HLA最新文献

{"title":"Foetal Microchimerism Correlates With Foetal-Maternal Histocompatibility Both During Pregnancy and Postpartum","authors":"Anne Cathrine Staff,&nbsp;Heidi E. Fjeldstad,&nbsp;Maria B. Olsen,&nbsp;Jonas Øgaard,&nbsp;Marte K. Viken,&nbsp;Cynthia S. M. Kramer,&nbsp;Michael Eikmans,&nbsp;Thomas Kroneis,&nbsp;Katja Sallinger,&nbsp;Sami B. Kanaan,&nbsp;Meryam Sugulle,&nbsp;Daniel P. Jacobsen","doi":"10.1111/tan.15717","DOIUrl":"10.1111/tan.15717","url":null,"abstract":"<p>Foetal cells are detectable in women decades postpartum, a state termed foetal microchimerism. The interplay between these semi-allogeneic foetal cells and the mother could be affected by genetic mismatches in the HLA loci. Here, we relate HLA allele and molecular mismatch values to the presence and quantity of foetal microchimerism in the maternal circulation during pregnancy and postpartum. A total of 76 pregnant women were included, of which 59 were followed up 1–8 years postpartum. Maternal and foetal DNA was genotyped for HLA class I and II loci. Foetal cells in maternal buffy coat were detected by qPCR, targeting inherited paternal alleles. Antibody-verified eplet mismatch and Predicted Indirectly Recognisable HLA Epitopes (PIRCHE) scores were calculated to quantify foetal-maternal histocompatibility from the mother's perspective. Circulating foetal cells were detected in 50.0% (38/76) of women during pregnancy, and 25.4% (15/59) postpartum. During pregnancy, HLA class II antibody-verified eplet mismatch load and PIRCHE scores correlated negatively with the presence and quantity of foetal cells in the maternal circulation. Postpartum, HLA class I allele mismatches correlated negatively with foetal microchimerism presence, while HLA class II allele mismatches, HLA class I and II antibody-verified eplet mismatch load, and PIRCHE-I and PIRCHE-II scores correlated negatively with both microchimerism presence and quantity. The correlation between mismatch parameters aimed at evaluating the risk of humoral and T cell-mediated allorecognition and foetal microchimerism was more evident postpartum than during pregnancy. The observed predictive effect of foetal-maternal histocompatibility on foetal microchimerism suggests that circulating foetal cells are subject to clearance by the maternal immune system. We propose that allorecognition of foetal cells in the maternal circulation and tissues influences any long-term effect that foetal microchimerism may have on maternal health.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/tan.15717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-DQB1*06:432 Allele by Sequence-Based Typing","authors":"John Jeongseok Yang,&nbsp;Heung-Bum Oh","doi":"10.1111/tan.15731","DOIUrl":"10.1111/tan.15731","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-DQB1*06:432 differs from HLA-DQB1*06:09:01:01 by a nonsynonymous nucleotide substitution in codon 186, changing Valine to Methionine.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognition of the HLA-B*55:39 Allele in a Taiwanese Individual","authors":"Kuo-Liang Yang,&nbsp;Py-Yu Lin","doi":"10.1111/tan.15718","DOIUrl":"10.1111/tan.15718","url":null,"abstract":"<div>\u0000 \u0000 <p>One nucleotide substitution in codon 118 of <i>HLA-B*55:02:01:01</i> results in a novel allele, <i>HLA-B*55:39.</i></p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Novel HLA-A*33:03:68 Allele in a Chinese Platelet Donor","authors":"Fan Yang,&nbsp;Su-Qing Gao,&nbsp;Wen-Xia Xia,&nbsp;Yun-Ping Xu","doi":"10.1111/tan.15711","DOIUrl":"10.1111/tan.15711","url":null,"abstract":"<div>\u0000 \u0000 <p>The novel HLA-A*33:03:68 allele differs from HLA-A*33:03:01:01 by 1 variation in exon 3.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel HLA-DPA1 Allele, HLA-DPA1*01:204, Was Identified by Next-Generation Sequencing","authors":"Xiong-jie He,&nbsp;Kun-Xiang Wang,&nbsp;Peng Zhang,&nbsp;Ti-Long Huang,&nbsp;Xian-Wen Zhang","doi":"10.1111/tan.15710","DOIUrl":"https://doi.org/10.1111/tan.15710","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-DPA1*01:204</i> has a single nucleotide substitution at position 426G &gt; T when compared to the <i>HLA-DPA1*01:03:01:15</i> allele.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial","authors":"Maria Christine Krog,&nbsp;Emma T. M. Peereboom,&nbsp;Kirsten Geneugelijk,&nbsp;Benedict M. Matern,&nbsp;Astrid Marie Kolte,&nbsp;Ole Bjarne Christiansen,&nbsp;Rudi Steffensen,&nbsp;Henriette Svarre Nielsen,&nbsp;Eric Spierings","doi":"10.1111/tan.15723","DOIUrl":"https://doi.org/10.1111/tan.15723","url":null,"abstract":"<div>\u0000 \u0000 <p>Recurrent pregnancy loss (RPL), defined as two or more pregnancy losses before the 24th week of gestation, affects 1%–3% of women worldwide. Approximately, 40% of RPL cases are secondary RPL (sRPL), where women have given birth before facing pregnancy losses. The underlying causes of RPL remain unclear, but immune-related factors may play a role. Previously, a randomised controlled trial using immunoglobulin (IVIG) in sRPL women with a history of four pregnancy losses performed in our RPL unit did not show significant effects of IVIG treatment overall. Yet, some evidence suggests potential benefits for a subset of sRPL patients. In the cohort used for the randomised controlled trial, we examined the role of maternal HLA class II-presented fetal HLA-derived epitopes in sRPL using the predicted indirectly recognisable HLA epitopes (PIRCHE-II) algorithm. In the placebo group, sRPL mothers with an anti-HLA antibody response had higher PIRCHE-II scores when having a live birth compared with sRPL women who experienced another pregnancy loss. This difference was not observed in the IVIG-treated group. Furthermore, as a proxy for T-cell memory, the number of overlapping peptides between the two paternal haplotypes in couples having live births without treatment displayed a larger number of overlapping peptides. This effect was primarily driven by class II-derived peptides. These results suggest that specific combinations of sRPL mothers and fathers, particularly those with an anti-HLA antibody response, may generate higher PIRCHE-II scores, which could contribute to successful live births. Understanding these immune interactions may provide insights for personalised diagnostic and therapeutic strategies in sRPL.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-DRB1*16:79 Allele Using Short- and Long-Read Sequencing Technologies","authors":"Gabriela Andrade,&nbsp;Mayara Cunha,&nbsp;Romulo Vianna,&nbsp;Luís Cristóvão Porto,&nbsp;Danielle Secco","doi":"10.1111/tan.15724","DOIUrl":"https://doi.org/10.1111/tan.15724","url":null,"abstract":"<p>The novel <i>HLA-DRB1*16:79</i> allele, first described in an individual from Brazil.</p>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Novel HLA-B*58:139 Allele by Next-Generation Sequencing","authors":"Qi Li,&nbsp;Nanying Chen,&nbsp;Lina Dong,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.15721","DOIUrl":"https://doi.org/10.1111/tan.15721","url":null,"abstract":"<div>\u0000 \u0000 <p>HLA-B*58:139 differs from the HLA-B*58:01:01:01 allele by one nucleotide substitution in exon 4.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of KIR and HLA Polymorphism in Chinese Individuals With COVID-19","authors":"Sudan Tao,&nbsp;Xuan You,&nbsp;Paul J. Norman,&nbsp;Katherine M. Kichula,&nbsp;Lina Dong,&nbsp;Nanying Chen,&nbsp;Ji He,&nbsp;Wei Zhang,&nbsp;Faming Zhu","doi":"10.1111/tan.15715","DOIUrl":"10.1111/tan.15715","url":null,"abstract":"<div>\u0000 \u0000 <p>Killer-cell immunoglobulin-like receptor (KIR) interactions with HLA class I have crucial roles in modulating NK cell function in response to viral infections. To explore the correlation between <i>KIR/HLA</i> and susceptibility to SARS-CoV-2 infection, we analysed polymorphism of <i>KIR</i> genes, haplotypes, HLA allotypes, and the interplay between <i>KIR</i> and <i>HLA</i> in individuals diagnosed with COVID-19. Compared to a population control group, we observed a significantly increased frequency of <i>KIR3DL3*00802</i> in the COVID-19 group. When encoded by the <i>HLA-B</i> gene, the frequency of HLA-Bw4, a ligand for KIR3DL1, was at lower frequency in the COVID-19 group. Additionally, significantly elevated frequencies of <i>KIR-Bx3</i>, <i>KIR3DL3*00301</i>, <i>3DL3*048</i>, and C1⁺HLA-C were identified in the COVID-19 group before multiple test correction, suggesting associations with susceptibility to SARS-CoV-2 infection. Our findings indicate that the <i>KIR3DL3*00802</i> allele may be a high-risk factor for SARS-CoV-2 infection, while Bw4 encoded by <i>HLA-B</i> gene may confer protective effects against the infection.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the Novel HLA-C*07:01:126 Allele by Sequencing-Based Typing","authors":"Vincent Elsermans,&nbsp;Jonathan Visentin,&nbsp;Thibault Pajot,&nbsp;Isabelle Top,&nbsp;Myriam Labalette","doi":"10.1111/tan.15713","DOIUrl":"10.1111/tan.15713","url":null,"abstract":"<div>\u0000 \u0000 <p><i>HLA-C*07:01:126</i> differs from <i>HLA-C*07:01:01:01</i> by one nucleotide substitution in codon 328 in exon 7.</p>\u0000 </div>","PeriodicalId":13172,"journal":{"name":"HLA","volume":"104 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}