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Human Vaccines & Immunotherapeutics最新文献

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Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review. 与Delta和其他变体相比，预Omicron COVID-19疫苗在减少感染、住院、严重程度和死亡率方面的有效性:一项系统综述。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 Epub Date: 2023-03-13 DOI: 10.1080/21645515.2023.2167410
Pradipta Paul, Ahmed El-Naas, Omar Hamad, Mohammad A Salameh, Nada Mhaimeed, Ibrahim Laswi, Ali A Abdelati, Jamal AlAnni, Bushra Khanjar, Dana Al-Ali, Krishnadev V Pillai, Abdallah Elshafeey, Hasan Alroobi, Zain Burney, Omar Mhaimeed, Mohammad Bhatti, Pratyaksha Sinha, Muna Almasri, Ahmed Aly, Khalifa Bshesh, Reem Chamseddine, Omar Khalil, Ashton D'Souza, Thanu Shree, Narjis Mhaimeed, Lina Yagan, Dalia Zakaria
{"title":"Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review.","authors":"Pradipta Paul, Ahmed El-Naas, Omar Hamad, Mohammad A Salameh, Nada Mhaimeed, Ibrahim Laswi, Ali A Abdelati, Jamal AlAnni, Bushra Khanjar, Dana Al-Ali, Krishnadev V Pillai, Abdallah Elshafeey, Hasan Alroobi, Zain Burney, Omar Mhaimeed, Mohammad Bhatti, Pratyaksha Sinha, Muna Almasri, Ahmed Aly, Khalifa Bshesh, Reem Chamseddine, Omar Khalil, Ashton D'Souza, Thanu Shree, Narjis Mhaimeed, Lina Yagan, Dalia Zakaria","doi":"10.1080/21645515.2023.2167410","DOIUrl":"10.1080/21645515.2023.2167410","url":null,"abstract":"<p><p>Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron variant called into question the effectiveness of the existing vaccines against infection, hospitalization, severity, and mortality compared to previous variants. This systematic review summarizes and compares the effectiveness of the COVID-19 vaccines, with respect to the above outcomes in adults, children, and adolescents. A comprehensive literature search was undertaken on several databases. Only 51 studies met our inclusion criteria, revealing that the protection from primary vaccination against Omicron infection is inferior to protection against Delta and Alpha infections and wanes faster over time. However, mRNA vaccine boosters were reported to reestablish effectiveness, although to a lower extent against Omicron. Nonetheless, primary vaccination was shown to preserve strong protection against Omicron-associated hospitalization, severity, and death, even months after last dose. However, boosters provide more robust and longer-lasting protection against hospitalizations due to Omicron as compared to only primary series.</p>","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2167410"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/3b/KHVI_19_2167410.PMC10054360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally. 皮内免疫小鼠双价灭活疫苗EV71-CA16的临床前安全性评价
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-31 DOI: 10.1080/21645515.2023.2209472
Yun Liao, Qinfang Jiang, Xinqian Huo, Li Yu, Jinling Yang, Heng Zhao, Dandan Li, Xingli Xu, Guorun Jiang, Caixing Zhang, Cong Li, Yun Li, Ying Zhang, Mingxiang Shao, Baofeng Liu, Lianzhong Shen, Shengtao Fan, Qihan Li
{"title":"Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally.","authors":"Yun Liao, Qinfang Jiang, Xinqian Huo, Li Yu, Jinling Yang, Heng Zhao, Dandan Li, Xingli Xu, Guorun Jiang, Caixing Zhang, Cong Li, Yun Li, Ying Zhang, Mingxiang Shao, Baofeng Liu, Lianzhong Shen, Shengtao Fan, Qihan Li","doi":"10.1080/21645515.2023.2209472","DOIUrl":"10.1080/21645515.2023.2209472","url":null,"abstract":"<p><p>Hand, foot and mouth disease is a common acute viral infectious disease that poses a serious threat to the life and health of young children. With the development of an effective inactivated EV71 vaccine, CA16 has become the main pathogen causing HFMD. Effective and safe vaccines against this disease are urgently needed. In our previous study, a bivalent inactivated vaccine was shown to have good immunogenicity and to induce neutralizing antibodies in mice and monkeys. Repeated administration toxicity is a critical safety test in the preclinical evaluation of vaccines. In this study, BALB/c mice were used to evaluate the toxicity of the bivalent vaccine after multiple intradermal administrations. Clinical observation was performed daily, and body weight, food intake, hematological characteristics, serum biochemical parameters, antinuclear antibodies, CD4<sup>+</sup>/CD8a<sup>+</sup> T-cell proportions, bone marrow smear results and pathology results were recorded. The results showed that there was no significant change at the injection site and no adverse reactions related to the vaccine. The bivalent inactivated EV71-CA16 vaccine exhibits good safety in mice, and these results provide a sufficient basis for further clinical trials.</p>","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"19 1","pages":"2209472"},"PeriodicalIF":4.8,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/fb/KHVI_19_2209472.PMC10208166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-lasting complete response to SHR-1701 plus famitinib in refractory advanced gallbladder cancer: A case report SHR-1701 加法米替尼治疗难治性晚期胆囊癌的持久完全反应：病例报告
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-21 DOI: 10.1080/21645515.2023.2294575
Lixia Yi, Xiaoyan Zhu, Jing Xie, Zhiqiang Meng
{"title":"Long-lasting complete response to SHR-1701 plus famitinib in refractory advanced gallbladder cancer: A case report","authors":"Lixia Yi, Xiaoyan Zhu, Jing Xie, Zhiqiang Meng","doi":"10.1080/21645515.2023.2294575","DOIUrl":"https://doi.org/10.1080/21645515.2023.2294575","url":null,"abstract":"Biliary tract cancer (BTC) is an aggressive malignancy with few options for advanced-stage treatment. The combination of PD-1/PD-L1 inhibitors with famitinib, a receptor tyrosine kinase (RTK) inhib...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"78 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138826726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the accessibility and capacity of SARS-CoV-2 vaccination and analyzing convenience-related factors during the Omicron variant epidemic in Beijing, China 在中国北京 Omicron 变种疫情期间评估 SARS-CoV-2 疫苗接种的可及性和能力，并分析与便利性相关的因素
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2289250
Yuping Duan, Mingyue Jiang, Luodan Suo, Mingyu Xu, Xiaomei Li, Qing Wang, Chengxu Bai, Jiang Wu, Zheng Xu, Weizhong Yang, Luzhao Feng, Juan Li
{"title":"Evaluating the accessibility and capacity of SARS-CoV-2 vaccination and analyzing convenience-related factors during the Omicron variant epidemic in Beijing, China","authors":"Yuping Duan, Mingyue Jiang, Luodan Suo, Mingyu Xu, Xiaomei Li, Qing Wang, Chengxu Bai, Jiang Wu, Zheng Xu, Weizhong Yang, Luzhao Feng, Juan Li","doi":"10.1080/21645515.2023.2289250","DOIUrl":"https://doi.org/10.1080/21645515.2023.2289250","url":null,"abstract":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination service system lacks standardized indicators to assess resource allocation. Moreover, data on specific vaccination-promo...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"215 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bibliometric and knowledge-map study of CAR-T cell-related cytokine release syndrome (CRS) from 2012 to 2023 2012年至2023年CAR-T细胞相关细胞因子释放综合征（CRS）的文献计量和知识图谱研究
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2291900
Huimin Li, Qing Huang, Yuan Zhang
{"title":"A bibliometric and knowledge-map study of CAR-T cell-related cytokine release syndrome (CRS) from 2012 to 2023","authors":"Huimin Li, Qing Huang, Yuan Zhang","doi":"10.1080/21645515.2023.2291900","DOIUrl":"https://doi.org/10.1080/21645515.2023.2291900","url":null,"abstract":"CAR-T cell therapy has demonstrated efficacy in treating certain hematological malignancies. However, the administration of CAR-T cells is accompanied by the occurrence of adverse events. Among the...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"144 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential motivators affecting parental intention in COVID-19 vaccination for children aged 6 months to 4 years: Implications for targeted vaccine interventions in Japan 影响家长为 6 个月至 4 岁儿童接种 COVID-19 疫苗意向的潜在动机：对日本有针对性的疫苗干预措施的影响
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2296737
Yukiko Kato, Tomohiro Shinozaki, Daisuke Sugiyama, Atsuko Taguchi, Satoko Nagata
{"title":"Potential motivators affecting parental intention in COVID-19 vaccination for children aged 6 months to 4 years: Implications for targeted vaccine interventions in Japan","authors":"Yukiko Kato, Tomohiro Shinozaki, Daisuke Sugiyama, Atsuko Taguchi, Satoko Nagata","doi":"10.1080/21645515.2023.2296737","DOIUrl":"https://doi.org/10.1080/21645515.2023.2296737","url":null,"abstract":"Although COVID-19 vaccination was approved for younger children in Japan in October 2022, uptake rates remain critically low. This study aimed to investigate Japanese parents’ intentions, hesitator...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"24 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the immune response and protective effect of COVID-19 vaccine under different vaccination strategies 比较不同接种策略下 COVID-19 疫苗的免疫反应和保护效果
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-19 DOI: 10.1080/21645515.2023.2273155
Tianyi Zhao, Xiaoping Huang, Yuelong Shu
{"title":"Comparing the immune response and protective effect of COVID-19 vaccine under different vaccination strategies","authors":"Tianyi Zhao, Xiaoping Huang, Yuelong Shu","doi":"10.1080/21645515.2023.2273155","DOIUrl":"https://doi.org/10.1080/21645515.2023.2273155","url":null,"abstract":"Although highly infectious respiratory viral infections spread rapidly, humans have evolved a precise and complex immune mechanism to deal with respiratory viruses, with strong intrinsic, highly ad...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"75 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-controlled and dose-escalation phase 1 clinical trials 在 18 岁或 18 岁以上的中国参与者中接种 SARS-CoV-2 mRNA 疫苗 (SYS6006) 的安全性和免疫原性：两项随机、观察者盲法、安慰剂对照和剂量递增的 1 期临床试验
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-18 DOI: 10.1080/21645515.2023.2285089
Gui-Ling Chen, Yuan-Zheng Qiu, Kai-Qi Wu, Ying Wu, Yuan-Hui Wang, Yu-Ying Zou, Cong-Gao Peng, Jie Zhao, Chang Su, Jun-Heng Ma, Shao-Nan Ni, Xing Wang, Ting-Han Jin, Qi Jiang, Tong Guo, Yan Xu, Chao-Chao Huang, Qing Zhang, Kai-Li Liu, Li Ji, Han-Yu Yang, Chun-Lei Li, Yu-Wen Su, Xiang Lu, Lan-Juan Li
{"title":"Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-controlled and dose-escalation phase 1 clinical trials","authors":"Gui-Ling Chen, Yuan-Zheng Qiu, Kai-Qi Wu, Ying Wu, Yuan-Hui Wang, Yu-Ying Zou, Cong-Gao Peng, Jie Zhao, Chang Su, Jun-Heng Ma, Shao-Nan Ni, Xing Wang, Ting-Han Jin, Qi Jiang, Tong Guo, Yan Xu, Chao-Chao Huang, Qing Zhang, Kai-Li Liu, Li Ji, Han-Yu Yang, Chun-Lei Li, Yu-Wen Su, Xiang Lu, Lan-Juan Li","doi":"10.1080/21645515.2023.2285089","DOIUrl":"https://doi.org/10.1080/21645515.2023.2285089","url":null,"abstract":"Vaccination plays a key role in preventing morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to evaluate the safety and immunogenicity of ...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"65 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138740845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humoral response against spike protein and fifth and sixth COVID-19 mRNA vaccine in the uninfected and infected subjects: What should be for the seventh dose? 未感染和已感染受试者对尖峰蛋白以及第五和第六剂 COVID-19 mRNA 疫苗的体液反应：第七剂疫苗应如何接种？
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-18 DOI: 10.1080/21645515.2023.2295074
Somsri Wiwanitkit, Viroj Wiwanitkit
{"title":"Humoral response against spike protein and fifth and sixth COVID-19 mRNA vaccine in the uninfected and infected subjects: What should be for the seventh dose?","authors":"Somsri Wiwanitkit, Viroj Wiwanitkit","doi":"10.1080/21645515.2023.2295074","DOIUrl":"https://doi.org/10.1080/21645515.2023.2295074","url":null,"abstract":"Published in Human Vaccines & Immunotherapeutics (Vol. 19, No. 3, 2023)","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"79 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Leptomeningeal metastasis of advanced nasopharyngeal carcinoma treated with chemoimmunotherapy 病例报告：化疗免疫疗法治疗晚期鼻咽癌的脑转移灶
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2023-12-18 DOI: 10.1080/21645515.2023.2294579
Mengting Shi, Dongchen Sun, Xilun Ma, Jiaqing Liu, Yaxiong Zhang, Tingting Liu, Xueyuan Chen, Silang Mo, Yuanyuan Zhao, Li Zhang
{"title":"Case report: Leptomeningeal metastasis of advanced nasopharyngeal carcinoma treated with chemoimmunotherapy","authors":"Mengting Shi, Dongchen Sun, Xilun Ma, Jiaqing Liu, Yaxiong Zhang, Tingting Liu, Xueyuan Chen, Silang Mo, Yuanyuan Zhao, Li Zhang","doi":"10.1080/21645515.2023.2294579","DOIUrl":"https://doi.org/10.1080/21645515.2023.2294579","url":null,"abstract":"Leptomeningeal metastasis (LM) of nasopharyngeal carcinoma (NPC) is rare and associated with a poor prognosis. Immune checkpoint inhibitors (ICIs) have been the standard first-line treatment for me...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"1 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138743122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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