HLA最新文献

{"title":"Asymptomatic SARS-CoV-2 Infection: Association Involving the HLA-B*15 Allele Group in Brazilian Individuals","authors":"Christiane Maria Ayo,&nbsp;Henrique Magalhães,&nbsp;Marcos Paulo Miola,&nbsp;Cinara Cássia Brandão,&nbsp;Maurício Lacerda Nogueira,&nbsp;Cássia Fernanda Estofolete,&nbsp;Victor Hugo de Souza,&nbsp;Jeane Eliete Laguila Visentainer,&nbsp;Luiz Carlos de Mattos","doi":"10.1111/tan.70262","DOIUrl":"https://doi.org/10.1111/tan.70262","url":null,"abstract":"<p>The aim of this study was to investigate the influence of <i>HLA-A</i>, <i>-B</i> and <i>-C</i> polymorphisms on the clinical course of SARS-CoV-2 infection and on the progression of COVID-19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (<i>n</i> = 309) or moderate/mild (<i>n</i> = 60) symptoms, and 109 were asymptomatic. The control group consisted of 150 volunteer bone marrow donors, recruited in the pre-pandemic period. The <i>HLA-B*15</i> allele group (adjusted <i>p</i> value &lt; 0.001) was associated with a protective factor against symptomatic infection. Investigating the effects of the distribution of <i>HLA</i> alleles on susceptibility and resistance to SARS-CoV-2 may provide a better understanding of the clinical course of infection in different geographical regions.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-DQB1*03:19:01:03, A Novel Allele Discovered in a Greek Volunteer Bone Marrow Donor","authors":"Vasiliki Kitsiou,&nbsp;Panagiota Mantziou,&nbsp;Theofilos Athanassiades,&nbsp;Diamanto Kouniaki,&nbsp;Alexandra Tsirogianni","doi":"10.1111/tan.70273","DOIUrl":"https://doi.org/10.1111/tan.70273","url":null,"abstract":"<div>\u0000 \u0000 <p>The HLA-DQB1*03:19:01:03 allele differs from HLA-DQB1*03:19:01:01 by a single nucleotide substitution in intron 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-Typing of Donor-Origin Cells Enriched From Urine Cell Culture of Kidney Transplanted Recipients","authors":"Desmond Y. H. Yap,&nbsp;Patrick Chu,&nbsp;Kitty Lau,&nbsp;Jenny Ho,&nbsp;Stephen Cheung,&nbsp;Lydia Tang,&nbsp;Charlie Ho,&nbsp;Tak Mao Chan,&nbsp;Janette Kwok","doi":"10.1111/tan.70253","DOIUrl":"https://doi.org/10.1111/tan.70253","url":null,"abstract":"<div>\u0000 \u0000 <p>The incomplete or lack of histocompatibility information constitutes a barrier for the early detection and management of de novo donor-specific antibodies (DSA). To improve the quantity and quality of DNA materials for HLA typing, we developed a non-invasive culture-based method, using DNA extracted from enriched donor-derived kidney stem cells (DKSC) selectively cultured from the urine of kidney transplant receipients (KTR) to allow high-resolution typing by next-generation sequencing. This prospective proof-of-concept study evaluated the feasibility and performance of this approach. DKSC were enriched from the urine of 60 KTRs. DNA extracted from culture-enriched DKSC showed significantly higher concentration and better quality than unbound cells, and with identical short tandem repeat (STR) and 100% concordance compared to that obtained from peripheral blood. Our results suggest that cultured-enriched DKSC are non-invasive and useful for determining HLA and other genes for KTRs where donor information is limited or lacking.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Full-Length Sequence of the HLA-DRB1*14:84 Allele, Identified by PacBio Sequencing","authors":"Yu-Li Zhu,&nbsp;Ying-Chun Wang,&nbsp;Zhi-Hui Feng,&nbsp;Shu-Xian Jiao,&nbsp;Shu-Tao Pang","doi":"10.1111/tan.70266","DOIUrl":"https://doi.org/10.1111/tan.70266","url":null,"abstract":"<div>\u0000 \u0000 <p>The genomic full-length sequence of the <i>HLA-DRB1*14:84</i> allele was identified using a PacBio sequencing approach from China.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-A*24:642 Allele Using New Next-Generation Sequencing Methods","authors":"Xin Li,&nbsp;Bin Xi,&nbsp;Zechang Shi,&nbsp;Jianing Yuan,&nbsp;Mingrui Huo","doi":"10.1111/tan.70239","DOIUrl":"https://doi.org/10.1111/tan.70239","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-A*24:642 differs from HLA-A*24:02:01:01 by a single nucleotide substitution at position 76 T&gt;C in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DPB1*29:01:02 Allele Using New Next-Generation Sequencing Methods","authors":"Maxime Raz,&nbsp;Patrice Dunoyer,&nbsp;Coralie Frassati,&nbsp;Jessica Marshall,&nbsp;Pascal Pedini","doi":"10.1111/tan.70272","DOIUrl":"https://doi.org/10.1111/tan.70272","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPB1*29:01:02</i> differs from <i>HLA-DPB1*29:01:01</i> by a single synonymous substitution in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The Novel HLA-DRB1 Allele, HLA-DRB1*09:54 Was Identified in a Chinese Individual”","authors":"","doi":"10.1111/tan.70267","DOIUrl":"https://doi.org/10.1111/tan.70267","url":null,"abstract":"<p>S. Zhao, C. Chen, F. Wang, W. Zhang, and F. Zhu, “The Novel HLA-DRB1 Allele, <i>HLA-DRB1*09:54</i> Was Identified in a Chinese Individual,” <i>HLA</i> 104, no. 1 (2024): e15596, https://doi.org/10.1111/tan.15596.</p><p>In the article, third paragraph, the accession number for HLA-DRB1*09:54 was incorrect, and it should be changed from OP459300 to OR101191.</p><p>The incorrect sentence reads:</p><p>The accession number OP459300 was assigned in the GenBank nucleotide sequence database for the nucleotide sequence of the <i>HLA-DRB1*09:54</i> allele.</p><p>The correct sentence should read:</p><p>The accession number OR101191 was assigned in the GenBank nucleotide sequence database for the nucleotide sequence of the <i>HLA-DRB1*09:54</i> allele.</p><p>We apologize for this error.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 6","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DQB1*05:357 Allele by Sequencing-Based Typing","authors":"Vincent Elsermans,&nbsp;Jonathan Visentin,&nbsp;Thibault Pajot,&nbsp;Isabelle Top,&nbsp;Myriam Labalette","doi":"10.1111/tan.70269","DOIUrl":"https://doi.org/10.1111/tan.70269","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DQB1*05:357</i> differs from <i>HLA-DQB1*05:03:01:01</i> by one nucleotide substitution in codon 6 in exon 2.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Identification of the MHC-DPA1 Alleles in Tibetan Macaques (Macaca thibetana)","authors":"S. K. Min,&nbsp;X. S. Zhang,&nbsp;H. Chen","doi":"10.1111/tan.70198","DOIUrl":"https://doi.org/10.1111/tan.70198","url":null,"abstract":"<div>\u0000 \u0000 <p>Ten novel MHC-DPA1 alleles were identified in Tibetan macaques (<i>Macaca thibetana</i>).</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between HLA-DRB1 Serotype and HLA-DQB1 Allele Mismatches and Acute Rejection in Kidney Transplantation","authors":"Renato de Marco,&nbsp;Isau H. Noronha,&nbsp;Luiza Zainotti Miguel Fahur Bottino,&nbsp;Tuila Bittencourt Mourão,&nbsp;Gisele Fabianne Rampim,&nbsp;João Campos,&nbsp;Alberto Cardoso Martins Lima,&nbsp;Lúcio Requião-Moura,&nbsp;Hélio Tedesco-Silva,&nbsp;José Medina Pestana,&nbsp;Maria Gerbase-DeLima","doi":"10.1111/tan.70228","DOIUrl":"https://doi.org/10.1111/tan.70228","url":null,"abstract":"<p>The purpose of this single-center case–control study was to investigate the association between HLA serotype mismatch (MM), compared to other HLA MM modalities, and the occurrence of acute rejection (AR) within the first year after deceased donor kidney transplantation. The study included 198 transplants in 99 pairs of recipients of kidneys from the same donor, where one recipient experienced AR and the other survived the first year without AR. Donors and recipients were typed with NGS for 11 HLA loci at high resolution. HLA MM categories included allele groups, alleles, serotypes, amino acids, EMMA, eplet and PIRCHE-II. Additionally, we investigated Cytomegalovirus LIL peptide (CMV LIL) MM. Recipients with AR presented higher frequencies of pre-transplant HLA-ABDR DSA (20.2% vs. 6.1%, <i>p</i> = 0.005) and CMV LIL MM (24.2% vs. 10.1%, <i>p</i> = 0.01). Univariate and multivariate Cox proportional hazards regression for matched-pair analyses were used to test the association between HLA MM and AR. Univariate analyses indicated significant association with DRB1 ST, HLA-DQB1 AG, HLA-DQB1 AL, EMMA C, EMMA DQB1, Eplet ABC and Eplet DQ MM. Different models were tested in multivariate analyses, all including pre-transplant HLA-ABDR DSA and CMV LIL MM. The models were compared using the Akaike Information Criterion (AIC). The best estimate for AR prediction (AIC = 97.6) was the model that included pre-transplant HLA-ABDR DSA (HR = 11.97; <i>p</i> = 0.003), CMV LIL MM (HR = 367.2; <i>p</i> &lt; 0.001), HLA-DRB1 serotype MM (9.65; <i>p</i> = 0.002) and HLA-DQB1 allele MM (HR = 3.54; <i>p</i> = 0.033). In conclusion, this original report demonstrates an association between the HLA-DRB1 serotype MM and AR, highlighting that serotypes are clinically relevant.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"105 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.70228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}