haplotypes and Diplotypes HLA-F和HLA-G 3'UTR多态性在子痫前期和胎儿生长受限中的研究表明HLA-F-HLA-G单倍型和双倍型可能起作用

IF 5.9 4区医学

HLA Pub Date : 2025-07-02 DOI: 10.1111/tan.70293

Hiba Iraqi Møller, Camilla Moldrup Christiansen, Freja Rueholm Klok, Nanna Heldager Pedersen, Thomas Blauenfeldt, Katrine Folmann Finne, Henriette Svarre Nielsen, Thomas Vauvert F. Hviid

{"title":"Investigations of HLA-F and HLA-G 3′UTR Polymorphisms in Preeclampsia and Fetal Growth Restriction Indicate a Possible Role of HLA-F-HLA-G Haplotypes and Diplotypes","authors":"Hiba Iraqi Møller, Camilla Moldrup Christiansen, Freja Rueholm Klok, Nanna Heldager Pedersen, Thomas Blauenfeldt, Katrine Folmann Finne, Henriette Svarre Nielsen, Thomas Vauvert F. Hviid","doi":"10.1111/tan.70293","DOIUrl":"https://doi.org/10.1111/tan.70293","url":null,"abstract":"HLA-F and HLA-G may be involved in the pathogeneses of preeclampsia and fetal growth restriction (FGR). However, the functions of HLA-F and HLA-G in placental dysfunction remain unclear. The aim was to investigate differences in the prevalence of specific HLA-F and HLA-G gene allelic polymorphisms, genotypes, haplotypes, and diplotypes between controls and cases with preeclampsia or FGR. In total, blood samples from 365 pregnant females (controls, n = 192; preeclampsia, n = 164; FGR, n = 19) in their second and third trimester, and corresponding cordial blood samples (reflecting newborns, n = 160) were obtained after delivery. Genomic DNA was sequenced with a focus on the specific gene polymorphisms in the HLA-F gene locus, especially the single nucleotide polymorphisms (SNPs) rs1362126 (G/A), rs2523405 (T/G) and rs2523393 (A/G), as well as the rs371194629 (14-bp ins/del) in the 3′UTR of HLA-G. Haplotype and diplotype distributions were obtained using PHASE v2.1, and linkage disequilibrium analyses were performed. SNPs in the HLA-F gene locus and the 3′UTR of HLA-G were not associated with the risk of preeclampsia or FGR. The SNPs did not correlate with fetal-placental weight ratio, deviation of birth weight at gestational age, and placental weight. However, a trend towards an absence of certain HLA-F-HLA-G extended diplotypes in preeclampsia was observed. The current study does not support associations of the investigated HLA-F SNPs with preeclampsia or FGR. However, further studies are needed to evaluate the possible role of certain fetal HLA-F-HLA-G extended haplotypes and diplotypes in preeclampsia.","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full Genomic Sequence of the HLA-C*01:289 Allele Identified by Next Generation Sequencing 下一代测序鉴定HLA-C*01:289等位基因全基因组序列

IF 5.9 4区医学

HLA Pub Date : 2025-06-30 DOI: 10.1111/tan.70294

John Jeongseok Yang, Sohyeon Eom, Eun-Suk Kang

引用次数: 0

Identification of the Novel HLA-C*15:271N Allele by Next Generation Sequencing 新HLA-C*15:271N等位基因的下一代测序鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-30 DOI: 10.1111/tan.70299

John Jeongseok Yang, Heung-Bum Oh

引用次数: 0

The Novel Allele, HLA-A*03:505, With a Non-Synonymous Mutation in Exon 2 新的等位基因HLA-A*03:505，在外显子2具有非同义突变

IF 5.9 4区医学

HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70311

Maria Loginova, Igor Paramonov, Maksim Zarubin

引用次数: 0

Characterisation of the Novel HLA-C*07:1187 Allele by Sequencing-Based Typing 新型HLA-C*07:1187等位基因的分型分析

IF 5.9 4区医学

HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70305

Lucie Blandin, Mamy Ralazamahaleo, Gwendaline Guidicelli, Paul Rouzaire, Richard Lemal

引用次数: 0

Identification of the Novel HLA-C*08:01:36 Allele Using Next-Generation Sequencing 新一代测序技术鉴定HLA-C*08:01:36等位基因

IF 5.9 4区医学

HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70303

Hyun-Jun Nam, Jun Young Hong, Sunmi Jung, Jina Lee, Younhee Park

引用次数: 0

Genomic Full-Length Sequence of the HLA-DQB1*06:47 Allele Was Identified by PacBio Sequencing 采用PacBio测序方法鉴定HLA-DQB1*06:47等位基因的基因组全长序列

IF 5.9 4区医学

HLA Pub Date : 2025-06-27 DOI: 10.1111/tan.70296

Ning Xie, Yi Duan, Yuping Yang, Zhihui Feng, Xiuxiang Liu

引用次数: 0

Deciphering the Interference of the Anti-Integrin α4β7 Vedolizumab With Cell Crossmatch 抗整合素α4β7 Vedolizumab对细胞交叉配伍的干扰

IF 5.9 4区医学

HLA Pub Date : 2025-06-27 DOI: 10.1111/tan.70301

Marine Cargou, Julien Lion, Intissar Dalhoumi, Elodie Wojciechowski, Mamy Ralazamahaleo, Gwendaline Guidicelli, Nicolas Guillaume, Jonathan Visentin

{"title":"Deciphering the Interference of the Anti-Integrin α4β7 Vedolizumab With Cell Crossmatch","authors":"Marine Cargou, Julien Lion, Intissar Dalhoumi, Elodie Wojciechowski, Mamy Ralazamahaleo, Gwendaline Guidicelli, Nicolas Guillaume, Jonathan Visentin","doi":"10.1111/tan.70301","DOIUrl":"https://doi.org/10.1111/tan.70301","url":null,"abstract":"<div>\u0000 \u0000 In organ transplantation, immunological risk assessment uses cell crossmatch (XM) results, which can be altered by several drugs. We observed two recipients awaiting kidney and liver transplantation with positive flow cytometry XM (FCXM) on T-cells in the absence of Donor Specific Antibodies (DSA). Both were treated with vedolizumab (VDZ) for an inflammatory bowel disease (IBD). VDZ is an IgG1 directed against integrin α4β7, expressed on T and B cell subsets, we therefore suspected that VDZ interfered with XM. We tested with Luminex screening and single antigen assays and with auto- and allo-FCXM on different HLA-typed cells several sera from the two recipients, collected before and during treatment with VDZ. To assess the intensity and the kinetics of the interference, the sera collected during VDZ treatment were from the induction and the maintenance phases at different times post-injection. All sera were DSA-negative with Luminex assays, indicating the absence of interference of VDZ with virtual XM. IgG allo-FCXM on T cells was positive during the maintenance phase while it was randomly positive on B cells. On T cells, the ratio was between 1.6 and 4.4 times the negative control (positivity threshold of 1.5) for the two recipients, and did not depend on the time between collection and injection. Unique T cell populations express Integrin α4β7, then we did not observe a global shift for T cells in the presence of VDZ but a shift for a small subset which was sufficient to induce a positive FCXM. VDZ treatment did not interfere with complement-dependent cytotoxicity XM or with IgM FCXM. Pronase treatment abrogated VDZ interference. In the event of unexpected positive FCXM on T cells in a recipient with IBD, the transplant team should seek VDZ treatment and interference.\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the Novel HLA-DPB1*19:01:02 Allele by Next-Generation Sequencing HLA-DPB1*19:01:02等位基因的新一代测序鉴定

IF 5.9 4区医学

HLA Pub Date : 2025-06-23 DOI: 10.1111/tan.70289

Chen Chen, Fang Wang, Wenwen Pi, Wei Zhang, Faming Zhu

引用次数: 0

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