Hormones and Behavior最新文献

{"title":"Gendered interests and behavior in women with congenital adrenal hyperplasia or complete androgen insensitivity syndrome","authors":"Anna Strandqvist ,&nbsp;Martin Asperholm ,&nbsp;Henrik Falhammar ,&nbsp;Angelica Lindén Hirschberg ,&nbsp;Anna Nordenström ,&nbsp;Agneta Herlitz","doi":"10.1016/j.yhbeh.2025.105748","DOIUrl":"10.1016/j.yhbeh.2025.105748","url":null,"abstract":"<div><div>Psychological outcomes in people with <em>congenital adrenal hyperplasia</em> (CAH) and <em>complete androgen insensitivity syndrome</em> (CAIS) may provide information contributing to the understanding of development of behaviors that typically show sex differences. In this study, we investigated gender identity, friendship quality and occupational choices. Participants were women with 46,XX classic CAH (C-CAH; <em>n</em> = 29), non-classic CAH (NC-CAH; <em>n</em> = 13), women with 46, XY CAIS (<em>n</em> = 11), male controls (<em>n</em> = 147) and female controls (<em>n</em> = 142). Participants completed an online survey with questions on gender identity, friendship, (sex of friends in childhood, adolescence, adulthood), friendship style, and occupation. Results showed that (1) female and male controls differed on most outcomes. (2) Women with CAIS and women with NC-CAH responded in a pattern not different from female controls on most questions regarding gendered behavior. (3) Women with C-CAH and women with CAIS responded more similarly to male controls than female controls on the friendship questionnaire. (4) Women with C-CAH worked in occupations with a male sex distribution whereas females with CAIS worked in occupations that were not different from those of female or male controls. (5) More severe forms of CAH were associated with a response pattern more in line with that of male controls, whereas the opposite was true for females with less severe forms of CAH.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105748"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal synchrony in older couples' everyday life: The role of situational stressors and buffers","authors":"Dora Hopf ,&nbsp;Corina Aguilar-Raab ,&nbsp;Johanna U. Gödde ,&nbsp;Ekaterina Schneider ,&nbsp;Beate Ditzen ,&nbsp;Monika Eckstein","doi":"10.1016/j.yhbeh.2025.105743","DOIUrl":"10.1016/j.yhbeh.2025.105743","url":null,"abstract":"<div><div>Synchrony in physiology in romantic couples has been suggested to be a result of joint interaction and co-regulation of stress and affect. However, it is subject of debate whether synchrony in endocrine levels - especially in oxytocin - is generally beneficial or if a reciprocal transmission of stress may even be stress-increasing. The aim of this study was to investigate hormonal synchrony in older couples in relation to situational mindfulness, relationship conflict (quarreling), as well as situational resilience and subjective stress levels. A total of <em>N</em> = 26 individuals (i.e., <em>N</em> = 13 couples) aged between 52 and 75 years provided saliva samples and self-report measures 12 times over the course of 2 days (312 measures in total). Superior to randomly scrambled dyads, multilevel models predicted cortisol, alpha-amylase, and oxytocin levels from one partner for the other. Synchrony was higher at times of high levels of quarreling but mitigated in moments of high mindfulness. Moreover, oxytocin synchrony was reduced in couples exerting higher average levels of stress. We interpret this finding as buffering personal factors to protect against the transmission of dyadic stress. To draw implications for clinical interventions to promote these factors and given the preliminary character of the sample and the effects, future studies need to systematically expand this field of research and application.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105743"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between prenatal bisphenol exposure, postnatal maternal care, and offspring sex in predicting DNA methylation relevant to anxiety-like behavior in rats","authors":"Samantha C. Lauby ,&nbsp;Isha Agarwal ,&nbsp;Hannah E. Lapp ,&nbsp;Melissa Salazar ,&nbsp;Sofiia Semyrenko ,&nbsp;Danyal Chauhan ,&nbsp;Amy E. Margolis ,&nbsp;Frances A. Champagne","doi":"10.1016/j.yhbeh.2025.105745","DOIUrl":"10.1016/j.yhbeh.2025.105745","url":null,"abstract":"<div><div>Prenatal exposure to endocrine disrupting chemicals, such as bisphenols, can alter neurodevelopmental trajectories and have a lasting neurobehavioral impact through epigenetic pathways. However, outcomes associated with prenatal bisphenol exposure may also be shaped by the postnatal environment and collectively these environmental effects may be sex-specific. Thus, an integrative research design that includes multiple early life exposures and considers sex differences may be essential for predicting outcomes. In the current study, we use a multivariate approach to examine the contributions of prenatal bisphenol exposure, postnatal maternal care, and offspring sex to variation in DNA methylation of well-studied candidate genes (NR3C1, BDNF, OXTR) in the ventral hippocampus and amygdala of adult Long-Evans rats. Main effects of postnatal maternal care and interactions with prenatal bisphenol exposure were consistently found for DNA methylation within the NR3C1 gene (ventral hippocampus) and within the BDNF and OXTR genes (amygdala). Sex-specific effects were also found across all analyses. Overall, our findings suggest that both early-life factors (prenatal and postnatal) and offspring sex contribute to variation in DNA methylation in genes and brain regions relevant for the expression of anxiety-like behavior. These results highlight the need to consider the brain region-specific effects of multiple exposures in males and females to understand the lasting effects of early environments.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105745"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microbiota shapes the development of the mouse hypothalamic paraventricular nucleus","authors":"Yvonne C. Milligan ,&nbsp;Nicole V. Peters ,&nbsp;Gabby West ,&nbsp;Laura R. Cortes ,&nbsp;Benoit Chassaing ,&nbsp;Geert J. de Vries ,&nbsp;Alexandra Castillo-Ruiz","doi":"10.1016/j.yhbeh.2025.105742","DOIUrl":"10.1016/j.yhbeh.2025.105742","url":null,"abstract":"<div><div>Microbes massively colonize the mammalian newborn at birth. We previously reported that the microbiota influences key neurodevelopmental events, e.g., when compared to their conventionally colonized (CC) counterparts, sterile newborn mice (“germ-free” or GF) show higher cell death in the hypothalamic paraventricular nucleus (PVN). Here, we tested the hypothesis that the microbiota, perhaps via cell death mechanisms, shapes PVN development. To this aim, we used a cross-fostering approach that also allowed us to test whether any potential effects are influenced by microbial colonization at birth or programmed prenatally via the maternal microbiota. Specifically, we cross-fostered GF pups to CC dams (GF → CC) immediately after birth and compared them to control groups cross-fostered within microbial status (CC → CC, GF → GF). At postnatal day 7, GF → GF and GF → CC newborns had fewer PVN cells than did CC → CC newborns, without affecting PVN volume. In a follow-up experiment, we confirmed a reduction in PVN cell number with no change in PVN volume in adult GF mice. Thus, the greater cell death previously observed in the PVN of newborn GF mice is associated with a permanent reduction in cell number. Because the deficit is not altered by introducing a microbiota at birth, our findings also suggest that the maternal microbiota shapes development of the PVN starting in utero.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"172 ","pages":"Article 105742"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats","authors":"Julio Sierra ,&nbsp;Timothy B. Simon ,&nbsp;Darine Abu Hilal ,&nbsp;Yaria Arroyo Torres ,&nbsp;José M. Santiago Santana ,&nbsp;Johnny D. Figueroa","doi":"10.1016/j.yhbeh.2025.105744","DOIUrl":"10.1016/j.yhbeh.2025.105744","url":null,"abstract":"<div><div>Childhood obesity is a multifactorial disease affecting &gt;160 million adolescents worldwide. Adolescent exposure to obesogenic environments, characterized by access to high-fat diets and stress, precipitates maladaptive eating habits in adulthood such as binge eating. Evidence suggests a strong association between Western-like high–saturated fat (WD) food consumption and dysregulated hormone fluctuations. However, few studies have explored the long-term impact of adolescent WD and psychosocial stress on brain and behavior. This longitudinal study aimed to investigate the impact of adolescent exposure to an obesogenic diet on stress resiliency and increased susceptibility for binge-like eating behaviors. Adolescent male Lewis rats were given WD (41% fat; <em>n</em> = 40) or control diet (CD, 16% fat; <em>n</em> = 38) for 4 weeks before undergoing a stress protocol of predator exposure and social instability (CDE, WDE, CDU, WDU; <em>n</em> = 16/group). Subjects were provided intermittent WD access (24 h/week) to evaluate binge-like eating behavior in adulthood. Fecal corticosterone and testosterone were measured at four timepoints throughout adolescence and adulthood. WD rats exhibited increased body weight (<em>p</em> = 0.0217) and elevated testosterone in mid-adolescence (<em>p</em> = 0.0312) and blunted stress-induced corticosterone response in mid-late adolescence (CDE:WDE, <em>p</em> = 0.028). Adolescent hormone levels were negatively correlated with binging and explained the variability between adult rats expressing hyperphagic and hypophagic behaviors. These results demonstrate that exposure to WD in adolescence disrupts hormone fluctuations and stress responsivity, with effects persisting into adulthood. This underscores the importance of addressing obesogenic environments early to mitigate their lasting impact on hormone regulation and stress responsiveness.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105744"},"PeriodicalIF":2.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between CAIDE risk score and episodic memory in middle-aged females: The impact of spontaneous menopause","authors":"Julia Kearley ,&nbsp;Rikki Lissaman ,&nbsp;Alix Laugier ,&nbsp;M. Natasha Rajah","doi":"10.1016/j.yhbeh.2025.105739","DOIUrl":"10.1016/j.yhbeh.2025.105739","url":null,"abstract":"<div><div>There is growing evidence that postmenopause is associated with episodic memory decline in some females. Although midlife vascular risk factors are established predictors of brain health, it is unclear whether episodic memory decline at postmenopause is related to vascular risk, and whether such effects affect specific mnemonic functions (e.g. recollective processing vs. novelty detection). This study investigated whether vascular risk, measured by the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score, predicts episodic memory in middle-aged females at pre- and post-menopause. Eighty-five cognitively unimpaired females (42 premenopausal, 43 postmenopausal) aged 39.5 to 65.1 years completed easy (low encoding load) and hard (high encoding load) versions of a face-location episodic memory task. Outcome measures were spatial source retrieval (correct source accuracy; CS) and detection of novel stimuli (correct rejections; CR). Linear-mixed models (LMMs) tested menopause group effects on CS and CR, while separate LMMs stratified by menopause status assessed whether CAIDE score predicted memory performance in each group. Results indicated that postmenopausal females performed worse than premenopausal females in both CS (β = 0.08, <em>p</em> &lt; 0.001) and CR (β = 0.05, <em>p</em> = 0.011), with postmenopausal females more sensitive to task difficulty in CS. Higher CAIDE scores were associated with poorer CS accuracy in postmenopausal females only (β = −0.14, <em>p</em> = 0.009), with no effect on CR. These findings highlight the significance of vascular risk in episodic memory decline and emphasize the role of reproductive status in midlife cognition.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105739"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activational and organizational actions of gonadal hormones on the sexual dimorphism of the α6-subunit containing GABAA receptor in Wistar rats with neuropathic pain","authors":"Juan Miguel Pizaña-Encarnación ,&nbsp;María José Escoto-Rosales ,&nbsp;Ana M. Islas-Espinoza ,&nbsp;Diana Karen Morales-Galindo ,&nbsp;Myrna Déciga-Campos ,&nbsp;Blanca Gómez Quintanar ,&nbsp;Rebeca Reyes ,&nbsp;Vinicio Granados-Soto ,&nbsp;Alonso Fernández-Guasti","doi":"10.1016/j.yhbeh.2025.105746","DOIUrl":"10.1016/j.yhbeh.2025.105746","url":null,"abstract":"<div><div>Sex differences in pain perception and response to analgesics are well documented, yet the underlying causes remain poorly understood. Here we investigate the sexual dimorphism in the function of α₆GABA_A receptors in neuropathic pain, focusing on activational and organizational actions of gonadal hormones. Using the nerve ligation model in rats, we found that the positive allosteric modulator, PZ-ll-029 (30 nmol, it), produced a robust antiallodynic effect in females but not in males. Ovariectomy abolished this effect, while a single dose of estradiol (20 μg/kg sc, −24 h), that returned to physiological serum levels, partially restored it, indicating that the activational effect of estradiol is crucial for α₆GABA_A receptor-mediated antiallodynia in females. Interestingly, adult or neonatal (at postnatal day 3) orchidectomy did not alter the male's insensitivity to PZ-ll-029, even after estradiol treatment. However, neonatal female's virilization (with testosterone propionate 120 μg/rat at postnatal day 3) induced a male-like insensitivity to PZ-ll-029, that was partial when the ovaries were present and complete after adult ovariectomy. These findings reveal that the neonatal organizational effects of testosterone determine the sex-specific insensitivity of α₆GABA_A receptors to modulate neuropathic pain, while the activational effects of estradiol can partly maintain the female-typical response, despite early androgen exposure. Our results provide new insights into hormonal regulation of pain modulation and suggest that both developmental exposure and adult status should be considered in basic research and preclinical studies investigating sex-based dimorphisms.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105746"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin administration rescues the negative impacts of social isolation on wound healing in mice","authors":"Sydney R. Steele ,&nbsp;Anna S. Ratuski ,&nbsp;Emily I. Hui ,&nbsp;Brigette S. Mahoney ,&nbsp;Jerome T. Geronimo ,&nbsp;Monika K. Huss ,&nbsp;Karen J. Parker ,&nbsp;Joseph P. Garner","doi":"10.1016/j.yhbeh.2025.105741","DOIUrl":"10.1016/j.yhbeh.2025.105741","url":null,"abstract":"<div><div>In humans and animals, social isolation leads to worsened health outcomes in many disease areas, including wound healing. Oxytocin, a prosocial hormone with anti-inflammatory properties, has been strongly implicated in the salutary benefits of social relationships. Oxytocin administration can mitigate the negative effects of social isolation on health outcomes, as demonstrated in rat and hamster wound healing models. However, little research has been conducted with mice, which are more common laboratory animal models, and which have markedly different social structures from these other rodent species. Moreover, the effects of social isolation and oxytocin administration on wound healing have not been investigated in mice within the same experiment, nor have they been compared between males and females. Here, we housed male and female C57BL/6 mice (<em>n</em> = 40) in social isolation or same-sex pairs. Mice received a subcutaneous biopsy punch wound and were subsequently administered IP oxytocin or placebo daily for 14 days. Socially isolated mice administered oxytocin, and pair-housed mice administered either oxytocin or placebo, showed a significantly faster decrease in wound area and more collagen fiber variance (i.e., less scar tissue) compared to socially isolated mice administered placebo. No sex differences were observed in any outcome measure. Thus, social housing and oxytocin administration each non-additively reduce the negative effects of social isolation on wound healing in mice. Oxytocin administration may be a promising pharmacological strategy by which to improve post-surgical healing in animals and humans, especially in those where limited social contact is necessary or in those with sparse social networks.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105741"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal changes in first-time human fathers in relation to paternal investment","authors":"James K. Rilling ,&nbsp;Minwoo Lee ,&nbsp;Carolyn Zhou ,&nbsp;Esther Jung ,&nbsp;Ella Arrant ,&nbsp;Agena Davenport-Nicholson ,&nbsp;Xing Zhang ,&nbsp;Kelly Ethun","doi":"10.1016/j.yhbeh.2025.105740","DOIUrl":"10.1016/j.yhbeh.2025.105740","url":null,"abstract":"<div><div>In many biparental species, males experience hormonal changes across the transition to fatherhood that prepare them for their new caregiving role. In humans, cross-sectional comparisons have revealed hormonal differences between fathers and nonfathers, however it is not clear when hormone levels change in new fathers, how such changes relate to paternal involvement and attachment, or even whether men with particular hormonal profiles are more likely to become fathers. In this longitudinal study, we aimed to elucidate the trajectory of hormonal changes in new fathers with greater temporal resolution than previous studies, and to provide further insight into the direction of causality between hormone levels and paternal behavior by asking whether hormone levels predict behavior at subsequent time points, or vice-versa. We recruited a sample of 51 first-time expecting fathers and measured levels of plasma testosterone, oxytocin, vasopressin and cortisol at four time points spanning 4–5 months gestation through 4 months postnatally, and we compared these changes to those found in a control sample of 57 adult male nonfathers. We also examined the concurrent and lagged relationships between hormone levels and fathers' self-reported paternal behaviors. From early in the prenatal period, fathers showed lower levels of both testosterone and vasopressin compared with nonfathers, and lower levels of these hormones during the prenatal period predicted greater postnatal paternal investment in the mother and child. Similar to what is known for human mothers, oxytocin levels increased across the gestational period in new fathers, but oxytocin levels were not associated with greater self-reported paternal involvement or attachment. Finally, cortisol levels did not differ between fathers and nonfathers, and were not predictive of paternal involvement or attachment. Our findings raise the possibility that low levels of vasopressin and testosterone found in expecting fathers anticipate a shift in life history strategy toward greater investment in parenting.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105740"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasotocin and oxytocin modulation of the endocrine and behavioral response to an aggressive challenge in male Siamese fighting fish","authors":"Bianca Fusani ,&nbsp;Andreia Ramos ,&nbsp;Sara D. Cardoso ,&nbsp;David Gonçalves","doi":"10.1016/j.yhbeh.2025.105728","DOIUrl":"10.1016/j.yhbeh.2025.105728","url":null,"abstract":"<div><div>Aggressive behavior is an adaptive trait present across all taxa. However, the neuroendocrine mechanisms regulating it, particularly in fish, are not well understood. Oxytocin (OXT) and arginine vasotocin (VT) are known modulators of aggression, but their actions remain controversial. This study tested the possible modulation of endocrine and behavioral responses to an aggression challenge by these nonapeptides in Siamese fighting fish, <em>Betta splendens</em>, a species known for its intrinsic aggressiveness. Male <em>B. splendens</em> were injected with different dosages of either Manning compound or L-368,899, VT and OXT receptor antagonists respectively, and were exposed to a mirror challenge for 30 min. While all fish displayed high levels of aggression toward their mirror image, no differences were observed between control-injected and treatment fish. However, blocking VT inhibited the post-fight increase in plasma levels of the androgen 11-ketotestosterone (KT). To further investigate this result, testis tissue from males was incubated with and without VT and Manning compound, and KT levels were measured after 180 min. Results showed a direct effect of VT on <em>in vitro</em> KT secretion, indicating the presence of VT receptors in the testes of this species. Overall, the study does not support a modulatory role of VT or OXT in aggressive behavior, although VT might be implicated in the regulation of peripheral androgen response to aggression in <em>B. splendens</em>.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"171 ","pages":"Article 105728"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}