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Identification of Four Novel HLA-A Alleles: HLA-A*02:1173, -A*03:01:128, -A*03:489, and -A*23:141
IF 5.9 4区 医学
HLA Pub Date : 2025-03-25 DOI: 10.1111/tan.70139
Anastasiia Ananeva, Iuliia Sergeeva, Shamil Nizamov, Elena Shagimardanova
{"title":"Identification of Four Novel HLA-A Alleles: HLA-A*02:1173, -A*03:01:128, -A*03:489, and -A*23:141","authors":"Anastasiia Ananeva,&nbsp;Iuliia Sergeeva,&nbsp;Shamil Nizamov,&nbsp;Elena Shagimardanova","doi":"10.1111/tan.70139","DOIUrl":"https://doi.org/10.1111/tan.70139","url":null,"abstract":"<div>\u0000 \u0000 <p>Four novel HLA-A alleles <i>HLA-A*02:1173</i>, -<i>A*03:01:128</i>, -<i>A*03:489</i>, and -<i>A*23:141</i> alleles were detected during routine next generation sequencing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-C*04:534 Allele by Sequencing-Based Typing 通过基于测序的分型鉴定新型 HLA-C*04:534 等位基因。
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70147
Lucie Blandin, Marine Cargou, Gwendaline Guidicelli, Richard Lemal, Paul Rouzaire
{"title":"Characterisation of the Novel HLA-C*04:534 Allele by Sequencing-Based Typing","authors":"Lucie Blandin,&nbsp;Marine Cargou,&nbsp;Gwendaline Guidicelli,&nbsp;Richard Lemal,&nbsp;Paul Rouzaire","doi":"10.1111/tan.70147","DOIUrl":"10.1111/tan.70147","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-C*04:534 differs from HLA-C*04:01:01:01 by two nucleotide substitutions in codons 166 and 167 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Six New Intronic Variants of HLA-A Detected by Next-Generation Sequencing
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70144
Luis Alberto Marín Rubio, Jesús Ontañón
{"title":"Six New Intronic Variants of HLA-A Detected by Next-Generation Sequencing","authors":"Luis Alberto Marín Rubio,&nbsp;Jesús Ontañón","doi":"10.1111/tan.70144","DOIUrl":"10.1111/tan.70144","url":null,"abstract":"<div>\u0000 \u0000 <p>Genomic sequence of HLA-A*01:01:01:119, -A*23:01:01:34, -A*23:01:01:35, -A*29:02:01:40, -A*33:01:01:17 and -A*33:01:01:19 alleles.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-A Allele, HLA-A*02:1133, Identified in a Chinese Individual
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70143
Xin Li, Bin Xi, Zechang Shi, Jianing Yuan, Mingrui Huo
{"title":"The Novel HLA-A Allele, HLA-A*02:1133, Identified in a Chinese Individual","authors":"Xin Li,&nbsp;Bin Xi,&nbsp;Zechang Shi,&nbsp;Jianing Yuan,&nbsp;Mingrui Huo","doi":"10.1111/tan.70143","DOIUrl":"10.1111/tan.70143","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-A*02:1133 differs from HLA-A*02:01:01:01 by a single nucleotide substitution at position 37 C&gt;T in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition of the HLA-A*11:01:79 Allele in a Taiwanese Individual
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70145
Kuo-Liang Yang, Py-Yu Lin
{"title":"Recognition of the HLA-A*11:01:79 Allele in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.70145","DOIUrl":"10.1111/tan.70145","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide substitution in codon 335 of <i>HLA-A*11:01:01:01</i> results in the novel allele <i>HLA-A*11:01:79.</i></p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Case of a Missing HLA-B Gene 缺失的 HLA-B 基因案例。
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70114
Noah Cline, Dario Merlo, Sandra Frater, Nicholas R. Pollock, Neema P. Mayor, Thomas R. Turner, Lisa Walsh, Sharon Vivers, Paul J. Norman
{"title":"The Case of a Missing HLA-B Gene","authors":"Noah Cline,&nbsp;Dario Merlo,&nbsp;Sandra Frater,&nbsp;Nicholas R. Pollock,&nbsp;Neema P. Mayor,&nbsp;Thomas R. Turner,&nbsp;Lisa Walsh,&nbsp;Sharon Vivers,&nbsp;Paul J. Norman","doi":"10.1111/tan.70114","DOIUrl":"10.1111/tan.70114","url":null,"abstract":"<div>\u0000 \u0000 <p>The Major Histocompatibility Complex (MHC) of human chromosome 6 contains multiple genes critical for immunity. The exceptional polymorphism of this genomic region that establishes and maintains immune diversity can be technically challenging to characterise and analyse. In this study, we present a family where the mother and one of her children have no HLA-B allele in common, implying the absence of HLA-B from the maternal haplotype. Homozygosity of the mother and child was confirmed using three independent PCR-based methods and high throughput DNA sequencing. Through probe-based MHC region enrichment, sequencing, and read mapping, we located the breakpoints of a large (36.5 kbp) deletion encompassing the entire HLA-B gene. Accordingly, the deletion was present on the maternal haplotype and transmitted to the child. This study demonstrates strategies for locating large deletions in complex genomic regions and highlights the dynamic nature of MHC structure and variation.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of the Novel HLA-C*08:301 Allele in an Individual From XinJiang, China 在中国新疆发现新型 HLA-C*08:301 等位基因
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70134
Min Chen, Muyesaier Yisimayili, Baohong Xu, Yan Zhang, GongLei Tong
{"title":"Discovery of the Novel HLA-C*08:301 Allele in an Individual From XinJiang, China","authors":"Min Chen,&nbsp;Muyesaier Yisimayili,&nbsp;Baohong Xu,&nbsp;Yan Zhang,&nbsp;GongLei Tong","doi":"10.1111/tan.70134","DOIUrl":"10.1111/tan.70134","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel HLA-C*08:301 allele has a C → A substitution in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DRB1*11:340 Allele by Sequencing-Based Typing
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70146
Lucie Blandin, Jonathan Visentin, Intissar Dalhoumi, Paul Rouzaire, Richard Lemal
{"title":"Characterisation of the Novel HLA-DRB1*11:340 Allele by Sequencing-Based Typing","authors":"Lucie Blandin,&nbsp;Jonathan Visentin,&nbsp;Intissar Dalhoumi,&nbsp;Paul Rouzaire,&nbsp;Richard Lemal","doi":"10.1111/tan.70146","DOIUrl":"10.1111/tan.70146","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DRB1*11:340 differs from HLA-DRB1*11:01:01:01 by one nucleotide substitution in codon 36 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of the Novel HLA-DPB1*1781:01 Allele Using Oxford Nanopore Sequencing Technology 利用牛津纳米孔测序技术确定新型 HLA-DPB1*1781:01 等位基因的特征。
IF 5.9 4区 医学
HLA Pub Date : 2025-03-21 DOI: 10.1111/tan.70142
Jizhi Wen, Haoqiang Ding, Ling Wei, Shuangshuang Jia, Yanli Ji
{"title":"Characterisation of the Novel HLA-DPB1*1781:01 Allele Using Oxford Nanopore Sequencing Technology","authors":"Jizhi Wen,&nbsp;Haoqiang Ding,&nbsp;Ling Wei,&nbsp;Shuangshuang Jia,&nbsp;Yanli Ji","doi":"10.1111/tan.70142","DOIUrl":"10.1111/tan.70142","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPB1*1781:01</i> differs from <i>HLA-DPB1*03:01:01:01</i> by one nonsynonymous nucleotide substitution in codon 5 in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Novel HLA-B*35:186 Allele Identified by Sequence-Based Typing in a Chinese Haematopoietic Stem Cell Donor
IF 5.9 4区 医学
HLA Pub Date : 2025-03-17 DOI: 10.1111/tan.70136
Xu Zhang, Feng-Qiu Lin, Xiao-Feng Li, Jian-Ping Li
{"title":"The Novel HLA-B*35:186 Allele Identified by Sequence-Based Typing in a Chinese Haematopoietic Stem Cell Donor","authors":"Xu Zhang,&nbsp;Feng-Qiu Lin,&nbsp;Xiao-Feng Li,&nbsp;Jian-Ping Li","doi":"10.1111/tan.70136","DOIUrl":"https://doi.org/10.1111/tan.70136","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-B*35:186</i> differs from <i>HLA-B*35:01:01:01</i> by 12 nucleotide substitutions in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 3","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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