IEEE Transactions on Biomedical Circuits and Systems最新文献_第7页

Proceedings of the 2011 IEEE International Symposium on Circuits and Systems (ISCAS 2011), May 15-18, 2011, Rio de Janeiro, Brazil. 2011年IEEE电路与系统国际研讨会论文集，2011年5月15-18日，巴西里约热内卢。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2012-04-01

引用次数: 0

Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection 基于介电泳的纳米和微粒子操作和电容检测集成芯片实验室

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2012-03-02 DOI: 10.1109/TBCAS.2013.2271727

M. A. Miled, G. Massicotte, M. Sawan

{"title":"Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection","authors":"M. A. Miled, G. Massicotte, M. Sawan","doi":"10.1109/TBCAS.2013.2271727","DOIUrl":"https://doi.org/10.1109/TBCAS.2013.2271727","url":null,"abstract":"We present in this paper a new Lab-on-Chip (LoC) architecture for dielectrophoresis-based cell manipulation, detection, and capacitive measurement. The proposed LoC is built around a CMOS full-custom chip and a microfluidic structure. The CMOS chip is used to deliver all parameters required to control the dielectrophoresis (DEP) features such as frequency, phase, and amplitude of signals spread on in-channel electrodes of the LoC. It is integrated to the LoC and experimental results are related to micro and nano particles manipulation and detection in a microfluidic platform. The proposed microsystem includes an on-chip 27-bit frequency divider, a digital phase controller with a 3.6° phase shift resolution and a 2.5 V dynamic range. The sensing module is composed of a 3 × 3 capacitive sensor array with 10 fF per mV sensitivity, and a dynamic range of 1.5 V. The obtained results show an efficient nano and micro-particles (PC05N, PA04N and PS03N) separation based on frequency segregation with low voltages less than 1.7 V and a fully integrated and reconfigurable system.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"6 1","pages":"120-132"},"PeriodicalIF":5.1,"publicationDate":"2012-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2013.2271727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62964615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

CMOS Low Current Measurement System for Biomedical Applications 生物医学应用CMOS低电流测量系统

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2011-05-15 DOI: 10.1109/ISCAS.2011.5937741

Brian Goldstein, Dongsoo Kim, A. Rottigni, Jian Xu, T. Vanderlick, E. Culurciello

引用次数: 64

A VLSI Neural Monitoring System With Ultra-Wideband Telemetry for Awake Behaving Subjects 基于超宽带遥测技术的清醒行为对象VLSI神经监测系统

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2010-08-03 DOI: 10.1109/ISCAS.2010.5537299

Elliot Greenwald, M. Mollazadeh, N. Thakor, Wei Tang, E. Culurciello

{"title":"A VLSI Neural Monitoring System With Ultra-Wideband Telemetry for Awake Behaving Subjects","authors":"Elliot Greenwald, M. Mollazadeh, N. Thakor, Wei Tang, E. Culurciello","doi":"10.1109/ISCAS.2010.5537299","DOIUrl":"https://doi.org/10.1109/ISCAS.2010.5537299","url":null,"abstract":"Long-term monitoring of neuronal activity in awake behaving subjects can provide fundamental information about brain dynamics for neuroscience and neuroengineering applications. Here, we present a miniature, lightweight, and low-power recording system for monitoring neural activity in awake behaving animals. The system integrates two custom designed very-large-scale integrated chips, a neural interface module fabricated in 0.5 μm complementary metal-oxide semiconductor technology and an ultra-wideband transmitter module fabricated in a 0.5 μm silicon-on-sapphire (SOS) technology. The system amplifies, filters, digitizes, and transmits 16 channels of neural data at a rate of 1 Mb/s. The entire system, which includes the VLSI circuits, a digital interface board, a battery, and a custom housing, is small and lightweight (24 g) and, thus, can be chronically mounted on small animals. The system consumes 4.8 mA and records continuously for up to 40 h powered by a 3.7-V, 200-mAh rechargeable lithium-ion battery. Experimental benchtop characterizations as well as in vivo multichannel neural recordings from awake behaving rats are presented here.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"1 1","pages":"112-119"},"PeriodicalIF":5.1,"publicationDate":"2010-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ISCAS.2010.5537299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62145620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Neural dynamics in reconfigurable silicon 可重构硅中的神经动力学

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2010-05-01 DOI: 10.1109/ISCAS.2010.5536960

Arindam Basu, Shubha Ramakrishnan, P. Hasler

引用次数: 0

Pain control on demand based on pulsed radio-frequency stimulation of the dorsal root ganglion using a batteryless implantable CMOS SoC 基于脉冲射频刺激背根神经节的疼痛控制需求，使用无电池植入式CMOS SoC

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2010-03-18 DOI: 10.1109/ISSCC.2010.5433936

Chii-Wann Lin, Hung-Wei Chiu, M. Lin, Chi-Heng Chang, I-Hsiu Ho, Po Hsiang Fang, Yi Chin Li, Chang Lun Wang, Yao-Chuan Tsai, Y. Wen, Win-Pin Shih, Y. Yang, Shey-Shi Lu

{"title":"Pain control on demand based on pulsed radio-frequency stimulation of the dorsal root ganglion using a batteryless implantable CMOS SoC","authors":"Chii-Wann Lin, Hung-Wei Chiu, M. Lin, Chi-Heng Chang, I-Hsiu Ho, Po Hsiang Fang, Yi Chin Li, Chang Lun Wang, Yao-Chuan Tsai, Y. Wen, Win-Pin Shih, Y. Yang, Shey-Shi Lu","doi":"10.1109/ISSCC.2010.5433936","DOIUrl":"https://doi.org/10.1109/ISSCC.2010.5433936","url":null,"abstract":"Although pain is interpreted as the fifth vital sign by many professions, the presence of different degrees of pain significantly affects quality of life for many patients, especially the elderly [1]. Electrical stimulation to the central or peripheral neural conduction paths has been utilized in clinics to achieve effective pain relief [2]. The conventional scheme for pulsed radio-frequency (PRF) pain therapy uses thermal coagulation to permanently damage nerves by heat. This destructive method can cause severe side-effects such as hyper-sensitivity to pain after nerves regenerate. Thus, repeated surgery is needed. Additionally, the conventional design of an implantable system requires a battery for operation, often accounting for over 2/3 of the entire device volume. Therefore, a non-destructive and batteryless method using PRF for pain control is key for implantable systems. This work uses a batteryless implantable pain-control SoC that is effective in pain reduction, using a low stimulation voltage that avoids causing thermal damage to dorsal root ganglion (DRG) tissue. An animal study of neuropathic pain was previously designed with PRF parameters to control tissue temperature at ≪40°C via an external function generator [3]. This work now presents the implementation of this functionality on a CMOS SoC. Its effectiveness is demonstrated by observing the behavior of rats receiving localized bipolar stimulus to the DRG of the lumbar nerve.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"1 1","pages":"234-235"},"PeriodicalIF":5.1,"publicationDate":"2010-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ISSCC.2010.5433936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62165546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Wireless IC for Wide-Range Neurochemical Monitoring Using Amperometry and Fast-Scan Cyclic Voltammetry 应用安培法和快速扫描循环伏安法进行大范围神经化学监测的无线集成电路

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2007-05-27 DOI: 10.1109/ISCAS.2007.378094

M. Roham, P. Mohseni

{"title":"A Wireless IC for Wide-Range Neurochemical Monitoring Using Amperometry and Fast-Scan Cyclic Voltammetry","authors":"M. Roham, P. Mohseni","doi":"10.1109/ISCAS.2007.378094","DOIUrl":"https://doi.org/10.1109/ISCAS.2007.378094","url":null,"abstract":"An integrated circuit for real-time wireless monitoring of neurochemical activity in the nervous system is described. The chip is capable of conducting measurements in both fast-scan cyclic voltammetry (FSCV) and amperometry modes for a wide input current range. The chip architecture employs a second-order DeltaSigma modulator (DeltaSigmaM) and a frequency-shift-keyed transmitter operating near 433 MHz. It is fabricated using the AMI 0.5-mum double-poly triple-metal n-well CMOS process, and requires only one off-chip component for operation. A measured current resolution of 12 pA at a sampling rate of 100 Hz and 132 pA at a sampling rate of 10 kHz is achieved in amperometry and 300-V/s FSCV modes, respectively, for any input current in the range of plusmn430 nA. The modulator core and the transmitter draw 22 and 400 muA from a 2.6-V power supply, respectively. The chip has been externally interfaced with a carbon-fiber microelectrode implanted acutely in the caudate-putamen of an anesthetized rat, and, for the first time, extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been successfully recorded wirelessly using 300-V/s FSCV.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"2 1","pages":"3-9"},"PeriodicalIF":5.1,"publicationDate":"2007-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ISCAS.2007.378094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62144839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Clinical Outcome Prediction Using Single-Cell Data. 利用单细胞数据预测临床预后。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2016.2577641

M. Pouyan, V. Jindal, M. Nourani

引用次数: 0

Analysis and Simple Circuit Design of Double Differential EMG Active Electrode. 双差动肌电有源电极分析及简单电路设计。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2015.2492944

F. Guerrero, E. Spinelli, M. Haberman

{"title":"Analysis and Simple Circuit Design of Double Differential EMG Active Electrode.","authors":"F. Guerrero, E. Spinelli, M. Haberman","doi":"10.1109/TBCAS.2015.2492944","DOIUrl":"https://doi.org/10.1109/TBCAS.2015.2492944","url":null,"abstract":"In this paper we present an analysis of the voltage amplifier needed for double differential (DD) sEMG measurements and a novel, very simple circuit for implementing DD active electrodes. The three-input amplifier that standalone DD active electrodes require is inherently different from a differential amplifier, and general knowledge about its design is scarce in the literature. First, the figures of merit of the amplifier are defined through a decomposition of its input signal into three orthogonal modes. This analysis reveals a mode containing EMG crosstalk components that the DD electrode should reject. Then, the effect of finite input impedance is analyzed. Because there are three terminals, minimum bounds for interference rejection ratios due to electrode and input impedance unbalances with two degrees of freedom are obtained. Finally, a novel circuit design is presented, including only a quadruple operational amplifier and a few passive components. This design is nearly as simple as the branched electrode and much simpler than the three instrumentation amplifier design, while providing robust EMG crosstalk rejection and better input impedance using unity gain buffers for each electrode input. The interference rejection limits of this input stage are analyzed. An easily replicable implementation of the proposed circuit is described, together with a parameter design guideline to adjust it to specific needs. The electrode is compared with the established alternatives, and sample sEMG signals are obtained, acquired on different body locations with dry contacts, successfully rejecting interference sources.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"10 3 1","pages":"787-95"},"PeriodicalIF":5.1,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2015.2492944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62964972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Graphical Features of Functional Genes in Human Protein Interaction Network. 人类蛋白质相互作用网络中功能基因的图形特征。

IF 5.1 2区医学

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 1900-01-01 DOI: 10.1109/TBCAS.2015.2487299

Pei Wang, Yao Chen, Jinhu Lü, Qingyun Wang, Xinghuo Yu

{"title":"Graphical Features of Functional Genes in Human Protein Interaction Network.","authors":"Pei Wang, Yao Chen, Jinhu Lü, Qingyun Wang, Xinghuo Yu","doi":"10.1109/TBCAS.2015.2487299","DOIUrl":"https://doi.org/10.1109/TBCAS.2015.2487299","url":null,"abstract":"With the completion of the human genome project, it is feasible to investigate large-scale human protein interaction network (HPIN) with complex networks theory. Proteins are encoded by genes. Essential, viable, disease, conserved, housekeeping (HK) and tissue-enriched (TE) genes are functional genes, which are organized and functioned via interaction networks. Based on up-to-date data from various databases or literature, two large-scale HPINs and six subnetworks are constructed. We illustrate that the HPINs and most of the subnetworks are sparse, small-world, scale-free, disassortative and with hierarchical modularity. Among the six subnetworks, essential, disease and HK subnetworks are more densely connected than the others. Statistical analysis on the topological structures of the HPIN reveals that the lethal, the conserved, the HK and the TE genes are with hallmark graphical features. Receiver operating characteristic (ROC) curves indicate that the essential genes can be distinguished from the viable ones with accuracy as high as almost 70%. Closeness, semi-local and eigenvector centralities can distinguish the HK genes from the TE ones with accuracy around 82%. Furthermore, the Venn diagram, cluster dendgrams and classifications of disease genes reveal that some classes of disease genes are with hallmark graphical features, especially for cancer genes, HK disease genes and TE disease genes. The findings facilitate the identification of some functional genes via topological structures. The investigations shed some light on the characteristics of the compete interactome, which have potential implications in networked medicine and biological network control.","PeriodicalId":13151,"journal":{"name":"IEEE Transactions on Biomedical Circuits and Systems","volume":"195 1","pages":"707-20"},"PeriodicalIF":5.1,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TBCAS.2015.2487299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62964882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8