Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: Diagnostic overlaps and defining features.

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2024-11-19 DOI:10.1016/j.humpath.2024.105697

Ashley K Volaric, Yuri Fedoriw

引用次数: 0

Abstract

This review explores four Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders (LPD) and lymphomas with significant diagnostic overlap: EBV(+) mucocutaneous ulcer (EBVMCU), EBV(+) polymorphic LPD, EBV(+) classic Hodgkin lymphoma (CHL), and EBV(+) diffuse large B-cell lymphoma (DLBCL). Each entity is compared for both overlapping and defining features of clinical presentation, morphology, immunohistochemical profile and EBV expression pattern and latency. Our aims for this review are to provide useful guidance to the practicing pathologist in the diagnosis of these EBV-associated entities.

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Epstein-Barr 病毒相关 B 细胞淋巴增生性疾病和淋巴瘤：诊断重叠和定义特征。

本综述探讨了四种与爱泼斯坦-巴氏病毒（EBV）相关的B细胞淋巴组织增生性疾病（LPD）和淋巴瘤，它们在诊断上有明显的重叠：EBV（+）粘膜溃疡（EBVMCU）、EBV（+）多形性LPD、EBV（+）典型霍奇金淋巴瘤（CHL）和EBV（+）弥漫大B细胞淋巴瘤（DLBCL）。我们比较了每个实体在临床表现、形态学、免疫组化特征、EBV表达模式和潜伏期等方面的重叠特征和定义特征。我们撰写这篇综述的目的是为执业病理学家诊断这些 EBV 相关实体提供有用的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.