Aberrant expression in lymphoma, a diagnostic pitfall.

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2024-12-16 DOI:10.1016/j.humpath.2024.105706

Joo Y Song, Zenggang Pan

引用次数: 0

Abstract

One of the major difficulties in practical hematopathology is to accurately assign cell lineage and thus ensure proper classification of lymphomas. The lineage-specific markers of lymphoma are detected by immunohistochemistry or flow cytometry immunophenotypic methods. However, aberrant gain or loss of these markers is occasionally encountered during daily practice, which often creates diagnostic challenges. In addition, lymphoma may aberrantly express non-hematopoietic markers, and vice versa. This review article provides an overview of aberrant gain of expression of lineage-associated antigens in mature lymphoid neoplasms, including recommendations to avoid diagnostic pitfalls and ultimately to reach accurate diagnoses.

查看原文本刊更多论文

在实际血液病理学中，准确划分细胞系从而确保淋巴瘤的正确分类是一大难题。淋巴瘤的细胞系特异性标记物是通过免疫组化或流式细胞术免疫分型方法检测到的。然而，在日常工作中偶尔会遇到这些标志物异常增减的情况，这往往给诊断带来挑战。此外，淋巴瘤可能异常表达非造血标志物，反之亦然。这篇综述文章概述了成熟淋巴肿瘤中系相关抗原的异常增殖表达，包括如何避免诊断陷阱并最终做出准确诊断的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.