Namsu Kim, Chang-Hoon Lee, Hwa Young Im, Joonhong Park
{"title":"Identification of a Novel HLA-DRB3 Allele, DRB3*03:85, in a Korean Individual","authors":"Namsu Kim, Chang-Hoon Lee, Hwa Young Im, Joonhong Park","doi":"10.1111/tan.70369","DOIUrl":"https://doi.org/10.1111/tan.70369","url":null,"abstract":"<div>\u0000 \u0000 <p>DRB3*03:85 is distinguished from HLA-DRB3*03:01:01:01 by a single nonsynonymous substitution at codon 122 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genomic Sequence of Six New Variants of HLA-DQB1*06","authors":"Luis Alberto Marin Rubio, Jesus Ontañon","doi":"10.1111/tan.70391","DOIUrl":"https://doi.org/10.1111/tan.70391","url":null,"abstract":"<div>\u0000 \u0000 <p>Genomic sequences of the HLA-DQB1*06:02:01:38, -DQB1*06:02:01:39, -DQB1*06:03:01:25, -DQB1*06:03:01:27, -DQB1*06:04:01:09 and -DQB1*06:529 alleles.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterisation of the Novel HLA-DRB1*13:371 Allele by Sequencing-Based Typing","authors":"Isabelle Nel, Isabelle Pinson, Guislaine Carcelain, Béatrice Pédron","doi":"10.1111/tan.70388","DOIUrl":"https://doi.org/10.1111/tan.70388","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel allele HLA-DRB1*13:371 differs from HLA-DRB1*13:02:01:01 by one nucleotide substitution in codon 127 in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Host Genetic Factors and Clinical Comorbidities Associated With Tuberculosis Risk","authors":"Shih-Ping Lin, I-Chieh Chen, Ching-Heng Lin, Tzu-Hung Hsiao, Po-Yu Liu, Yi-Ming Chen","doi":"10.1111/tan.70384","DOIUrl":"https://doi.org/10.1111/tan.70384","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA influence the immune response, shaping genetic susceptibility or resistance to tuberculosis (TB). This study aimed to investigate the associations of host genetics and comorbidities with TB infection in Taiwanese populations. This retrospective case–control study utilised data from the Taiwan Precision Medicine Initiative. TB cases and non-TB controls were compared using genome-wide association studies (GWAS), HLA allele typing, and genotype data. Multivariate logistic regression identified independent predictors of TB and interactions between risk factors. A total of 390 TB cases and 3,909 controls were analysed. Risk factors for TB included bronchiectasis (OR = 2.76; 95% CI 1.54–4.44; <i>p</i> < 0.001), diabetes mellitus (OR = 1.30; 95% CI 1.00–1.68; <i>p</i> = 0.050), malignancy (OR = 1.46; 95% CI 1.15–1.85; <i>p</i> = 0.002), smoking (OR = 1.42; 95% CI 1.08–1.88; <i>p</i> = 0.012), and steroid use (OR = 1.66; 95% CI 1.29–2.13; <i>p</i> < 0.001). <i>HLA-DRB1*16:02</i> was associated with a higher frequency in the TB group (OR = 1.47; 95% CI 1.04–2.09; <i>p</i> = 0.030). Interaction analysis showed <i>HLA-DRB1*16:02</i> increased TB risk in non-smokers (OR = 1.58; 95% CI 1.02–2.46; <i>p</i> = 0.042), but not in smokers. <i>HLA-DRB1*16:02</i> was associated with a higher risk for TB. While carriers of <i>HLA-DRB1*16:02</i> did not exhibit an increased risk of TB among smokers, we demonstrated a heightened risk among non-smokers.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disha Agarwal, Gaurav Sharma, Alka Khadwal, Pankaj Malhotra, Reena Das
{"title":"Identification of KIR3DL1*0080105, KIR3DL1*0150224 and KIR2DL4*060 by Next Generation Sequencing","authors":"Disha Agarwal, Gaurav Sharma, Alka Khadwal, Pankaj Malhotra, Reena Das","doi":"10.1111/tan.70376","DOIUrl":"https://doi.org/10.1111/tan.70376","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel KIR3DL1*0080105, KIR3DL1*0150224, and KIR2DL4*060 is identified in healthy individuals from the Indian population.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Novel HLA-DQA1*03:63 Allele Was Identified by Next-Generation Sequencing","authors":"Ying Li, Chen Chen, Fang Wang, Wei Zhang, Faming Zhu","doi":"10.1111/tan.70377","DOIUrl":"https://doi.org/10.1111/tan.70377","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DQA1*03:63 differs from HLA-DQA1*03:02:01:01 by a single nucleotide substitution at position 722 G>A.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genomic Sequence of the HLA-B*07:62:02 and HLA-C*07:02:165 Alleles","authors":"Maria Loginova, Nadezhda Morozova, Igor Paramonov","doi":"10.1111/tan.70380","DOIUrl":"https://doi.org/10.1111/tan.70380","url":null,"abstract":"<div>\u0000 \u0000 <p>The sequences of <i>HLA-B*07:62:02</i> and <i>HLA-C*07:02:165</i> alleles are reported.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three Novel Alleles, HLA-DRB1*01:159, HLA-DRB1*04:402 and HLA-DRB1*15:240, Identified by Next Generation Sequencing","authors":"Maria Loginova, Olga Makhova, Igor Paramonov","doi":"10.1111/tan.70381","DOIUrl":"https://doi.org/10.1111/tan.70381","url":null,"abstract":"<div>\u0000 \u0000 <p>Three novel HLA-DRB1 alleles were identified during routine next generation sequencing.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 3","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}