Human Vaccines & Immunotherapeutics最新文献

Emerging insights into thyroid cancer from immunotherapy perspective: A bibliometric analysis. 从免疫疗法角度看甲状腺癌的新进展：文献计量分析。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-18 DOI: 10.1080/21645515.2024.2403170

Qianyu Wang,Gang Pan,Yu Zhang,Yiqin Ni,Yuzhu Mu,Dingcun Luo

{"title":"Emerging insights into thyroid cancer from immunotherapy perspective: A bibliometric analysis.","authors":"Qianyu Wang,Gang Pan,Yu Zhang,Yiqin Ni,Yuzhu Mu,Dingcun Luo","doi":"10.1080/21645515.2024.2403170","DOIUrl":"https://doi.org/10.1080/21645515.2024.2403170","url":null,"abstract":"Thyroid cancer is a common endocrine malignancy that poses considerable therapeutic challenges in treating anaplastic carcinoma and advanced aggressive disease. Immunotherapy has become a prominent strategy for cancer treatment, and has shown remarkable advancements in recent years. In this study, we utilized visualization and bibliometric tools to analyze publications on thyroid cancer immunotherapy from the Web of Science Core Collection (WoSCC). A total of 409 articles were included, with an annual increase in both publications and citations since 2016. China leads research efforts in this area, while the University of Texas System and UTMD Anderson Cancer Center rank first in publication output. The journal Thyroid has garnered the highest citations. Notable authors contributing to this field include Antonelli Alessandro, Fallahi Poupak, and Wang Yu. Current research hotspots include immune checkpoint inhibitors, combination therapies involving immunotherapy with targeted therapy, CAR-T cell therapy, and modulation of the tumor microenvironment, all of which underscore the evolving landscape and potential for innovative treatments in thyroid cancer.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COBRA N2 NA vaccines induce protective immune responses against influenza viral infection. COBRA N2 NA 疫苗可诱导针对流感病毒感染的保护性免疫反应。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-18 DOI: 10.1080/21645515.2024.2403175

Xiaojian Zhang,Amanda L Skarlupka,Hua Shi,Ted M Ross

{"title":"COBRA N2 NA vaccines induce protective immune responses against influenza viral infection.","authors":"Xiaojian Zhang,Amanda L Skarlupka,Hua Shi,Ted M Ross","doi":"10.1080/21645515.2024.2403175","DOIUrl":"https://doi.org/10.1080/21645515.2024.2403175","url":null,"abstract":"Influenza neuraminidase (NA) is a promising target for a broadly protective vaccine. In this study, the Computationally Optimized Broadly Reactive Antigen (COBRA) methodology was used to develop N2 NA vaccine candidates. The unique wild type (WT) N2 sequences of human and swine influenza strains isolated between 1957 and 2019 were used to design the COBRA N2-A NA vaccine, while the unique WT N2 sequences of human influenza strains isolated between 2000 and 2019 were used to design the COBRA N2-B NA vaccine. Sera collected from COBRA N2 NA vaccinated mice showed more broadly reactive antibody responses against a broad panel of H×N2 influenza virus strains than sera collected from mice vaccinated with WT N2 NA vaccines. Antibodies elicited by COBRA or WT N2 NA antigens cross react with recent human H3N2 influenza viruses from different clades, while the antibodies elicited by A/Switzerland/9715293/2013 hemagglutinin (HA) reacted with viruses from the same clade. Furthermore, mice vaccinated with COBRA N2-B NA vaccine had lower viral lung titers compared to mock vaccinated mice when challenged with human H3N2 influenza viruses. Thus, the COBRA N2 NA vaccines elicit broadly protective murine anti-NA antibodies against multiple strains across subtypes and the viral loads were significantly decreased in the lungs of the mice in the COBRA N2 NA vaccine groups, compared to the mice in the mock vaccinated group, indicating that the COBRA-based N2 subtype NA vaccines have a potential to be a component in a universal influenza vaccine.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing HPV vaccine hesitancy among university students in China: A cross-sectional survey utilizing the 3Cs model. 影响中国大学生HPV疫苗接种犹豫不决的因素：利用 3Cs 模型进行的横断面调查。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2400750

Yuancheng He,Xiuqing Zhang,Jie Li,Yuehua Chen,Lin Zhang,Yuehong Wei

{"title":"Factors influencing HPV vaccine hesitancy among university students in China: A cross-sectional survey utilizing the 3Cs model.","authors":"Yuancheng He,Xiuqing Zhang,Jie Li,Yuehua Chen,Lin Zhang,Yuehong Wei","doi":"10.1080/21645515.2024.2400750","DOIUrl":"https://doi.org/10.1080/21645515.2024.2400750","url":null,"abstract":"The HPV vaccine, which has been demonstrated to be an effective method of reducing the risk of developing cervical cancer, is still being underutilized among college students in China. To assess the current status of HPV vaccine hesitancy among college students in Guangdong Province after the COVID-19 outbreak, and to systematically analyze the influencing factors of HPV vaccine hesitancy and construct a prediction model based on the WHO 3Cs model. A cross-sectional web-based survey was conducted in June 2023 among female college students in four cities in Guangdong Province. The data were analyzed using binary logistic regression with a focus on the 3Cs model: Complacency, Convenience, and Confidence. LASSO regression was employed to analyze the variables deemed to be of significance and to construct predictive models. Out of 1399 participants, 86.5% expressed no hesitancy toward HPV vaccination. However, 11.9% exhibited hesitancy, and 1.6% refused vaccination altogether. Factors such as trust in vaccine efficacy, perception of HPV infection risk, price considerations, and constraints like distance or time were significant contributors to hesitancy. Knowledge of the HPV vaccine, socio-demographic characteristics, and the educational level of participants' mothers also played a role in vaccine hesitancy. It is recommended that targeted interventions be implemented within educational institutions with the aim of raising awareness of cervical cancer and HPV vaccines, simplifying the scheduling of vaccination appointments, and increasing affordability through the implementation of strategic purchasing measures or subsidy schemes.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human vaccines and immunotherapeutics: News August 2024 人类疫苗和免疫疗法：2024 年 8 月新闻

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2402171

Ronald Ellis, Adam Weiss

引用次数: 0

Uptake, adverse effect, and associated factors of COVID-19 vaccine among those living with human immunodeficiency virus, at Bole sub-city health facility Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴 Bole 次城市卫生机构中人类免疫缺陷病毒感染者对 COVID-19 疫苗的接种率、不良反应及相关因素

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2389576

Sendu Seid, Teferi Gebru Gebremeskel

引用次数: 0

Immunotherapy and delivery systems for melanoma 黑色素瘤的免疫疗法和给药系统

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2394252

Hui Liu, Xi Gou, Yuanfang Tan, Qiuying Fan, Juanjuan Chen

引用次数: 0

A cross-sectional study on the understanding and attitudes toward influenza and influenza vaccines among different occupational groups in China. 关于中国不同职业人群对流感和流感疫苗的理解和态度的横断面研究。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2397214

Xinkun Zhao,Xin Hu,Junyi Wang,Mingshuai Shen,Kaifeng Zhou,Xianjie Han,Milton Thomas,Kezhou Wang,Li Wang,Zhao Wang

{"title":"A cross-sectional study on the understanding and attitudes toward influenza and influenza vaccines among different occupational groups in China.","authors":"Xinkun Zhao,Xin Hu,Junyi Wang,Mingshuai Shen,Kaifeng Zhou,Xianjie Han,Milton Thomas,Kezhou Wang,Li Wang,Zhao Wang","doi":"10.1080/21645515.2024.2397214","DOIUrl":"https://doi.org/10.1080/21645515.2024.2397214","url":null,"abstract":"This study aimed to assess the level of knowledge regarding influenza viruses and vaccines among different professional groups to investigate the reasons for vaccine hesitancy. We collected 2190 questionnaires regarding influenza vaccines in China in 2022. The respondents were categorized into the general population (GP), foreign affairs workforce population (FAWP), and veterinary workforce population (VWP) according to their job positions. Linear regression was used to assess the association between multiple factors and influenza vaccination rates. The association between work and influenza vaccination rates was also assessed by grouping different workforce populations. The vaccination rate of the GP was higher than that of the VWP (odds ratio: 1.342, 95% confidence interval: 1.025-1.853), surpassing the rates reported in previous studies. This may be attributed to heightened concerns about infectious diseases influenced by the ongoing coronavirus disease 2019 pandemic. Despite the VWP's more in-depth knowledge of the VWP on zoonotic diseases and their recognition of their importance, there was no significant difference in influenza knowledge among the three populations. This discrepancy contrasts with the observed differences in vaccination rates. Further investigation revealed that, compared with FAWP, the price of vaccines emerged as a primary influencing factor for vaccination rates (odds ratio:0.398, 95%CI; 0.280-0.564). General concerns regarding the protective effects and side effects of vaccines were also noted.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021-23. 孕期接种疫苗对降低 12 个月以下婴儿感染 SARS-CoV-2 的风险的效果。普利亚（意大利），2021-23。

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-17 DOI: 10.1080/21645515.2024.2403831

Cesare De Virgilio Suglia,Pasquale Stefanizzi,Giusy Graziano,Lorenza Moscara,Arianna Delle Fontane,Martina Minelli,Silvio Tafuri

{"title":"Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021-23.","authors":"Cesare De Virgilio Suglia,Pasquale Stefanizzi,Giusy Graziano,Lorenza Moscara,Arianna Delle Fontane,Martina Minelli,Silvio Tafuri","doi":"10.1080/21645515.2024.2403831","DOIUrl":"https://doi.org/10.1080/21645515.2024.2403831","url":null,"abstract":"This retrospective cohort study evaluated the effectiveness of maternal vaccination against COVID-19 in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. The study, conducted at the \"Policlinico\" University Hospital of Bari, included 3346 newborns and their mothers. The study explored the degree of protection offered by maternal vaccination depending on the timing, type, and trimester of vaccination, also taking into account the mother's history of infection. We compared the incidence rate of infection between children of vaccinated and unvaccinated mothers; the values were 10.2% and 18.1%, respectively, and the difference was statistically significant. The overall effectiveness of the vaccine against the infection was 45%. Further analysis revealed increasing efficacy as the doses of vaccine administered to the mother increased and in case of a previous history of maternal infection. Dual immune stimulation (vaccination and natural infection) was 83% effective in preventing infection among newborns. The multivariable models confirmed the protective effect of vaccination with all types of vaccines used. The analysis of infection's incidence in newborns revealed an interesting temporal trend, with increasing incidence with time, suggesting a possible correlation with the persistence of maternal antibodies or with the gradual weaning. The results on the protective capacity of vaccines are in line with the global literature. Strengths of study include sample size, robust methodology, and multivariate analyses. Institutions could intensify awareness campaigns to encourage both pregnant women and all those who would like to become pregnant to receive SARS-CoV-2 vaccination.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coverage of influenza vaccination and influencing factors among healthcare workers in Shandong Province, China, 2021–2022 2021-2022 年中国山东省医护人员流感疫苗接种覆盖率及影响因素

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-16 DOI: 10.1080/21645515.2024.2402116

Yuwei Liu, Ti Liu, Mingxiao Yao, Qiang Wang, Renpeng Li, Zengqiang Kou

引用次数: 0

Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant 作为疫苗佐剂的硫酸化乳糖古菌素（SLA）古菌体

IF 4.8 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2024-09-15 DOI: 10.1080/21645515.2024.2395081

Bassel Akache, Michael J. McCluskie

引用次数: 0