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The Novel HLA-C*05:298 and HLA-DRB1*01:151 Alleles Identified in Russian Bone Marrow Donors 在俄罗斯骨髓捐献者中发现新的 HLA-C*05:298 和 HLA-DRB1*01:151 等位基因。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-28 DOI: 10.1111/tan.15743
Maria Loginova, Julia Dudina, Igor Paramonov
{"title":"The Novel HLA-C*05:298 and HLA-DRB1*01:151 Alleles Identified in Russian Bone Marrow Donors","authors":"Maria Loginova,&nbsp;Julia Dudina,&nbsp;Igor Paramonov","doi":"10.1111/tan.15743","DOIUrl":"10.1111/tan.15743","url":null,"abstract":"<div>\u0000 \u0000 <p>Identification of two novel HLA alleles in Russian bone marrow donors.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel HLA-DQB1*05:02:01:19 Allele in a Candidate Bone Marrow Donor by Next Generation Sequencing 通过新一代测序鉴定候选骨髓捐献者的新型 HLA-DQB1*05:02:01:19 等位基因。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-28 DOI: 10.1111/tan.15740
Diamanto Kouniaki, Katerina Tarassi, Alexandra Tsirogianni
{"title":"Identification of the Novel HLA-DQB1*05:02:01:19 Allele in a Candidate Bone Marrow Donor by Next Generation Sequencing","authors":"Diamanto Kouniaki,&nbsp;Katerina Tarassi,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.15740","DOIUrl":"10.1111/tan.15740","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-DQB1*05:02:01:19</i> allele differs from <i>HLA-DQB1*05:02:01:01</i> by a single nucleotide substitution in intron 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eight Novel HLA Class I Alleles Identified in Unrelated Haematopoietic Cell Donors and Recipients 在非亲缘造血细胞供体和受体中发现八个新的 HLA I 类等位基因
IF 5.9 4区 医学
HLA Pub Date : 2024-10-28 DOI: 10.1111/tan.15734
Elizabeth J. Minshall, Charlotte A. Cambridge, Sebastian J. F. Hopper, Steven G. E. Marsh, Neema P. Mayor
{"title":"Eight Novel HLA Class I Alleles Identified in Unrelated Haematopoietic Cell Donors and Recipients","authors":"Elizabeth J. Minshall,&nbsp;Charlotte A. Cambridge,&nbsp;Sebastian J. F. Hopper,&nbsp;Steven G. E. Marsh,&nbsp;Neema P. Mayor","doi":"10.1111/tan.15734","DOIUrl":"10.1111/tan.15734","url":null,"abstract":"<div>\u0000 \u0000 <p>Eight novel HLA class I alleles have been identified using full gene sequencing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of classical HLA alleles with sleep behaviours 经典 HLA 等位基因与睡眠行为的关联。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-28 DOI: 10.1111/tan.15658
Ruixue Zhou, Bolun Cheng, Wenming Wei, Yifan Gou, Jingni Hui, Meijuan Kang, Chen Liu, Ye Liu, Panxing Shi, Bingyi Wang, Feng Zhang
{"title":"Associations of classical HLA alleles with sleep behaviours","authors":"Ruixue Zhou,&nbsp;Bolun Cheng,&nbsp;Wenming Wei,&nbsp;Yifan Gou,&nbsp;Jingni Hui,&nbsp;Meijuan Kang,&nbsp;Chen Liu,&nbsp;Ye Liu,&nbsp;Panxing Shi,&nbsp;Bingyi Wang,&nbsp;Feng Zhang","doi":"10.1111/tan.15658","DOIUrl":"10.1111/tan.15658","url":null,"abstract":"<p>Immune dysregulation has been observed in individuals with sleep disturbance, with HLA molecules play a crucial role in the immune response. This study aimed to investigate the associations between HLA alleles and sleep behaviours, considering several environmental factors. Data were sourced from the UK Biobank. Logistic regression analyses were performed to explore the associations between 359 HLA alleles and 4 sleep behaviours, including chronotype (<i>n</i> = 204,636), insomnia (<i>n</i> = 227,553), snoring (<i>n</i> = 214,350) and daytime dozing (<i>n</i> = 227,197). Furthermore, gene-environmental interaction studies (GEIS) were conducted to evaluate the interactions of HLA alleles with environmental factors on sleep behaviours. This study analysed a total sample and subgroups stratified by sex to elucidate the impact of HLA alleles on sleep behaviours. Our findings revealed several associations between specific HLA alleles and sleep behaviours. Notably, <i>HLA-A*23:01</i> was associated with evening chronotype in the total sample (OR = 0.918, 95%CI: 0.872–0.965), while <i>HLA-A*32:01</i> was associated with evening chronotype in males (OR = 1.089, 95%CI: 1.037–1.144). Furthermore, GEIS identified multiple sets of interactions associated with sleep behaviours. For example, the interaction of <i>HLA-DPA1*01:04</i> with alcohol consumption was associated with daytime dozing in the total sample (OR = 1.993, 95%CI: 1.351–2.941), while the interaction of <i>HLA-DQB1*05:04</i> with ever suffered mental distress preventing usual activities was associated with insomnia in males (OR = 0.409, 95%CI: 0.254–0.658). Our findings highlight the involvement of HLA in sleep regulation and underscore the potential interactions between HLA alleles and environmental factors in modulating susceptibility to sleep behaviours.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of the Novel HLA-A*11:479N Allele in a Taiwanese Individual 在一名台湾人身上发现新型 HLA-A*11:479N 等位基因
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15727
Kuo-Liang Yang, Py-Yu Lin
{"title":"Discovery of the Novel HLA-A*11:479N Allele in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.15727","DOIUrl":"10.1111/tan.15727","url":null,"abstract":"<div>\u0000 \u0000 <p>A nucleotide mutation in codon 113 of <i>HLA-A*11:01:01:01</i> results in a novel allele <i>HLA-A*11:479N</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-Generation Sequencing Reveals the Novel HLA-DQA1*06:01:04 Allele in a Bone Marrow Donor 下一代测序发现一名骨髓捐献者体内存在新型 HLA-DQA1*06:01:04 等位基因。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15729
Ahmed Gaballa, Anna Söderström, Nina Lundin, Torsten Eich
{"title":"Next-Generation Sequencing Reveals the Novel HLA-DQA1*06:01:04 Allele in a Bone Marrow Donor","authors":"Ahmed Gaballa,&nbsp;Anna Söderström,&nbsp;Nina Lundin,&nbsp;Torsten Eich","doi":"10.1111/tan.15729","DOIUrl":"10.1111/tan.15729","url":null,"abstract":"<div>\u0000 \u0000 <p>A single nucleotide mismatch within exon 2 of HLA-DQA1 differentiates the novel <i>DQA1*06:01:04</i> allele from <i>DQA1*06:01:01:01</i>.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic full-length sequence of the HLA-B*40:96 allele was identified by full length group-specific sequencing 通过全长组特异性测序，确定了 HLA-B*40:96 等位基因的基因组全长序列。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15686
Jiyong Zhou, Yi Duan, Ke Yuan, Zhihui Feng, Xiuxiang Liu
{"title":"Genomic full-length sequence of the HLA-B*40:96 allele was identified by full length group-specific sequencing","authors":"Jiyong Zhou,&nbsp;Yi Duan,&nbsp;Ke Yuan,&nbsp;Zhihui Feng,&nbsp;Xiuxiang Liu","doi":"10.1111/tan.15686","DOIUrl":"10.1111/tan.15686","url":null,"abstract":"<p>Genomic full-length sequence of <i>HLA-B*40:96</i> was identified by a group-specific sequencing approach in a Chinese individual.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of the Novel HLA-B*15:358 Allele by Sanger Dideoxy Nucleotide Sequencing 通过桑格双脱氧核苷酸测序检测新型 HLA-B*15:358 等位基因
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15736
Jian-Ping Li, Xu Zhang, Feng-Qiu Lin, Xiao-Feng Li
{"title":"Detection of the Novel HLA-B*15:358 Allele by Sanger Dideoxy Nucleotide Sequencing","authors":"Jian-Ping Li,&nbsp;Xu Zhang,&nbsp;Feng-Qiu Lin,&nbsp;Xiao-Feng Li","doi":"10.1111/tan.15736","DOIUrl":"10.1111/tan.15736","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*15:358</i> differs from <i>HLA-B*15:02:01:01</i> by one nucleotide substitution at position 685 in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the Novel Non-classical HLA-G*01:24:02 Allele by Next-Generation Sequencing 通过下一代测序鉴定新型非经典 HLA-G*01:24:02 等位基因。
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15728
Yogini Mujumdar, Shramika Vasant Thakur, Deepika Baban Talge, Vikrant M. Bhor, Itta Krishna Chaaithanya
{"title":"Identification of the Novel Non-classical HLA-G*01:24:02 Allele by Next-Generation Sequencing","authors":"Yogini Mujumdar,&nbsp;Shramika Vasant Thakur,&nbsp;Deepika Baban Talge,&nbsp;Vikrant M. Bhor,&nbsp;Itta Krishna Chaaithanya","doi":"10.1111/tan.15728","DOIUrl":"10.1111/tan.15728","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-G*01:24:02</i> differs from <i>HLA-G*01:01:03:03</i> by one nucleotide substitution in codon 304 in exon 5.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of Two New HLA Alleles: HLA-C*04:524 and -DQB1*03:524 两个新 HLA 等位基因的特征：HLA-C*04:524 和 -DQB1*03:524
IF 5.9 4区 医学
HLA Pub Date : 2024-10-27 DOI: 10.1111/tan.15726
Maria Loginova, Igor Paramonov
{"title":"Characterisation of Two New HLA Alleles: HLA-C*04:524 and -DQB1*03:524","authors":"Maria Loginova,&nbsp;Igor Paramonov","doi":"10.1111/tan.15726","DOIUrl":"10.1111/tan.15726","url":null,"abstract":"<p>Two new alleles were identified during routine next generation sequencing.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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