Hormones and Behavior最新文献_第2页

Hormonal contraceptives modulate resilience to psychiatric and neurodegenerative disease 激素避孕药调节对精神和神经退行性疾病的恢复力

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-22 DOI: 10.1016/j.yhbeh.2025.105823

Kristen M. Schuh, Leah M. Conrad, Natalie C. Tronson

引用次数: 0

Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking 中枢甲状腺激素受体- β：对酒精的敏感性和调节饮酒的作用。

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-18 DOI: 10.1016/j.yhbeh.2025.105822

Michael C. Johnson , Michelle A. Nipper , Kelly M. Abshire , Jessica E. Rehmann , Jonathan A. Zweig , Theresa N. Vu , Mandee A. Bell , Tapasree Banerji , Thomas S. Scanlan , Andrey E. Ryabinin , Deena M. Walker

{"title":"Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking","authors":"Michael C. Johnson , Michelle A. Nipper , Kelly M. Abshire , Jessica E. Rehmann , Jonathan A. Zweig , Theresa N. Vu , Mandee A. Bell , Tapasree Banerji , Thomas S. Scanlan , Andrey E. Ryabinin , Deena M. Walker","doi":"10.1016/j.yhbeh.2025.105822","DOIUrl":"10.1016/j.yhbeh.2025.105822","url":null,"abstract":"<div><div>Clinical and preclinical evidence indicate that both peripheral and central elements of the hypothalamic-pituitary-thyroid (HPT) axis are dysregulated in alcohol use disorder, and that thyroid hormone system dysregulation is associated alcohol craving and co-morbid mood and depression-related disorders. Yet, no study has investigated if central nervous system (CNS) thyroid hormone receptors, primary targets of thyroid hormone and major regulators of the HPT axis are involved in alcohol consumption. We utilized a 24-h access two-bottle choice (2BC) voluntary ethanol (EtOH) drinking paradigm to assess if the expression of CNS thyroid hormone receptors is sensitive to voluntary alcohol consumption in C57BL/6 J mice. We found that thyroid hormone receptor-beta (<em>Thrb</em>/THRβ) mRNA expression was significantly reduced in the paraventricular nucleus of the hypothalamus of EtOH drinking mice compared to water controls. In addition, EtOH drinking mice exhibited peripheral elevation of serum triiodothyronine. Next, we utilized the CNS selective THRβ agonist, Sob-AM2, to determine if central activation of THRβ would influence voluntary alcohol drinking in mice in the same EtOH 2BC drinking paradigm. We found that repeated treatment with Sob-AM2 significantly reduced daily EtOH intake and preference, while in conjunction increasing water intake. In summary, we found that hypothalamic <em>Thrb</em> expression is sensitive to voluntary alcohol drinking, and that CNS THRβ activity regulates alcohol consumption in mice. Taken together, our results highlight an important role of central thyroid hormone receptor signalling in alcohol drinking and indicate therapeutic potential of CNS selective thyromimetics in treatment of alcohol use disorder.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105822"},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder 微/纳米塑料诱导的啮齿动物内分泌干扰的系统综述和实验研究：与自闭症谱系障碍的潜在联系

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-15 DOI: 10.1016/j.yhbeh.2025.105818

Lucas F. Fowler , T. Nadine Burry , Alexandre S. Maekawa , Lindsay S. Cahill

{"title":"A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder","authors":"Lucas F. Fowler , T. Nadine Burry , Alexandre S. Maekawa , Lindsay S. Cahill","doi":"10.1016/j.yhbeh.2025.105818","DOIUrl":"10.1016/j.yhbeh.2025.105818","url":null,"abstract":"<div><div>Recent research shows that microplastic (diameter < 5 mm) and nanoplastic (diameter < 1 μm) exposures can have endocrine-disrupting effects and lead to autism spectrum disorder (ASD)-like behaviours in rodent models. We combine both a (i) systematic literature review and (ii) experimental study to synthesize the potential mechanisms underlying the link between micro−/nanoplastic (MNP) exposure and ASD, focusing on endocrine disruption and articles utilizing rodent models. First, we identify and discuss trends in the literature, outline research gaps, and suggest future directions. Most articles measured gonadal hormones in male adult rodents and consistently reported decreased testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with MNP exposure. Females were understudied, with no trends emerging in exposure-induced hormone disruption. Second, we present experimental data demonstrating direct effects of maternal polystyrene NP exposure on neuroendocrine systems and inflammatory markers in the fetal brain. Cytokines, interleukin-2 (IL-2) and interleukin-6 (IL-6), and triiodothyronine (T3) were significantly altered in the fetal brain following prenatal exposure to NPs, and thyroxine (T4) and T were significantly suppressed in female NP-exposed fetuses but not in males. Together, these findings demonstrate that MNP exposure during adulthood and early development affect multiple endocrine systems, including those implicated in autism spectrum disorder, in a sex-dependent manner. We synthesize how such results are important to motivate exposure studies in animals and humans and future regulatory guidelines on MNPs.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105818"},"PeriodicalIF":2.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans 人际感觉运动同步中的催产素动力学：人类对照实验

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-13 DOI: 10.1016/j.yhbeh.2025.105817

Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina

{"title":"Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans","authors":"Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina","doi":"10.1016/j.yhbeh.2025.105817","DOIUrl":"10.1016/j.yhbeh.2025.105817","url":null,"abstract":"<div><div>Interpersonal sensorimotor synchronisation is the coordination of movement between individuals that underlies successful interpersonal communication. Previous research has indicated the potential involvement of oxytocin (OXT) in the process of synchronisation.</div><div>We conducted 2 randomised controlled experiments to test the effect of synchronisation on salivary OXT concentrations. In Experiment 1, 90 volunteers (65 women) performed either synchronous or asynchronous a 5-min hand gesture task with an unfamiliar partner. In Experiment 2, 67 familiar dyads of volunteers (47 female dyads) performed the same task. Salivary OXT concentrations were measured before and after the gesture task (Experiment 1) or before, after and 10 min after the gesture task (Experiment 2). Saliva samples were analysed using the ELISA method to estimate OXT concentrations.</div><div>In Experiment 1, we found no significant differences between salivary OXT levels at baseline and after the 5-min task in either synchronous or asynchronous conditions. We also found no evidence for increased liking of a stranger after sensorimotor synchrony. In Experiment 2, the asynchronous condition led to a decrease in OXT levels over time, whereas synchronous interactions led to stable OXT levels over time. The effect of condition on OXT was not moderated by closeness or attachment style. The results are discussed in relation to research methodology used to study interpersonal synchrony.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105817"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in steroid hormone levels based on a plastic behavioral role in two biparental cichlids, Julidochromis transcriptus and Julidochromis marlieri: A test of the Ancestral Modulation Hypothesis 基于可塑性行为作用的两种双亲本稚鱼（转录稚鱼和玛利稚鱼）类固醇激素水平变化：祖先调节假说的检验

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105820

A.P. Anderson, F. Noble, W. Cantlon, S.C.P. Renn

{"title":"Changes in steroid hormone levels based on a plastic behavioral role in two biparental cichlids, Julidochromis transcriptus and Julidochromis marlieri: A test of the Ancestral Modulation Hypothesis","authors":"A.P. Anderson, F. Noble, W. Cantlon, S.C.P. Renn","doi":"10.1016/j.yhbeh.2025.105820","DOIUrl":"10.1016/j.yhbeh.2025.105820","url":null,"abstract":"<div><div>Cross-sexual transfer describes the situation when one sex takes on the phenotypic values of the other sex, either plastically or over evolutionary time. The underlying regulatory mechanisms of this process have been generally assumed to be related to sex-biased hormonal regulation, but explicit empirical tests have not been conducted. More recently, the Ancestral Modulation Hypothesis (AMH) has been proposed as a framework to understand the hormonal regulation that underlies cross-sexual transfer. We leverage the behavioral changes in two species of biparental cichlid, <em>Julidochromis transcriptus</em> and <em>Julidochromis marlieri</em>, to test hormonal changes when cross-sexual transfer occurs and provide an empirical test of the AMH. One species, <em>J. transcriptu</em>s, typically forms male-larger pairs, which is generally considered to be the ancestral condition; yet females take on male behaviors when they are the larger individual in the pair. The other species, <em>J. marlieri</em>, typically forms female-larger pairs, a cross-sexual transfer, but can likewise shift behaviors when paired atypically. We established pairs by giving males and females of both species both larger and smaller partners and measured behavioral and hormonal changes. We found <em>J. transcriptus</em> females increased 11-ketotestorerone (11-KT) when becoming the larger partner and 11-KT and estradiol (E2) correlated with behaviors associated with the larger partner. We did not find any changes in hormone levels based on size or sex in <em>J. marlieri</em>, though behaviors did correlate with testosterone (T). These results provide qualified support for the tested prediction from the AMH framework that cross-sexual transfer can occur by coopting hormonal signaling by adjusting circulating hormones.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105820"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of oxytocin in enhancing group-based guilt and promoting intergroup reconciliation in a collectivist context 在集体主义背景下，催产素在增强群体内疚和促进群体间和解中的作用

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105819

Zhiai Li , Mengsi Xu , Shiyao Huang , An Yang

{"title":"The role of oxytocin in enhancing group-based guilt and promoting intergroup reconciliation in a collectivist context","authors":"Zhiai Li , Mengsi Xu , Shiyao Huang , An Yang","doi":"10.1016/j.yhbeh.2025.105819","DOIUrl":"10.1016/j.yhbeh.2025.105819","url":null,"abstract":"<div><div>Group-based guilt, arising from the awareness of harmful or immoral actions committed by fellow group members, is a powerful negative emotion. It motivates various forms of reparative behavior which mitigates the intergroup conflicts. However, the widespread expression of group-based guilt remains relatively infrequent. Therefore, how to enhance the utility of group-based guilt remains a paramount issue in the field of intergroup conflict. Oxytocin is widely recognized for its pivotal role in positively influencing social cognition and behavior. Consequently, our research aimed to investigate the potential modulation of oxytocin on group-based guilt by examining whether oxytocin enhances group-based responsibility, guilt and compensation within a collectivist cultural context. To achieve this, we conducted a double-blind, placebo-controlled experimental design: 2 (Treatment: Placebo vs. Oxytocin) × 2 (Group membership: In-group vs. Out-group). The results showed that the administration of oxytocin could enhance group-based responsibility, guilt, and compensation. In conclusion, the study of oxytocin and group-based guilt highlights the potential role of biological processes in shaping social emotions and cognition, then enhancing altruistic behavior toward the victimized group and moderating intergroup relations.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105819"},"PeriodicalIF":2.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal contraceptive use in relation to basal and reactive testosterone, DHEAS, and cortisol 激素避孕药的使用与基础和反应性睾酮，DHEAS和皮质醇的关系

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-29 DOI: 10.1016/j.yhbeh.2025.105806

Kathleen V. Casto , Sally Farah , Ariel Castro , Modupe Akinola , Pranjal H. Mehta

{"title":"Hormonal contraceptive use in relation to basal and reactive testosterone, DHEAS, and cortisol","authors":"Kathleen V. Casto , Sally Farah , Ariel Castro , Modupe Akinola , Pranjal H. Mehta","doi":"10.1016/j.yhbeh.2025.105806","DOIUrl":"10.1016/j.yhbeh.2025.105806","url":null,"abstract":"<div><div>A burgeoning area of research has begun to uncover a wide range of potential neurological and psychological correlates of hormonal contraceptive (HC) use. Yet there remains a limited understanding of the underlying mechanisms for how HC use alters aspects of neurobiology and related behavioral outcomes. Uncovering these processes has the potential for new discovery in the field of behavioral neuroendocrinology, particularly in the complex interplay between steroid hormone subclasses. Although prior research has often focused on the effects of HC use on progestogen and estrogen disruption, basal and reactive androgens and cortisol may also be significantly impacted by HC use and serve critical functions throughout the brain and body. We discuss important background information on the synthesis and function of three steroid hormones – testosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol, review prior research showing how HC use is related to circulating (basal) and reactive levels, and provide sample data on salivary levels from our own research. The combined evidence shows that HC use, specifically of the OC pill, is associated with significantly reduced total, free, and salivary androgens, increased total cortisol in blood but not saliva, and a blunted salivary cortisol response to social stressors. Limited evidence provides initial indication that the specific estrogen and progestin compounds in HC formulas may differentially impact steroid hormone levels. Finally, we discuss the mechanisms by which HCs alter steroid hormone levels, the potential implications of these effects on brain and behavior outcomes, and considerations for future research.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105806"},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational effects of maternal androgens on vocal ontogeny and developmental plasticity in a cooperatively breeding mammal 雌性雄激素对合作繁殖哺乳动物发声个体发育和发育可塑性的代际影响

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-20 DOI: 10.1016/j.yhbeh.2025.105814

Britta Walkenhorst , Ines Braga Goncalves , Christine M. Drea , Marta B. Manser

{"title":"Intergenerational effects of maternal androgens on vocal ontogeny and developmental plasticity in a cooperatively breeding mammal","authors":"Britta Walkenhorst , Ines Braga Goncalves , Christine M. Drea , Marta B. Manser","doi":"10.1016/j.yhbeh.2025.105814","DOIUrl":"10.1016/j.yhbeh.2025.105814","url":null,"abstract":"<div><div>Developmental plasticity, the ability to adapt one's phenotype to environmental cues, is crucial during early-life stages and can affect fitness. Despite significant androgenic variation between females of select species, the impact of maternal hormones on offspring ontogeny in wild mammals has been rarely investigated. Here, we rely on natural and experimentally induced variation in androgen action between dominant and subordinate female meerkats, <em>Suricata suricatta</em>, to examine plasticity of vocal development in their offspring. Meerkats are cooperatively breeding mongooses that have a rich vocal repertoire. We recorded calls produced at distinct developmental stages by offspring from dominant and subordinate control mothers that naturally differ in absolute androgen concentrations and from dominant treated mothers that had received an androgen-receptor blocker in late gestation. Using call types as indicators, we found that the offspring of dominant control mothers had a robust vocal trajectory, even under adverse environmental conditions; following full nutritional dependence, their vocal development was accelerated relative to that of other offspring. Conversely, offspring from both subordinate control and dominant antiandrogen treated mothers suffered ontogenetic delays; they showed distinct sex differences in trajectory and a greater sensitivity to socio-ecological influences. Antiandrogen-exposed offspring also showed atypical early call usage. These findings provide rare evidence of the potential for maternal androgens to mediate mammalian offspring development in accordance with demands of the socio-ecological environment.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105814"},"PeriodicalIF":2.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal intrauterine device use is related to mental rotations but not verbal memory skills 激素宫内节育器的使用与心理旋转有关，但与语言记忆能力无关

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-18 DOI: 10.1016/j.yhbeh.2025.105804

Ran Yan, Christel Portengen, T. Ariel Yang, Gwyneth Reece, Zoe Dunnum, Esmeralda Hidalgo-Lopez, Adriene M. Beltz

{"title":"Hormonal intrauterine device use is related to mental rotations but not verbal memory skills","authors":"Ran Yan, Christel Portengen, T. Ariel Yang, Gwyneth Reece, Zoe Dunnum, Esmeralda Hidalgo-Lopez, Adriene M. Beltz","doi":"10.1016/j.yhbeh.2025.105804","DOIUrl":"10.1016/j.yhbeh.2025.105804","url":null,"abstract":"<div><div>There is perennial public and scientific interest in the neuroendocrine mechanisms underlying the large gender difference in three-dimensional (3D) mental rotation skills (favoring men) and small-to-moderate difference in verbal memory (favoring women). Past research has linked androgenic progestins in oral contraceptives to enhanced spatial skills, particularly 3D mental rotations, and estradiol to enhanced verbal memory skills. Hormonal intrauterine devices (IUDs) contain an androgenic progestin (i.e., levonorgestrel) without synthetic estradiol, but there is little-to-no systematic research on the cognitive impacts of use. The current study filled this knowledge gap in a sample of 343 participants (<em>M</em><sub>age</sub> = 21.75, <em>SD</em> <em>=</em> 4.52; 57.0 % White; 84.8 % non-Latine), comparing 50 hormonal IUD users to 135 naturally cycling (NC) females who were not menstruating and to 158 males. Compared to NC females, IUD users had better 3D mental rotation performance, but similar verbal memory. Compared to males, IUD users had similar 3D mental rotations performance, but better verbal memory. Group differences were generally moderate in size, and the pattern of results persisted when both age and general cognitive ability were covaried. Findings in IUD users are consistent with hypotheses, evidencing a potential and selective impact of exogenous androgenic progestin exposure on spatial cognition, and no effects on verbal memory, as expected given the preservation of endogenous ovarian hormone function that is not suppressed as it is in other hormonal contraceptives (e.g., oral).</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105804"},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What do we measure when we measure pubertal development? Conceptual challenges in measuring and interpreting pubertal effects on brain and behavior 当我们测量青春期发育时，我们测量的是什么？测量和解释青春期对大脑和行为影响的概念挑战

IF 2.4 3区医学

Hormones and Behavior Pub Date : 2025-08-14 DOI: 10.1016/j.yhbeh.2025.105803

Thiago F.A. França , Hugo Cogo-Moreira , Sabine Pompeia

{"title":"What do we measure when we measure pubertal development? Conceptual challenges in measuring and interpreting pubertal effects on brain and behavior","authors":"Thiago F.A. França , Hugo Cogo-Moreira , Sabine Pompeia","doi":"10.1016/j.yhbeh.2025.105803","DOIUrl":"10.1016/j.yhbeh.2025.105803","url":null,"abstract":"<div><div>Pubertal development is believed to influence cognitive and behavioral development during adolescence, but measuring puberty is challenging. Difficulties stem not only from practical issues, which have been extensively discussed in the literature, but also from the inherent complexity of pubertal development from a physiological perspective. Here we discuss conceptual issues related to measuring and interpreting pubertal effects on brain, cognitive, and behavioral development. Our analysis shows that all currently used measures, both those based on the assessment of external physical characteristics and those based on measuring relevant hormones form biological samples, share significant limitations that hinder their interpretation. These limitations arise from the fact that puberty is not a unitary phenomenon, cannot be measured directly nor be defined by individual makers, and its different markers are often discordant. Moreover, its effects on brain development, cognition, and behavior are bound to involve a complex causal thicket, requiring an integrative assessment of pubertal development. We argue that a possible compromise between practical issues (building feasible/reliable measures) and theoretical ones (building conceptually sound and interpretable measures) is to treat puberty as the variance shared among multiple pubertal indicators, combining physical markers and hormonal measures.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105803"},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0