Human Vaccines & Immunotherapeutics最新文献

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An economic evaluation of pneumococcal conjugate vaccines, PCV20 versus PCV15, for the prevention of pneumococcal disease in the Swedish pediatric population. 对肺炎球菌结合疫苗 PCV20 和 PCV15 在瑞典儿科人群中预防肺炎球菌疾病的经济评估。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-15 DOI: 10.1080/21645515.2024.2400751
Ann-Charlotte Fridh,Andreas Palmborg,An Ta,Donata Freigofaite,Sophie Warren,Johnna Perdrizet
{"title":"An economic evaluation of pneumococcal conjugate vaccines, PCV20 versus PCV15, for the prevention of pneumococcal disease in the Swedish pediatric population.","authors":"Ann-Charlotte Fridh,Andreas Palmborg,An Ta,Donata Freigofaite,Sophie Warren,Johnna Perdrizet","doi":"10.1080/21645515.2024.2400751","DOIUrl":"https://doi.org/10.1080/21645515.2024.2400751","url":null,"abstract":"In September 2023, 10-valent pneumococcal conjugate vaccine (PCV) was replaced by 15-valent PCV (PCV15) in Sweden's pediatric national immunization program. Following European approval of 20-valent PCV (PCV20) in March 2024, we assessed the cost-effectiveness of PCV20 versus PCV15, both under 2 + 1 schedule, among Sweden's pediatric population. A Markov state-transition model evaluated the economic and health benefits of PCV20 versus PCV15 among all ages over a 10-year time horizon. The base case adopted a Swedish payer perspective with an annual cycle length and 3.0% discount rate for costs and outcomes. Country-specific data informed population size, epidemiology, costs, and quality of life estimates. PCV15/PCV20 effect estimates were informed by PCV13 clinical effectiveness and impact studies plus PCV7 efficacy studies. Sensitivity analyses evaluated model robustness, including PCV20 under a 3 + 1 schedule. PCV20 was associated with higher quality-adjusted life year gains versus PCV15, averting an estimated 3,116 invasive pneumococcal disease cases 21,109 inpatient pneumonia cases, 6,618 outpatient pneumonia cases, and 36,209 otitis media cases, plus 3,281 pneumococcal disease-related deaths. PCV20 yielded substantial cost savings exceeding 5.4 billion SEK over a 10-year time horizon, primarily attributed to reduced direct medical costs due to improved health outcomes compared with PCV15. The findings confirmed the dominance of PCV20 in the base case, which remained robust across deterministic and probabilistic sensitivity analyses as well as scenario assessments. PCV20 was the dominant strategy versus PCV15 over 10 years. The broader serotype coverage of PCV20 suggests superior clinical and economic advantages over PCV15, warranting inclusion in Sweden's pediatric immunization program.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of COVID-19 vaccination and factors influencing COVID-19 vaccine acceptance among indigenous peoples in Quebec, Canada: Insights from a facebook posts and comments analysis. 加拿大魁北克原住民对 COVID-19 疫苗接种的看法以及影响 COVID-19 疫苗接受度的因素:从 facebook 帖子和评论分析中获得的启示。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-15 DOI: 10.1080/21645515.2024.2397868
Fabienne Labbé,Mathilde Lapointe,Eve Dubé,Christopher Fletcher
{"title":"Perceptions of COVID-19 vaccination and factors influencing COVID-19 vaccine acceptance among indigenous peoples in Quebec, Canada: Insights from a facebook posts and comments analysis.","authors":"Fabienne Labbé,Mathilde Lapointe,Eve Dubé,Christopher Fletcher","doi":"10.1080/21645515.2024.2397868","DOIUrl":"https://doi.org/10.1080/21645515.2024.2397868","url":null,"abstract":"Vaccination rates in Canada tend to be lower among Indigenous peoples than the rest of the population. The COVID-19 pandemic provided an unprecedented opportunity to better understand Indigenous perceptions about vaccination. The aim of this study was to explore perceptions of COVID-19 vaccine and other factors influencing COVID-19 vaccine acceptance as evidenced by public posts and comments on Facebook by Indigenous peoples in Quebec, Canada. We collected data on 95 Facebook pages or groups used by Indigenous peoples in Quebec between November 1, 2020, to June 15, 2021. To identify posts relating to COVID-19 vaccination, a keyword search (\"vaccination,\" \"vaccine,\" \"shot,\" \"does,\" \"Moderna,\" \"Pfizer\") was carried out in English and French in the search bar of each Facebook page/group. Results show that First Nations peoples and Inuit in Quebec had important concerns about the usefulness, safety and effectiveness of COVID-19 vaccine. They also expressed fear of being used as test subjects for the rest of the population. Motivations mentioned by First Nations peoples and Inuit to get vaccinated against COVID-19 included to travel again and return to normal life with their loved ones, and the desire to protect the most vulnerable in their communities, especially Elders. Results show that Indigenous health care professionals were considered as reliable and trustful source of information regarding COVID-19, and that seeing role models being vaccinated build confidence and foster acceptance of the vaccine. Culturally adapted messages and vaccination campaigns by and for Indigenous peoples appear to be key to building trust toward COVID-19 vaccination.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health impact of rotavirus vaccination in China 轮状病毒疫苗接种对中国健康的影响
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-13 DOI: 10.1080/21645515.2024.2386750
Sharomi Oluwaseun, Chelsey Yang, Su Jian Si Tu, Jia Yin, Yan Song, Qiang Sun, Nabi Kanibir, Susanne Hartwig, Cristina Carias
{"title":"Health impact of rotavirus vaccination in China","authors":"Sharomi Oluwaseun, Chelsey Yang, Su Jian Si Tu, Jia Yin, Yan Song, Qiang Sun, Nabi Kanibir, Susanne Hartwig, Cristina Carias","doi":"10.1080/21645515.2024.2386750","DOIUrl":"https://doi.org/10.1080/21645515.2024.2386750","url":null,"abstract":"Rotavirus (RV) vaccines have demonstrated substantial effectiveness in reducing the healthcare burden caused by gastroenteritis (RVGE) worldwide. This study aims to understand the differential impa...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving United States HPV vaccination rates: Factors predictive of parental attitudes towards middle school entry requirements. 提高美国 HPV 疫苗接种率:家长对初中入学要求态度的预测因素。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-13 DOI: 10.1080/21645515.2024.2390231
Jill Desch,Erika Thompson,Jason Beckstead,Heather Owens,Morgan Richardson Cayama,Paula Hernandez,Jacqueline Valencia,Gregory Zimet,Cheryl Vamos,Ellen Daley
{"title":"Improving United States HPV vaccination rates: Factors predictive of parental attitudes towards middle school entry requirements.","authors":"Jill Desch,Erika Thompson,Jason Beckstead,Heather Owens,Morgan Richardson Cayama,Paula Hernandez,Jacqueline Valencia,Gregory Zimet,Cheryl Vamos,Ellen Daley","doi":"10.1080/21645515.2024.2390231","DOIUrl":"https://doi.org/10.1080/21645515.2024.2390231","url":null,"abstract":"Although the human papillomavirus (HPV) vaccine is effective at preventing infection and certain types of cancer, uptake is suboptimal. HPV vaccine requirements for school entry are an underutilized strategy to increase HPV vaccine uptake among adolescents. The purpose of this study was to understand the factors that are predictive of parents' attitudes toward schools requiring the HPV vaccine for entry into middle school. Parents of adolescents ages 11-12 y were recruited to participate in an online survey via Qualtrics. Descriptive frequencies were obtained, and sequential regression analyses were conducted controlling for demographic characteristics. A total of 1,046 participants were included in the analysis. The mean age was 40.3 y (SD = 6.3) and the majority of participants were White (74.4%) and had some college education or higher (80.9%). Participant's gender, political affiliation, urban/rural setting, and education level were significantly associated with attitudes toward school entry requirements. Adding psychosocial items related to perceptions of benefits, risks, and social norms significantly increased the amount of variance explained in the model [(ΔR2 = .312, F(5, 1036) = 132.621)]. Perceived social norms was the strongest predictor of attitudes [β = 0.321]. The results of this study can be used to inform policy changes around school-entry requirements in the United States. Further studies are needed to assess the influence of perceived social norms in vaccine hesitant groups.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of near-term prediction models for severe immune-related adverse events in malignant tumor PD-1 inhibitor therapy. 恶性肿瘤 PD-1 抑制剂治疗中严重免疫相关不良事件的近期预测模型的预测价值。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-13 DOI: 10.1080/21645515.2024.2398309
Yunyi Du,Ying Zhang,Wenqi Zhao,Yuexiang Zhang,Fei Su,Xiaoling Zhang,Weiling Li,Wenqing Hu,Yongai Li,Jun Zhao
{"title":"Predictive value of near-term prediction models for severe immune-related adverse events in malignant tumor PD-1 inhibitor therapy.","authors":"Yunyi Du,Ying Zhang,Wenqi Zhao,Yuexiang Zhang,Fei Su,Xiaoling Zhang,Weiling Li,Wenqing Hu,Yongai Li,Jun Zhao","doi":"10.1080/21645515.2024.2398309","DOIUrl":"https://doi.org/10.1080/21645515.2024.2398309","url":null,"abstract":"Immune-related adverse events (irAEs) impact outcomes, with most research focusing on early prediction (baseline data), rather than near-term prediction (one cycle before the occurrence of irAEs and the current cycle). We aimed to explore the near-term predictive value of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), absolute eosinophil count (AEC) for severe irAEs induced by PD-1 inhibitors. Data were collected from tumor patients treated with PD-1 inhibitors. NLR, PLR, and AEC data were obtained from both the previous and the current cycles of irAEs occurrence. A predictive model was developed using elastic net logistic regression Cutoff values were determined using Youden's Index. The predicted results were compared with actual data using Bayesian survival analysis. A total of 138 patients were included, of whom 47 experienced grade 1-2 irAEs and 18 experienced grade 3-5 irAEs. The predictive model identified optimal α and λ through 10-fold cross-validation. The Shapiro-Wilk test, Kruskal-Wallis test and logistic regression showed that only current cycle data were meaningful. The NLR was statistically significant in predicting irAEs in the previous cycle. Both NLR and AEC were significant predictors of irAEs in the current cycle. The model achieved an area under the ROC curve (AUC) of 0.783, with a sensitivity of 77.8% and a specificity of 80.8%. A probability ≥ 0.1345 predicted severe irAEs. The model comprising NLR, AEC, and sex may predict the irAEs classification in the current cycle, offering a near-term predictive advantage over baseline models and potentially extending the duration of immunotherapy for patients.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single and two-dose typhoid conjugate vaccine safety and immunogenicity in HIV-exposed uninfected and HIV-unexposed uninfected Malawian children 未感染艾滋病毒和未感染艾滋病毒的马拉维儿童接种单剂和双剂伤寒结合疫苗的安全性和免疫原性
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-12 DOI: 10.1080/21645515.2024.2384760
Nginache Nampota-Nkomba, Osward M. Nyirenda, Victoria Mapemba, Rhoda Masonga, Priyanka D. Patel, Theresa Misiri, Felistas Mwakiseghile, Richard Wachepa, John M. Ndaferankhande, Bright Lipenga, Pratiksha Patel, Happy Banda, Jennifer Oshinsky, Marcela F. Pasetti, Robert S. Heyderman, Leslie P. Jamka, Divya Hosangadi, Shrimati Datta, Melita A. Gordon, Kathleen M. Neuzil, Matthew B. Laurens
{"title":"Single and two-dose typhoid conjugate vaccine safety and immunogenicity in HIV-exposed uninfected and HIV-unexposed uninfected Malawian children","authors":"Nginache Nampota-Nkomba, Osward M. Nyirenda, Victoria Mapemba, Rhoda Masonga, Priyanka D. Patel, Theresa Misiri, Felistas Mwakiseghile, Richard Wachepa, John M. Ndaferankhande, Bright Lipenga, Pratiksha Patel, Happy Banda, Jennifer Oshinsky, Marcela F. Pasetti, Robert S. Heyderman, Leslie P. Jamka, Divya Hosangadi, Shrimati Datta, Melita A. Gordon, Kathleen M. Neuzil, Matthew B. Laurens","doi":"10.1080/21645515.2024.2384760","DOIUrl":"https://doi.org/10.1080/21645515.2024.2384760","url":null,"abstract":"Vaccine safety and immunogenicity data in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children are important for decision-making in HIV and typhoid co-endemic countries. In an open-...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Policies for the immunization against serogroup B meningococcus for adolescents immunized during the first two years of life: A mini review 为出生后头两年接受免疫接种的青少年制定的 B 血清群脑膜炎球菌免疫接种政策:微型综述
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-12 DOI: 10.1080/21645515.2024.2396220
Claudia Palmieri, Lorenza Moscara, Silvio Tafuri, Pasquale Stefanizzi
{"title":"Policies for the immunization against serogroup B meningococcus for adolescents immunized during the first two years of life: A mini review","authors":"Claudia Palmieri, Lorenza Moscara, Silvio Tafuri, Pasquale Stefanizzi","doi":"10.1080/21645515.2024.2396220","DOIUrl":"https://doi.org/10.1080/21645515.2024.2396220","url":null,"abstract":"Two vaccines are available to prevent serogroup B meningococcal disease, i.e. the four-component meningococcal serogroup B vaccine (4CMenB) and the bivalent-factor-H-binding-protein meningococcal s...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syphilis vaccine development: Aligning vaccine design with manufacturing requirements. 梅毒疫苗开发:使疫苗设计符合生产要求。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-11 DOI: 10.1080/21645515.2024.2399915
Sean Waugh,Caroline E Cameron
{"title":"Syphilis vaccine development: Aligning vaccine design with manufacturing requirements.","authors":"Sean Waugh,Caroline E Cameron","doi":"10.1080/21645515.2024.2399915","DOIUrl":"https://doi.org/10.1080/21645515.2024.2399915","url":null,"abstract":"Syphilis, caused by Treponema pallidum subsp. pallidum, is a global health concern with increasing rates worldwide. Current prevention strategies, including screen-and-treat approaches, are not sufficient to resolve rising infection rates, emphasizing the need for a vaccine. Developing a syphilis vaccine necessitates a range of cross-disciplinary considerations, including essential disease-specific protection, technical requirements, economic feasibility, manufacturing constraints, public acceptance, equitable vaccine access, alignment with global public vaccination programs, and identification of essential populations to be vaccinated to achieve herd immunity. Central to syphilis vaccine development is prioritization of global vaccine availability, including access in low- to middle-income settings. Various vaccine platforms, including subunit, virus-like particle (VLP), mRNA, and outer membrane vesicle (OMV) vaccines, present both advantages and challenges. The proactive consideration of both manufacturing feasibility and efficacy throughout the pre-clinical research and development stages is essential for producing an efficacious, inexpensive, and scalable syphilis vaccine to address the growing global health burden caused by this disease.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Europe and the Middle East in the post-licensure period. 关于欧洲和中东地区轮状病毒基因型流行情况的系统文献综述和荟萃分析。
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-10 DOI: 10.1080/21645515.2024.2389606
Tim Jesudason,Oluwaseun Sharomi,Kelly Fleetwood,Alex Lapting Cheuk,Maria Bermudez,Hannah Schirrmacher,Christian Hauck,Jelle Matthijnssens,Daniel Hungerford,David Tordrup,Cristina Carias
{"title":"Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Europe and the Middle East in the post-licensure period.","authors":"Tim Jesudason,Oluwaseun Sharomi,Kelly Fleetwood,Alex Lapting Cheuk,Maria Bermudez,Hannah Schirrmacher,Christian Hauck,Jelle Matthijnssens,Daniel Hungerford,David Tordrup,Cristina Carias","doi":"10.1080/21645515.2024.2389606","DOIUrl":"https://doi.org/10.1080/21645515.2024.2389606","url":null,"abstract":"Previous systematic literature reviews of rotavirus genotype circulation in Europe and the Middle East are limited because they do not include country-specific prevalence data. This study documents country-specific evidence on the prevalence of rotavirus genotypes in Europe and the Middle East to enable more precise epidemiological modeling and contribute to the evidence-base about circulating rotavirus genotypes in the post-vaccination era. This study systematically searched PubMed, Embase and Scopus for all empirical epidemiological studies that presented genotype-specific surveillance data for countries in Europe and the Middle East published between 2006 and 2021. The STROBE checklist was used to assess the quality of included studies. Proportional meta-analysis was conducted using the generic inverse variance method with arcsine transformation and generalized linear-mixed models to summarize genotype prevalence. Our analysis estimated the genotype prevalence by country across three date categories corresponding with rotavirus seasons: 2006-2010, 2011-2015, 2016-2021. A total of 7601 deduplicated papers were identified of which 88 studies were included in the final review. Rotavirus genotypes exhibited significant variability across regions and time periods, with G1P[8], G2P[4], G3P[8], G4P[8], G9P[8], and, to a lesser extent G12P[8], being the most prevalent genotypes through different regions and time-periods. Uncommon genotypes included G3P[9] in Poland, G2P[6] in Iraq, G4P[4] in Qatar, and G9P[4] as reported by the European Rotavirus Network. There was high genotype diversity with routinely identified genotypes being G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]; there was high variability across time periods and regions. Continued surveillance at the national and regional levels is relevant to support further research and inform public health decision-making.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity 从基因组学角度了解 mRNA COVID-19 疫苗的功效:将基因多态性与免疫力下降联系起来
IF 4.8 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2024-09-10 DOI: 10.1080/21645515.2024.2399382
Min-Jia Hsieh, Ping-Hsing Tsai, Pin-Hsuan Chiang, Zih-Kai Kao, Zi-Qing Zhuang, Ai-Ru Hsieh, Hsiang-Ling Ho, Shih-Hwa Chiou, Kung-Hao Liang, Yu-Chun Chen
{"title":"Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity","authors":"Min-Jia Hsieh, Ping-Hsing Tsai, Pin-Hsuan Chiang, Zih-Kai Kao, Zi-Qing Zhuang, Ai-Ru Hsieh, Hsiang-Ling Ho, Shih-Hwa Chiou, Kung-Hao Liang, Yu-Chun Chen","doi":"10.1080/21645515.2024.2399382","DOIUrl":"https://doi.org/10.1080/21645515.2024.2399382","url":null,"abstract":"Genetic polymorphisms have been linked to the differential waning of vaccine-induced immunity against COVID-19 following vaccination. Despite this, evidence on the mechanisms behind this waning and...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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