Heart, Lung and Circulation最新文献

{"title":"Development of a Pacific Values-Based Framework and Wellbeing Questionnaire for Heart Health Research","authors":"M. Heath ∗ , S. McGaffin , G. Quill , A. Lydon , K. Poppe , R. Doughty , B. Lowe , M. Nash , D. Zhao","doi":"10.1016/j.hlc.2025.05.036","DOIUrl":"10.1016/j.hlc.2025.05.036","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page S72"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Evaluation to Action: Strengthening ARF and RHD CCHO Care","authors":"M. O'Bryan ∗ , L. Lawrie , M. Pascoe , T. Ahmat , M. McDonald","doi":"10.1016/j.hlc.2025.05.063","DOIUrl":"10.1016/j.hlc.2025.05.063","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page S84"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S1443-9506(25)00450-0","DOIUrl":"10.1016/S1443-9506(25)00450-0","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page i"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Injury Following Immune Checkpoint Inhibitors: An Australian Experience","authors":"Briella K. Egberts BBioSci, BMedSci ,&nbsp;Rajiv Ananthakrishna MBBS, MD, DM ,&nbsp;Rebecca Perry PhD ,&nbsp;Richard J. Woodman PhD ,&nbsp;Alison Sutton MMedRad ,&nbsp;Sivabaskari Pasupathy PhD ,&nbsp;Teresa Hecker BSN, RDMS ,&nbsp;Tonia A. Bromley BSN ,&nbsp;Woo Sze Yang MD ,&nbsp;Christos Karapetis MD, PhD ,&nbsp;Joseph B. Selvanayagam MBBS, DPhil","doi":"10.1016/j.hlc.2024.11.018","DOIUrl":"10.1016/j.hlc.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment, becoming a cornerstone therapy for various malignancies. Despite their efficacy, there are concerns about their potential cardiotoxicity, particularly, subclinical myocardial injury. However, there remains a scarcity of local data on the precise incidence of such cardiac complications. This prospective pilot study aims to assess myocardial injury in patients undergoing ICI therapy without known cardiovascular disease, using biochemical and cardiac imaging markers of myocardial injury.</div></div><div><h3>Method</h3><div>A total of 41 patients (median age 68 years, 63% male) receiving ICI therapy without previous cardiac disease were prospectively enrolled. Serial assessments were conducted at baseline and 6 weeks, including measurement of cardiac troponin I (cTnI), N-terminal pro–brain natriuretic peptide (NT-proBNP), and two-dimensional transthoracic echocardiography with speckle tracking strain. Cardiac magnetic resonance imaging (CMR) was performed at 6 weeks. A control group (n=10, median age 66 years, 50% male) with no ICI treatment with matched oncological profile was established. The primary outcome was the incidence of cTnI increase at 6 weeks, with secondary outcomes including changes in NT-proBNP, left ventricular (LV) ejection fraction, LV global longitudinal strain (LV-GLS), right ventricular free wall systolic strain, myocardial injury on CMR, and major adverse cardiac events.</div></div><div><h3>Results</h3><div>Median baseline cTnI levels measured 4.0 (interquartile range 3.0–7.0) ng/L, with only one patient (2.7%) demonstrating significant cTnI increase after ICI therapy. Follow-up assessments revealed no significant mean differences in cTnI, NT-proBNP, LV ejection fraction, or right ventricular free wall systolic strain. However, a significant change in LV-GLS was noted in the ICI group (−1.2%, p=0.004) compared with controls (−0.7%, p=0.50, p=0.02). A total of 20 patients (54%) underwent CMR, with 11 (55%) exhibiting abnormalities (T1/T2 mapping and late gadolinium enhancement). Of the nine patients (45%) with increased T1 mapping on CMR, all demonstrated a reduction in LV-GLS between baseline and 6 weeks, with a mean reduction of 5% (3%–12%). Within 1 year, major adverse cardiac events occurred in 17 (45.9%) patients.</div></div><div><h3>Conclusions</h3><div>Although the occurrence of significant cTnI increase was low, subclinical myocardial injury can be detected through advanced cardiac imaging after ICI initiation. This underscores the importance of conducting larger studies to further elucidate the prevalence, mechanisms, and clinical implications of myocardial injury in patients receiving ICI treatment.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 6","pages":"Pages 596-605"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Equity: A Guide to Equitable and Transformative Cardiovascular Health in Indigenous Communities","authors":"M. Hudson ∗","doi":"10.1016/j.hlc.2025.05.017","DOIUrl":"10.1016/j.hlc.2025.05.017","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Pages S63-S64"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘Culture at the Heart’: Cardiac Care in East Gippsland, Beyond the Social Constructs of Whiteness","authors":"C. Alkemade ∗,&nbsp;N. Bragg","doi":"10.1016/j.hlc.2025.05.003","DOIUrl":"10.1016/j.hlc.2025.05.003","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Pages S57-S58"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gout Content Analysis on TikTok","authors":"M. Manako ∗ ,&nbsp;T. Tabokaai ,&nbsp;M. Tohi ,&nbsp;S. Tu'akoi ,&nbsp;S. Ofanoa","doi":"10.1016/j.hlc.2025.05.059","DOIUrl":"10.1016/j.hlc.2025.05.059","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page S83"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Holistic Heart and Brain Health Knowledge Assessment Tool for Use With Aboriginal and Torres Strait Islander Communities","authors":"K. Brown ∗ ,&nbsp;C. Renehan","doi":"10.1016/j.hlc.2025.05.043","DOIUrl":"10.1016/j.hlc.2025.05.043","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page S76"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interdisciplinary Assessment of the Heart Health Environment","authors":"N. Daniels ∗ ,&nbsp;R. McGowan ,&nbsp;S. Smith ,&nbsp;J. Cotter ,&nbsp;K. Reihana ,&nbsp;C. Bullen ,&nbsp;K. Matthews ,&nbsp;N. Burton ,&nbsp;H. Berning ,&nbsp;B. Roxburgh ,&nbsp;L. Davies ,&nbsp;A. Rolleston","doi":"10.1016/j.hlc.2025.05.008","DOIUrl":"10.1016/j.hlc.2025.05.008","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Pages S59-S60"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summarising the Evidence Regarding Access to Publicly Funded Bariatric Surgery in Aotearoa, New Zealand—A Systematic Review","authors":"N. Appleby ∗ ,&nbsp;E. Tuivaiti ,&nbsp;S. Ada ,&nbsp;M. Kahi ,&nbsp;M. Harwood ,&nbsp;V. Selak ,&nbsp;J. Rahiri","doi":"10.1016/j.hlc.2025.05.039","DOIUrl":"10.1016/j.hlc.2025.05.039","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 ","pages":"Page S74"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}