Hormones and Behavior最新文献_第10页

Longitudinal changes in sexual desire and attraction among women who started using the Natural Cycles app 开始使用 "自然周期 "应用程序的女性在性欲和吸引力方面的纵向变化

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-18 DOI: 10.1016/j.yhbeh.2024.105546

Jeffrey Gassen , Summer Mengelkoch , Divya Shanmugam , Jack T. Pearson , Agathe van Lamsweerde , Eleonora Benhar , Sarah E. Hill

{"title":"Longitudinal changes in sexual desire and attraction among women who started using the Natural Cycles app","authors":"Jeffrey Gassen , Summer Mengelkoch , Divya Shanmugam , Jack T. Pearson , Agathe van Lamsweerde , Eleonora Benhar , Sarah E. Hill","doi":"10.1016/j.yhbeh.2024.105546","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105546","url":null,"abstract":"<div><p>Many women experience sexual side effects, such as decreased libido, when taking hormonal contraceptives (HCs). However, little is known about the extent to which libido recovers after discontinuing HCs, nor about the timeframe in which recovery is expected to occur. Given that HCs suppress the activities of multiple endogenous hormones that regulate both the ovulatory cycle and women's sexual function, resumption of cycles should predict libido recovery. Here, using a combination of repeated and retrospective measures, we examined changes in sexual desire and partner attraction (among partnered women) across a three-month period in a sample of Natural Cycles users (Survey 1: <em>n</em> = 1596; Survey 2: <em>n</em> = 550) who recently discontinued HCs. We also tested whether changes in these outcomes coincided with resumption of the ovulatory cycle and whether they were associated with additional factors related to HC use (e.g., duration of HC use) or relationship characteristics (e.g., relationship length). Results revealed that both sexual desire and partner attraction, on average, increased across three months after beginning to use Natural Cycles. While the prediction that changes in sexual desire would co-occur with cycle resumption was supported, there was also evidence that libido continued to increase even after cycles resumed. Together, these results offer new insights into relationships between HC discontinuation and women's sexual psychology and lay the groundwork for future research exploring the mechanisms underlying these effects.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105546"},"PeriodicalIF":3.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24000710/pdfft?md5=581c84ca7962c0f31d48e5f4173b3e27&pid=1-s2.0-S0018506X24000710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovulatory cycle shifts in human motivational prioritisation of sex and food 人类性与食物动机优先顺序的排卵周期变化

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-17 DOI: 10.1016/j.yhbeh.2024.105542

Lara Schleifenbaum , Julia Stern , Julie C. Driebe , Larissa L. Wieczorek , Tanja M. Gerlach , Ruben C. Arslan , Lars Penke

{"title":"Ovulatory cycle shifts in human motivational prioritisation of sex and food","authors":"Lara Schleifenbaum , Julia Stern , Julie C. Driebe , Larissa L. Wieczorek , Tanja M. Gerlach , Ruben C. Arslan , Lars Penke","doi":"10.1016/j.yhbeh.2024.105542","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105542","url":null,"abstract":"<div><p>Previous research on the endogenous effects of ovarian hormones on motivational states in women has focused on sexual motivation. The Motivational Priority Shifts Hypothesis has a broader scope. It predicts a shift from somatic to reproductive motivation when fertile. In a highly powered preregistered online diary study across 40 days, we tested whether 390 women report such an ovulatory shift in sexual and eating motivation and behaviour. We compared 209 naturally cycling women to 181 women taking hormonal contraceptives (HC) to rule out non-ovulatory changes across the cycle as confounders. We found robust ovulatory decreases in food intake and increases in general sexual desire, in-pair sexual desire and initiation of dyadic sexual behaviour. Extra-pair sexual desire increased mid-cycle, but the effect did not differ significantly in HC women, questioning an ovulatory effect. Descriptively, solitary sexual desire and behaviour, dyadic sexual behaviour, appetite, and satiety showed expected mid-cycle changes that were diminished in HC women, but these failed to reach our strict preregistered significance level. Our results provide insight into current theoretical debates about ovulatory cycle shifts while calling for future research to determine motivational mechanisms behind ovulatory changes in food intake and considering romantic partners' motivational states to explain the occurrence of dyadic sexual behaviour.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105542"},"PeriodicalIF":3.5,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24000679/pdfft?md5=034f5e16ff1dbdee809c84b158e1bc22&pid=1-s2.0-S0018506X24000679-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid hormone deficiency affects anxiety-related behaviors and expression of hippocampal glutamate transporters in male congenital hypothyroid rat offspring 甲状腺激素缺乏会影响雄性先天性甲状腺功能减退大鼠后代的焦虑相关行为和海马谷氨酸转运体的表达

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-17 DOI: 10.1016/j.yhbeh.2024.105548

Zohreh Zare , Sakineh Shafia , Moslem Mohammadi

{"title":"Thyroid hormone deficiency affects anxiety-related behaviors and expression of hippocampal glutamate transporters in male congenital hypothyroid rat offspring","authors":"Zohreh Zare , Sakineh Shafia , Moslem Mohammadi","doi":"10.1016/j.yhbeh.2024.105548","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105548","url":null,"abstract":"<div><p>Thyroid hormones are crucial for brain development and their deficiency during fetal and postnatal periods can lead to mood and cognitive disorders. We aimed to examine the consequences of thyroid hormone deficiency on anxiety-related behaviors and protein expression of hippocampal glutamate transporters in congenital hypothyroid male offspring rats. Possible beneficial effects of treadmill exercise have also been examined. Congenital hypothyroidism was induced by adding propylthiouracil (PTU) to drinking water of pregnant Wistar rats from gestational day 6 until the end of the weaning period (postnatal day 28). Next, following 4 weeks of treadmill exercise (5 days per week), anxiety-related behaviors were examined using elevated plus maze (EPM) and light/dark box tests. Thereafter, protein expression of astrocytic (GLAST and GLT-1) and neuronal (EAAC1) glutamate transporters were measured in the hippocampus by immunoblotting. Hypothyroid rats showed decreased anxiety-like behavior, as measured by longer time spent in the open arms of the EPM and in the light area of the light/dark box, compared to control rats. Hypothyroid rats had significantly higher GLAST and GLT-1 and lower EAAC1 protein levels in the hippocampus than did the euthyroid rats. Following exercise, anxiety levels decreased in the euthyroid group while protein expression of EAAC1 increased and returned to normal levels in the hypothyroid group. Our findings indicate that thyroid hormone deficiency was associated with alterations in protein expression of glutamate transporters in the hippocampus. Up-regulation of hippocampal GLAST and GLT-1 could be at least one of the mechanisms associated with the anxiolytic effects of congenital hypothyroidism.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105548"},"PeriodicalIF":3.5,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social niche shapes social behavior and cortisol concentrations during adolescence in female guinea pigs 社会生态位影响雌性豚鼠青春期的社会行为和皮质醇浓度

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-11 DOI: 10.1016/j.yhbeh.2024.105539

Taylor L. Rystrom, S. Helene Richter, Norbert Sachser, Sylvia Kaiser

{"title":"Social niche shapes social behavior and cortisol concentrations during adolescence in female guinea pigs","authors":"Taylor L. Rystrom, S. Helene Richter, Norbert Sachser, Sylvia Kaiser","doi":"10.1016/j.yhbeh.2024.105539","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105539","url":null,"abstract":"<div><p>Individualized social niches arise in social groups, resulting in divergent social behavior profiles among group members. During sensitive life phases, the individualized social niche can profoundly impact the development of social behavior and associated phenotypes such as hormone (e.g. cortisol) concentrations. Focusing on adolescence, we investigated the relationship between the individualized social niche, social behavior, and cortisol concentrations (baseline and responsiveness) in female guinea pigs. Females were pair-housed in early adolescence (initial social pair formation), and a social niche transition was induced after six weeks by replacing the partner with either a larger or smaller female. Regarding social behavior, dominance status was associated with aggression in both the initial social pairs and after the social niche transition, and the results suggest that aggression was rapidly and completely reshaped after the social niche transition. Meanwhile, submissive behavior was rapidly reshaped after the social niche transition, but this was incomplete. The dominance status attained in the initial social pair affected the extent of submissive behavior after the social niche transition, and this effect was still detected three weeks after the social niche transition. Regarding cortisol concentrations, higher baseline cortisol concentrations were measured in dominant females in the initial social pairs. After the social niche transition, cortisol responsiveness significantly increased for the females paired with a larger, older female relative to those paired with a smaller, younger female. These findings demonstrate that the social niche during adolescence plays a significant role in shaping behavior and hormone concentrations in females.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105539"},"PeriodicalIF":3.5,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24000643/pdfft?md5=6da61779df9857f77d95d410915cdc1b&pid=1-s2.0-S0018506X24000643-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in responses to aggressive encounters among California mice 加州小鼠对攻击性遭遇反应的性别差异

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-06 DOI: 10.1016/j.yhbeh.2024.105537

Jace X. Kuske, Alexandra Serna Godoy, Alison V. Ramirez, Brian C. Trainor

{"title":"Sex differences in responses to aggressive encounters among California mice","authors":"Jace X. Kuske, Alexandra Serna Godoy, Alison V. Ramirez, Brian C. Trainor","doi":"10.1016/j.yhbeh.2024.105537","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105537","url":null,"abstract":"<div><p>Despite how widespread female aggression is across the animal kingdom, there remains much unknown about its neuroendocrine mechanisms, especially in females that engage in aggression outside the peripartum period. Although the impact of aggressive experience on steroid hormone responses have been described, little is known about the impact of these experiences on female behavior or the subsequent neuropeptide responses to performing aggression. In this study, we compared behavioral responses in both male and female adult California mice based on if they had 0, 1, or 3 aggressive encounters using a resident intruder paradigm. We measured how arginine vasopressin and oxytocin cells in the paraventricular nucleus responded to aggression using c-fos immunohistochemistry. We saw that both sexes disengaged from intruders with repeated aggressive encounters, but that on the final day of testing females were more likely to freeze when they encountered intruders compared to no aggression controls – which was not significant in males. Finally, we saw that percent of arginine vasopressin and c-fos co-localizations in the posterior region of the paraventricular nucleus increased in males who fought compared to no aggression controls. No difference was observed in females. Overall, there is evidence that engaging in aggression induces stress responses in both sexes, and that females may be more sensitive to the effects of fighting.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105537"},"PeriodicalIF":3.5,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generalization of a positive-feature interoceptive morphine occasion setter across the rat estrous cycle 在大鼠发情周期中普遍推广具有积极特征的内感知吗啡场合设定器

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-06 DOI: 10.1016/j.yhbeh.2024.105541

Davin R. Peart , Ella V. Claridge , Jessica M. Karlovcec , Rita El Azali , Kathleen E. LaDouceur , Anita Sikic , Abina Thomas , Adiia P. Stone , Jennifer E. Murray

{"title":"Generalization of a positive-feature interoceptive morphine occasion setter across the rat estrous cycle","authors":"Davin R. Peart , Ella V. Claridge , Jessica M. Karlovcec , Rita El Azali , Kathleen E. LaDouceur , Anita Sikic , Abina Thomas , Adiia P. Stone , Jennifer E. Murray","doi":"10.1016/j.yhbeh.2024.105541","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105541","url":null,"abstract":"<div><h3>Introduction</h3><p>Interoceptive stimuli elicited by drug administration acquire conditioned modulatory properties of the induction of conditioned appetitive behaviours by exteroceptive cues. This effect may be modeled using a drug discrimination task in which the drug stimulus is trained as a positive-feature (FP) occasion setter (OS) that disambiguates the relation between an exteroceptive light conditioned stimulus (CS) and a sucrose unconditioned stimulus (US). We previously reported that females are less sensitive to generalization of a FP morphine OS than males, so we investigated the role of endogenous ovarian hormones in this difference.</p></div><div><h3>Methods</h3><p>Male and female rats received intermixed injections of 3.2 mg/kg morphine or saline before each daily training session. Training consisted of 8 presentations of the CS, each followed by access to sucrose on morphine, but not saline sessions. Following acquisiton, rats were tested for generalization of the morphine stimulus to 0, 1.0, 3.2, and 5.4 mg/kg morphine. Female rats were monitored for estrous cyclicity using vaginal cytology throughout the study.</p></div><div><h3>Results</h3><p>Both sexes acquired stable drug discrimination. A gradient of generalization was measured across morphine doses and this behaviour did not differ by sex, nor did it differ across the estrous cycle in females.</p></div><div><h3>Conclusions</h3><p>Morphine generalization is independent of fluctuations in levels of sex and endogenous gonadal hormones in females under these experimental conditions.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105541"},"PeriodicalIF":3.5,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the combination of chronic unpredictable stress and environmental enrichment on anxiety-like behavior assessed using the elevated plus maze in Swiss male mice: Hypothalamus-Pituitary-Adrenal Axis-mediated mechanisms 利用高架加迷宫评估慢性不可预测应激和环境富集对瑞士雄性小鼠焦虑样行为的影响：下丘脑-垂体-肾上腺轴介导的机制

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-04-04 DOI: 10.1016/j.yhbeh.2024.105538

Ariadne Elisa Belo-Silva , Nivea Karla de Gusmão Taveiros Silva , Priscila Marianno , Gabriel de Araújo Costa , Veridiana Petenati da Rovare , Alexis Bailey , Carolina Demarchi Munhoz , Leonardo Santana Novaes , Rosana Camarini

{"title":"Effects of the combination of chronic unpredictable stress and environmental enrichment on anxiety-like behavior assessed using the elevated plus maze in Swiss male mice: Hypothalamus-Pituitary-Adrenal Axis-mediated mechanisms","authors":"Ariadne Elisa Belo-Silva , Nivea Karla de Gusmão Taveiros Silva , Priscila Marianno , Gabriel de Araújo Costa , Veridiana Petenati da Rovare , Alexis Bailey , Carolina Demarchi Munhoz , Leonardo Santana Novaes , Rosana Camarini","doi":"10.1016/j.yhbeh.2024.105538","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105538","url":null,"abstract":"<div><p>Environmental enrichment (EE) is a paradigm that offers the animal a plethora of stimuli, including physical, cognitive, sensory, and social enrichment. Exposure to EE can modulate both anxiety responses and plasma corticosterone. In this study, our objective was to explore how chronic unpredictable stress (CUS) impacts anxiety-related behaviors in male Swiss mice raised in EE conditions. Additionally, we investigated corticosterone and adrenocorticotropic hormone (ACTH) levels to assess the involvement of the hypothalamic-pituitary-adrenal (HPA) axis in mediating these responses. Mice were housed under either EE or standard housing conditions for 21 days. Afterward, they were exposed to 11 days of CUS while still reared in their distinct housing conditions, with half of the mice receiving daily pretreatment with the vehicle and the other half receiving daily metyrapone (MET) injections, an inhibitor of steroid synthesis, 30 mins before CUS exposure. Blood samples were obtained to assess plasma corticosterone and ACTH levels. The 11-day CUS protocol induced anxiety-like phenotype and elevated ACTH levels in EE mice. Chronic MET pretreatment prevented anxiety-like behavior in the EE-CUS groups, by mechanisms involving increased plasma corticosterone levels and decreased ACTH. These results suggest a role of the HPA axis in the mechanism underlying the anxiogenic phenotype induced by CUS in EE mice and shed light on the complex interplay between environmental factors, stress, and the HPA axis in anxiety regulation.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105538"},"PeriodicalIF":3.5,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140345003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of paternal deprivation on empathetic behavior and the involvement of oxytocin receptors in the anterior cingulate cortex 父爱剥夺对移情行为的影响以及前扣带回皮层催产素受体的参与

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-03-23 DOI: 10.1016/j.yhbeh.2024.105536

Wenjuan Hou , Huan Ma , Caihong Huang , Yin Li , Lu Li , Lizi Zhang , Yishan Qu , Yufeng Xun , Qixuan Yang , Zhixiong He , Fadao Tai

{"title":"Effects of paternal deprivation on empathetic behavior and the involvement of oxytocin receptors in the anterior cingulate cortex","authors":"Wenjuan Hou , Huan Ma , Caihong Huang , Yin Li , Lu Li , Lizi Zhang , Yishan Qu , Yufeng Xun , Qixuan Yang , Zhixiong He , Fadao Tai","doi":"10.1016/j.yhbeh.2024.105536","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105536","url":null,"abstract":"<div><p>Paternal deprivation (PD) impairs social cognition and sociality and increases levels of anxiety-like behavior. However, whether PD affects the levels of empathy in offspring and its underlying mechanisms remain unknown. The present study found that PD increased anxiety-like behavior in mandarin voles (<em>Microtus mandarinus</em>), impaired sociality, reduced the ability of emotional contagion, and the level of consolation behavior. Meanwhile, PD reduced OT neurons in the paraventricular nucleus (PVN) in both male and female mandarin voles. PD decreased the level of OT receptor (OTR) mRNA in the anterior cingulate cortex (ACC) of male and female mandarin voles. Besides, OTR overexpression in the ACC reversed the PD-induced changes in anxiety-like behavior, social preference, emotional contagion, and consolation behavior. Interference of OTR expression in the ACC increased levels of anxiety-like behaviors, while it reduced levels of sociality, emotional contagion, and consolation. These results revealed that the OTR in the ACC is involved in the effects of PD on empathetic behaviors, and provide mechanistic insight into how social experiences affect empathetic behaviors.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105536"},"PeriodicalIF":3.5,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety 来曲唑可延迟雌性 BALB/c 小鼠对水迷宫任务的掌握：可能与焦虑有关

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-03-21 DOI: 10.1016/j.yhbeh.2024.105524

Jacek Mamczarz , Malcolm Lane , Istvan Merchenthaler

{"title":"Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety","authors":"Jacek Mamczarz , Malcolm Lane , Istvan Merchenthaler","doi":"10.1016/j.yhbeh.2024.105524","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105524","url":null,"abstract":"<div><p>Letrozole, an aromatase inhibitor preventing estrogen synthesis from testosterone, is used as an adjuvant therapy in estrogen receptor-positive breast cancer patients. However, like other aromatase inhibitors, it induces many side effects, including impaired cognition. Despite its negative effect in humans, results from animal models are inconsistent and suggest that letrozole can either impair or improve cognition. Here, we studied the effects of chronic letrozole treatment on cognitive behavior of adult female BALB/c mice, a relevant animal model for breast cancer studies, to develop an appropriate animal model aimed at testing therapies to mitigate side effects of letrozole. In Morris water maze, letrozole 0.1 mg/kg impaired reference learning and memory. Interestingly, most of the letrozole 0.1 mg/kg-treated mice were able to learn the new platform position in reversal training and performed similar to control mice in a reversal probe test. Results of the reversal test suggest that letrozole did not completely disrupt spatial navigation, but rather delayed acquisition of spatial information. The delay might be related to increased anxiety as suggested by increased thigmotactic behavior during the reference memory training. The learning impairment was water maze-specific since we did not observe impairment in other spatial tasks such as in Y-maze or object location test. In contrast, the dose of 0.3 mg/kg did not have effect on water maze learning and facilitated locomotor habituation and recognition in novel object recognition test. The current study shows that letrozole dose-dependently modulates behavioral response and that its effects are task-dependent.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105524"},"PeriodicalIF":3.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140181200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life conditions reduce similarity between reproductive partners in HPA axis response to stress 早期生活条件降低了生殖伴侣之间在 HPA 轴对压力反应方面的相似性

IF 3.5 3区医学

Hormones and Behavior Pub Date : 2024-03-20 DOI: 10.1016/j.yhbeh.2024.105508

Buddhamas P. Kriengwatana, Christopher J. Marshall, Tyler Stevenson, Pat Monaghan

{"title":"Early life conditions reduce similarity between reproductive partners in HPA axis response to stress","authors":"Buddhamas P. Kriengwatana, Christopher J. Marshall, Tyler Stevenson, Pat Monaghan","doi":"10.1016/j.yhbeh.2024.105508","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105508","url":null,"abstract":"<div><p>Social environments modulate endocrine function, yet it is unclear whether individuals can become like their social partners in how they physiologically respond to stressors. This social transmission of hypothalamic-pituitary-adrenal (HPA) axis reactivity could have long-term consequences for health and lifespan of individuals if their social partners react to stressors with an exaggerated HPA axis response. We tested whether glucocorticoid levels in response to stress of breeding partners changes after breeding depending on whether partners had similar or dissimilar postnatal conditions. We manipulated postnatal conditions by mimicking early life stress in zebra finch chicks (<em>Taeniopygia guttata</em>) via postnatal corticosterone exposure. When they reached adulthood, we created breeding pairs where the female and male had experienced either the same or different early life hormonal treatment (corticosterone or control). Before and after breeding, we obtained blood samples within 3 min and after 10 min or 30 min of restraint stress (baseline, cort10, cort30). We found that corticosterone levels of individuals in response to restraint were affected by their own and their partner's early life conditions, but did not change after breeding. However, across all pairs, partners became more similar in cort30 levels after breeding, although differences between partners in cort10 remained greater in pairs with a corticosterone-treated female. Thus, we show that HPA axis response to stressors in adulthood can be modulated by reproductive partners and that similarity between partners is reduced when females are postnatally exposed to elevated glucocorticoids.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"162 ","pages":"Article 105508"},"PeriodicalIF":3.5,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24000333/pdfft?md5=f937204a0c8e3863c387cc9bbff9d165&pid=1-s2.0-S0018506X24000333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140163859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0