Hormones and Behavior最新文献

{"title":"Corticosterone unlikely indicates departure readiness in migratory European robins","authors":"Julia Loshchagina ,&nbsp;Sergey Naidenko ,&nbsp;Arseny Tsvey","doi":"10.1016/j.yhbeh.2025.105764","DOIUrl":"10.1016/j.yhbeh.2025.105764","url":null,"abstract":"<div><div>During migration, birds must repeatedly decide when to terminate stopover and resume migratory flight. Such decisions greatly affect their overall migration success and, ultimately, fitness. Departure probability increases with higher levels of energy reserves, positive wind support and progression of the migration season. However, our knowledge of the endocrine mechanisms underlying this process is still incomplete. To evaluate the possible role of baseline corticosterone (CORT thereafter) in regulation of migratory departure, we analyzed the relationships between CORT levels and factors associated with departure probability in European robins (<em>Erithacus rubecula</em>) blood sampled at two nearby stopover sites during six autumn and six spring migration seasons. Contrary to predictions, in both migration seasons we observed higher CORT levels in lean birds, which are assumed to have low departure motivation. We found no indication that CORT concentrations increased in fat individuals captured around sunset, presumably shortly before departure. In parallel with departure likelihood, CORT levels increased towards the end of migration season in autumn, but there was no seasonal trend in spring, when motivation to continue migration is higher. Finally, CORT levels were positively related to tailwind component in autumn, whereas the opposite trend was observed in spring. In summary, our results provide mixed support for the hypothesis that CORT indicates departure readiness in songbirds. We propose that the observed relationships are more consistent with metabolic functions of CORT. Our study highlights the value of multiyear data and seasonal comparisons in studies of the endocrine regulation of such complex behaviors as departure decision.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105764"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles","authors":"Lanikea B. King,&nbsp;Hasse Walum,&nbsp;Yao Xiao,&nbsp;Asha Y. Caslin,&nbsp;Fuad C. Haddad,&nbsp;Larry J. Young,&nbsp;Zachary V. Johnson","doi":"10.1016/j.yhbeh.2025.105761","DOIUrl":"10.1016/j.yhbeh.2025.105761","url":null,"abstract":"<div><div>Oxytocin is a conserved neuropeptide that regulates social and reproductive behaviors in diverse species. Genetic variation in <em>Oxtr,</em> the gene encoding the oxytocin receptor (OXTR), is associated with variation in social attachment behaviors in rodents and humans; however, it is unclear how genetic variation in <em>Oxtr</em> shapes the function of specific neural systems during social contexts. Here we address this question using the socially monogamous prairie vole (<em>Microtus ochrogaster</em>), a species that expresses an array of OXTR-dependent social behaviors and possesses <em>Oxtr</em> gene polymorphisms that predict individual variation in brain region-specific OXTR expression. We test the neural and behavioral effects of an <em>Oxtr</em> gene polymorphism that has previously been associated with brain region-specific OXTR expression and social attachment behaviors in male prairie voles. Our results suggest that, during brief mating encounters, <em>Oxtr</em> genotype is not associated with differences in mating behavior or in expression levels of the activity-dependent immediate early gene product FOS within brain regions, but it is associated with differences in correlated FOS expression patterns across brain regions.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105761"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression, distribution, and function of sex hormone receptors in the rabbit brain","authors":"Beatriz Molina ,&nbsp;Gabriela González-Mariscal ,&nbsp;Ignacio Camacho-Arroyo","doi":"10.1016/j.yhbeh.2025.105762","DOIUrl":"10.1016/j.yhbeh.2025.105762","url":null,"abstract":"<div><div>Sex hormones such as estradiol, progesterone, and testosterone are crucial for vertebrate brain functions by interacting with their specific receptors. In rabbits, these hormones regulate sexual behavior, scent marking, nest building, and nipple searching across different brain regions. However, information on sex hormone receptors in the rabbit brain is limited. We examined intracellular progesterone (PR), estrogen (ER), and androgen receptors (AR) in the rabbit brain. PR activation by progesterone is associated with pregnancy and maternal behaviors like nest building and nipple searching. PR is expressed in female and male rabbits' cerebral cortex, hypothalamus, preoptic area, and hippocampus. In males, it is also found in the olfactory bulb, mesencephalon, and cerebellum. Rabbits express two ER subtypes, ERα and ERβ, with different expression patterns and functions. The former is in the amygdala, bed nucleus of the stria terminalis, hippocampus, hypothalamus, preoptic area, septum, and thalamus of females. In males, ERα is expressed in the hypothalamus, olfactory bulb, prefrontal cortex, preoptic area, mesencephalon, and cerebellum. Both ERs are located in male rabbits' amygdala, claustrum, and hippocampus. ERs influence estrous behavior and chinning. ERα has a role in rabbit hippocampus development and plasticity. AR is expressed in male rabbit hypothalamus, olfactory bulb, prefrontal cortex, hippocampus, preoptic area, mesencephalon, and cerebellum, related to sexual behavior and chinning.</div><div>Interestingly, sex hormones regulate their own receptor expression and those of other sex hormones. Thus, estradiol regulates PR expression. This review summarizes the expression and distribution of sex hormone receptors in the rabbit brain and their behavioral role.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105762"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of deep brain photoreceptors in regulation of daily and seasonal responses in birds","authors":"Diego J. Valdez","doi":"10.1016/j.yhbeh.2025.105760","DOIUrl":"10.1016/j.yhbeh.2025.105760","url":null,"abstract":"<div><div>Birds exhibit an extraordinary morphological, physiological, and behavioral diversity that allows them to adapt to the diverse environments of our planet. To achieve this, they utilize different sensory structures. One of these structures is located in the deep brain and contains neurons with photopigments (Deep Brain Photoreceptors, DBP) that detect daily and seasonal changes in ambient light (photoperiod), allowing the individual to adjust and synchronize physiological processes with the environment. This DBPs detects and transmits light information to the hypothalamic-pituitary-gonadal axis, regulating the gonadal recrudescence/regression cycle and possibly daily responses in birds.</div><div>This work reviews and discusses the state of the art about the presence and functionality of DBPs in a phylogenetic context, with a particular focus on annual reproductive responses and their little-known relationship with daily responses. Exceptions to the seasonal reproductive regulation mechanism, as observed in opportunistic bird species such as the eared dove, where food availability appears to drive the activity of the gonadal oscillator are also discussed. Finally, the possible neural pathways through which DBPs transmit photoperiodic information to the circadian system in birds are proposed.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105760"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finger pointing: Why bias against 2D:4D ratios doesn't add up","authors":"Ashlyn Swift-Gallant ,&nbsp;S. Marc Breedlove","doi":"10.1016/j.yhbeh.2025.105759","DOIUrl":"10.1016/j.yhbeh.2025.105759","url":null,"abstract":"<div><div>In response to our invited review of the use of digit ratios such as 2D:4D as a retrospective marker of prenatal androgen exposure, the Editor-In-Chief of this journal published a Commentary disputing the findings we had reported, citing a preprint suggesting the sex difference in digit ratios was an artifact of “allometry”, and casting doubt on a previously published meta-analysis concluding that lesbians, on average, have lower digit ratios than straight women, suggesting there may be a bias against submitting negative results. Here we respond to those points and conclude that 2D:4D of the right hand remains the best available non-invasive retrospective indicator of prenatal androgen exposure in humans. Further, we offer a new dataset replicating once again the numerous previous reports that lesbians have significantly lower right-hand 2D:4D, indicative of greater prenatal androgen exposure, than heterosexual women, and further report that the ratios of bisexual women are intermediate between those of gay and straight women, without being significantly different from either. Together with previous reports, these new data further indicate that androgens act before birth in humans to promote the likelihood of being sexually attracted to women in adulthood.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105759"},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroanatomy of menopause","authors":"Eileen Luders ,&nbsp;Inger Sundström Poromaa ,&nbsp;Florian Kurth","doi":"10.1016/j.yhbeh.2025.105749","DOIUrl":"10.1016/j.yhbeh.2025.105749","url":null,"abstract":"<div><div>Sex hormones are known to affect brain structure. Given that menopause is marked by a significant decline in female sex hormones, there might be structural brain alterations around menopause. The aim of this article is to provide a narrative review on what we know today with respect to links between brain anatomy and menopause, while also considering potential effects of menopausal hormone therapy (MHT). The review is focused on neuroimaging studies analyzing the macro-anatomy or micro-anatomy of the human brain as based on structural magnetic resonance imaging (MRI) or diffusion tensor imaging (DTI). Out of the 32 studies reviewed here, 22 studies revealed at least some findings that suggest beneficial effects of estrogen. However, overall, findings are rather mixed pointing to both beneficial and adverse effects (or to no effects at all). The nature of the effects seemed to be unrelated to the spatial scales applied, the morphometric measures obtained, and the brain tissues targeted. Nevertheless, there were some intriguing effects in terms of the study design: Cross-sectionally, there seemed to be a trend for beneficial effects in small-scale studies and for adverse effects in large-scale studies. Longitudinally, there seemed to be a trend for beneficial effects in purely observational studies and for beneficial as well as adverse effects in controlled clinical trials. With particular respect to MHT, early treatment (short after the onset of menopause) might be more beneficial than later treatment. However, overall, data are insufficient to draw final conclusions and further research is required.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105749"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consequences of menopause for brain health","authors":"Nicole J. Gervais ,&nbsp;Claudia Barth ,&nbsp;Agnès Lacreuse","doi":"10.1016/j.yhbeh.2025.105727","DOIUrl":"10.1016/j.yhbeh.2025.105727","url":null,"abstract":"","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105727"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of dietary emulsifiers increases sensitivity to social stress in mice: A potential role for the COX molecular pathway","authors":"Amanda R. Arnold ,&nbsp;Benoit Chassaing ,&nbsp;Kiran Lakhani ,&nbsp;Coralie Bergeron ,&nbsp;Emma K. Shaughnessy ,&nbsp;Anna M. Rosenhauer ,&nbsp;Maura C. Stoehr ,&nbsp;Benjamin Horne ,&nbsp;Tyler Wilkinson ,&nbsp;Kim L. Huhman","doi":"10.1016/j.yhbeh.2025.105750","DOIUrl":"10.1016/j.yhbeh.2025.105750","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation and exposure to stress are key contributing factors in the etiology and progression of many neuropsychiatric disorders. Dietary emulsifiers, such as carboxymethylcellulose (CMC) and polysorbate-80 (P80), are commonly added to processed foods and drinks and are classified by the Food and Drug Administration (FDA) as generally recognized as safe (GRAS). Recently, however, we and others have reported that these additives at translationally relevant doses cause low-grade intestinal inflammation, microbiota dysbiosis, and alterations in gene expression in brain areas that mediate behavioral and neuroendocrine responses to stress-provoking stimuli.</div></div><div><h3>Methods</h3><div>To test whether emulsifier exposure sensitizes behavioral, hormonal, and neuronal responses to stress, C57BL/6 J male mice were given water +1 % emulsifier (CMC or P80) or water alone for 12 weeks after which they were exposed to social defeat stress. We previously found increased PTGS2 (COX-2) gene expression in the amygdala following emulsifier consumption. To determine whether inflammation, potentially through the COX pathway, is a potential mechanism driving emulsifier-induced increases in stress sensitivity, we administered the COX inhibitor aspirin (25 mg/kg/day) in conjunction with emulsifiers for the last six weeks of treatment.</div></div><div><h3>Results</h3><div>In defeated mice, CMC increased circulating corticosterone, while both emulsifiers increased social avoidance behavior and altered defeat-induced c-Fos immunofluorescence in various brain regions. Moreover, behavioral and hormonal alterations were attenuated by aspirin.</div></div><div><h3>Conclusions</h3><div>These data demonstrate that ingestion of at least some dietary emulsifiers at concentrations analogous to those ingested by humans increases sensitivity to social stress in mice and that the COX pathway may be a mechanistic candidate by which emulsifier-induced increases in sensitivity to social stress occur.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105750"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gendered interests and behavior in women with congenital adrenal hyperplasia or complete androgen insensitivity syndrome","authors":"Anna Strandqvist ,&nbsp;Martin Asperholm ,&nbsp;Henrik Falhammar ,&nbsp;Angelica Lindén Hirschberg ,&nbsp;Anna Nordenström ,&nbsp;Agneta Herlitz","doi":"10.1016/j.yhbeh.2025.105748","DOIUrl":"10.1016/j.yhbeh.2025.105748","url":null,"abstract":"<div><div>Psychological outcomes in people with <em>congenital adrenal hyperplasia</em> (CAH) and <em>complete androgen insensitivity syndrome</em> (CAIS) may provide information contributing to the understanding of development of behaviors that typically show sex differences. In this study, we investigated gender identity, friendship quality and occupational choices. Participants were women with 46,XX classic CAH (C-CAH; <em>n</em> = 29), non-classic CAH (NC-CAH; <em>n</em> = 13), women with 46, XY CAIS (<em>n</em> = 11), male controls (<em>n</em> = 147) and female controls (<em>n</em> = 142). Participants completed an online survey with questions on gender identity, friendship, (sex of friends in childhood, adolescence, adulthood), friendship style, and occupation. Results showed that (1) female and male controls differed on most outcomes. (2) Women with CAIS and women with NC-CAH responded in a pattern not different from female controls on most questions regarding gendered behavior. (3) Women with C-CAH and women with CAIS responded more similarly to male controls than female controls on the friendship questionnaire. (4) Women with C-CAH worked in occupations with a male sex distribution whereas females with CAIS worked in occupations that were not different from those of female or male controls. (5) More severe forms of CAH were associated with a response pattern more in line with that of male controls, whereas the opposite was true for females with less severe forms of CAH.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105748"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal synchrony in older couples' everyday life: The role of situational stressors and buffers","authors":"Dora Hopf ,&nbsp;Corina Aguilar-Raab ,&nbsp;Johanna U. Gödde ,&nbsp;Ekaterina Schneider ,&nbsp;Beate Ditzen ,&nbsp;Monika Eckstein","doi":"10.1016/j.yhbeh.2025.105743","DOIUrl":"10.1016/j.yhbeh.2025.105743","url":null,"abstract":"<div><div>Synchrony in physiology in romantic couples has been suggested to be a result of joint interaction and co-regulation of stress and affect. However, it is subject of debate whether synchrony in endocrine levels - especially in oxytocin - is generally beneficial or if a reciprocal transmission of stress may even be stress-increasing. The aim of this study was to investigate hormonal synchrony in older couples in relation to situational mindfulness, relationship conflict (quarreling), as well as situational resilience and subjective stress levels. A total of <em>N</em> = 26 individuals (i.e., <em>N</em> = 13 couples) aged between 52 and 75 years provided saliva samples and self-report measures 12 times over the course of 2 days (312 measures in total). Superior to randomly scrambled dyads, multilevel models predicted cortisol, alpha-amylase, and oxytocin levels from one partner for the other. Synchrony was higher at times of high levels of quarreling but mitigated in moments of high mindfulness. Moreover, oxytocin synchrony was reduced in couples exerting higher average levels of stress. We interpret this finding as buffering personal factors to protect against the transmission of dyadic stress. To draw implications for clinical interventions to promote these factors and given the preliminary character of the sample and the effects, future studies need to systematically expand this field of research and application.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105743"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}