HLA最新文献

{"title":"Identification of Four New HLA-B*44 Alleles","authors":"Maria Loginova,&nbsp;Nadezhda Morozova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70379","DOIUrl":"https://doi.org/10.1111/tan.70379","url":null,"abstract":"<div>\u0000 \u0000 <p>Four new HLA-B*44 alleles characterised by Next Generation Sequencing, HLA-B*44:431Q, -B*44:432Q, -B*44:433 and -B*44:434.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal–Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders in a Genetically Isolated Population","authors":"Liseanne J. van’t Hof,&nbsp;Marie-Louise P. van der Hoorn,&nbsp;Selena Migdis,&nbsp;Geert W. Haasnoot,&nbsp;Emma T. M. Peereboom,&nbsp;Eric Spierings,&nbsp;Pieter J. E. van der Linden,&nbsp;Jacqueline D. H. Anholts,&nbsp;Heleen de Vreede,&nbsp;Winnie Ottenhof,&nbsp;Dave L. Roelen,&nbsp;Michael Eikmans,&nbsp;Inge B. Mathijssen,&nbsp;Lisa E. E. L. O. Lashley","doi":"10.1111/tan.70374","DOIUrl":"https://doi.org/10.1111/tan.70374","url":null,"abstract":"<p>In pregnancy, semi-allogenic foetal trophoblasts express a specific HLA profile mediating maternal leukocyte contact, crucial for placentation. Paradoxically, maternal immunomodulation requires foetal antigen recognition, especially involving certain HLA molecules. Pre-eclampsia, a severe hypertensive complication, has been linked to antigenic similarity. Previously, we showed no selection for HLA (in)compatibility in uncomplicated naturally conceived pregnancies. However, pre-eclamptic pregnancies were associated with increased total maternal–foetal HLA and HLA-C matching. These associations suggest a role for HLA mismatches in immune regulation leading to an uncomplicated pregnancy. To better understand HLA homozygosity in human reproduction, we aimed to determine if there is a preferential selection for HLA compatibility in a genetically isolated population, and its relation to hypertensive complications. A nested case-control study, comprising 125 uncomplicated pregnancies and 50 with hypertensive complications (29 with pregnancy-induced hypertension, 21 with pre-eclampsia) was conducted in a genetically isolated Dutch population (F_ROH 1.3–3.1). Maternal and foetal HLA-A, -B, -C, -DRB1, -DQA1, -DQB1 and maternal killer-cell immunoglobulin-like receptor (KIR) genotyping were performed. Maternal–foetal HLA (mis)match counts were compared to expected values from randomisation of paternal HLA haplotypes over maternal haplotypes of the foetuses. Mismatched CD4⁺ T cell epitopes presented by maternal HLA class II were predicted using the PIRCHE-II algorithm. In uncomplicated pregnancies, no difference was found between observed and expected maternal–foetal HLA (mis)matches. However, pregnancies with hypertensive complications showed significantly higher observed HLA-DQB1 mismatches, reflected in PIRCHE-II scores. No significant differences were found in KIR/HLA-C frequencies. Interpretation is limited by the small sample size and the grouping of distinct hypertensive disorders. Nonetheless, maternal–foetal HLA-DQB1 mismatch seems to play a role in the aetiology of hypertensive complications during pregnancy in this population.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel HLA-B*07:02:01:132 and HLA-B*54:51 Alleles, Extension of HLA-B*40:70:01, and Confirmation of HLA-C*01:283","authors":"Si-Hwan Kim,&nbsp;John Jeongseok Yang,&nbsp;Heung-Bum Oh","doi":"10.1111/tan.70355","DOIUrl":"https://doi.org/10.1111/tan.70355","url":null,"abstract":"<div>\u0000 \u0000 <p>Two novel HLA-B alleles, one extended HLA-B allele, and one confirmatory HLA-C allele were reported.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Five Novel and Confirmation of Two HLA Class II Alleles","authors":"Maria Loginova,&nbsp;Olga Makhova,&nbsp;Igor Paramonov","doi":"10.1111/tan.70375","DOIUrl":"https://doi.org/10.1111/tan.70375","url":null,"abstract":"<div>\u0000 \u0000 <p>Seven HLA class II alleles were detected and confirmed.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Novel Null HLA-B Alleles Identified in Bone Marrow Donors","authors":"Maria Loginova,&nbsp;Natalia Onuchina,&nbsp;Igor Paramonov","doi":"10.1111/tan.70371","DOIUrl":"https://doi.org/10.1111/tan.70371","url":null,"abstract":"<div>\u0000 \u0000 <p>Three novel HLA-B alleles, <i>HLA-B*08:336 N, HLA-B*18:258 N</i> and <i>HLA-B*51:425 N</i> were identified in bone marrow donors.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-Length Sequence of the HLA-DQB1*05:02:01:17 Allele Using Next-Generation Sequencing","authors":"Diamanto Kouniaki,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70370","DOIUrl":"https://doi.org/10.1111/tan.70370","url":null,"abstract":"<div>\u0000 \u0000 <p>The <i>HLA-DQB1*05:02:01:17</i> allele differs from <i>HLA-DQB1*05:02:01:01</i> by a single nucleotide substitution in intron 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-A*25:95 Allele by Next Generation Sequencing","authors":"Maria Loginova,&nbsp;Igor Paramonov,&nbsp;Maksim Zarubin","doi":"10.1111/tan.70373","DOIUrl":"https://doi.org/10.1111/tan.70373","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel <i>HLA-A*25:95</i> allele differs from <i>HLA-A*25:01:01:01</i> by one nucleotide substitution in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of Nine New HLA Alleles","authors":"Maria Loginova,&nbsp;Julia Dudina,&nbsp;Igor Paramonov","doi":"10.1111/tan.70372","DOIUrl":"https://doi.org/10.1111/tan.70372","url":null,"abstract":"<div>\u0000 \u0000 <p>Nine novel HLA alleles were detected during the HLA typing process.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DRB4*01:03:38 Allele in a Chinese Individual Using PacBio HiFi Sequencing","authors":"Peng Zhao,&nbsp;Hui Liu,&nbsp;Lin Xiang,&nbsp;Bo Deng,&nbsp;Yanju Li","doi":"10.1111/tan.70367","DOIUrl":"https://doi.org/10.1111/tan.70367","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DRB4*01:03:38</i> differs from <i>HLA-DRB4*01:03:01:01</i> by one nucleotide substitution at position 42 (G → A) in exon 1.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novel HLA-C*07:01:130 Allele, Identified by Next-Generation Sequencing in a Greek Haematopoietic Stem Cell Donor","authors":"Vasiliki Kitsiou,&nbsp;Theofilos Athanassiades,&nbsp;Petros Mantzios,&nbsp;Diamanto Kouniaki,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70362","DOIUrl":"https://doi.org/10.1111/tan.70362","url":null,"abstract":"<div>\u0000 \u0000 <p>The HLA-C*07:01:130 allele differs from the HLA-C*07:01:01:01 allele by a single nucleotide substitution in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"106 2","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}