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Characterisation of the Novel HLA-C*06:406 Allele by Sequencing-Based Typing 新型HLA-C*06:406等位基因的测序分型分析
IF 5.9 4区 医学
HLA Pub Date : 2025-07-03 DOI: 10.1111/tan.70315
Thibault Pajot, Vincent Elsermans, Isabelle Top, Myriam Labalette
{"title":"Characterisation of the Novel HLA-C*06:406 Allele by Sequencing-Based Typing","authors":"Thibault Pajot,&nbsp;Vincent Elsermans,&nbsp;Isabelle Top,&nbsp;Myriam Labalette","doi":"10.1111/tan.70315","DOIUrl":"https://doi.org/10.1111/tan.70315","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*06:406</i> differs from <i>HLA-C*06:02:01:01</i> by one nucleotide substitution in codon 201 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DRB4*01:193 Allele by Sequencing-Based Typing 新型HLA-DRB4*01:193等位基因的测序分型分析
IF 5.9 4区 医学
HLA Pub Date : 2025-07-02 DOI: 10.1111/tan.70308
Lucie Blandin, Elodie Wojciechowski, Mamy Ralazamahaleo, Richard Lemal, Paul Rouzaire
{"title":"Characterisation of the Novel HLA-DRB4*01:193 Allele by Sequencing-Based Typing","authors":"Lucie Blandin,&nbsp;Elodie Wojciechowski,&nbsp;Mamy Ralazamahaleo,&nbsp;Richard Lemal,&nbsp;Paul Rouzaire","doi":"10.1111/tan.70308","DOIUrl":"https://doi.org/10.1111/tan.70308","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DRB4*01:193 differs from HLA-DRB4*01:03:01:01 by one nucleotide substitution in codon 166 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the HLA-DPB1*1748:01 Allele by Next-Generation Sequencing HLA-DPB1*1748:01等位基因的新一代测序分析
IF 5.9 4区 医学
HLA Pub Date : 2025-07-02 DOI: 10.1111/tan.70313
He Zhao, Destinie Webster, Twyla Perace, Ahmed Mostafa
{"title":"Characterisation of the HLA-DPB1*1748:01 Allele by Next-Generation Sequencing","authors":"He Zhao,&nbsp;Destinie Webster,&nbsp;Twyla Perace,&nbsp;Ahmed Mostafa","doi":"10.1111/tan.70313","DOIUrl":"https://doi.org/10.1111/tan.70313","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DPB1*1748:01 differs from HLA-DPB1*04:01:01:01 by one nucleotide substitution in codon-1 in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigations of HLA-F and HLA-G 3′UTR Polymorphisms in Preeclampsia and Fetal Growth Restriction Indicate a Possible Role of HLA-F-HLA-G Haplotypes and Diplotypes HLA-F和HLA-G 3'UTR多态性在子痫前期和胎儿生长受限中的研究表明HLA-F-HLA-G单倍型和双倍型可能起作用
IF 5.9 4区 医学
HLA Pub Date : 2025-07-02 DOI: 10.1111/tan.70293
Hiba Iraqi Møller, Camilla Moldrup Christiansen, Freja Rueholm Klok, Nanna Heldager Pedersen, Thomas Blauenfeldt, Katrine Folmann Finne, Henriette Svarre Nielsen, Thomas Vauvert F. Hviid
{"title":"Investigations of HLA-F and HLA-G 3′UTR Polymorphisms in Preeclampsia and Fetal Growth Restriction Indicate a Possible Role of HLA-F-HLA-G Haplotypes and Diplotypes","authors":"Hiba Iraqi Møller,&nbsp;Camilla Moldrup Christiansen,&nbsp;Freja Rueholm Klok,&nbsp;Nanna Heldager Pedersen,&nbsp;Thomas Blauenfeldt,&nbsp;Katrine Folmann Finne,&nbsp;Henriette Svarre Nielsen,&nbsp;Thomas Vauvert F. Hviid","doi":"10.1111/tan.70293","DOIUrl":"https://doi.org/10.1111/tan.70293","url":null,"abstract":"<p>HLA-F and HLA-G may be involved in the pathogeneses of preeclampsia and fetal growth restriction (FGR). However, the functions of HLA-F and HLA-G in placental dysfunction remain unclear. The aim was to investigate differences in the prevalence of specific HLA-F and HLA-G gene allelic polymorphisms, genotypes, haplotypes, and diplotypes between controls and cases with preeclampsia or FGR. In total, blood samples from 365 pregnant females (controls, <i>n</i> = 192; preeclampsia, <i>n</i> = 164; FGR, <i>n</i> = 19) in their second and third trimester, and corresponding cordial blood samples (reflecting newborns, <i>n</i> = 160) were obtained after delivery. Genomic DNA was sequenced with a focus on the specific gene polymorphisms in the HLA-F gene locus, especially the single nucleotide polymorphisms (SNPs) rs1362126 (G/A), rs2523405 (T/G) and rs2523393 (A/G), as well as the rs371194629 (14-bp ins/del) in the 3′UTR of HLA-G. Haplotype and diplotype distributions were obtained using PHASE v2.1, and linkage disequilibrium analyses were performed. SNPs in the HLA-F gene locus and the 3′UTR of HLA-G were not associated with the risk of preeclampsia or FGR. The SNPs did not correlate with fetal-placental weight ratio, deviation of birth weight at gestational age, and placental weight. However, a trend towards an absence of certain HLA-F-HLA-G extended diplotypes in preeclampsia was observed. The current study does not support associations of the investigated HLA-F SNPs with preeclampsia or FGR. However, further studies are needed to evaluate the possible role of certain fetal HLA-F-HLA-G extended haplotypes and diplotypes in preeclampsia.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Genomic Sequence of the HLA-C*01:289 Allele Identified by Next Generation Sequencing 下一代测序鉴定HLA-C*01:289等位基因全基因组序列
IF 5.9 4区 医学
HLA Pub Date : 2025-06-30 DOI: 10.1111/tan.70294
John Jeongseok Yang, Sohyeon Eom, Eun-Suk Kang
{"title":"Full Genomic Sequence of the HLA-C*01:289 Allele Identified by Next Generation Sequencing","authors":"John Jeongseok Yang,&nbsp;Sohyeon Eom,&nbsp;Eun-Suk Kang","doi":"10.1111/tan.70294","DOIUrl":"https://doi.org/10.1111/tan.70294","url":null,"abstract":"<div>\u0000 \u0000 <p>Full-length sequence of HLA<i>-C*01:289</i> covers the 5′-untranslated region (UTR), all exons and introns and the 3′ UTR.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-C*15:271N Allele by Next Generation Sequencing 新HLA-C*15:271N等位基因的下一代测序鉴定
IF 5.9 4区 医学
HLA Pub Date : 2025-06-30 DOI: 10.1111/tan.70299
John Jeongseok Yang, Heung-Bum Oh
{"title":"Identification of the Novel HLA-C*15:271N Allele by Next Generation Sequencing","authors":"John Jeongseok Yang,&nbsp;Heung-Bum Oh","doi":"10.1111/tan.70299","DOIUrl":"https://doi.org/10.1111/tan.70299","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*15:271N</i> differs from <i>HLA-C*15:02:01:01</i> by an insertion in exon 3 leading to a premature termination codon.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel Allele, HLA-A*03:505, With a Non-Synonymous Mutation in Exon 2 新的等位基因HLA-A*03:505，在外显子2具有非同义突变
IF 5.9 4区 医学
HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70311
Maria Loginova, Igor Paramonov, Maksim Zarubin
{"title":"The Novel Allele, HLA-A*03:505, With a Non-Synonymous Mutation in Exon 2","authors":"Maria Loginova,&nbsp;Igor Paramonov,&nbsp;Maksim Zarubin","doi":"10.1111/tan.70311","DOIUrl":"https://doi.org/10.1111/tan.70311","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-A*03:505 contains a single nucleotide substitution at nucleotide position 236 (GAG to GCG).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-C*07:1187 Allele by Sequencing-Based Typing 新型HLA-C*07:1187等位基因的分型分析
IF 5.9 4区 医学
HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70305
Lucie Blandin, Mamy Ralazamahaleo, Gwendaline Guidicelli, Paul Rouzaire, Richard Lemal
{"title":"Characterisation of the Novel HLA-C*07:1187 Allele by Sequencing-Based Typing","authors":"Lucie Blandin,&nbsp;Mamy Ralazamahaleo,&nbsp;Gwendaline Guidicelli,&nbsp;Paul Rouzaire,&nbsp;Richard Lemal","doi":"10.1111/tan.70305","DOIUrl":"https://doi.org/10.1111/tan.70305","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*07:1187 differs from HLA-C*07:02:01:01 by one nucleotide substitution in codon 304 in exon 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-C*08:01:36 Allele Using Next-Generation Sequencing 新一代测序技术鉴定HLA-C*08:01:36等位基因
IF 5.9 4区 医学
HLA Pub Date : 2025-06-28 DOI: 10.1111/tan.70303
Hyun-Jun Nam, Jun Young Hong, Sunmi Jung, Jina Lee, Younhee Park
{"title":"Identification of the Novel HLA-C*08:01:36 Allele Using Next-Generation Sequencing","authors":"Hyun-Jun Nam,&nbsp;Jun Young Hong,&nbsp;Sunmi Jung,&nbsp;Jina Lee,&nbsp;Younhee Park","doi":"10.1111/tan.70303","DOIUrl":"https://doi.org/10.1111/tan.70303","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-C*08:01:36</i> allele differs from <i>HLA-C*08:01:01:01</i> allele by a single nucleotide at position 42 G &gt; C in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Full-Length Sequence of the HLA-DQB1*06:47 Allele Was Identified by PacBio Sequencing 采用PacBio测序方法鉴定HLA-DQB1*06:47等位基因的基因组全长序列
IF 5.9 4区 医学
HLA Pub Date : 2025-06-27 DOI: 10.1111/tan.70296
Ning Xie, Yi Duan, Yuping Yang, Zhihui Feng, Xiuxiang Liu
{"title":"Genomic Full-Length Sequence of the HLA-DQB1*06:47 Allele Was Identified by PacBio Sequencing","authors":"Ning Xie,&nbsp;Yi Duan,&nbsp;Yuping Yang,&nbsp;Zhihui Feng,&nbsp;Xiuxiang Liu","doi":"10.1111/tan.70296","DOIUrl":"https://doi.org/10.1111/tan.70296","url":null,"abstract":"<div>\u0000 \u0000 <p>The complete genomic sequence of <i>HLA-DQB1*06:47</i> was determined using a PacBio sequencing approach conducted in China.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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