Hormones and Behavior最新文献_第4页

Different social experiences drive the development of divergent stress coping styles in female swordtails (Xiphophorus nigrensis) 不同的社会经历促使雌性剑尾鱼（xiphohorus nigrensis）发展出不同的应激应对方式。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-02-01 DOI: 10.1016/j.yhbeh.2025.105675

Sunishka Thakur, Elena Adams, Chloe Prahl, Alan Vuong, Mary Ramsey, Molly E. Cummings

{"title":"Different social experiences drive the development of divergent stress coping styles in female swordtails (Xiphophorus nigrensis)","authors":"Sunishka Thakur, Elena Adams, Chloe Prahl, Alan Vuong, Mary Ramsey, Molly E. Cummings","doi":"10.1016/j.yhbeh.2025.105675","DOIUrl":"10.1016/j.yhbeh.2025.105675","url":null,"abstract":"<div><div>Individual variation in stress coping styles is widespread and consequential to health and fitness. Proactive (bold behavior, low stress reactivity, low cognitive flexibility) and reactive (shy behavior, high stress reactivity, high cognitive flexibility) coping styles are found in many species, but the developmental forces shaping them remain elusive. We examined how social influences, specifically mating interactions, shape the development of adult female coping styles with a manipulative rearing experiment using El Abra swordtails, <em>Xiphophorus nigrensis</em>. We raised juvenile females in environments with different male reproductive phenotypes: coercive-only, courting-only, or complex (both coercive and courting males). At adulthood, we measured female stress reactivity (cortisol release following acute stress), boldness (scototaxis and open field responses), and cognitive flexibility (as inhibitory control in a detour task). Females raised in coercive and complex environments developed higher cortisol reactivity than females raised with only courtship. Stress coping trait correlations varied significantly across social environments producing different coping styles across treatments. Traditional proactive and reactive stress coping styles developed in the coercive-only environment with negative correlations between stress response and boldness, stress response and cognitive flexibility, and boldness and cognitive flexibility. Meanwhile, the courtship-only environment produced a negative correlation between stress response and boldness. We thus demonstrate that the relationship between stress response and boldness can be socially modulated. These findings suggest that developmental variation in social experiences can shape suites of traits with complex relationships; and that highly stressful social interactions, such as sexual coercion, can be a strong driver of stress coping styles.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"168 ","pages":"Article 105675"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dominance and aggressiveness are associated with vasotocin neuron numbers in a cooperatively breeding cichlid fish 在合作繁殖的慈鲷中，优势性和攻击性与后叶催产素神经元数量有关。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-02-01 DOI: 10.1016/j.yhbeh.2025.105677

Tommaso Ruberto, William T. Swaney, Adam R. Reddon

{"title":"Dominance and aggressiveness are associated with vasotocin neuron numbers in a cooperatively breeding cichlid fish","authors":"Tommaso Ruberto, William T. Swaney, Adam R. Reddon","doi":"10.1016/j.yhbeh.2025.105677","DOIUrl":"10.1016/j.yhbeh.2025.105677","url":null,"abstract":"<div><div>Within dominance hierarchies, individuals must interact in a rank-appropriate manner, thus behavior and its underlying neural mechanisms must change with social status. One such potential neural mechanism is arginine vasotocin (AVT), a nonapeptide which has been implicated in the regulation of dominance and aggression across vertebrate taxa. We investigated the relationship between social status, dominance-related behaviors, and vasotocin neuron counts in daffodil cichlids (<em>Neolamprologus pulcher</em>). Daffodil cichlids live in stable, mixed-sex, cooperatively breeding social groups that are organised into linear dominance hierarchies. Group members of both sexes exhibit complex behavioral repertoires which differ depending on their current social status. We recorded agonistic behaviors within groups of daffodil cichlids and correlated these with the number of AVT cells within the three distinct neuronal populations in the preoptic area of the brain, comparing across social status and sex. We found that parvocellular AVT neurons were more abundant in dominant individuals than subordinates. We also found that numbers of both parvocellular and magnocellular AVT neurons were positively associated with aggression in dominant individuals. AVT neuron counts were unrelated to submissive behavior in subordinate fish. Our data emphasise the role of AVT in modulating status and aggression in social vertebrates.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"168 ","pages":"Article 105677"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal variation in aggression and physiological stress in wild female and male redfronted lemurs (Eulemur rufifrons) 野生雌、雄性红毛狐猴攻击性和生理应激的季节变化。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105669

Lea Prox , Michael Heistermann , Zafimahery Rakotomala , Claudia Fichtel , Peter M. Kappeler

{"title":"Seasonal variation in aggression and physiological stress in wild female and male redfronted lemurs (Eulemur rufifrons)","authors":"Lea Prox , Michael Heistermann , Zafimahery Rakotomala , Claudia Fichtel , Peter M. Kappeler","doi":"10.1016/j.yhbeh.2024.105669","DOIUrl":"10.1016/j.yhbeh.2024.105669","url":null,"abstract":"<div><div>Intraspecific competition with fellow group members represents an unavoidable cost of group living. However, the causes of competition can vary among group members, and ecological and reproductive challenges faced by individuals throughout the year can trigger physical conflicts and or physiological responses. To date, few studies in mammals have described both physiological and behavioral responses to competition simultaneously across the year in both males and females. However, such an approach may shed light on ultimate drivers of sex-specific competitive strategies. In this six-year study on multiple groups of wild redfronted lemurs (<em>Eulemur rufifrons</em>), a primate species from Madagascar, we intended to identify the relative importance of feeding vs. reproductive competition for both sexes. We combined data on fecal glucocorticoid metabolite (FGCM) levels, a proxy for the physiological stress response, with behavioral observations on agonistic interactions during ecologically and socially challenging phases across the year. We found that while FGCM levels increased in both sexes with decreasing fruit consumption, this increase was not accompanied by concomitant changes in agonistic behavior. Female aggression and FGCM levels instead peaked during the birth season, while for males, aggression remained fairly constant across the year. Our results suggest that redfronted lemurs have mechanisms to avoid direct competition through aggression at times when individuals may need to conserve energy.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105669"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral administration of ethinyl estradiol and the brain-selective estrogen prodrug DHED in a female common marmoset model of menopause: Effects on cognition, thermoregulation, and sleep 雌性狨猴更年期模型中口服炔雌醇和脑选择性雌激素前药ded：对认知、体温调节和睡眠的影响

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105670

Emily S. Rothwell , Shaun S. Viechweg , Laszlo Prokai , Jessica A. Mong , Agnès Lacreuse

{"title":"Oral administration of ethinyl estradiol and the brain-selective estrogen prodrug DHED in a female common marmoset model of menopause: Effects on cognition, thermoregulation, and sleep","authors":"Emily S. Rothwell , Shaun S. Viechweg , Laszlo Prokai , Jessica A. Mong , Agnès Lacreuse","doi":"10.1016/j.yhbeh.2024.105670","DOIUrl":"10.1016/j.yhbeh.2024.105670","url":null,"abstract":"<div><div>Menopausal symptoms of sleep disturbances, cognitive deficits, and hot flashes are understudied, in part due to the lack of animal models in which they co-occur. Common marmosets (<em>Callithrix jacchus</em>) are valuable nonhuman primates for studying these symptoms, and we examined changes in cognition (reversal learning), sleep (48 h/wk of sleep recorded by telemetry), and thermoregulation (nose temperature in response to mild external warming) in middle-aged, surgically-induced menopausal marmosets studied at baseline, during 3-week phases of ethinyl estradiol (EE<sub>2</sub>, 4 μg/kg/day, p.o.) treatment and after EE<sub>2</sub> withdrawal. We also assessed a brain-selective hormonal therapy devoid of estrogenic effects in peripheral tissues on the same measures (cognition, sleep, thermoregulation) after treatment with the estrogen prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED, 100 μg/kg/day, p.o) and DHED withdrawal. Reversal learning performance was improved with EE<sub>2</sub> or DHED treatment relative to phases without hormone administration, as indicated by a faster reversal of the stimulus/reward contingencies. Both EE<sub>2</sub> and DHED increased non-REM sleep and reduced nighttime awakenings relative to baseline, but to the detriment of REM sleep which was highest at baseline. Nasal temperature in response to mild external warming was highest, and overnight core body temperature lowest, in the DHED treatment phase compared to both the EE<sub>2</sub> and baseline phases. These results suggest that low dose estradiol, delivered either peripherally or centrally via DHED, benefits selective aspects of cognition and sleep in a marmoset menopause model. DHED appears a promising therapeutic candidate for alleviating the cognitive and sleep disruptions associated with estrogen deficiency in primates.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105670"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reward of tactile genital stimulation is sexually equivalent, but mechanistically differentiated in mice 触觉生殖器刺激的奖励在性别上是等同的，但在小鼠中有机械上的区别。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105672

Thanh Phung, D. Ashley Monks

{"title":"Reward of tactile genital stimulation is sexually equivalent, but mechanistically differentiated in mice","authors":"Thanh Phung, D. Ashley Monks","doi":"10.1016/j.yhbeh.2024.105672","DOIUrl":"10.1016/j.yhbeh.2024.105672","url":null,"abstract":"<div><div>Gonadal steroid hormones are thought to activate sexual behavior by actions on multiple organ systems, including the nervous system and genitalia. We previously characterized ovarian hormone dependent behavioral and neural responses to clitoral stimulation in female mice. Here we investigate whether sex differences exist in the responses to tactile genital stimulation, and whether these might depend on gonadal androgens. We measured conditioned place preference (CPP) in response to manual tactile stimulation of either the prepuce or dorsum and subsequently measured neural activation. Behavioral and neural responses to genital stimulation were sexually equivalent in gonadally intact mice, with males exhibiting CPP and neural activation responses similar to those previously reported in females, with the exception of the Arcuate nucleus, which was activated to a greater extent in females. An unexpected sex difference in response to dorsal stimulation was observed, with only males developing CPP and increased FOS expression in the nucleus accumbens. Unlike females, the reward value of tactile stimulation was unaffected by gonadectomy in males. However, neural responses to tactile stimulation were disrupted by gonadectomy in both sexes. Testosterone treatment was only partially effective in restoring neural responses to genital stimulation and did so in a sexually diffentiated manner. We conclude that behavioral and neural responses of sexually-naïve mice to genital stimulation are largely similar between males and females, but that non-genital tactile stimulation is more reinforcing to males. Further, the relationship between gonadal steroid hormones and genital reward is sexually differentiated.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105672"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats Kisspeptin参与有节奏交配诱导的积极奖励状态，调节雌性大鼠的性接受性和有节奏交配行为。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105671

M. Bedos , E. Ponce , R. Corona , R.G. Paredes

{"title":"Kisspeptin participates in the positive reward state induced by paced mating and modulates sexual receptivity and paced mating behavior in female rats","authors":"M. Bedos , E. Ponce , R. Corona , R.G. Paredes","doi":"10.1016/j.yhbeh.2024.105671","DOIUrl":"10.1016/j.yhbeh.2024.105671","url":null,"abstract":"<div><div>Kisspeptin (Kp), a potent regulator of the hypothalamic-pituitary-gonad axis, was recently shown to be involved in partner preference and sexual receptivity in females. Interestingly, Kp and its receptor (Kiss1r) are expressed in brain regions involved in the reward and motivation of reinforcing behaviors. Therefore, in the present study, we designed 3 experiments to determine the participation of Kp in female sexual behavior and the positive affective (PA) reward state induced by paced mating (PM). In all experiments, we used sexually naïve ovariectomized Wistar female rats primed with estradiol benzoate (EB, 2.5 μg/rat) 48 h before behavioral tests. In experiment 1 (<em>n</em> = 9), we tested the effect of Kp on PM. We demonstrated that Kp-10 (14 nmol) induced similar levels of receptivity to treatment with EB + progesterone and facilitated PM by reducing the return latency after intromissions. In experiment 2 (<em>n</em> = 8), we evaluated the effect of p234 penetratin, a Kiss1r antagonist, on PM. The administration of p234 in doses of 7.5 nmol and 15 nmol reduced the mean lordosis intensity and increased mount and intromission return latencies. Finally, in Experiment 3, we tested the capacity of Kp to induce a PA state or the antagonist to block the reward state induced by PM. Kp-10 (7 and 14 nmol) induced a clear conditioned place preference. This reward state and that produced by PM were blocked by p234 (15 nmol). Our findings underscore the critical role of Kp in modulating female sexual behavior and the PA state associated with PM, highlighting its potential to enhance sexual motivation.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105671"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous estradiol impacts anxiety-like behavior of juvenile male and female Siberian hamsters in a dose-dependent manner 外源性雌二醇对幼年西伯利亚仓鼠焦虑样行为的影响呈剂量依赖性。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105674

Zoey Forrester-Fronstin , Abigal R. Barrett , Amanda S. Mondschein , Jordan M. Johnson , Chloe N. Cordes , Tamijah S. Lawton-Stone , Kelcie C. Schatz , Matthew J. Paul

{"title":"Exogenous estradiol impacts anxiety-like behavior of juvenile male and female Siberian hamsters in a dose-dependent manner","authors":"Zoey Forrester-Fronstin , Abigal R. Barrett , Amanda S. Mondschein , Jordan M. Johnson , Chloe N. Cordes , Tamijah S. Lawton-Stone , Kelcie C. Schatz , Matthew J. Paul","doi":"10.1016/j.yhbeh.2024.105674","DOIUrl":"10.1016/j.yhbeh.2024.105674","url":null,"abstract":"<div><div>Anxiety is among the most prevalent mental health issues in children. While it is well established that gonadal steroids influence anxiety-like behavior in adulthood, a potential role in prepubertal juveniles has been overlooked because it is commonly thought that the gonads are quiescent during the juvenile period. However, the juvenile gonads secrete measurable amounts of steroids, and we have recently found that prepubertal ovariectomy decreases anxiety-like behavior of juvenile Siberian hamsters in the light/dark box test. The present study tested whether an injection of estradiol benzoate (1 μg or 10 μg, SC) to gonadectomized hamsters (Exp. 1) or chronic suppression of endogenous estradiol with the aromatase inhibitor, letrozole (2 mg/kg, PO), to intact hamsters (Exp. 2) affects anxiety-like behavior in the light/dark box test during the juvenile phase. Estradiol benzoate altered anxiety-like behavior of both male and female juveniles in a dose-dependent manner, with anxiolytic actions at the low dose, but no effect at the high dose. Similar effects were seen for activity measures, albeit only in females. Letrozole suppressed uterine weights demonstrating an active role for endogenous estradiol during the juvenile phase. Anxiety-like behavior, however, was impacted by the administration procedure itself, preventing conclusions on letrozole's actions on behavior. While the role for endogenous estradiol in juvenile anxiety-like behavior remains unresolved, the present findings indicate that the neural centers regulating affective behavior are responsive to exogenous estradiol prior to puberty. These findings highlight the potential impact of exogenous estrogen exposures on juvenile affective behavior.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105674"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of ovariectomy, 17β-estradiol treatment, and progesterone treatment on dopaminergic regulation of prepulse inhibition in adult and adolescent female mice 卵巢切除、17β-雌二醇和黄体酮处理对成年和青春期雌性小鼠脉前抑制多巴胺能调节的影响。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2025-01-01 DOI: 10.1016/j.yhbeh.2024.105673

Maarten van den Buuse , Jenny Sun , Andrea Gogos

{"title":"The effect of ovariectomy, 17β-estradiol treatment, and progesterone treatment on dopaminergic regulation of prepulse inhibition in adult and adolescent female mice","authors":"Maarten van den Buuse , Jenny Sun , Andrea Gogos","doi":"10.1016/j.yhbeh.2024.105673","DOIUrl":"10.1016/j.yhbeh.2024.105673","url":null,"abstract":"<div><div>The aim of the present study was to investigate the role of ovarian hormones on dopaminergic regulation of prepulse inhibition (PPI), a measure of sensorimotor gating deficient in schizophrenia and other psychiatric illnesses. Either in adulthood (11 weeks of age) or adolescence (5 weeks of age), female mice underwent ovariectomy (OVX) and were implanted with 17β-estradiol, progesterone, or a combination of these hormones. All mice were tested in adulthood for the acute effect of the dopamine receptor agonist, apomorphine, on PPI.</div><div>Apomorphine treatment reduced PPI in intact mice and this effect was blocked after OVX in adulthood. A low dose implant of 17β-estradiol prevented this OVX effect and reinstated apomorphine-induced PPI disruption. Following adolescent OVX, the effect of apomorphine was not altered and it significantly reduced PPI in adulthood. A low dose implant of 17β-estradiol following adolescent OVX effect blocked apomorphine-induced PPI disruption in adulthood. Apomorphine had no effect on PPI in any of the mice treated with the high dose of 17β-estradiol or a combination of low-dose 17β-estradiol and progesterone, irrespective of treatment age, suggesting an antipsychotic action. Apomorphine tended to disrupt PPI in mice treated with progesterone only, irrespective of age of OVX.</div><div>These results suggest that in adult mice, circulating 17β-estradiol and progesterone play an important role in dopaminergic regulation of PPI. This role may develop during adolescence as similar effects of OVX and ovarian hormones were not observed following interventions in 5-week old mice. Our results also confirm and extend previous evidence that 17β-estradiol may have antipsychotic properties.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105673"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parenthood and gene expression of oxytocin receptors and vasopressin receptors in sensory cortices of the male California mouse (Peromyscus californicus) 父母身份与雄性加利福尼亚小鼠（Peromyscus californicus）感觉皮层中催产素受体和血管加压素受体的基因表达。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-11-15 DOI: 10.1016/j.yhbeh.2024.105661

Kerianne M. Wilson , Tjien Dwyer , Alison V. Ramirez , April M. Arquilla , Adele M.H. Seelke , Brian C. Trainor , Wendy Saltzman

{"title":"Parenthood and gene expression of oxytocin receptors and vasopressin receptors in sensory cortices of the male California mouse (Peromyscus californicus)","authors":"Kerianne M. Wilson , Tjien Dwyer , Alison V. Ramirez , April M. Arquilla , Adele M.H. Seelke , Brian C. Trainor , Wendy Saltzman","doi":"10.1016/j.yhbeh.2024.105661","DOIUrl":"10.1016/j.yhbeh.2024.105661","url":null,"abstract":"<div><div>The onset of parental care is associated with shifts in parents' perception of sensory stimuli from infants, mediated by neural plasticity in sensory systems. In new mothers, changes in auditory and olfactory processing have been linked to plasticity at several points along both sensory pathways, including cortical changes that are modulated, at least in part, by oxytocin. In males of biparental species, vasopressin, in addition to oxytocin, is important for modulating parental behavior; however, little is known about sensory plasticity in new fathers. We examined variation in the mRNA expression of oxytocin and vasopressin receptors (<em>Oxtr</em> and <em>Avpr1a)</em> in sensory cortices of virgin males, paired nonbreeding males, and new fathers in the biparental California mouse (<em>Peromyscus californicus</em>), and variation among cortices using the visual cortex for comparison. Reproductive status did not affect gene expression for either receptor, but compared to the visual cortex, expression of both receptors was higher in the left auditory cortex and lower in the anterior olfactory nucleus. Additionally, expression for both receptors was higher in the left auditory cortex compared to the right auditory cortex. While oxytocin and vasopressin receptor expression may remain stable across reproductive stages in male California mice, our findings provide support for auditory cortex lateralization, with the left auditory cortex possibly displaying higher sensitivity to both oxytocin and vasopressin compared to the right.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"167 ","pages":"Article 105661"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin treatment during the breeding season increases testosterone in male green anole lizards (Anolis carolinensis) 在繁殖季节使用褪黑激素会增加雄性绿鬣蜥（Anolis carolinensis）体内的睾酮。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-11-01 DOI: 10.1016/j.yhbeh.2024.105655

Nicholas T. Shankey, Bernadette L. Igo, Taylor L. Grossen, Rachel E. Cohen

{"title":"Melatonin treatment during the breeding season increases testosterone in male green anole lizards (Anolis carolinensis)","authors":"Nicholas T. Shankey, Bernadette L. Igo, Taylor L. Grossen, Rachel E. Cohen","doi":"10.1016/j.yhbeh.2024.105655","DOIUrl":"10.1016/j.yhbeh.2024.105655","url":null,"abstract":"<div><div>Melatonin is a natural hormone that regulates seasonal behaviors in vertebrates by binding to its receptors (MT1 and MT2). Specifically, high levels of melatonin are associated with short photoperiods, often coinciding with the non-breeding season, meaning that melatonin may inhibit seasonal reproduction. Green anole lizards (<em>Anolis carolinensis</em>), have large, active gonads, increased levels of testosterone and estradiol, and increased reproductive behaviors during the breeding season. Previous studies have examined the role of melatonin in seasonal reproduction in this species, but it is unclear how melatonin receptors change seasonally or if melatonin treatment during the early breeding season influences reproduction. In Experiment 1, we measured MT1 and MT2 mRNA expression in the brains and gonads of unmanipulated anoles between breeding and non-breeding seasons. MT1 mRNA expression was significantly higher in the male brain during the breeding season compared to the non-breeding season, and MT1 mRNA levels were generally higher compared to MT2. This suggests that melatonin may regulate seasonal reproduction through MT1 in the brain, and higher levels during the breeding season may compensate for low seasonal levels of melatonin. In Experiment 2, anoles were treated with melatonin or a blank control for 10 weeks during the breeding season. In males, melatonin treatment increased testosterone levels. This suggests that rather than inhibiting reproduction, continuous high doses of melatonin may increase reproductive hormones during the breeding season. Our findings support the role of melatonin in modulating seasonal reproduction, but the exact mechanisms behind melatonin's stimulatory effect is unclear.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"166 ","pages":"Article 105655"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0