Hormones and Behavior最新文献_第4页

Chronic periadolescent leuprolide exposure affects the expression of multiple genes in the hypothalamus and pituitary gland with a different pattern of expression in female and male Long-Evans rats 长期暴露于青春期前后的leuprolide会影响雌性和雄性Long-Evans大鼠下丘脑和垂体中多种基因的表达，且表达模式不同

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-24 DOI: 10.1016/j.yhbeh.2025.105798

Fay A. Guarraci , Ian M. Klepcyk , Lindsay M. Thompson , Madeline Streifer , Emily N. Hilz , Grace Hudson , Sarah H. Meerts , Andrea C. Gore

{"title":"Chronic periadolescent leuprolide exposure affects the expression of multiple genes in the hypothalamus and pituitary gland with a different pattern of expression in female and male Long-Evans rats","authors":"Fay A. Guarraci , Ian M. Klepcyk , Lindsay M. Thompson , Madeline Streifer , Emily N. Hilz , Grace Hudson , Sarah H. Meerts , Andrea C. Gore","doi":"10.1016/j.yhbeh.2025.105798","DOIUrl":"10.1016/j.yhbeh.2025.105798","url":null,"abstract":"<div><div>Protracted exposure to drugs like Lupron Depot® suppresses pubertal development. How the brain responds and develops in the face of pharmacological suppression is not well understood. The present study tested the effects of daily leuprolide acetate (LEU) treatment (50 μg/kg, postnatal day (PD) 25–50) on gene expression (<em>Kiss1</em>, <em>Esr1</em>, <em>Esr2</em>, <em>Ar</em>, <em>Gnrh1</em>, <em>Gnrhr</em>) in the hypothalamus and pituitary of female and male Long-Evans rats using real-time PCR. Brains and trunk blood were harvested on PD 50. In the pituitary gland of both sexes, expression of <em>Esr2</em> and <em>Gnrhr</em> expression was higher in LEU-treated rats than in saline controls. <em>Esr1</em> expression in females was lower and <em>Ar</em> expression in males was higher in LEU-treated rats than saline controls. In the preoptic area of the hypothalamus in male rats, <em>Kiss1</em> expression was significantly lower in LEU than in saline controls. In the mediobasal hypothalamus, <em>Gnrh1</em> and <em>Kiss1</em> expression was higher in LEU-treated male rats than in saline controls; for females, only <em>Kiss1</em> was increased by LEU. Serum gonadal hormone levels were not significantly different in LEU-treated rats than saline controls at the end of treatment, although hormones trended lower in the LEU-treated rats. LEU affected expression of genes involved in reproduction, potentially explaining sex-specific effects of LEU on behavior reported earlier. The changes in hypothalamic and pituitary gene expression may represent compensation that permits early stages of pubertal development (e.g., VO and PPS), but not complete maturation (e.g., estrous cyclicity, sexual behavior) during LEU treatment.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105798"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dopamine agonist affects the social decision-making of calling male túngara frogs 多巴胺激动剂影响雄性túngara蛙的社会决策

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-23 DOI: 10.1016/j.yhbeh.2025.105797

Logan S. James , Sarah C. Woolley , Michael J. Ryan

{"title":"A dopamine agonist affects the social decision-making of calling male túngara frogs","authors":"Logan S. James , Sarah C. Woolley , Michael J. Ryan","doi":"10.1016/j.yhbeh.2025.105797","DOIUrl":"10.1016/j.yhbeh.2025.105797","url":null,"abstract":"<div><div>When vocalizing, many animals engage in decision-making processes that integrate information regarding the current social context. The midbrain dopaminergic system may provide a conserved mechanism underlying this process. For instance, in songbirds, modulation of dopamine release appears to contribute to social context-dependent changes to song. However, relatively little is known about the degree to which dopamine may contribute to similar vocal production and decision-making processes in other taxa, particularly the highly vocal anurans (frogs and toads). Here, we treated wild-caught male túngara frogs (<em>Engystomops pustulosus</em>) with a general dopamine agonist (apomorphine) and assessed its effects on motor performance and motivation as well as vocal decision-making in response to auditory stimuli that varied in social relevance. We found that the dopamine agonist generally increased vocal speed, with decreases in response latencies and call durations. Additionally, we found that dopamine increased call complexity, but only in response to the most socially relevant auditory stimulus (conspecific call). Finally, dopamine treatment and auditory stimulus interacted to affect decision-making regarding call timing and overlap with the stimulus. Compared to controls, frogs with apomorphine were more likely to overlap the playback stimulus in a manner predicted to be more attractive to females. These results highlight a role of dopaminergic circuits in modulating vocal outputs based on social inputs within a species of basal tetrapod.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105797"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal and sex-specific functional genomic pathways of genetic risk candidates in autism spectrum disorder: evidence of sex-over-chance effects 自闭症谱系障碍遗传风险候选者的激素和性别特异性功能基因组途径：性别机会效应的证据

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-23 DOI: 10.1016/j.yhbeh.2025.105795

Camilo Briones-Valdivieso , Francisco Córdova , Heidy Kaune , Juan F. Montiel

{"title":"Hormonal and sex-specific functional genomic pathways of genetic risk candidates in autism spectrum disorder: evidence of sex-over-chance effects","authors":"Camilo Briones-Valdivieso , Francisco Córdova , Heidy Kaune , Juan F. Montiel","doi":"10.1016/j.yhbeh.2025.105795","DOIUrl":"10.1016/j.yhbeh.2025.105795","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a complex neurodevelopmental condition marked by substantial sex differences in prevalence, with males more frequently diagnosed than females. While genetic and environmental factors contribute to ASD, there is growing evidence that sex-specific endocrine pathways, particularly those involving sex hormones, may play a critical role in ASD etiology. This study aimed to investigate the functional network robustness and annotations of autism spectrum disorder genetic risk candidates (ASD-GRCs), with a focus on endocrine pathways and their impact on network connectivity. Using data from the Simon's Foundation Autism Research Initiative (SFARI) and functional network analysis via the STRING database, we assessed the connectivity of ASD-related genes by randomly subtracting sets of genes from the whole ASD gene network in subsets associated with androgen-testosterone, estrogen-progesterone, and other hormone pathways.</div><div>Our findings reveal a significant “sex-over-chance” association, with androgen- and estrogen-related gene subsets showing marked connectivity within the ASD gene network compared to non-sex hormone genes. These results suggest that sex hormones may uniquely influence ASD-related neural development, providing support for the “female protective effect” and the androgen-driven model of ASD. Additional analyses of other hormonal pathways, such as oxytocin and cortisol, showed a lower connectivity impact, reinforcing the distinctive role of sex hormones in ASD. This study highlights the potential of endocrine-focused genetic analysis in understanding ASD, emphasizing sex-specific biological mechanisms that may inform future diagnostic and therapeutic strategies.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105795"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus 矿化皮质激素受体缺失改变了自动家庭笼监测装置中的自发行为

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-21 DOI: 10.1016/j.yhbeh.2025.105794

Dalisa R. Kendricks , Sarah Jo Sleiman , Sydney A. Fry , Jariatu Stallone , Briana J. Bernstein , Korey D. Stevanovic , Leslie R. Aksu , Georgia M. Alexander , Katharine E. McCann , Serena M. Dudek , Jesse D. Cushman

{"title":"Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus","authors":"Dalisa R. Kendricks , Sarah Jo Sleiman , Sydney A. Fry , Jariatu Stallone , Briana J. Bernstein , Korey D. Stevanovic , Leslie R. Aksu , Georgia M. Alexander , Katharine E. McCann , Serena M. Dudek , Jesse D. Cushman","doi":"10.1016/j.yhbeh.2025.105794","DOIUrl":"10.1016/j.yhbeh.2025.105794","url":null,"abstract":"<div><div>Mineralocorticoid receptors (MRs) are transcription factors expressed throughout the body and brain, with especially high expression in the hippocampal area CA2. MRs are essential for maintaining the physiological stress response and regulating the hypothalamic-pituitary adrenal (HPA) axis. Further, MRs function through the diurnal modulation of corticosterone activity. The aim of the current study was to determine the role MRs play in the modulation of spontaneous behavior throughout the day/night cycle. Three conditional MR knockout mouse lines were utilized: one with broad embryonic neuronal deletion (Nestin-Cre), one with embryonic forebrain deletion (EMX-Cre), and one with postnatal CA2-targeted deletion (Amigo2-Cre). Behavior in these strains was assessed using an automated home cage monitoring system to track spontaneous behavior over a 60-h period. Broad deletion of MRs disrupted behavior in a sex-dependent manner, with alteration in motor activity and shelter behavior at night. Forebrain deletion of MRs produced similar, but less pronounced, differences in motor activity and shelter behavior, while CA2-targeted deletion produced little alteration in behavior either during the day or at night. These findings provide evidence for the essential role of MRs in the regulation of behavior across the day/night cycle and shed a light on the role of MR development and expression on behavior.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105794"},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and verbal performance relate to the duration of combined oral contraceptive use but do not change during the pill-free interval 空间和语言表现与联合口服避孕药使用的持续时间有关，但在无药间隔期间没有变化

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-17 DOI: 10.1016/j.yhbeh.2025.105790

Isabel Noachtar, Belinda Pletzer

{"title":"Spatial and verbal performance relate to the duration of combined oral contraceptive use but do not change during the pill-free interval","authors":"Isabel Noachtar, Belinda Pletzer","doi":"10.1016/j.yhbeh.2025.105790","DOIUrl":"10.1016/j.yhbeh.2025.105790","url":null,"abstract":"<div><h3>Background</h3><div>Ovarian hormones and testosterone have been related to verbal and spatial processing. Oral contraceptives are taken by approximately 150 million women worldwide often for extended time periods. To date, the literature on long-term effects of COCs on cognition is sparse, and results and methodology are inconsistent.</div></div><div><h3>Objectives</h3><div>In this manuscript we examined whether verbal and spatial performance changed (i) during short-term hormonal withdrawal as during the monthly pill pause and (ii) related to the duration of COC-use. We assessed the moderating effects of progestin type (androgenicity) and task complexity.</div></div><div><h3>Methods</h3><div>180 participants (60 androgenic COC-users, 60 anti-androgenic COC-users and 60 non-users with a menstrual cycle) were tested once during their active pill phase/luteal phase and once during their pill pause/menses. We compared mental rotation, navigation and verbal fluency performance between the pill pause and active intake phase in COC users and assessed how the differences compared to fluctuations along the menstrual cycle in naturally cycling women.</div></div><div><h3>Results</h3><div>No differences between active pill intake and pill pause were found in mental rotation, navigation or verbal fluency in long-term users. Irrespective of COC-phase, androgenic COC-users demonstrated higher orientation accuracy compared to anti-androgenic COC-users and non-users. Longer pill duration was associated with better orientation accuracy and decreased phonemic word and switching production in COC-users independent of the pill's androgenicity.</div></div><div><h3>Conclusion</h3><div>The association of verbal and spatial performance to COC use duration in the absence of short-term changes during the pill-free interval may hint at cumulative effects of long-term COC-use on spatial and verbal processing.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105790"},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conspecifics confer survival advantage in the face of night-light polluted environment: Evidence from melatonin secretion, sleep, mood and cognitive performance in Indian house crows 同种生物在面对夜间光线污染的环境时赋予生存优势：来自印度家鸦褪黑素分泌、睡眠、情绪和认知表现的证据

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-17 DOI: 10.1016/j.yhbeh.2025.105793

Amaan Buniyaadi , Sanjay Kumar Bhardwaj , Vinod Kumar

{"title":"Conspecifics confer survival advantage in the face of night-light polluted environment: Evidence from melatonin secretion, sleep, mood and cognitive performance in Indian house crows","authors":"Amaan Buniyaadi , Sanjay Kumar Bhardwaj , Vinod Kumar","doi":"10.1016/j.yhbeh.2025.105793","DOIUrl":"10.1016/j.yhbeh.2025.105793","url":null,"abstract":"<div><div>The survival advantage of group living remains poorly understood. Here, this was investigated by using several physiological and neurobehavioral traits in Indian house crows (<em>Corvus splendens</em>) in the face of a temporally disrupted day-night environment. Crows were housed singly or with two other conspecifics and subjected to daily 12-h light and 12-h periods of complete (0 lx) or dimly lighted (∼6 lx) dark nights. Nocturnal melatonin and sleep levels were measured as indices of the direct and circadian effects, while mood (feeding, preening, and self-mutilation) and cognition (innovative problem-solving task) performances were considered reflecting the higher-order brain function effects. Under 6-lx dim light at night (dLAN) condition, group housing alleviated the depressive-like responses and enhanced cognitive performance but had no effect on the midnight melatonin levels and nocturnal sleep consolidation. Concurrently, there were increased <em>nr4a2</em> and decreased <em>tnfr1</em> gene expressions in hippocampus, increased <em>dcx</em> and <em>darpp-32</em> gene expressions in the nidopallium caudolaterale, and <em>th</em> expression in midbrain. We interpret that an increased conspecific interaction improved mood and cognitive performance without affecting the melatonin secretion and sleep in communally roosting house crows. Perhaps, living with conspecifics is part of an overall evolutionary strategy to enhance the survival in a highly social species like the Indian house crow.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105793"},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to novel females increases fecundity in adult male prairie voles 接触新的雌性会增加成年雄性草原田鼠的繁殖力

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-07-07 DOI: 10.1016/j.yhbeh.2025.105779

Jessica A. Hurd , Yurika L. Watanabe , Gracie J. Toben , Alexandra K. Ford , Craig A. Miller , Casey E. Sergott , Dale Kelley , Zoe R. Donaldson , Elizabeth A. McCullagh

{"title":"Exposure to novel females increases fecundity in adult male prairie voles","authors":"Jessica A. Hurd , Yurika L. Watanabe , Gracie J. Toben , Alexandra K. Ford , Craig A. Miller , Casey E. Sergott , Dale Kelley , Zoe R. Donaldson , Elizabeth A. McCullagh","doi":"10.1016/j.yhbeh.2025.105779","DOIUrl":"10.1016/j.yhbeh.2025.105779","url":null,"abstract":"<div><div>Social circuitry of the mammalian brain can influence male reproductive physiology. This often manifests as plasticity in sperm production or allocation, particularly in response to male-male competition. However, socially mediated testicular plasticity has not been investigated with respect to mating and parental strategy. Testis mass and sperm production of sexually naïve and female-exposed adult male individuals of three rodent species were compared: the socially monogamous and paternal prairie vole (<em>Microtus ochrogaster</em>), the promiscuous meadow vole (<em>Microtus pennsylvanicus</em>), and the promiscuous house mouse (<em>Mus musculus</em>). Monogamously paired prairie vole males exhibited significantly larger testes and greater sperm production than naïve prairie vole males. Comparatively, there were no significant differences between naïve and monogamously paired male meadow voles or mice. To investigate the role of olfactory cues for regulating this phenomenon in prairie voles, a group of naïve males exposed to soiled bedding from novel females was used. These males were more similar to paired males than to naïve males not exposed to novel female odors, demonstrating a strong role of the social olfactory system. Further, the predictions of sperm competition theory (species with greater female promiscuity have larger testes than closely related species with less female promiscuity) are not observed between prairie voles and meadow voles. This demonstrates the complexity of intraspecies social dynamics and reproductive pressures which socially monogamous paternal males face and the evolutionary adaptations that may develop in response.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"174 ","pages":"Article 105779"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal immune activation during the lactational period alters offspring behavior, reproductive development, and immune function in mice 哺乳期母体免疫激活会改变小鼠后代的行为、生殖发育和免疫功能

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-20 DOI: 10.1016/j.yhbeh.2025.105776

Jailyn A. Merengueli, Amanda C. Kentner

{"title":"Maternal immune activation during the lactational period alters offspring behavior, reproductive development, and immune function in mice","authors":"Jailyn A. Merengueli, Amanda C. Kentner","doi":"10.1016/j.yhbeh.2025.105776","DOIUrl":"10.1016/j.yhbeh.2025.105776","url":null,"abstract":"<div><div>Exposure to infection during early life can lead to lasting neurodevelopmental changes. Animal models of maternal immune activation (MIA) typically assess neurobehavioral alterations in offspring following a prenatal inflammatory challenge. However, MIA effects on offspring can extend to challenges that occur during the lactational period. In the present study, we adapted previous methods focused on rats and challenged nursing C57BL/6J mouse mothers on postnatal day (P)8 with either the bacterial mimetic lipopolysaccharide (LPS; 250 μg/kg, i.p.) or saline (control, i.p.). By exposing only the mother to LPS, this modeled a postpartum infection in the dam. Similar to the rat model, lactational MIA did not detrimentally alter maternal care but induced displays of maternal sickness, as expected. While neonatal offspring behaviors (e.g., huddling, ultrasonic vocalizations, negative geotaxis) were unaffected, significant effects of lactational MIA emerged in juvenile (e.g., social preference, accelerated reproductive milestones) and adult (e.g., mechanical allodynia, prepulse inhibition) offspring. In a separate set of animals, the developmental programming potential of lactational MIA on immune function was evident following a “second hit” LPS challenge in adulthood (e.g., altered plasma concentrations of interleukin-6 and leukocytes, including neutrophils, and lymphocytes). These findings confirm the generalizability of the lactational MIA model across species and highlight the importance of supporting caregiver health and wellness across the critical nursing period.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105776"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex- and site-specific effects of GPER-1 activation on saccharin vs cocaine preference in male and female rats GPER-1激活对雌雄大鼠对糖精和可卡因偏好的性别和位点特异性影响

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-18 DOI: 10.1016/j.yhbeh.2025.105777

Christopher A. Turner , Jill B. Becker

{"title":"Sex- and site-specific effects of GPER-1 activation on saccharin vs cocaine preference in male and female rats","authors":"Christopher A. Turner , Jill B. Becker","doi":"10.1016/j.yhbeh.2025.105777","DOIUrl":"10.1016/j.yhbeh.2025.105777","url":null,"abstract":"<div><div>Estradiol (E2) receptor signaling has a sex-specific impact on the brain's reward pathway, enhancing cocaine reinforcement in females but not in males. Selective activation of G-Protein Coupled Estradiol Receptor 1 (GPER-1) in the dorsolateral striatum (DLS) attenuates the reinforcing effects of 0.1 % saccharin (SACC) and cocaine in males but not females. This study investigated GPER-1 activation in the DLS and systemically using the GPER-1 agonist G1 to assess its effect on SACC and cocaine preference in male and female rats. Five experiments were conducted using gonad-intact and gonadectomized animals to determine dose-response effects and the influence of circulating hormones. Intra-DLS GPER-1 activation with 20 % G1 selectively reduced SACC preference in intact males but not females, while higher and lower concentrations had no effect. Systemic G1 administration attenuated cocaine-induced conditioned place preference (CPP) in both sexes in a dose-dependent way. Interestingly, systemic administration of G1 did not alter SACC preference in either sex, regardless of the presence or absence of gonadal hormones. These findings suggest that GPER-1 activation influences reward processing in a site-, reward-, and sex-dependent manner.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105777"},"PeriodicalIF":2.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral sex differences in the developmental emergence and selectivity of partner preferences in prairie voles 草原田鼠择偶行为的性别差异

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-06-17 DOI: 10.1016/j.yhbeh.2025.105778

Ciara A. Schaepe, Lisa C. Hiura

{"title":"Behavioral sex differences in the developmental emergence and selectivity of partner preferences in prairie voles","authors":"Ciara A. Schaepe, Lisa C. Hiura","doi":"10.1016/j.yhbeh.2025.105778","DOIUrl":"10.1016/j.yhbeh.2025.105778","url":null,"abstract":"<div><div>Convergent evidence across foundational and clinical research has demonstrated the expansive functions and health consequences of adult pair bonding. For decades now, study of the socially monogamous prairie vole (<em>Microtus ochrogaster</em>) has provided valuable mechanistic insights into the neuromolecular substrates that enable adult pair bond formation and maintenance. Despite this rapidly growing literature, substantially less is known about the lifespan development of pair bonding behavior and the organization of the monogamous brain. To characterize the age at which prairie voles are capable of pair bonding, we tested if male and female prairie voles between juvenile and adult stages of development could exhibit an other-sex partner preference after 48 h of cohabitation. We found that females paired by early adolescence (P31–36) preferred to huddle with their partner over a novel male conspecific, but this selective social preference was not observed in males until adulthood (P60+). Further, the degree of preference for the pair bond partner was greater in females compared to males, suggesting that there is a robust sex difference in the developmental onset and strength of pair bonding in this species. Identifying the typical developmental trajectories of sex-specific pair bonding behavior will enable novel inquiries into the neuroscience and endocrinology of age-specific social attachments.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"173 ","pages":"Article 105778"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0