Human pathology最新文献

{"title":"Idiopathic hyalinizing fibrosclerosis: A systemic steroid-resistant condition distinct from IgG4-related disease","authors":"Yoh Zen,&nbsp;Deepak Joshi","doi":"10.1016/j.humpath.2024.105638","DOIUrl":"10.1016/j.humpath.2024.105638","url":null,"abstract":"<div><p>Since the concept of IgG4-related disease (IgG4-RD) was proposed, that diagnosis has been considered in idiopathic fibroinflammatory diseases in various organs, particularly in cases with multi-organ involvement. We have recently encountered three cases of fibrosing disease of uncertain etiology with shared microscopic appearances. Case 1 (56-year-old man) had an irregular mass at the base of mesentery. Case 2 (29-year-old woman) presented with obstructive jaundice due to an ill-defined mass at the hepatic hilum and two lung nodules. Case 3 (53-year-old man) had multiple solid nodules in the mediastinum, peritoneum, retroperitoneum, and mesentery; he also had diffuse irregular narrowing of the intra- and extra-hepatic bile ducts in keeping with sclerosing cholangitis. Serum IgG4 concentrations were not elevated. Biopsies from the nodular lesions showed extensive hyalinizing fibrosis with an only focal lymphoplasmacytic infiltrate. Thick collagenous bundles are arranged in an irregular or partly whorl pattern. Typical storiform fibrosis or obliterative phlebitis was not observed. The number of IgG4-positive plasma cells was &lt;10 cells/high-power field; the ratio of IgG4/IgG-positive plasma cells was &lt;30%. After the histological diagnosis of sclerosing mesenteritis, pulmonary hyalinizing granuloma, and mediastinal fibrosis was made, they were treated with a trial of steroids, but none showed a significant response. In conclusion, a hyalinizing fibrotic condition can occur at various anatomical sites. They have shared microscopic findings, and are steroid-resistant. Although the clinical presentation may mimic IgG4-RD, the two conditions are likely distinct. We would propose a diagnostic term of ‘idiopathic hyalinizing fibrosclerosis’ for this under-recognized, rare, systemic condition.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"151 ","pages":"Article 105638"},"PeriodicalIF":2.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of histological subtyping in triple-negative breast cancer","authors":"Claudia Grosse ,&nbsp;Petar Noack ,&nbsp;Alexandra Grosse ,&nbsp;Caroline Ines Preuss ,&nbsp;Heike Kathleen Schwarz ,&nbsp;Thomas Gitter ,&nbsp;Peter Schrenk ,&nbsp;Heike Frauchiger-Heuer ,&nbsp;Bärbel Papassotiropoulos ,&nbsp;Christoph Tausch ,&nbsp;Umberto Maccio ,&nbsp;Holger Moch ,&nbsp;Rupert Langer ,&nbsp;Zsuzsanna Varga","doi":"10.1016/j.humpath.2024.105640","DOIUrl":"10.1016/j.humpath.2024.105640","url":null,"abstract":"<div><p>The impact of special histological types (ST) in triple-negative breast cancer (TNBC) and its association with overall outcome has gained increasing relevance as survival has been linked to specific histological TNBC subtypes. We evaluated the clinicopathological and survival data of 598 patients with 613 TNBCs, including 464 TNBCs of no special type (NST) and 149 TNBCs ST (low-grade, n = 12, 8.1%; high-grade, n = 112, 75.2%; apocrine and androgen receptor-positive [APO AR], n = 25, 16.8%). Patients with low-grade TNBC ST and TNBC ST APO AR were significantly older (<em>P</em> &lt; 0.001) and had a lower Ki67 index (<em>P</em> &lt; 0.001) than those with TNBC NST. Patients with high-grade TNBC ST were significantly older (<em>P</em> = 0.006) and had poorer pathological responses to neoadjuvant chemotherapy (NAC) (<em>P</em> &lt; 0.001) than those with TNBC NST. Significant survival differences were observed between low-grade TNBC ST, TNBC ST APO AR, high-grade TNBC ST, and TNBC NST in the entire study group (DFS, <em>P</em> = 0.002; DDFS, <em>P</em> = 0.001) and in the non-NAC subgroup (OS, <em>P</em> = 0.034; DFS, <em>P</em> = 0.001; DDFS, <em>P</em> &lt; 0.001). Patients with low-grade TNBC ST had the best survival outcomes. Patients with high-grade TNBC ST showed significantly worse outcomes than those with TNBC NST (entire study group: OS, <em>P</em> = 0.049; DFS, <em>P</em> &lt; 0.001; DDFS, <em>P</em> = 0.001; non-NAC subgroup: OS, <em>P</em> = 0.014; DFS, <em>P</em> &lt; 0.001; DDFS, <em>P</em> &lt; 0.001). We conclude that prognostic stratification of TNBC ST is ultimately important for optimizing the therapeutic management of patients with these rare tumor entities.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"152 ","pages":"Article 105640"},"PeriodicalIF":2.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0046817724001497/pdfft?md5=cfd7d47b57341ac2977bc52ec60208e1&pid=1-s2.0-S0046817724001497-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DICER1-sarcomas of GYN tract: Expanding on an emerging entity","authors":"Nooshin K. Dashti ,&nbsp;Amy A. Swanson ,&nbsp;Jessica Bentz ,&nbsp;Deyin Xing ,&nbsp;John S.A. Chrisinger ,&nbsp;Bonnie Balzer ,&nbsp;Ray Guo ,&nbsp;J. Kenneth Schoolmeester ,&nbsp;Horacio Maluf","doi":"10.1016/j.humpath.2024.105636","DOIUrl":"10.1016/j.humpath.2024.105636","url":null,"abstract":"<div><p>Tumors with pathogenic <em>DICER1</em> mutation are rare and encompass sporadic or hereditary benign, intermediate and malignant tumors. <em>DICER1</em>-associated sarcomas are heterogeneous; however, the prototypical ones in the GYN-tract include embryonal rhabdomyosarcoma, adenosarcoma and moderately to poorly differentiated Sertoli-Leydig tumor. In this report, we present three unique uterine sarcomas with <em>DICER1</em> mutation and remarkable diffuse round/spindle cell morphology. The tumors occurred in cervix (n = 1), and uterine corpus (n = 2). The patient ages were 30, 37 and 59 years with tumor size of 8.8, 10 and 8.6 cm, respectively. Morphologically all three tumors were characterized by distinct spindle/round cell morphology and various amounts of neuroectodermal differentiation (yolk sac-like tubules, blastomatous areas and rosette formation). Other morphologic features of <em>DICER1</em>-sarcoma reported in the literature including cambium layer, focal or diffuse anaplasia, solid and cystic architecture, and chondroid/osteoid areas were absent. All three sarcomas were positive for SALL4 and had variable neuroendocrine marker expression. Whole genome methylation analysis was performed on one of the uterine sarcomas, which clustered the tumor with embryonal tumor with multilayered rosettes. Follow up information was available on all three cases. Two patients were alive with no evidence of disease 13 and 14 months post operation, while one patient had imaging evidence of local recurrence 4 months post operation. In summary, we describe three unique <em>DICER1</em>-sarcomas and expand the phenotypic spectrum of this emerging entity, particularly with GYN-tract origin.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"152 ","pages":"Article 105636"},"PeriodicalIF":2.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALK-positive histiocytosis in 12 Asian children","authors":"Xiao Feng ,&nbsp;Jing Tao ,&nbsp;Nan He ,&nbsp;Jianwen Wang ,&nbsp;Lejian He ,&nbsp;Nan Zhang","doi":"10.1016/j.humpath.2024.105637","DOIUrl":"10.1016/j.humpath.2024.105637","url":null,"abstract":"<div><p>Anaplastic lymphoma kinase-positive histiocytosis, first reported in 2008, is a rare, novel type of neoplasm. To date, no more than 100 cases of anaplastic lymphoma kinase-positive histiocytosis have been reported. In this retrospective study, 12 cases of anaplastic lymphoma kinase-positive histiocytosis, including clinical symptoms, histological features, molecular pathology, treatment, and prognosis, in children were analyzed to gain a deeper understanding of the disease. All patients were Asian children, aged 2 months to 8 years and 2 months (mean 3.1 years), and the male-to-female ratio was 5:7. All patients were followed up closely. One patient died during the follow-up period, seven (case 1–7) had focal anaplastic lymphoma kinase-positive histiocytosis, and five (case 8–12) had multisystem anaplastic lymphoma kinase-positive histiocytosis. In addition, we report the case of a patient who benefited from anaplastic lymphoma kinase-targeted therapy and a patient with the rare <em>EML4-ALK</em> fusion gene. The current study is expected to substantially contribute to increasing the awareness of anaplastic lymphoma kinase-positive histiocytosis.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"152 ","pages":"Article 105637"},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary extraskeletal osteosarcomas of the pleura: A clinicopathological, immunohistochemical, and molecular analysis of 4 cases","authors":"Annikka Weissferdt,&nbsp;Cesar A. Moran","doi":"10.1016/j.humpath.2024.105635","DOIUrl":"10.1016/j.humpath.2024.105635","url":null,"abstract":"<div><p>Four primary extraskeletal osteosarcomas of the pleura are presented. The patients were men between the ages of 63 and 78 years (average: 70.5 years) who presented with symptoms of chest pain, cough, and shortness of breath. Diagnostic imaging showed variably calcified, pleural-based masses and/or diffuse pleural thickening, clinically mimicking mesothelioma. Thoracoscopic surgical material was obtained for histopathological diagnosis. Histological findings showed the presence of a neoplastic spindle cell proliferation composed of fusiform cells with scant cytoplasm, elongated nuclei and inconspicuous nucleoli. Mitotic activity was easily identified. Additionally, all tumors showed extensive osseous differentiation in the form of osteoid matrix production; one tumor demonstrated additional chondrosarcomatous elements and another showed focal myxoid changes. Immunohistochemical analysis revealed that the tumor cells were uniformly negative for a wide variety of antibodies, including keratin AE1/AE3, keratin 5/6, D2-40, EMA, calretinin, WT-1, BerEP4, and HEG1; BAP1 was retained in all cases. In addition, fluorescence in situ hybridization for <em>CDKN2A (p16)</em> was negative for homozygous deletion in all tumors. Clinical follow-up showed that one patient had died 8 months after diagnosis and one had remained alive with short post-diagnostic follow-up. The tumors herein described highlight a challenging issue in the separation of mesothelioma with heterologous elements from true osteosarcomas of pleural origin. We propose that a diagnosis of extraskeletal osteosarcoma of the pleura is rendered for tumors with malignant osseous and/or cartilaginous differentiation in which comprehensive immunohistochemical studies and FISH analysis have failed to provide support for a diagnosis of mesothelioma with heterologous elements.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"152 ","pages":"Article 105635"},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right vs. Left colorectal cancer – Where do we draw the line?","authors":"Joshua Lansom ,&nbsp;Ian Liew ,&nbsp;Kheng-Seong Ng ,&nbsp;Theresa Ly ,&nbsp;Krishanth Naidu ,&nbsp;Pierre Chapuis ,&nbsp;Charles Chan","doi":"10.1016/j.humpath.2024.105634","DOIUrl":"10.1016/j.humpath.2024.105634","url":null,"abstract":"<div><h3>Purpose</h3><p>No consensus on the definition of right and left colorectal cancer (CRC) exists, nor studies offering histological or molecular basis for such categorisation. This study investigated the regional variations in the histological and molecular characteristics of CRCs, with the objective of determining an optimal division point between right and left CRCs.</p></div><div><h3>Materials and methods</h3><p>An observational study of consecutive patients who underwent CRC resection (1995–2022) at Concord Hospital, Sydney was performed. Clinicopathological data were extracted from a prospective database and seven permutations of right-left divisions considered. Logistic regression tested association between the right-left divisions and pathological characteristics. Receiver operating characteristic and area under the curve (AUC) analyses determined the discriminative ability of each division to predict 18 pathology characteristics.</p></div><div><h3>Results</h3><p>3753 patients underwent a CRC resection (2120 male; mean 69.5yrs [SD12.6]). There was regional variation in tumours with respect to tumour infiltrating lymphocytes (TILs), mismatch repair deficiency (dMMR), and mutant BRAF (mBRAF). Left-sided tumours were less likely to demonstrate TILs (P &lt; 0.001), be dMMR (P &lt; 0.001), and express mBRAF (P &lt; 0.001). Division at the descending-sigmoid junction yielded highest discriminative abilities: TILs – AUC 0.66, dMMR – AUC 0.76, and mBRAF – AUC 0.73.</p></div><div><h3>Conclusion</h3><p>This is the first study to provide a pathological basis on which right- and left-sided cancers may be defined, and found the optimal division point between the right and left colorectum to be at the descending-sigmoid junction. Further research is needed to determine whether this can facilitate individualised patient management.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"151 ","pages":"Article 105634"},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0046817724001436/pdfft?md5=4db8783ec2236c2ed8f2d3cbb3a740f3&pid=1-s2.0-S0046817724001436-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside front cover - Masthead","authors":"","doi":"10.1016/S0046-8177(24)00133-3","DOIUrl":"10.1016/S0046-8177(24)00133-3","url":null,"abstract":"","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"150 ","pages":"Page IFC"},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Authors","authors":"","doi":"10.1016/S0046-8177(24)00136-9","DOIUrl":"10.1016/S0046-8177(24)00136-9","url":null,"abstract":"","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"150 ","pages":"Page iv"},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights","authors":"Ziyad Alsugair ,&nbsp;Charles Lépine ,&nbsp;Françoise Descotes ,&nbsp;Marie-Delphine Lanic ,&nbsp;Daniel Pissaloux ,&nbsp;Franck Tirode ,&nbsp;Jonathan Lopez ,&nbsp;Philippe Céruse ,&nbsp;Pierre Philouze ,&nbsp;Maxime Fieux ,&nbsp;Michel Wassef ,&nbsp;Anne-Catherine Baglin ,&nbsp;Onea Mihaela ,&nbsp;Claire Castain ,&nbsp;Anne Sudaka ,&nbsp;Emmanuelle Uro-Coste ,&nbsp;Anne Champagnac ,&nbsp;Valérie Costes-Martineau ,&nbsp;Marick Laé ,&nbsp;Nazim Benzerdjeb ,&nbsp;S. Wong","doi":"10.1016/j.humpath.2024.105633","DOIUrl":"10.1016/j.humpath.2024.105633","url":null,"abstract":"<div><h3>Aims</h3><p>Most salivary gland neoplasms are distinguished by specific recurrent gene fusions. Recently, a subset of pleomorphic adenomas (PAs) originated from the parotid gland harboring the <em>HMGA2</em>:<em>WIF1</em> fusion was described with a canalicular adenoma-like morphology and a greater propensity for recurrence and carcinomatous transformation.</p></div><div><h3>Methods and results</h3><p>This study delineates the clinicopathological attributes of 54 cases of PAs exhibiting <em>HMGA2</em> alterations, predominantly characterized by the <em>HMGA2</em>:<em>WIF1</em> fusion, alongside a comparative analysis of their morphological and immunohistochemical profiles. The cohort consisted of 23 females and 31 males (n = 54), mean age was 56.7 (25–84), tumors predominantly originated from the parotid gland (94.4%, 51/54), with 3 cases from seromucous glands (5.6%). Mean tumor size was 2.6 cm (0.8–7.5). No clinical difference (demographic, follow-up) was observed among histological subsets (conventional, hybrid, and pure). Complete excision was performed in all cases, with follow-up data available for 41% (22/54) of patients, showing 13.6% of recurrence (3/22) between 5 and 8 months. Various histological growth patterns were identified, with the pure hypercellular monomorphic subset being the most prevalent. The <em>HMGA2</em>:<em>WIF1</em> gene was identified in all subsets without any particular predominance. Novel gene partners of <em>HMGA2</em> were identified, comprising <em>NRXN1</em>, <em>INPP4B</em>, <em>MSRB3</em>, <em>PHLDA1</em>, and FLJ41278.</p></div><div><h3>Conclusions</h3><p>The present study reports that the <em>HMGA2</em>:<em>WIF1</em> gene fusion was present in all subsets of PAs without significant predominance. However, further investigations are warranted to explore the relationship between histological subsets of PAs and the molecular alterations underlying them.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"152 ","pages":"Article 105633"},"PeriodicalIF":2.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0046817724001424/pdfft?md5=ccb1fc1a00cbacd5092e8291a6db1e61&pid=1-s2.0-S0046817724001424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving histotyping precision: The impact of immunohistochemical algorithms on epithelial ovarian cancer classification","authors":"Hein S. Zelisse ,&nbsp;Frederike Dijk ,&nbsp;Mignon D.J.M. van Gent ,&nbsp;Gerrit K.J. Hooijer ,&nbsp;Constantijne H. Mom ,&nbsp;Marc J. van de Vijver ,&nbsp;Malou L.H. Snijders","doi":"10.1016/j.humpath.2024.105631","DOIUrl":"10.1016/j.humpath.2024.105631","url":null,"abstract":"<div><p>To improve the precision of epithelial ovarian cancer histotyping, Köbel et al. (2016) developed immunohistochemical decision-tree algorithms. These included a six- and four-split algorithm, and separate six-split algorithms for early- and advanced stage disease. In this study, we evaluated the efficacy of these algorithms. A gynecological pathologist determined the hematoxylin and eosin (H&amp;E)-based histotypes of 230 patients. Subsequently, the final histotypes were established by re-evaluating the H&amp;E-stained sections and immunohistochemistry outcomes. For histotype prediction using the algorithms, the immunohistochemical markers Napsin A, p16, p53, progesterone receptor (PR), trefoil factor 3 (TFF3), and Wilms’ tumor 1 (WT1) were scored. The algorithmic predictions were compared with the final histotypes to assess their precision, for which the early- and advanced stage algorithms were assessed together as six-split-stages algorithm. The six-split algorithm demonstrated 96.1% precision, whereas the six-split-stages and four-split algorithms showed 93.5% precision. Of the 230 cases, 16 (7%) showed discordant original and final diagnoses; the algorithms concurred with the final diagnosis in 14/16 cases (87.5%). In 12.4%–13.3% of cases, the H&amp;E-based histotype changed based on the algorithmic outcome. The six-split stages algorithm had a lower sensitivity for low-grade serous carcinoma (80% versus 100%), while the four-split stages algorithm showed reduced sensitivity for endometrioid carcinoma (78% versus 92.7–97.6%). Considering the higher sensitivity of the six-split algorithm for endometrioid and low-grade serous carcinoma compared with the four-split and six-split-stages algorithms, respectively, we recommend the adoption of the six-split algorithm for histotyping epithelial ovarian cancer in clinical practice.</p></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"151 ","pages":"Article 105631"},"PeriodicalIF":2.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0046817724001400/pdfft?md5=b87eac33d8406884627fd1aac7a57ac9&pid=1-s2.0-S0046817724001400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}