Hormones and Behavior最新文献_第6页

Defining the brain control of physiological stability 确定大脑对生理稳定性的控制。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-08-01 DOI: 10.1016/j.yhbeh.2024.105607

Tyler J. Stevenson

引用次数: 0

Prolactin modulates changes in parental care behaviour in response to perceived paternity in bluegill sunfish (Lepomis macrochirus) 催乳素调节蓝鳃太阳鱼（Lepomis macrochirus）的亲子照顾行为变化，以应对感知到的父子关系。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-08-01 DOI: 10.1016/j.yhbeh.2024.105610

Emma K.L. Churchman, Timothy J.A. Hain, Bryan D. Neff

{"title":"Prolactin modulates changes in parental care behaviour in response to perceived paternity in bluegill sunfish (Lepomis macrochirus)","authors":"Emma K.L. Churchman, Timothy J.A. Hain, Bryan D. Neff","doi":"10.1016/j.yhbeh.2024.105610","DOIUrl":"10.1016/j.yhbeh.2024.105610","url":null,"abstract":"<div><p>Prolactin is a hormone conserved across all vertebrates and is renowned for its role in reproduction and parental care. Previous studies on prolactin in fish have primarily relied on administration of mammalian prolactin and have suggested that increases in prolactin lead to greater parental care. However, the influence of endogenous prolactin on fish parental care remains unknown. Here, we measure circulating concentrations of endogenous prolactin during parental care in a fish and link these concentrations to parental care behaviour. We provide evidence that male bluegill sunfish with higher circulating concentrations of prolactin provide more parental care to their offspring. Furthermore, we show that nesting males with experimentally reduced perceived paternity have lower circulating prolactin concentrations and perform fewer parental behaviours, facilitating an adaptive investment in offspring in response to paternity cues. Our findings not only confirm the role of endogenous prolactin in modulating parental care behaviour in a fish but also provide a mechanism underlying the adaptive changes in parental care made in response to perceived paternity.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105610"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24001351/pdfft?md5=bb2782e665bd0c61901e1c00a232e512&pid=1-s2.0-S0018506X24001351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary testosterone across the menstrual cycle 整个月经周期的唾液睾酮。

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-08-01 DOI: 10.1016/j.yhbeh.2024.105608

Julia Stern , Kathleen Casto

{"title":"Salivary testosterone across the menstrual cycle","authors":"Julia Stern , Kathleen Casto","doi":"10.1016/j.yhbeh.2024.105608","DOIUrl":"10.1016/j.yhbeh.2024.105608","url":null,"abstract":"<div><p>Testosterone production in women is thought to systematically shift across the menstrual cycle, peaking during the mid-cycle ovulatory window, and potentially influencing women's behavior. Testosterone is a molecular intermediary to the production of estradiol, which is necessary for ovulation to occur, but the amount of testosterone escape and exposure to the peripheral tissues is not fully understood. Salivary testosterone is a common biomarker in behavioral neuroendocrinological studies and is thought to reflect the bioactive portions in serum. In <em>N</em> = 339 women with confirmed ovulation via luteinizing hormone tests, salivary testosterone, assayed with LC-MS/MS, was sampled four times across the mid-cycle ovulatory window the luteal phase. Within-subject analysis revealed a significant but small pattern of a mid-cycle peak and a luteal decrease at the aggregate level. However, at the individual level, there was substantial variability in the direction and magnitude of the testosterone-cycle pattern. We discuss the relevant underlying physiology, background research, issues with assay methodolody, and considerations for researchers studying testosterone levels in women.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105608"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24001338/pdfft?md5=7b49a9926ea27b94a7621810327c4ab5&pid=1-s2.0-S0018506X24001338-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgen signaling in LMAN regulates song stereotypy in male canaries LMAN中的雄性激素信号调节雄性金丝雀的鸣唱刻板性

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-31 DOI: 10.1016/j.yhbeh.2024.105611

Beau A. Alward , Jacques Balthazart , Gregory F. Ball

{"title":"Androgen signaling in LMAN regulates song stereotypy in male canaries","authors":"Beau A. Alward , Jacques Balthazart , Gregory F. Ball","doi":"10.1016/j.yhbeh.2024.105611","DOIUrl":"10.1016/j.yhbeh.2024.105611","url":null,"abstract":"<div><p>During breeding when testosterone concentrations are high, male songbirds that are open-ended vocal learners like canaries (<em>Serinus canaria</em>) tend to produce a stable, stereotyped song that facilitates mate attraction or territory defense. Outside breeding contexts, song becomes more variable. The neuroendocrine mechanisms controlling this vocal variability across seasons are not entirely clear. We tested whether androgen signaling within the lateral magnocellular nucleus of the anterior nidopallium (LMAN), a cortical-like brain region of the vocal control system known as a vocal variability generator, plays a role in seasonal vocal variability. We first characterized song in birds housed alone on a short day (SD) photoperiod, which simulates non-breeding conditions. Then, cannulae filled with the androgen receptor (AR) blocker flutamide or left empty as control were implanted bilaterally in LMAN. Birds were then transferred to long days (LD) to simulate the breeding season and song was analyzed again. Blocking AR in LMAN increased acoustic variability of song and the acoustic variability of syllables. However, blocking AR in LMAN did not impact the variability of syllable usage nor their sequencing in LD birds, song features that are controlled by androgen signaling in a somatosensory brain region of the vocal control system called HVC. These findings highlight the multifactorial, non-redundant actions of steroid hormones in controlling complex social behaviors such as birdsong. They also support the hypothesis that LMAN is a key brain area for the effects of testosterone on song plasticity both seasonally in adults and during the song crystallization process at sexual maturity.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"165 ","pages":"Article 105611"},"PeriodicalIF":2.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paternal absence and increased caregiving independently and interactively shape the development of male prairie voles at subadult and adult life stages 父系缺失和照顾的增加在亚成体和成体生命阶段独立并相互作用地影响雄性草原田鼠的发育

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-19 DOI: 10.1016/j.yhbeh.2024.105605

Lisa C. Hiura, Vanessa A. Lazaro, Alexander G. Ophir

{"title":"Paternal absence and increased caregiving independently and interactively shape the development of male prairie voles at subadult and adult life stages","authors":"Lisa C. Hiura, Vanessa A. Lazaro, Alexander G. Ophir","doi":"10.1016/j.yhbeh.2024.105605","DOIUrl":"10.1016/j.yhbeh.2024.105605","url":null,"abstract":"<div><p>The influence of maternal caregiving is a powerful force on offspring development. The absence of a father during early life in biparental species also has profound implications for offspring development, although it is far less studied than maternal influences. Moreover, we have limited understanding of the interactive forces that maternal and paternal caregiving impart on offspring. We investigated if behaviorally upregulating maternal care compensates for paternal absence on prairie vole (<em>Microtus ochrogaster</em>) pup development. We used an established handling manipulation to increase levels of caregiving in father-absent and biparental families, and later measured male offspring behavioral outcomes at sub-adulthood and adulthood. Male offspring raised without fathers were more prosocial (or possibly less socially anxious) than those raised biparentally. Defensive behavior and responses to contextual novelty were also influenced by the absence of fathers, but only in adulthood. Offensive aggression and movement in the open field test changed as a function of life-stage but not parental exposure. Notably, adult pair bonding was not impacted by our manipulations. Boosting parental care produced males that moved more in the open field test. Parental handling also increased oxytocin immunoreactive cells within the supraoptic nucleus of the hypothalamus (SON), and in the paraventricular nucleus (PVN) of biparentally-reared males. We found no differences in vasopressinergic cell groups. We conclude that male prairie voles are contextually sensitive to the absence of fathers and caregiving intensity. Our study highlights the importance of considering the ways early experiences synergistically shape offspring behavioral and neural phenotypes across the lifespan.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105605"},"PeriodicalIF":2.5,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141729051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological characteristics associated with gender identity: Findings from neuroimaging studies in the Amsterdam cohort of children and adolescents experiencing gender incongruence 与性别认同相关的神经生物学特征：阿姆斯特丹性别不协调儿童和青少年队列的神经成像研究结果

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-18 DOI: 10.1016/j.yhbeh.2024.105601

Julie Bakker

{"title":"Neurobiological characteristics associated with gender identity: Findings from neuroimaging studies in the Amsterdam cohort of children and adolescents experiencing gender incongruence","authors":"Julie Bakker","doi":"10.1016/j.yhbeh.2024.105601","DOIUrl":"10.1016/j.yhbeh.2024.105601","url":null,"abstract":"<div><p>This review has been based on my invited lecture at the annual meeting of the Society for Behavioral Neuroendocrinology in 2023. Gender incongruence is defined as a marked and persistent incongruence between an individual's experienced gender and the sex assigned at birth. A prominent hypothesis on the etiology of gender incongruence proposes that it is related to an altered or less pronounced sexual differentiation of the brain. This hypothesis has primarily been based on postmortem studies of the hypothalamus in transgender individuals. To further address this hypothesis, a series of structural and functional neuroimaging studies were conducted in the Amsterdam cohort of children and adolescents experiencing gender incongruence. Additional research objectives were to determine whether any sex and gender differences are established before or after puberty, as well as whether gender affirming hormone treatment would affect brain development and function. We found some evidence in favor of the sexual differentiation hypothesis at the functional level, but this was less evident at the structural level. We also observed some specific transgender neural signatures, suggesting that they might present a unique brain phenotype rather than being shifted towards either end of the male-female spectrum. Our results further suggest that the years between childhood and mid-adolescence represent an important period in which puberty-related factors influence several neural characteristics, such as white matter development and functional connectivity patterns, in both a sex and gender identity specific way. These latter observations thus lead to the important question about the possible negative consequences of delaying puberty on neurodevelopment. To further address this question, larger-scale, longitudinal studies are required to increase our understanding of the possible neurodevelopmental impacts of delaying puberty in transgender youth.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105601"},"PeriodicalIF":2.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal protein malnutrition alters maternal behavior and leads to maladaptive stress response, neurodevelopmental delay and disruption on DNA methylation machinery in female mice offspring 围产期蛋白质营养不良会改变母体行为，导致雌性小鼠后代适应性应激反应不良、神经发育迟缓和 DNA 甲基化机制紊乱

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-18 DOI: 10.1016/j.yhbeh.2024.105603

Carolina D. Alberca , Erika I. Georgieff , Bruno G. Berardino , Nadina M. Ferroni , Estefanía A. Fesser , Verónica I. Cantarelli , Marina F. Ponzio , Eduardo T. Cánepa , Mariela Chertoff

{"title":"Perinatal protein malnutrition alters maternal behavior and leads to maladaptive stress response, neurodevelopmental delay and disruption on DNA methylation machinery in female mice offspring","authors":"Carolina D. Alberca , Erika I. Georgieff , Bruno G. Berardino , Nadina M. Ferroni , Estefanía A. Fesser , Verónica I. Cantarelli , Marina F. Ponzio , Eduardo T. Cánepa , Mariela Chertoff","doi":"10.1016/j.yhbeh.2024.105603","DOIUrl":"10.1016/j.yhbeh.2024.105603","url":null,"abstract":"<div><p>Deficiencies in maternal nutrition have long-term consequences affecting brain development of the progeny and its behavior. In the present work, female mice were exposed to a normal-protein or a low-protein diet during gestation and lactation. We analyzed behavioral and molecular consequences of malnutrition in dams and how it affects female offspring at weaning. We have observed that a low-protein diet during pregnancy and lactation leads to anxiety-like behavior and anhedonia in dams. Protein malnutrition during the perinatal period delays physical and neurological development of female pups. Glucocorticoid levels increased in the plasma of malnourished female offspring but not in dams when compared to the control group. Interestingly, the expression of glucocorticoid receptor (GR) was reduced in hippocampus and amygdala on both malnourished dams and female pups. In addition, malnourished pups exhibited a significant increase in the expression of <em>Dnmt3b</em>, <em>Gadd45b,</em> and <em>Fkbp5</em> and a reduction in <em>Bdnf</em> VI variant mRNA in hippocampus. In contrast, a reduction on <em>Dnmt3b</em> has been observed on the amygdala of weaned mice. No changes have been observed on global methylation levels (5-methylcytosine) in hippocampal genomic DNA neither in dams nor female offspring.</p><p>In conclusion, deregulated behaviors observed in malnourished dams might be mediated by a low expression of GR in brain regions associated with emotive behaviors. Additionally, low-protein diet differentially deregulates the expression of genes involved in DNA methylation/demethylation machinery in female offspring but not in dams, providing an insight into regional- and age-specific mechanisms due to protein malnutrition.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105603"},"PeriodicalIF":2.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dynamics of sociality and glucocorticoids in wild male Assamese macaques 野生雄性阿萨姆猕猴的社会性和糖皮质激素的动态变化

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-15 DOI: 10.1016/j.yhbeh.2024.105604

James Stranks , Michael Heistermann , Somboon Sangmaneedet , Oliver Schülke , Julia Ostner

{"title":"The dynamics of sociality and glucocorticoids in wild male Assamese macaques","authors":"James Stranks , Michael Heistermann , Somboon Sangmaneedet , Oliver Schülke , Julia Ostner","doi":"10.1016/j.yhbeh.2024.105604","DOIUrl":"10.1016/j.yhbeh.2024.105604","url":null,"abstract":"<div><p>For males of gregarious species, dominance status and the strength of affiliative relationships can have major fitness consequences. Social dynamics also impose costs by affecting glucocorticoids, mediators of homeostasis and indicators of the physiological response to challenges and within-group competition. We investigated the relationships between dominance, social bonds, seasonal challenges, and faecal glucocorticoid metabolite (fGC) measures in wild Assamese macaques (<em>Macaca assamensis</em>) at Phu Khieo Wildlife Sanctuary, Thailand, combining behavioural data with 4129 samples from 62 adult males over 15 years. Our previous work on this population suggested that increased competition during the mating season was associated with elevated fGC levels and that, unusually for male primates, lower rank position correlated with higher fGC levels. With a much larger dataset and dynamic measures of sociality, we re-examined these relationships and additionally tested the potentially fGC-attenuating effect of social support. Contrary to our previous study, yet consistent with the majority of work on male primates, dominance rank had a positive relationship with fGC levels, as high status correlated with elevated glucocorticoid measures. fGC levels were increased at the onset of the mating season. We demonstrated an fGC-reducing effect of supportive relationships in males and showed that dynamics in affiliation can correlate with dynamics in physiological responses. Our results suggest that in a system with intermediate contest potential, high dominance status can impose physiological costs on males that may potentially be moderated by social relationships. We highlight the need to consider the dynamics of sociality and competition that influence hormonal processes.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105604"},"PeriodicalIF":2.5,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal and cycle phase predictors of within-women shifts in self-perceived attractiveness: Tests of alternative functional models 荷尔蒙和周期阶段对女性内部自我感觉吸引力变化的预测：替代功能模型的测试

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-14 DOI: 10.1016/j.yhbeh.2024.105602

Goirik Gupta , Zachary L. Simmons , James R. Roney

{"title":"Hormonal and cycle phase predictors of within-women shifts in self-perceived attractiveness: Tests of alternative functional models","authors":"Goirik Gupta , Zachary L. Simmons , James R. Roney","doi":"10.1016/j.yhbeh.2024.105602","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105602","url":null,"abstract":"<div><p>Prior research has produced mixed findings regarding whether women feel more attractive during the fertile phase of the menstrual cycle. Here, we analyzed cycle phase and hormonal predictors of women's self-perceived attractiveness (SPA) assessed within a daily diary study. Forty-three women indicated their SPA, sexual desire, and interest in their own partners or other potential mates each day across 1–2 menstrual cycles; saliva samples collected on corresponding days were assayed for estradiol, progesterone, and testosterone; and photos of the women taken at weekly intervals were rated for attractiveness. Contrary to some prior studies, we did not find a significant increase in SPA within the estimated fertile window (i.e., cycle days when conception is possible). However, within-cycle fluctuations in progesterone were significantly negatively associated with shifts in SPA, with a visible nadir in SPA in the mid-luteal phase. Women's sexual desire and SPA were positively associated, and the two variables fluctuated in very similar ways across the cycle. Third-party ratings of women's photos provided no evidence that women's SPA simply tracked actual changes in their visible attractiveness. Finally, for partnered women, changes in SPA correlated with shifts in attraction to own partners at least as strongly as it did with shifts in fantasy about extra-pair partners. Our findings provide preliminary evidence for the idea that SPA is a component of women's sexual motivation that may change in ways similar to other hormonally regulated shifts in motivational priorities. Additional large-scale studies are necessary to test replication of these preliminary findings.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105602"},"PeriodicalIF":2.5,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0018506X24001272/pdfft?md5=a6bd34ea76a121020d9a810fc8607431&pid=1-s2.0-S0018506X24001272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats 皮质酮会破坏中年卵巢切除雌性大鼠在高度负荷下进行的保持测试期间的空间工作记忆，这与大鼠的抑郁样行为呈正相关

IF 2.5 3区医学

Hormones and Behavior Pub Date : 2024-07-14 DOI: 10.1016/j.yhbeh.2024.105600

Cheryl D. Conrad, Dylan N. Peay, Amanda M. Acuña, Kennedy Whittaker, Megan E. Donnay

{"title":"Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats","authors":"Cheryl D. Conrad, Dylan N. Peay, Amanda M. Acuña, Kennedy Whittaker, Megan E. Donnay","doi":"10.1016/j.yhbeh.2024.105600","DOIUrl":"https://doi.org/10.1016/j.yhbeh.2024.105600","url":null,"abstract":"<div><p>Major Depressive Disorder affects 8.4 % of the U.S. population, particularly women during perimenopause. This study implemented a chronic corticosterone manipulation (CORT, a major rodent stress hormone) using middle-aged, ovariectomized female rats to investigate depressive-like behavior, anxiety-like symptoms, and cognitive ability. CORT (400 μg/ml, in drinking water) was administered for four weeks before behavioral testing began and continued throughout all behavioral assessments. Compared to vehicle-treated rats, CORT significantly intensified depressive-like behaviors: CORT decreased sucrose preference, enhanced immobility on the forced swim test, and decreased sociability on a choice task between a novel conspecific female rat and an inanimate object. Moreover, CORT enhanced anxiety-like behavior on a marble bury task by reducing time investigating tabasco-topped marbles. No effects were observed on novelty suppressed feeding or the elevated plus maze. For spatial working memory using an 8-arm radial arm maze, CORT did not alter acquisition but disrupted performance during retention. CORT enhanced the errors committed during the highest working memory load following a delay and during the last trial requiring the most items to remember; this cognitive metric positively correlated with a composite depressive-like score to reveal that as depressive-like symptoms increased, cognitive performance worsened. This protocol allowed for the inclusion of multiple behavioral assessments without stopping the CORT treatment needed to produce a MDD phenotype and to assess a battery of behaviors. Moreover, that when middle-age was targeted, chronic CORT produced a depressive-like phenotype in ovariectomized females, who also comorbidly expressed aspects of anxiety and cognitive dysfunction.</p></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"164 ","pages":"Article 105600"},"PeriodicalIF":2.5,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0