Hormones and Behavior最新文献

Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans 人际感觉运动同步中的催产素动力学：人类对照实验

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-13 DOI: 10.1016/j.yhbeh.2025.105817

Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina

{"title":"Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans","authors":"Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina","doi":"10.1016/j.yhbeh.2025.105817","DOIUrl":"10.1016/j.yhbeh.2025.105817","url":null,"abstract":"<div><div>Interpersonal sensorimotor synchronisation is the coordination of movement between individuals that underlies successful interpersonal communication. Previous research has indicated the potential involvement of oxytocin (OXT) in the process of synchronisation.</div><div>We conducted 2 randomised controlled experiments to test the effect of synchronisation on salivary OXT concentrations. In Experiment 1, 90 volunteers (65 women) performed either synchronous or asynchronous a 5-min hand gesture task with an unfamiliar partner. In Experiment 2, 67 familiar dyads of volunteers (47 female dyads) performed the same task. Salivary OXT concentrations were measured before and after the gesture task (Experiment 1) or before, after and 10 min after the gesture task (Experiment 2). Saliva samples were analysed using the ELISA method to estimate OXT concentrations.</div><div>In Experiment 1, we found no significant differences between salivary OXT levels at baseline and after the 5-min task in either synchronous or asynchronous conditions. We also found no evidence for increased liking of a stranger after sensorimotor synchrony. In Experiment 2, the asynchronous condition led to a decrease in OXT levels over time, whereas synchronous interactions led to stable OXT levels over time. The effect of condition on OXT was not moderated by closeness or attachment style. The results are discussed in relation to research methodology used to study interpersonal synchrony.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105817"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in steroid hormone levels based on a plastic behavioral role in two biparental cichlids, Julidochromis transcriptus and Julidochromis marlieri: A test of the Ancestral Modulation Hypothesis 基于可塑性行为作用的两种双亲本稚鱼（转录稚鱼和玛利稚鱼）类固醇激素水平变化：祖先调节假说的检验

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105820

A.P. Anderson, F. Noble, W. Cantlon, S.C.P. Renn

{"title":"Changes in steroid hormone levels based on a plastic behavioral role in two biparental cichlids, Julidochromis transcriptus and Julidochromis marlieri: A test of the Ancestral Modulation Hypothesis","authors":"A.P. Anderson, F. Noble, W. Cantlon, S.C.P. Renn","doi":"10.1016/j.yhbeh.2025.105820","DOIUrl":"10.1016/j.yhbeh.2025.105820","url":null,"abstract":"<div><div>Cross-sexual transfer describes the situation when one sex takes on the phenotypic values of the other sex, either plastically or over evolutionary time. The underlying regulatory mechanisms of this process have been generally assumed to be related to sex-biased hormonal regulation, but explicit empirical tests have not been conducted. More recently, the Ancestral Modulation Hypothesis (AMH) has been proposed as a framework to understand the hormonal regulation that underlies cross-sexual transfer. We leverage the behavioral changes in two species of biparental cichlid, <em>Julidochromis transcriptus</em> and <em>Julidochromis marlieri</em>, to test hormonal changes when cross-sexual transfer occurs and provide an empirical test of the AMH. One species, <em>J. transcriptu</em>s, typically forms male-larger pairs, which is generally considered to be the ancestral condition; yet females take on male behaviors when they are the larger individual in the pair. The other species, <em>J. marlieri</em>, typically forms female-larger pairs, a cross-sexual transfer, but can likewise shift behaviors when paired atypically. We established pairs by giving males and females of both species both larger and smaller partners and measured behavioral and hormonal changes. We found <em>J. transcriptus</em> females increased 11-ketotestorerone (11-KT) when becoming the larger partner and 11-KT and estradiol (E2) correlated with behaviors associated with the larger partner. We did not find any changes in hormone levels based on size or sex in <em>J. marlieri</em>, though behaviors did correlate with testosterone (T). These results provide qualified support for the tested prediction from the AMH framework that cross-sexual transfer can occur by coopting hormonal signaling by adjusting circulating hormones.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105820"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of oxytocin in enhancing group-based guilt and promoting intergroup reconciliation in a collectivist context 在集体主义背景下，催产素在增强群体内疚和促进群体间和解中的作用

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105819

Zhiai Li , Mengsi Xu , Shiyao Huang , An Yang

{"title":"The role of oxytocin in enhancing group-based guilt and promoting intergroup reconciliation in a collectivist context","authors":"Zhiai Li , Mengsi Xu , Shiyao Huang , An Yang","doi":"10.1016/j.yhbeh.2025.105819","DOIUrl":"10.1016/j.yhbeh.2025.105819","url":null,"abstract":"<div><div>Group-based guilt, arising from the awareness of harmful or immoral actions committed by fellow group members, is a powerful negative emotion. It motivates various forms of reparative behavior which mitigates the intergroup conflicts. However, the widespread expression of group-based guilt remains relatively infrequent. Therefore, how to enhance the utility of group-based guilt remains a paramount issue in the field of intergroup conflict. Oxytocin is widely recognized for its pivotal role in positively influencing social cognition and behavior. Consequently, our research aimed to investigate the potential modulation of oxytocin on group-based guilt by examining whether oxytocin enhances group-based responsibility, guilt and compensation within a collectivist cultural context. To achieve this, we conducted a double-blind, placebo-controlled experimental design: 2 (Treatment: Placebo vs. Oxytocin) × 2 (Group membership: In-group vs. Out-group). The results showed that the administration of oxytocin could enhance group-based responsibility, guilt, and compensation. In conclusion, the study of oxytocin and group-based guilt highlights the potential role of biological processes in shaping social emotions and cognition, then enhancing altruistic behavior toward the victimized group and moderating intergroup relations.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105819"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal contraceptive use in relation to basal and reactive testosterone, DHEAS, and cortisol 激素避孕药的使用与基础和反应性睾酮，DHEAS和皮质醇的关系

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-29 DOI: 10.1016/j.yhbeh.2025.105806

Kathleen V. Casto , Sally Farah , Ariel Castro , Modupe Akinola , Pranjal H. Mehta

{"title":"Hormonal contraceptive use in relation to basal and reactive testosterone, DHEAS, and cortisol","authors":"Kathleen V. Casto , Sally Farah , Ariel Castro , Modupe Akinola , Pranjal H. Mehta","doi":"10.1016/j.yhbeh.2025.105806","DOIUrl":"10.1016/j.yhbeh.2025.105806","url":null,"abstract":"<div><div>A burgeoning area of research has begun to uncover a wide range of potential neurological and psychological correlates of hormonal contraceptive (HC) use. Yet there remains a limited understanding of the underlying mechanisms for how HC use alters aspects of neurobiology and related behavioral outcomes. Uncovering these processes has the potential for new discovery in the field of behavioral neuroendocrinology, particularly in the complex interplay between steroid hormone subclasses. Although prior research has often focused on the effects of HC use on progestogen and estrogen disruption, basal and reactive androgens and cortisol may also be significantly impacted by HC use and serve critical functions throughout the brain and body. We discuss important background information on the synthesis and function of three steroid hormones – testosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol, review prior research showing how HC use is related to circulating (basal) and reactive levels, and provide sample data on salivary levels from our own research. The combined evidence shows that HC use, specifically of the OC pill, is associated with significantly reduced total, free, and salivary androgens, increased total cortisol in blood but not saliva, and a blunted salivary cortisol response to social stressors. Limited evidence provides initial indication that the specific estrogen and progestin compounds in HC formulas may differentially impact steroid hormone levels. Finally, we discuss the mechanisms by which HCs alter steroid hormone levels, the potential implications of these effects on brain and behavior outcomes, and considerations for future research.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105806"},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational effects of maternal androgens on vocal ontogeny and developmental plasticity in a cooperatively breeding mammal 雌性雄激素对合作繁殖哺乳动物发声个体发育和发育可塑性的代际影响

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-20 DOI: 10.1016/j.yhbeh.2025.105814

Britta Walkenhorst , Ines Braga Goncalves , Christine M. Drea , Marta B. Manser

{"title":"Intergenerational effects of maternal androgens on vocal ontogeny and developmental plasticity in a cooperatively breeding mammal","authors":"Britta Walkenhorst , Ines Braga Goncalves , Christine M. Drea , Marta B. Manser","doi":"10.1016/j.yhbeh.2025.105814","DOIUrl":"10.1016/j.yhbeh.2025.105814","url":null,"abstract":"<div><div>Developmental plasticity, the ability to adapt one's phenotype to environmental cues, is crucial during early-life stages and can affect fitness. Despite significant androgenic variation between females of select species, the impact of maternal hormones on offspring ontogeny in wild mammals has been rarely investigated. Here, we rely on natural and experimentally induced variation in androgen action between dominant and subordinate female meerkats, <em>Suricata suricatta</em>, to examine plasticity of vocal development in their offspring. Meerkats are cooperatively breeding mongooses that have a rich vocal repertoire. We recorded calls produced at distinct developmental stages by offspring from dominant and subordinate control mothers that naturally differ in absolute androgen concentrations and from dominant treated mothers that had received an androgen-receptor blocker in late gestation. Using call types as indicators, we found that the offspring of dominant control mothers had a robust vocal trajectory, even under adverse environmental conditions; following full nutritional dependence, their vocal development was accelerated relative to that of other offspring. Conversely, offspring from both subordinate control and dominant antiandrogen treated mothers suffered ontogenetic delays; they showed distinct sex differences in trajectory and a greater sensitivity to socio-ecological influences. Antiandrogen-exposed offspring also showed atypical early call usage. These findings provide rare evidence of the potential for maternal androgens to mediate mammalian offspring development in accordance with demands of the socio-ecological environment.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105814"},"PeriodicalIF":2.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal intrauterine device use is related to mental rotations but not verbal memory skills 激素宫内节育器的使用与心理旋转有关，但与语言记忆能力无关

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-18 DOI: 10.1016/j.yhbeh.2025.105804

Ran Yan, Christel Portengen, T. Ariel Yang, Gwyneth Reece, Zoe Dunnum, Esmeralda Hidalgo-Lopez, Adriene M. Beltz

{"title":"Hormonal intrauterine device use is related to mental rotations but not verbal memory skills","authors":"Ran Yan, Christel Portengen, T. Ariel Yang, Gwyneth Reece, Zoe Dunnum, Esmeralda Hidalgo-Lopez, Adriene M. Beltz","doi":"10.1016/j.yhbeh.2025.105804","DOIUrl":"10.1016/j.yhbeh.2025.105804","url":null,"abstract":"<div><div>There is perennial public and scientific interest in the neuroendocrine mechanisms underlying the large gender difference in three-dimensional (3D) mental rotation skills (favoring men) and small-to-moderate difference in verbal memory (favoring women). Past research has linked androgenic progestins in oral contraceptives to enhanced spatial skills, particularly 3D mental rotations, and estradiol to enhanced verbal memory skills. Hormonal intrauterine devices (IUDs) contain an androgenic progestin (i.e., levonorgestrel) without synthetic estradiol, but there is little-to-no systematic research on the cognitive impacts of use. The current study filled this knowledge gap in a sample of 343 participants (<em>M</em><sub>age</sub> = 21.75, <em>SD</em> <em>=</em> 4.52; 57.0 % White; 84.8 % non-Latine), comparing 50 hormonal IUD users to 135 naturally cycling (NC) females who were not menstruating and to 158 males. Compared to NC females, IUD users had better 3D mental rotation performance, but similar verbal memory. Compared to males, IUD users had similar 3D mental rotations performance, but better verbal memory. Group differences were generally moderate in size, and the pattern of results persisted when both age and general cognitive ability were covaried. Findings in IUD users are consistent with hypotheses, evidencing a potential and selective impact of exogenous androgenic progestin exposure on spatial cognition, and no effects on verbal memory, as expected given the preservation of endogenous ovarian hormone function that is not suppressed as it is in other hormonal contraceptives (e.g., oral).</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105804"},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What do we measure when we measure pubertal development? Conceptual challenges in measuring and interpreting pubertal effects on brain and behavior 当我们测量青春期发育时，我们测量的是什么？测量和解释青春期对大脑和行为影响的概念挑战

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-14 DOI: 10.1016/j.yhbeh.2025.105803

Thiago F.A. França , Hugo Cogo-Moreira , Sabine Pompeia

{"title":"What do we measure when we measure pubertal development? Conceptual challenges in measuring and interpreting pubertal effects on brain and behavior","authors":"Thiago F.A. França , Hugo Cogo-Moreira , Sabine Pompeia","doi":"10.1016/j.yhbeh.2025.105803","DOIUrl":"10.1016/j.yhbeh.2025.105803","url":null,"abstract":"<div><div>Pubertal development is believed to influence cognitive and behavioral development during adolescence, but measuring puberty is challenging. Difficulties stem not only from practical issues, which have been extensively discussed in the literature, but also from the inherent complexity of pubertal development from a physiological perspective. Here we discuss conceptual issues related to measuring and interpreting pubertal effects on brain, cognitive, and behavioral development. Our analysis shows that all currently used measures, both those based on the assessment of external physical characteristics and those based on measuring relevant hormones form biological samples, share significant limitations that hinder their interpretation. These limitations arise from the fact that puberty is not a unitary phenomenon, cannot be measured directly nor be defined by individual makers, and its different markers are often discordant. Moreover, its effects on brain development, cognition, and behavior are bound to involve a complex causal thicket, requiring an integrative assessment of pubertal development. We argue that a possible compromise between practical issues (building feasible/reliable measures) and theoretical ones (building conceptually sound and interpretable measures) is to treat puberty as the variance shared among multiple pubertal indicators, combining physical markers and hormonal measures.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105803"},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion regulation strategies differentially impact memory in hormonal contraceptive users 情绪调节策略对激素避孕药使用者记忆的影响存在差异

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-14 DOI: 10.1016/j.yhbeh.2025.105805

Beatriz M. Brandao , Madelyn Castro , Jacob B. Buergler , Kayla R. Clark , Bryan T. Denny , Stephanie L. Leal

{"title":"Emotion regulation strategies differentially impact memory in hormonal contraceptive users","authors":"Beatriz M. Brandao , Madelyn Castro , Jacob B. Buergler , Kayla R. Clark , Bryan T. Denny , Stephanie L. Leal","doi":"10.1016/j.yhbeh.2025.105805","DOIUrl":"10.1016/j.yhbeh.2025.105805","url":null,"abstract":"<div><div>Hormonal contraceptives (HCs) are widely used, yet their effects on emotional and cognitive processes remain poorly understood. This study examined how HC use may influence emotional reactivity, emotion regulation, and emotional memory. Female participants (<em>N</em> = 179), either using HCs (<em>N</em> = 87) or naturally cycling (NC; <em>N</em> = 92), were randomly assigned to one of three groups: no emotion regulation (control), distancing and immersion, or reinterpretation and immersion. The emotion regulation groups completed emotion regulation training in which they viewed emotional images while applying different emotion regulation strategies, followed by a surprise memory test. Overall, HC users showed greater emotional reactivity to emotional images compared to NC participants. Both HC and NC groups successfully applied emotion regulation strategies as measured by changes in emotional affect; however, distancing led to a greater reduction in negative emotions compared to reinterpretation, particularly among HC users. Both HC and NC groups showed better memory for positive images after applying immersion. For negative images, HC users showed reduced memory performance when applying either distancing or reinterpretation, an effect not observed in NC participants. These findings suggest that HC use may influence specific aspects of emotional processing and memory, highlighting the need for more nuanced research on the cognitive and emotional effects of hormonal contraceptives.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105805"},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy modulates responses to male odors in house mice. 怀孕调节家鼠对雄性气味的反应。

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-08 DOI: 10.1016/j.yhbeh.2025.105802

Caitlin H Miller, Tess M Reichard, Jay Yang, Brandon Carlson-Clarke, Caleb C Vogt, Melissa R Warden, Michael J Sheehan

{"title":"Pregnancy modulates responses to male odors in house mice.","authors":"Caitlin H Miller, Tess M Reichard, Jay Yang, Brandon Carlson-Clarke, Caleb C Vogt, Melissa R Warden, Michael J Sheehan","doi":"10.1016/j.yhbeh.2025.105802","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2025.105802","url":null,"abstract":"<p><p>Pregnancy induces widespread physiological and behavioral changes, yet its impact on social decision-making remains poorly understood. Here, we show that reproductive status modulates female responses to male odors in house mice, revealing striking status-specific behavioral patterns. Estrous females displayed attraction to novel male odors, consistent with a motivation to mate. In contrast, pregnant females exhibited strong aversion - an anticipatory shift likely aimed at avoiding future infanticidal males. This status-dependent approach-avoidance response was recapitulated to the male urinary pheromone darcin, highlighting its robustness as a male signal. These findings suggest that reproductive status modulates odor-driven decision-making, balancing mating opportunities with offspring protection. This shift is likely mediated by hormonal fluctuations such as rising progesterone and estrogen, that act on neural circuits involved in olfaction, threat detection, and social motivation. Behavioral responses were further shaped by the richness and context of social odors, supporting combinatorial processing of urinary pheromones. This aligns with mechanisms such as stud odor imprinting and self-referential matching for inbreeding avoidance. Overall, our results point to anticipatory behavioral adaptations during pregnancy that prepare females for the challenges of motherhood.</p>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"105802"},"PeriodicalIF":2.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tectal CRF receptors modulate the behavioral response of Xenopus laevis to live prey but not visual prey cues. 皮层CRF受体调节非洲爪蟾对活体猎物的行为反应，而不是视觉猎物线索。

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-06 DOI: 10.1016/j.yhbeh.2025.105801

Breanna N Harris, Christine M Prater, Ryann Lockwood, Allison Kennedy, M Ghufran Murtuza, James A Carr

{"title":"Tectal CRF receptors modulate the behavioral response of Xenopus laevis to live prey but not visual prey cues.","authors":"Breanna N Harris, Christine M Prater, Ryann Lockwood, Allison Kennedy, M Ghufran Murtuza, James A Carr","doi":"10.1016/j.yhbeh.2025.105801","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2025.105801","url":null,"abstract":"<p><p>Tradeoffs between feeding and defensive behaviors are critical for survival, but their physiological underpinnings are not well known. Here, we investigate how a satiety peptide, corticotropin-releasing factor (CRF), acts within a novel location, the visual system (the optic tectum, OT), to modulate multisensory prey detection and the microstructure of feeding behavior. The OT has CRF-producing interneurons and CRF receptors, threat exposure increases OT CRF concentrations, and that CRF acts on receptors in the OT to decrease feeding behavior. We hypothesized that CRF in the OT may impact visual, lateral line, and/or multiple sensory processing to alter feeding. We predicted that OT CRF decreases responses to 1) a purely visual prey cue and 2) a live, multisensory prey item. We microinjected one of four doses of CRF bilaterally into the tecta of newly metamorphosed Xenopus laevis. We then exposed frogs to visual prey cues and then to live, multi-sensory prey (worms). We repeated the behavioral assays after 72 h to determine if any effects were long-lasting. Overall, frogs robustly responded to live and visual prey cues. CRF did not alter behavioral responses to the visual prey cues but did decrease select prey-capture behaviors and increase select avoidance-like behaviors following exposure to live prey. Our results suggest visual processing is not the primary sensory modality impacted by tectal CRF. These data provide a novel (i.e., extrahypothalamic) location for satiety peptide action and link neuroendocrine responses to ecological context of feed/flee tradeoffs.</p>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"105801"},"PeriodicalIF":2.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0