Hormones and Behavior最新文献_第5页

Effects of racial discrimination tasks on salivary cortisol reactivity among racially minoritized groups: A meta-analysis 种族歧视任务对少数种族群体唾液皮质醇反应的影响：一项荟萃分析

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-06 DOI: 10.1016/j.yhbeh.2025.105775

Anik Obomsawin , Samantha R. Pejic , Claudia Koziol

{"title":"Effects of racial discrimination tasks on salivary cortisol reactivity among racially minoritized groups: A meta-analysis","authors":"Anik Obomsawin , Samantha R. Pejic , Claudia Koziol","doi":"10.1016/j.yhbeh.2025.105775","DOIUrl":"10.1016/j.yhbeh.2025.105775","url":null,"abstract":"<div><h3>Rationale</h3><div>Racial discrimination can be specifically defined as the differential treatment of an individual or group based on their racial identity. Increasingly, the experience of racial discrimination is characterized as a social stressor that elicits physiological responses and increases the risk of poor health over the lifespan. However, recent attempts at synthesizing the literature surrounding racial discrimination and cortisol output, specifically, have produced mixed results. This is likely due to the inclusion of broad research designs (e.g., cross-sectional, experimental), measures of cortisol activity, and measures of racial discrimination.</div></div><div><h3>Objectives</h3><div>The primary goal of the current study was to apply a narrow lens to the synthesis of the racial discrimination and cortisol output literature. Specifically, by examining the association between acute racial discrimination and salivary cortisol reactivity, we aimed to demonstrate a clear pattern within the research area.</div></div><div><h3>Results</h3><div>Using five studies (composed of seven unique datasets; <em>N</em> = 650), we conducted a random effects model using the CMA software. Results indicate that racial discrimination stressors are associated with elevated acute cortisol levels (standard difference in means = 0.189, 95 % CI [0.083, 0.295]).</div></div><div><h3>Conclusion</h3><div>By approaching the literature with a narrow lens, this meta-analysis provides support for the association between acute experiences of racism and salivary cortisol reactivity. Findings also demonstrate a clear need for future research and highlight the influence of methodological decisions on synthesis efforts.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105775"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief 不是你母亲的激素疗法：高选择性雌激素受体激动剂作为新一代治疗更年期症状的疗法

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-06 DOI: 10.1016/j.yhbeh.2025.105773

Karyn M. Frick , Aaron W. Fleischer , Miranda R. Schwabe , Farah A. Abdelazim , Daniel S. Sem , William A. Donaldson

{"title":"Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief","authors":"Karyn M. Frick , Aaron W. Fleischer , Miranda R. Schwabe , Farah A. Abdelazim , Daniel S. Sem , William A. Donaldson","doi":"10.1016/j.yhbeh.2025.105773","DOIUrl":"10.1016/j.yhbeh.2025.105773","url":null,"abstract":"<div><div>Although the menopausal transition causes a panoply of unpleasant and disruptive symptoms, many women are reluctant to use estrogen-based treatments due to risks of cancer, cardiovascular disease, and stroke. As we learn more about how estrogens regulate the cellular and circuit mechanisms underlying menopausal symptoms such as hot flashes and brain fog, drug development that specifically targets these mechanisms could provide the therapeutic benefits of estrogens without adverse health effects. This review discusses the rationale for targeting estrogen receptor beta (ERß) with highly selective synthetic agonists to alleviate two common menopausal symptoms: memory dysfunction and hot flashes. We begin by reviewing the history of estrogen-based menopausal hormone therapy, including conjugated equine estrogens and related products. We then describe the neurobiological mechanisms underlying estrogenic regulation of memory and hot flashes, with a particular focus on the role of ERß. Finally, we discuss past and current clinical trials of ERß agonists and highlight pre-clinical data showing that a highly potent and selective synthetic ERß agonist can enhance object recognition and spatial memory, and reduce a drug-induced hot flash, in mouse models of ovarian hormone loss and Alzheimer's disease. Collectively, this work supports the targeted development of highly selective ERß agonists to relieve memory and vasomotor symptoms of menopause.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105773"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apelin-13 elicits lordosis behavior in female rats through the oxytocin/prostaglandin E2/GnRH signaling system Apelin-13通过催产素/前列腺素E2/GnRH信号系统诱导雌性大鼠前凸行为

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-04 DOI: 10.1016/j.yhbeh.2025.105774

Raymundo Domínguez-Ordóñez , Marcos García-Juárez , José Luis Encarnación-Sánchez , Berenice Téllez-Angulo , Jonathan Palafox-Moreno , Ailyn Luna-Hernández , James G. Pfaus , Oscar González-Flores

{"title":"Apelin-13 elicits lordosis behavior in female rats through the oxytocin/prostaglandin E2/GnRH signaling system","authors":"Raymundo Domínguez-Ordóñez , Marcos García-Juárez , José Luis Encarnación-Sánchez , Berenice Téllez-Angulo , Jonathan Palafox-Moreno , Ailyn Luna-Hernández , James G. Pfaus , Oscar González-Flores","doi":"10.1016/j.yhbeh.2025.105774","DOIUrl":"10.1016/j.yhbeh.2025.105774","url":null,"abstract":"<div><div>The present study investigated the role of the oxytocin (OT)/prostaglandin E2 (PGE2)/gonadotropin-releasing hormone (GnRH) and the progesterone receptor (PR) pathways in facilitating lordosis behavior induced by intrahypothalamic administration of 0.75 μg of apelin-13 in ovariectomized (OVX) rats primed with estradiol benzoate (EB). To explore this pathway, various inhibitors were administered bilaterally into the ventromedial hypothalamus (VMH) of EB-primed rats 30 min before the infusion of apelin-13. The inhibitors used included atosiban (ATO), an OT receptor antagonist; acetylsalicylic acid (aspirin), a cyclooxygenase-2 (COX-2) inhibitor; ONOAE3–208 (ONO), a PGE2 receptor antagonist; RU486, an antiprogestin for the PR; and antide, a GnRH-1 receptor antagonist. Apelin-13 at this dosage used, consistently induced lordosis at 30, 120, and 240 min post-infusion. The administration of atosiban, ONO, antide, and RU486, significantly reduced both the lordosis quotient (LQ) and lordosis reflex score (LS) at all assessed time points. In contrast, aspirin only decreased the LQ at 30 and 120 min, while the LS was reduced at all times tested. Because the OT/PGE2/GnRH pathway has been widely demonstrated in hypothalamic astrocytes as a regulator of GnRH release, it may also play a role in regulating female sexual behavior in estradiol-pretreated rats.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105774"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered regional gray matter in Congenital Adrenal Hyperplasia (CAH) 先天性肾上腺增生症（CAH）的局部灰质改变

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-04 DOI: 10.1016/j.yhbeh.2025.105766

Eileen Luders , Debra Spencer , Christian Gaser , Ajay Thankamony , Ieuan Hughes , Umasuthan Srirangalingam , Helena Gleeson , Melissa Hines , Florian Kurth

{"title":"Altered regional gray matter in Congenital Adrenal Hyperplasia (CAH)","authors":"Eileen Luders , Debra Spencer , Christian Gaser , Ajay Thankamony , Ieuan Hughes , Umasuthan Srirangalingam , Helena Gleeson , Melissa Hines , Florian Kurth","doi":"10.1016/j.yhbeh.2025.105766","DOIUrl":"10.1016/j.yhbeh.2025.105766","url":null,"abstract":"<div><div>Congenital Adrenal Hyperplasia (CAH) has been reported to present with gray matter aberrations, but further research is required as the results of existing studies are inconsistent. These inconsistences might be due to small sample sizes, differences in sample composition (some studies only included females), or the spatial scale of the analyses (some studies focused on selected regions of interest). Here we compiled the largest CAH sample to date comprising 33 women and 20 men matched to 33 control women and 20 control men on sex, age, education, and verbal intelligence. Gray matter was examined with a voxel-wise regional specificity across the entire brain, assessing the main effects of CAH and sex, and the CAH-by-sex interaction (the latter reflecting effects of prenatal androgen exposure). Individuals with CAH had significantly less gray matter compared to controls within the amygdala, calcarine cortex (specifically the primary visual area), and parahippocampal cortex (specifically the subiculum). There also was a main effect of sex, with more gray matter in females than males in medial frontal regions and more gray matter in males than females within the cerebellum. There was no CAH-by-sex interaction. Our findings indicate less regional gray matter in individuals with CAH, which seems to be caused by the medical condition itself and/or its treatment with glucocorticoids, rather than by elevated prenatal androgen exposure.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105766"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial ability, episodic memory, and emotion recognition in women with congenital adrenal hyperplasia or complete androgen insensitivity syndrome 先天性肾上腺增生或完全雄激素不敏感综合征女性的空间能力、情景记忆和情绪识别

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-28 DOI: 10.1016/j.yhbeh.2025.105747

Martin Asperholm , Anna Strandqvist , Henrik Falhammar , Karolina Frankling , Ida Åkerlund , Petri Laukka , Angelica Lindén Hirschberg , Anna Nordenström , Agneta Herlitz

{"title":"Spatial ability, episodic memory, and emotion recognition in women with congenital adrenal hyperplasia or complete androgen insensitivity syndrome","authors":"Martin Asperholm , Anna Strandqvist , Henrik Falhammar , Karolina Frankling , Ida Åkerlund , Petri Laukka , Angelica Lindén Hirschberg , Anna Nordenström , Agneta Herlitz","doi":"10.1016/j.yhbeh.2025.105747","DOIUrl":"10.1016/j.yhbeh.2025.105747","url":null,"abstract":"<div><div>Conditions like congenital adrenal hyperplasia (CAH) and complete androgen insensitivity syndrome (CAIS) may provide information contributing to the explanation of sex differences in cognition. Using online tests and questionnaires, we examined how prenatal androgen exposure and/or sex chromosomes influence spatial ability, episodic memory, and emotion recognition in women with classic CAH (C-CAH; <em>n</em> = 29), non-classic CAH (NC-CAH; <em>n</em> = 13), CAIS (<em>n</em> = 11), and female (<em>n</em> = 147) and male (<em>n</em> = 142) controls. Results showed that (1) female and male controls differed on most cognitive tasks, whereas (2) women with C-CAH or CAIS did not consistently differ from either female or male controls. Investigating the relative advantage on either the female (episodic memory, emotion recognition) or male-favoring tasks (spatial ability), indicated that women with (3) C-CAH had a cognitive profile that was different from female and male controls, (4) CAIS were not different from male controls, whereas (5) NC-CAH had a relative advantage on female-favoring tasks. These findings suggest that excessive prenatal androgen exposure (C-CAH) may shift cognitive performance toward a male-typical pattern, though not to the male level. Additionally, aspects associated with having 46,XY karyotype, but lacking prenatal androgen receptivity (CAIS) may also influence cognition in a male-typical direction, providing mixed support for the prenatal androgen hypothesis.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105747"},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apomorphine-induced disruption of paced mating behavior in female rats is attenuated by eticlopride, a D2 receptor antagonist, but not SCH 23390, a D1 receptor antagonist 阿波吗啡引起的雌性大鼠有节律性交配行为的破坏可以通过D2受体拮抗剂eticlopride而不是D1受体拮抗剂SCH 23390来减弱

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-28 DOI: 10.1016/j.yhbeh.2025.105765

Alexa A.H. Kong, Tyler R. Beasley, Han Jing F. Munson, Sarah H. Meerts

{"title":"Apomorphine-induced disruption of paced mating behavior in female rats is attenuated by eticlopride, a D2 receptor antagonist, but not SCH 23390, a D1 receptor antagonist","authors":"Alexa A.H. Kong, Tyler R. Beasley, Han Jing F. Munson, Sarah H. Meerts","doi":"10.1016/j.yhbeh.2025.105765","DOIUrl":"10.1016/j.yhbeh.2025.105765","url":null,"abstract":"<div><div>Dopamine is linked to sexual motivation and genital arousal in female rats. The present study investigated the effects of systemic apomorphine, a dopamine receptor-type 1 (D1) and -type 2 (D2) agonist, on no contact partner preference and paced mating behavior. Ovariectomized, hormone-primed, sexually experienced female rats received 80 μg/kg apomorphine or vehicle 10 min before a partner preference test followed immediately by a paced mating test (Experiment 1). Partner preference did not differ by treatment. However, apomorphine-treated rats exhibited significantly longer contact-return latencies to mounts, intromissions, and ejaculations, greater likelihood of withdrawal after mounts and intromissions, longer intervals between intromissions, reduced time with male, and fewer proceptive behaviors compared to rats receiving vehicle. To test whether effects of apomorphine on paced mating behavior were mediated primarily by D1 or D2 receptors, rats were pretreated with 25 μg/kg eticlopride, a D2 antagonist, or 25 μg/kg SCH 23390, a D1 antagonist, 10 min before receiving 80 μg/kg apomorphine. Rats were then tested for partner preference and paced mating as in Experiment 1. Eticlopride pretreatment attenuated effects of apomorphine; eticlopride → apomorphine-treated rats displayed significantly shorter contact-return latencies to intromission, reduced percentage of exit after mounts, shorter intervals between intromissions, decreased time with male, and more proceptive behaviors relative to saline → apomorphine-treated rats. Effects of apomorphine were not altered by SCH 23390 pretreatment. Apomorphine only affects sexual motivation when mating is possible, indicating that dopamine manipulation influences the physiology that supports behavioral response to sexual stimulation.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105765"},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frank Beach Award Winner: In pursuit of adventure: Studying social behavior in beautiful birds and odd rodents, as well as peering into the unknown 弗兰克海滩奖得主：追求冒险：研究美丽的鸟类和奇怪的啮齿动物的社会行为，以及窥视未知的事物

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-27 DOI: 10.1016/j.yhbeh.2025.105763

Aubrey M. Kelly

引用次数: 0

Corticosterone unlikely indicates departure readiness in migratory European robins 皮质酮不太可能表明迁徙的欧洲知更鸟准备好离开

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-27 DOI: 10.1016/j.yhbeh.2025.105764

Julia Loshchagina , Sergey Naidenko , Arseny Tsvey

{"title":"Corticosterone unlikely indicates departure readiness in migratory European robins","authors":"Julia Loshchagina , Sergey Naidenko , Arseny Tsvey","doi":"10.1016/j.yhbeh.2025.105764","DOIUrl":"10.1016/j.yhbeh.2025.105764","url":null,"abstract":"<div><div>During migration, birds must repeatedly decide when to terminate stopover and resume migratory flight. Such decisions greatly affect their overall migration success and, ultimately, fitness. Departure probability increases with higher levels of energy reserves, positive wind support and progression of the migration season. However, our knowledge of the endocrine mechanisms underlying this process is still incomplete. To evaluate the possible role of baseline corticosterone (CORT thereafter) in regulation of migratory departure, we analyzed the relationships between CORT levels and factors associated with departure probability in European robins (<em>Erithacus rubecula</em>) blood sampled at two nearby stopover sites during six autumn and six spring migration seasons. Contrary to predictions, in both migration seasons we observed higher CORT levels in lean birds, which are assumed to have low departure motivation. We found no indication that CORT concentrations increased in fat individuals captured around sunset, presumably shortly before departure. In parallel with departure likelihood, CORT levels increased towards the end of migration season in autumn, but there was no seasonal trend in spring, when motivation to continue migration is higher. Finally, CORT levels were positively related to tailwind component in autumn, whereas the opposite trend was observed in spring. In summary, our results provide mixed support for the hypothesis that CORT indicates departure readiness in songbirds. We propose that the observed relationships are more consistent with metabolic functions of CORT. Our study highlights the value of multiyear data and seasonal comparisons in studies of the endocrine regulation of such complex behaviors as departure decision.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105764"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles 一种催产素受体基因多态性与雄性草原田鼠交配时不同的神经反应有关

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-24 DOI: 10.1016/j.yhbeh.2025.105761

Lanikea B. King, Hasse Walum, Yao Xiao, Asha Y. Caslin, Fuad C. Haddad, Larry J. Young, Zachary V. Johnson

{"title":"An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles","authors":"Lanikea B. King, Hasse Walum, Yao Xiao, Asha Y. Caslin, Fuad C. Haddad, Larry J. Young, Zachary V. Johnson","doi":"10.1016/j.yhbeh.2025.105761","DOIUrl":"10.1016/j.yhbeh.2025.105761","url":null,"abstract":"<div><div>Oxytocin is a conserved neuropeptide that regulates social and reproductive behaviors in diverse species. Genetic variation in <em>Oxtr,</em> the gene encoding the oxytocin receptor (OXTR), is associated with variation in social attachment behaviors in rodents and humans; however, it is unclear how genetic variation in <em>Oxtr</em> shapes the function of specific neural systems during social contexts. Here we address this question using the socially monogamous prairie vole (<em>Microtus ochrogaster</em>), a species that expresses an array of OXTR-dependent social behaviors and possesses <em>Oxtr</em> gene polymorphisms that predict individual variation in brain region-specific OXTR expression. We test the neural and behavioral effects of an <em>Oxtr</em> gene polymorphism that has previously been associated with brain region-specific OXTR expression and social attachment behaviors in male prairie voles. Our results suggest that, during brief mating encounters, <em>Oxtr</em> genotype is not associated with differences in mating behavior or in expression levels of the activity-dependent immediate early gene product FOS within brain regions, but it is associated with differences in correlated FOS expression patterns across brain regions.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105761"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression, distribution, and function of sex hormone receptors in the rabbit brain 性激素受体在兔脑中的表达、分布和功能

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-05-21 DOI: 10.1016/j.yhbeh.2025.105762

Beatriz Molina , Gabriela González-Mariscal , Ignacio Camacho-Arroyo

{"title":"Expression, distribution, and function of sex hormone receptors in the rabbit brain","authors":"Beatriz Molina , Gabriela González-Mariscal , Ignacio Camacho-Arroyo","doi":"10.1016/j.yhbeh.2025.105762","DOIUrl":"10.1016/j.yhbeh.2025.105762","url":null,"abstract":"<div><div>Sex hormones such as estradiol, progesterone, and testosterone are crucial for vertebrate brain functions by interacting with their specific receptors. In rabbits, these hormones regulate sexual behavior, scent marking, nest building, and nipple searching across different brain regions. However, information on sex hormone receptors in the rabbit brain is limited. We examined intracellular progesterone (PR), estrogen (ER), and androgen receptors (AR) in the rabbit brain. PR activation by progesterone is associated with pregnancy and maternal behaviors like nest building and nipple searching. PR is expressed in female and male rabbits' cerebral cortex, hypothalamus, preoptic area, and hippocampus. In males, it is also found in the olfactory bulb, mesencephalon, and cerebellum. Rabbits express two ER subtypes, ERα and ERβ, with different expression patterns and functions. The former is in the amygdala, bed nucleus of the stria terminalis, hippocampus, hypothalamus, preoptic area, septum, and thalamus of females. In males, ERα is expressed in the hypothalamus, olfactory bulb, prefrontal cortex, preoptic area, mesencephalon, and cerebellum. Both ERs are located in male rabbits' amygdala, claustrum, and hippocampus. ERs influence estrous behavior and chinning. ERα has a role in rabbit hippocampus development and plasticity. AR is expressed in male rabbit hypothalamus, olfactory bulb, prefrontal cortex, hippocampus, preoptic area, mesencephalon, and cerebellum, related to sexual behavior and chinning.</div><div>Interestingly, sex hormones regulate their own receptor expression and those of other sex hormones. Thus, estradiol regulates PR expression. This review summarizes the expression and distribution of sex hormone receptors in the rabbit brain and their behavioral role.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105762"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0