Classic Hodgkin lymphoma: An illustrative review of select diagnostic limitations and immunomorphological challenges.

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2024-11-02 DOI:10.1016/j.humpath.2024.105678

Siba El Hussein, Dennis P O'Malley

引用次数: 0

Abstract

The diagnosis of classic Hodgkin lymphoma (CHL) in clinical practice remains reliant on tissue morphological and immunohistochemical evaluation. In this article, we illustrate specific scenarios that we have encountered in our clinical practice pertaining to diagnostic challenges in CHL. We begin with select presentations of morphologic variants of CHL and then discuss certain immunophenotypic deviations from what is deemed "normal patterns" of antigen expression by HRS cells. Lastly, we discuss mimickers of HRS cells, in lymphomatous and non-lymphomatous conditions.

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经典霍奇金淋巴瘤：对部分诊断局限性和免疫形态学挑战的说明性回顾。

在临床实践中，典型霍奇金淋巴瘤（CHL）的诊断仍然依赖于组织形态学和免疫组化评估。本文将阐述我们在临床实践中遇到的有关 CHL 诊断难题的具体情况。我们首先介绍 CHL 的一些形态变异，然后讨论某些免疫表型偏离 HRS 细胞抗原表达 "正常模式 "的情况。最后，我们将讨论淋巴瘤和非淋巴瘤情况下的HRS细胞模仿者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.