Human Vaccines & Immunotherapeutics最新文献

{"title":"Health impact of rotavirus vaccination in China","authors":"Sharomi Oluwaseun, Chelsey Yang, Su Jian Si Tu, Jia Yin, Yan Song, Qiang Sun, Nabi Kanibir, Susanne Hartwig, Cristina Carias","doi":"10.1080/21645515.2024.2386750","DOIUrl":"https://doi.org/10.1080/21645515.2024.2386750","url":null,"abstract":"Rotavirus (RV) vaccines have demonstrated substantial effectiveness in reducing the healthcare burden caused by gastroenteritis (RVGE) worldwide. This study aims to understand the differential impa...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"49 1","pages":"2386750"},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving United States HPV vaccination rates: Factors predictive of parental attitudes towards middle school entry requirements.","authors":"Jill Desch,Erika Thompson,Jason Beckstead,Heather Owens,Morgan Richardson Cayama,Paula Hernandez,Jacqueline Valencia,Gregory Zimet,Cheryl Vamos,Ellen Daley","doi":"10.1080/21645515.2024.2390231","DOIUrl":"https://doi.org/10.1080/21645515.2024.2390231","url":null,"abstract":"Although the human papillomavirus (HPV) vaccine is effective at preventing infection and certain types of cancer, uptake is suboptimal. HPV vaccine requirements for school entry are an underutilized strategy to increase HPV vaccine uptake among adolescents. The purpose of this study was to understand the factors that are predictive of parents' attitudes toward schools requiring the HPV vaccine for entry into middle school. Parents of adolescents ages 11-12 y were recruited to participate in an online survey via Qualtrics. Descriptive frequencies were obtained, and sequential regression analyses were conducted controlling for demographic characteristics. A total of 1,046 participants were included in the analysis. The mean age was 40.3 y (SD = 6.3) and the majority of participants were White (74.4%) and had some college education or higher (80.9%). Participant's gender, political affiliation, urban/rural setting, and education level were significantly associated with attitudes toward school entry requirements. Adding psychosocial items related to perceptions of benefits, risks, and social norms significantly increased the amount of variance explained in the model [(ΔR2 = .312, F(5, 1036) = 132.621)]. Perceived social norms was the strongest predictor of attitudes [β = 0.321]. The results of this study can be used to inform policy changes around school-entry requirements in the United States. Further studies are needed to assess the influence of perceived social norms in vaccine hesitant groups.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"43 1","pages":"2390231"},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of near-term prediction models for severe immune-related adverse events in malignant tumor PD-1 inhibitor therapy.","authors":"Yunyi Du,Ying Zhang,Wenqi Zhao,Yuexiang Zhang,Fei Su,Xiaoling Zhang,Weiling Li,Wenqing Hu,Yongai Li,Jun Zhao","doi":"10.1080/21645515.2024.2398309","DOIUrl":"https://doi.org/10.1080/21645515.2024.2398309","url":null,"abstract":"Immune-related adverse events (irAEs) impact outcomes, with most research focusing on early prediction (baseline data), rather than near-term prediction (one cycle before the occurrence of irAEs and the current cycle). We aimed to explore the near-term predictive value of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), absolute eosinophil count (AEC) for severe irAEs induced by PD-1 inhibitors. Data were collected from tumor patients treated with PD-1 inhibitors. NLR, PLR, and AEC data were obtained from both the previous and the current cycles of irAEs occurrence. A predictive model was developed using elastic net logistic regression Cutoff values were determined using Youden's Index. The predicted results were compared with actual data using Bayesian survival analysis. A total of 138 patients were included, of whom 47 experienced grade 1-2 irAEs and 18 experienced grade 3-5 irAEs. The predictive model identified optimal α and λ through 10-fold cross-validation. The Shapiro-Wilk test, Kruskal-Wallis test and logistic regression showed that only current cycle data were meaningful. The NLR was statistically significant in predicting irAEs in the previous cycle. Both NLR and AEC were significant predictors of irAEs in the current cycle. The model achieved an area under the ROC curve (AUC) of 0.783, with a sensitivity of 77.8% and a specificity of 80.8%. A probability ≥ 0.1345 predicted severe irAEs. The model comprising NLR, AEC, and sex may predict the irAEs classification in the current cycle, offering a near-term predictive advantage over baseline models and potentially extending the duration of immunotherapy for patients.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"96 1","pages":"2398309"},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Policies for the immunization against serogroup B meningococcus for adolescents immunized during the first two years of life: A mini review","authors":"Claudia Palmieri, Lorenza Moscara, Silvio Tafuri, Pasquale Stefanizzi","doi":"10.1080/21645515.2024.2396220","DOIUrl":"https://doi.org/10.1080/21645515.2024.2396220","url":null,"abstract":"Two vaccines are available to prevent serogroup B meningococcal disease, i.e. the four-component meningococcal serogroup B vaccine (4CMenB) and the bivalent-factor-H-binding-protein meningococcal s...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"6 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Europe and the Middle East in the post-licensure period.","authors":"Tim Jesudason,Oluwaseun Sharomi,Kelly Fleetwood,Alex Lapting Cheuk,Maria Bermudez,Hannah Schirrmacher,Christian Hauck,Jelle Matthijnssens,Daniel Hungerford,David Tordrup,Cristina Carias","doi":"10.1080/21645515.2024.2389606","DOIUrl":"https://doi.org/10.1080/21645515.2024.2389606","url":null,"abstract":"Previous systematic literature reviews of rotavirus genotype circulation in Europe and the Middle East are limited because they do not include country-specific prevalence data. This study documents country-specific evidence on the prevalence of rotavirus genotypes in Europe and the Middle East to enable more precise epidemiological modeling and contribute to the evidence-base about circulating rotavirus genotypes in the post-vaccination era. This study systematically searched PubMed, Embase and Scopus for all empirical epidemiological studies that presented genotype-specific surveillance data for countries in Europe and the Middle East published between 2006 and 2021. The STROBE checklist was used to assess the quality of included studies. Proportional meta-analysis was conducted using the generic inverse variance method with arcsine transformation and generalized linear-mixed models to summarize genotype prevalence. Our analysis estimated the genotype prevalence by country across three date categories corresponding with rotavirus seasons: 2006-2010, 2011-2015, 2016-2021. A total of 7601 deduplicated papers were identified of which 88 studies were included in the final review. Rotavirus genotypes exhibited significant variability across regions and time periods, with G1P[8], G2P[4], G3P[8], G4P[8], G9P[8], and, to a lesser extent G12P[8], being the most prevalent genotypes through different regions and time-periods. Uncommon genotypes included G3P[9] in Poland, G2P[6] in Iraq, G4P[4] in Qatar, and G9P[4] as reported by the European Rotavirus Network. There was high genotype diversity with routinely identified genotypes being G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]; there was high variability across time periods and regions. Continued surveillance at the national and regional levels is relevant to support further research and inform public health decision-making.","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"10 1","pages":"2389606"},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity","authors":"Min-Jia Hsieh, Ping-Hsing Tsai, Pin-Hsuan Chiang, Zih-Kai Kao, Zi-Qing Zhuang, Ai-Ru Hsieh, Hsiang-Ling Ho, Shih-Hwa Chiou, Kung-Hao Liang, Yu-Chun Chen","doi":"10.1080/21645515.2024.2399382","DOIUrl":"https://doi.org/10.1080/21645515.2024.2399382","url":null,"abstract":"Genetic polymorphisms have been linked to the differential waning of vaccine-induced immunity against COVID-19 following vaccination. Despite this, evidence on the mechanisms behind this waning and...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"39 1","pages":"2399382"},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus (HPV) vaccination in a privately funded program in Ghana: A qualitative case study","authors":"Emmanuel Marfo, Bukola Salami, Charles Adjei, Shannon MacDonald","doi":"10.1080/21645515.2024.2397219","DOIUrl":"https://doi.org/10.1080/21645515.2024.2397219","url":null,"abstract":"HPV vaccination is one of the safest and most effective interventions against HPV-related cancers. From 2013 to 2018, HPV vaccination was piloted in Ghana in preparation for a national program. Yet...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"13 1","pages":"2397219"},"PeriodicalIF":4.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context matters: How to research vaccine attitudes and uptake after the COVID-19 crisis","authors":"Jeremy K. Ward, Patrick Peretti-Watel, Eve Dubé, Pierre Verger, Katie Attwell","doi":"10.1080/21645515.2024.2367268","DOIUrl":"https://doi.org/10.1080/21645515.2024.2367268","url":null,"abstract":"The pandemic dramatically accelerated research on vaccine attitudes and uptake, a field which mobilizes researchers from the social sciences and humanities as well as biomedical and public health d...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"354 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of vaccination against atherosclerosis","authors":"Bochao Jia, Rui Wei, Chenlu Yuan, Tao Cheng, Shuai Shi, Yuguang Chu, Yuanhui Hu","doi":"10.1080/21645515.2024.2365500","DOIUrl":"https://doi.org/10.1080/21645515.2024.2365500","url":null,"abstract":"A growing body of research indicates the promising potential of vaccines in both preventing and treating atherosclerosis (AS). To gain a comprehensive understanding of the current research landscap...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"25 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the influenza vaccine for preventing laboratory-confirmed influenza infections in outpatient immunocompromised adults, 2017–2018","authors":"Kailey Hughes Kramer, Richard K. Zimmerman, Catherine L. Haggerty, G. K. Balasubramani, Mary Patricia Nowalk, Emily T. Martin, Manjusha Gaglani, C. Hallie Phillips, Edward Belongia, Jessie Chung, Fernanda P. Silveira","doi":"10.1080/21645515.2024.2354013","DOIUrl":"https://doi.org/10.1080/21645515.2024.2354013","url":null,"abstract":"While the number of immunocompromised (IC) individuals continues to rise, the existing literature on influenza vaccine effectiveness (VE) in IC populations is limited. Understanding the vaccine eff...","PeriodicalId":13058,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"9 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}