Human Brain Mapping最新文献

{"title":"Simultaneous EEG-fMRI Reveals a Visual Working Memory Encoding Network Related to Theta Oscillatory Activity in Healthy Subjects","authors":"Gregor Leicht,&nbsp;Jonas Rauh,&nbsp;Marius Mußmann,&nbsp;Sebastian Vauth,&nbsp;Saskia Steinmann,&nbsp;Moritz Haaf,&nbsp;Corinna Haenschel,&nbsp;Christoph Mulert","doi":"10.1002/hbm.70216","DOIUrl":"https://doi.org/10.1002/hbm.70216","url":null,"abstract":"<p>Working memory (WM) is crucially involved in many aspects of higher cognitive functions and goal-directed behavior. The encoding of sensory information necessitates the conversion of sensory stimuli into maintainable constructs. Oscillatory activity in the theta frequency range (4–8 Hz) of the human electroencephalogram (EEG) has been related to this. However, so far, no study has investigated the neurophysiological mechanisms and the brain network structure underlying the WM encoding process simultaneously. Thus, this study aimed to test whether theta oscillatory activity would be specifically related to the activity within a WM encoding brain network in healthy subjects by means of simultaneous recordings of EEG and functional magnetic resonance imaging (fMRI). Simultaneous recordings of EEG and fMRI were conducted in 32 healthy subjects during the performance of a visual working memory delayed matched to sample task. The fMRI analysis was informed by single-trial theta oscillatory responses to encoding stimuli. This analysis revealed a working memory encoding network mediated by theta oscillatory activity. The network included regions within the dorsolateral prefrontal cortex and parietal areas. Our results give reason to assume that the formation of a working memory network might take place during the encoding of information utilizing theta synchrony as a binding mechanism.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders","authors":"Farshid Ghiyamihoor,&nbsp;Payam Paymani,&nbsp;Jarrad Perron,&nbsp;Azam Asemi-Rad,&nbsp;Mehdi Marzban,&nbsp;Aashka Mohite,&nbsp;Karen Ardila,&nbsp;Bara Aljada,&nbsp;Asghar Marzban,&nbsp;Mehnosh Toback,&nbsp;Sherif Eltonsy,&nbsp;Ji Hyun Ko,&nbsp;Tabrez J. Siddiqui,&nbsp;Christopher J. Steele,&nbsp;Jiming Kong,&nbsp;Mario Manto,&nbsp;M. Ethan MacDonald,&nbsp;Jason S. Gill,&nbsp;Roy V. Sillitoe,&nbsp;Fuat Balcı,&nbsp;Iman Beheshti,&nbsp;Hassan Marzban","doi":"10.1002/hbm.70214","DOIUrl":"https://doi.org/10.1002/hbm.70214","url":null,"abstract":"<p>Cerebellar volumetric changes are intricately linked to aging, with distinct patterns across its <i>transverse zones</i>, the functional subdivisions characterized by unique cytoarchitectural and connectivity profiles. Despite research efforts, the cerebellar aging process in health and neurological disorders remains poorly understood. In this study, we investigated the effects of age and sex on total cerebellum, <i>transverse zone</i>, and lobule volumes using MRI data from over 45,000 participants compiled from six neuroimaging datasets. We also propose a framework for estimating cerebellum age as an indicator of cerebellar health. Significant age-dependent volume reductions were observed across <i>transverse zones</i>, with the central zone (<i>CZ</i>; lobules VI and VII) exhibiting the steepest decline in both health and neurological disorders. This finding highlights the <i>CZ's</i> vulnerability to aging and its critical role in cognitive and emotional processing. We also found prominent sex differences in age-dependent volumetric changes. Males exhibited smaller total intracranial volume (TIV)-adjusted cerebellum volume and faster age-dependent volume reduction than females in both health and mild cognitive impairment (MCI), Alzheimer disease (AD), and Parkinson disease (PD). In contrast, females with schizophrenia (SZ) and cocaine use disorder (CUD) revealed faster age-dependent cerebellar volume reduction than males. Patients with MCI, AD, and PD experienced more pronounced atrophy in the posterior (<i>PZ</i>) and nodular (<i>NZ</i>) zones compared to age-matched healthy controls, while SZ patients were characterized by a more prominent reduction in <i>CZ</i>. In CUD, a non-significant volume decline was observed in all zones compared to the controls. Moreover, our framework for estimating cerebellum age revealed a notable difference in cerebellar aging between healthy individuals and neurological patients. Finally, we charted age-dependent changes in cerebellar volume in healthy individuals, focusing on <i>transverse zones</i> capturing the functional subdivisions. These findings underscore the potential of cerebellar volumetric analysis as a biomarker for early detection and monitoring of neurodegenerative and neuropsychiatric disorders. Our novel approach complements and enhances MRI-based analyses, providing essential insights into the pathogenesis of aging, neurodegeneration, and chronic neuropsychiatric conditions.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change","authors":"Max Korbmacher,&nbsp;Didac Vidal-Pineiro,&nbsp;Meng-Yun Wang,&nbsp;Dennis van der Meer,&nbsp;Thomas Wolfers,&nbsp;Hajer Nakua,&nbsp;Eli Eikefjord,&nbsp;Ole A. Andreassen,&nbsp;Lars T. Westlye,&nbsp;Ivan I. Maximov","doi":"10.1002/hbm.70203","DOIUrl":"https://doi.org/10.1002/hbm.70203","url":null,"abstract":"<p>The concept of brain age (BA) describes an integrative imaging marker of brain health, often suggested to reflect aging processes. However, the degree to which cross-sectional MRI features, including BA, reflect past, ongoing, and future brain changes across different tissue types from macro- to microstructure remains controversial. Here, we use multimodal imaging data of 39,325 UK Biobank participants, aged 44–82 years at baseline and 2,520 follow-ups within 1.12–6.90 years to examine BA changes and their relationship to anatomical brain changes. We find insufficient evidence to conclude that BA reflects the rate of brain aging. However, modality-specific differences in brain ages reflect the state of the brain, highlighting diffusion and multimodal MRI brain age as potentially useful cross-sectional markers.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Functional Network Connectivity Pattern of the Amygdalohippocampal Complex in Individuals With Subjective Cognitive Decline","authors":"Chih-Kai Lee,&nbsp;Xiao-Ya Wei,&nbsp;Ze-Yi Wang,&nbsp;Hang Zhou,&nbsp;Chao-Qun Yan,&nbsp;Xin-Yuan Jiang,&nbsp;Guang-Xia Shi,&nbsp;Xu Wang,&nbsp;Cun-Zhi Liu","doi":"10.1002/hbm.70194","DOIUrl":"https://doi.org/10.1002/hbm.70194","url":null,"abstract":"<p>Subjective cognitive decline (SCD) is a potential early marker of cognitive decline and dementia. The amygdalohippocampal structure and function are closely related to cognitive decline, but few studies have investigated large-scale amygdalohippocampal brain functional network connectivity in individuals with SCD. Here, we aim to explore how the dynamic functional network connectivity (dFNC) between the amygdalohippocampal complex and other brain networks contributes to the understanding of early cognitive decline. Independent component analysis (ICA) and dFNC analysis were applied to functional magnetic resonance imaging (fMRI) data from 66 individuals with SCD to extract the amygdalohippocampal complex and identify distinct connectivity states. Cognitive performance was assessed through a composite Z score derived from a battery of neuropsychological tests. Correlation analyses were performed to examine the associations between the dFNC patterns and cognitive performance. Three distinct dFNC states were identified, each characterized by varying levels of within- and inter-network connectivity, with occurrences of 65%, 18%, and 17% respectively. Cognitive function, measured using a composite Z score, was positively correlated with amygdalohippocampal-sensorimotor network (SM) and amygdalohippocampal-visual network (VI) dFNC in State 2. Significant correlations were observed between the amygdalohippocampal complex and the left precentral gyrus (<i>r</i> = 0.517, FDR-corrected <i>p</i> = 0.005), postcentral gyrus (<i>r</i> = 0.487, FDR-corrected <i>p</i> = 0.034), and multiple visual network regions, including the lingual gyrus and lateral occipital cortex (all <i>P</i>s &lt; 0.05, FDR-corrected). These associations remained significant after adjusting for sex and age. These findings extend the current understanding of amygdalohippocampal dysfunction in cognitive decline and demonstrate that cognitive function is associated with distinct large-scale amygdalohippocampal network dynamics.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Association of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping","authors":"Lezlie Y. España,&nbsp;Benjamin L. Brett,&nbsp;Andrew R. Mayer,&nbsp;Andrew S. Nencka,&nbsp;Brad Swearingen,&nbsp;Kevin M. Koch,&nbsp;Timothy B. Meier","doi":"10.1002/hbm.70213","DOIUrl":"https://doi.org/10.1002/hbm.70213","url":null,"abstract":"<p>A growing body of evidence suggests that repeated concussions and exposure to repetitive head impacts may be associated with subtle abnormalities in neurological health. Prior studies have demonstrated associations of prior concussion and repetitive head impacts with the brain's microstructure, typically using diffusion magnetic resonance imaging, though the direction of these relationships has varied across groups. Quantitative susceptibility mapping is a quantitative extension of susceptibility weighted imaging that is sensitive to pathophysiology associated with neurotrauma and thus represents an alternative method to characterize the effects of concussion and repetitive head impact exposure on brain microstructure. The goal of this work was to characterize the association of prior concussion and years of contact sport exposure (a proxy of repetitive head impacts) with magnetic susceptibility in a cohort of otherwise healthy male and female collegiate-aged athletes. We hypothesized that concussion and contact sport exposure would be independently associated with lower susceptibility in white matter regions. Higher general symptom severity and psychological symptoms were observed in athletes with a greater history of concussion, but not years of contact sport exposure. No associations between concussion or years of exposure with cognitive performance were observed. Voxel-wise analyses found that individuals with more prior concussions also had lower magnetic susceptibility in two predominantly white matter clusters including the superior longitudinal fasciculi and forceps major. No associations of susceptibility and contact sport exposure were observed. Finally, lower susceptibility in the identified regions was associated with worse psychological symptoms, worse general symptoms, and worse performance on a composite measure of fluid cognition tasks. Current results suggest that more prior concussions in otherwise healthy collegiate-aged athletes are associated with decreases in susceptibility that are in turn associated with elevated symptom reporting and poorer cognitive performance.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Cortical Targets for Modulating Function Supported by the Human Hippocampal Network","authors":"Hsin-Ju Lee,&nbsp;Fa-Hsuan Lin","doi":"10.1002/hbm.70167","DOIUrl":"https://doi.org/10.1002/hbm.70167","url":null,"abstract":"<p>Individualized transcranial magnetic stimulation (TMS) targeting using functional connectivity analysis of functional magnetic resonance imaging (fMRI) has been demonstrated to be advantageous in inducing neuroplasticity. However, how this approach can benefit modulating the episodic memory function supported by the hippocampal network remains elusive. We use the resting-state fMRI data from a large cohort to reveal tentative TMS targets at cortical regions within the hippocampal network. Functional MRI from 1,133 individuals in the Human Connectome Project was used to analyze the hippocampal network using seed-based functional connectivity. Using a weighted sum of time series at the cortex, we identified the average centroids of individualized targets at the medial prefrontal cortex (mPFC) and posterior parietal cortices (PPCs) at (−10, 49, 7) and (−40, −67, 30) in the left hemisphere, respectively. The mPFC and PPC coordinate at the right hemispheres are (11, 51, 6) and (48, −59, 24) in the right hemisphere, respectively. Centroids of the individualized functional connectivity at the mPFC and PPC were reproducible between sessions with separations in average about 2 and 4 mm, respectively. These separations were significantly smaller than the distance to average functional connectivity centroids (~10 mm) and atlas coordinate (~20 mm). These coordinates can be reliably identified (&gt; 90% of individuals) using cortical “seedmaps.” Our results suggest candidate TMS target coordinates to modulate the hippocampal function.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State","authors":"Clayton R. Coleman,&nbsp;Kenneth Shinozuka,&nbsp;Robert Tromm,&nbsp;Ottavia Dipasquale,&nbsp;Mendel Kaelen,&nbsp;Leor Roseman,&nbsp;Suresh Muthukumaraswamy,&nbsp;David J. Nutt,&nbsp;Lionel Barnett,&nbsp;Robin Carhart-Harris","doi":"10.1002/hbm.70209","DOIUrl":"https://doi.org/10.1002/hbm.70209","url":null,"abstract":"<p>Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces a profoundly altered conscious state. In conjunction with psychological support, it is currently being explored as a treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) is a brain region that is known to be involved in mood regulation and disorders; hypofunction in the left DLPFC is associated with depression. This study investigated the role of the DLPFC in the psycho-emotional effects of LSD with functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) data of healthy human participants during the acute LSD experience. In the fMRI data, we measured the correlation between changes in resting-state functional connectivity (RSFC) of the DLPFC and post-scan subjective ratings of positive mood, emotional arousal, and ego dissolution. We found significant, positive correlations between ego dissolution and functional connectivity between the left &amp; right DLPFC, thalamus, and a higher-order visual area, the fusiform face area (FFA). Additionally, emotional arousal was significantly associated with increased connectivity between the right DLPFC, intraparietal sulcus (IPS), and the salience network (SN). A confirmational “reverse” analysis, in which the outputs of the original RSFC analysis were used as input seeds, substantiated the role of the right DLPFC and the aforementioned regions in both ego dissolution and emotional arousal. Subsequently, we measured the effects of LSD on directed functional connectivity in MEG data that was source-localized to the input and output regions of both the original and reverse analyses. The Granger causality (GC) analysis revealed that LSD increased information flow between two nodes of the ‘ego dissolution network’, the thalamus and the DLPFC, in the theta band, substantiating the hypothesis that disruptions in thalamic gating underlie the experience of ego dissolution. Overall, this multimodal study elucidates a role for the DLPFC in LSD-induced states of consciousness and sheds more light on the brain basis of ego dissolution.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TractCloud-FOV: Deep Learning-Based Robust Tractography Parcellation in Diffusion MRI With Incomplete Field of View","authors":"Yuqian Chen,&nbsp;Leo Zekelman,&nbsp;Yui Lo,&nbsp;Suheyla Cetin-Karayumak,&nbsp;Tengfei Xue,&nbsp;Yogesh Rathi,&nbsp;Nikos Makris,&nbsp;Fan Zhang,&nbsp;Weidong Cai,&nbsp;Lauren J. O'Donnell","doi":"10.1002/hbm.70201","DOIUrl":"https://doi.org/10.1002/hbm.70201","url":null,"abstract":"<p>Tractography parcellation classifies streamlines reconstructed from diffusion MRI into anatomically defined fiber tracts for clinical and research applications. However, clinical scans often have incomplete fields of view (FOV) where brain regions are partially imaged, leading to partial, or truncated fiber tracts. To address this challenge, we introduce TractCloud-FOV, a deep learning framework that robustly parcellates tractography under conditions of incomplete FOV. We propose a novel training strategy, FOV-Cut Augmentation (FOV-CA), in which we synthetically cut tractograms to simulate a spectrum of real-world inferior FOV cutoff scenarios. This data augmentation approach enriches the training set with realistic truncated streamlines, enabling the model to achieve superior generalization. We evaluate the proposed TractCloud-FOV on both synthetically cut tractography and two real-life datasets with incomplete FOV. TractCloud-FOV significantly outperforms several state-of-the-art methods on all testing datasets in terms of streamline classification accuracy, generalization ability, tract anatomical depiction, and computational efficiency. Overall, TractCloud-FOV achieves efficient and consistent tractography parcellation in diffusion MRI with incomplete FOV.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthalamic Deep Brain Stimulation: Mapping Non-Motor Outcomes to Structural Connections","authors":"Garance M. Meyer,&nbsp;Ilkem Aysu Sahin,&nbsp;Barbara Hollunder,&nbsp;Konstantin Butenko,&nbsp;Nanditha Rajamani,&nbsp;Clemens Neudorfer,&nbsp;Lauren A. Hart,&nbsp;Jan Niklas Petry-Schmelzer,&nbsp;Haidar S. Dafsari,&nbsp;Michael T. Barbe,&nbsp;Veerle Visser-Vandewalle,&nbsp;Philip E. Mosley,&nbsp;Andreas Horn","doi":"10.1002/hbm.70207","DOIUrl":"https://doi.org/10.1002/hbm.70207","url":null,"abstract":"<p>In Parkinson's Disease (PD), deep brain stimulation of the subthalamic nucleus (STN-DBS) reliably improves motor symptoms, and the circuits mediating these effects have largely been identified. However, non-motor outcomes are more variable, and it remains unclear which specific brain circuits need to be modulated or avoided to improve them. Since numerous non-motor symptoms potentially respond to DBS, it is challenging to independently identify the circuits mediating each one of them. Data compression algorithms such as principal component analysis (PCA) may provide a powerful alternative. This study aimed at providing a proof of concept for this approach by mapping changes along extensive score batteries to a few anatomical fiber bundles and, in turn, estimating changes in individual scores based on stimulation of these tracts. Retrospective data from 56 patients with PD and bilateral STN-DBS was included. The patients had undergone comprehensive clinical assessments covering changes in appetitive behaviors, mood, anxiety, impulsivity, cognition, and empathy. PCA was implemented to identify the main dimensions of neuropsychiatric and neuropsychological outcomes. Using DBS fiber filtering, we identified the structural connections whose stimulation was associated with change along these dimensions. Then, estimates of individual symptom outcomes were derived based on the stimulation of these connections by inverting the PCA. Finally, changes along a specific non-motor score were estimated in an independent validation dataset (<i>N</i> = 68) using the tract model. Four principal components were retained, which could be interpreted to reflect (i) general non-motor improvement; (ii) improvement of mood and cognition and worsening of trait impulsivity; (iii) improvement of cognition; and (iv) improvement of empathy and worsening of impulsive-compulsive behaviors. Each component was associated with the stimulation of spatially segregated fiber bundles connecting regions of the frontal cortex with the subthalamic nucleus. The extent of stimulation of these tracts was able to explain significant amounts of variance in outcomes for individual symptoms in the original cohort (circular analysis), as well as in the rank of depression outcomes in the independent validation cohort. Our approach represents an innovative concept for mapping changes along extensive score batteries to a few anatomical fiber bundles and could pave the way toward personalized deep brain stimulation.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age Differences in Brain Functional Connectivity Underlying Proactive Interference in Working Memory","authors":"P. Andersson,&nbsp;M. G. S. Schrooten,&nbsp;J. Persson","doi":"10.1002/hbm.70189","DOIUrl":"https://doi.org/10.1002/hbm.70189","url":null,"abstract":"<p>Aging is typically accompanied by a decline in working memory (WM) capacity, even in the absence of pathology. Proficient WM requires cognitive control processes that can retain goal-relevant information for easy retrieval and resolve interference from irrelevant information. Aging has been associated with a reduced ability to resolve proactive interference (PI) in WM, leading to impaired retrieval of goal-relevant information. It remains unclear how age-related differences in the ability to resolve PI in WM are related to patterns of resting-state functional connectivity (rsFC) in the brain. Here, we investigated the association between PI in WM and rsFC cross-sectionally (<i>n</i> = 237) and 5 years longitudinally (<i>n</i> = 134) across the adult life span by employing both seed-based and data-driven approaches. Results revealed that the ability to resolve PI was associated with differential patterns of inferior frontal gyrus (IFG) rsFC in younger/middle-aged adults (25–60 years) and older adults (65–80 years) in two clusters centered in the vermis and caudate. Specifically, more PI was associated with stronger inferior frontal gyrus—vermis connectivity and weaker inferior frontal gyrus—caudate connectivity in older adults, while younger/middle-aged adults showed associations in the opposite directions with the identified clusters. Longitudinal analyses revealed that a reduced ability to control PI was associated with reduced inferior frontal gyrus—insula and inferior frontal gyrus—anterior cingulate cortex connectivity in older adults, while younger/middle-aged adults showed associations in the opposite direction with these clusters. Whole brain multivariate pattern analyses showed age-differential patterns of rsFC indicative of age-related structural decline and age-related compensation. The current results show that rsFC is associated with the ability to control PI in WM and that these associations are modulated by age.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}