David Makarious MD , Yehuan Zhou MD , Jason Z.Y. Chung MBBS , Andrew T.L. Ong MBBS, PhD , Gopal Sivagangabalan MBBS, PhD , A. Robert Denniss MBBS , Jay B. Thakkar MBBS, PhD , Clara K. Chow MBBS, PhD
{"title":"Macrotroponin: A Case Series and Review of the Literature","authors":"David Makarious MD , Yehuan Zhou MD , Jason Z.Y. Chung MBBS , Andrew T.L. Ong MBBS, PhD , Gopal Sivagangabalan MBBS, PhD , A. Robert Denniss MBBS , Jay B. Thakkar MBBS, PhD , Clara K. Chow MBBS, PhD","doi":"10.1016/j.hlc.2025.03.006","DOIUrl":"10.1016/j.hlc.2025.03.006","url":null,"abstract":"<div><div>Cardiac troponin is a cornerstone biomarker in assessing myocardial injury, yet its interpretation is nuanced by conditions such as macrotroponins—benign immunoglobulin-troponin complexes that may result in false increases. This article presents three cases of macrotroponin-associated troponin increase, each demonstrating the diagnostic challenges posed by persistent troponin increases without clinical evidence of myocardial injury. Diagnostic workups, including imaging and immunoglobulin depletion assays, confirmed macrotroponin presence in all cases. A comprehensive literature review highlights the prevalence, mechanisms, and clinical implications of macrotroponins, emphasising the need for careful interpretation of troponin levels in biochemical-clinical discordance. The findings underscore the importance of collaboration between clinicians and laboratories to mitigate unnecessary investigations and optimise patient care.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages e134-e139"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Factors for Peripartum Cardiomyopathy: A Systematic Review and Meta-Analysis","authors":"Xiang Wang MM , Kaiwen Zheng MM , Quan Zhang MD","doi":"10.1016/j.hlc.2025.03.010","DOIUrl":"10.1016/j.hlc.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>Peripartum cardiomyopathy (PPCM) refers to heart failure following the last month of gestation or within 5 months postpartum, which is a major cause of pregnancy-related death. However, the risk factors for PPCM remain unclear. Therefore, this meta-analysis aimed to identify the risk factors for PPCM.</div></div><div><h3>Method</h3><div>All studies on risk factors for PPCM published up to April 2024 in Embase, PubMed, the Cochrane Library, and Web of Science were systematically searched. The quality of the included studies was assessed with the Newcastle–Ottawa scale (NOS).</div></div><div><h3>Results</h3><div>Eighteen studies involving 203,374,478 participants were included. It was found that obesity (OR 1.43, 95% CI 1.24–1.65; p<0.001), parity (OR 1.79, 95% CI 1.21–2.67; p=0.004), gestational hypertension (OR 2.00, 95% CI 1.35–2.95; p=0.001), diabetes (OR 1.33, 95% CI 1.06–1.68; p=0.015), and pre-eclampsia (OR 3.28, 95% CI 1.64–6.55; p=0.001) all raised the PPCM risk. Smoking had no statistical association with the development of PPCM (OR 0.97, 95% CI 0.57–1.65; p=0.903). The PPCM risk tended to rise in multiple pregnancies (OR 1.82, 95% CI 0.97–3.43; p=0.063).</div></div><div><h3>Conclusions</h3><div>This study demonstrated that obesity, multiparity, gestational hypertension, diabetes, and pre-eclampsia are risk factors for PPCM. Smoking is not associated with the development of PPCM, and the PPCM risk tends to rise in multiple pregnancies. Caesarean section and acute kidney injury are common in pregnant women and their association with PPCM needs to be interpreted with caution. Understanding the risk factors for PPCM can provide medical workers with a theoretical basis for patient management and treatment.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages e125-e133"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacqueline M. Williamson BSc , Gillian A. Whalley PhD , Peter S. Morris MBBS, PhD , Dianne Bruce BSc , Michael Cursaro BMS , Ari Horton MBBS , Robert Justo MBBS , Catherine H. Mylrea GradDipCardiacUltrasound , Suzanne Davy-Snow BSc , Sela Takau BASc , Gavin R. Wheaton MBBS , Amy N. Zanker BSc , Zhiqiang Wang PhD , Bo Remenyi MBBS, PhD
{"title":"Echocardiographic Diagnosis of Rheumatic Heart Disease: Substantial Agreement, Inter-Rater Reliability and Accuracy Between Cardiac Sonographers and Paediatric Cardiologists","authors":"Jacqueline M. Williamson BSc , Gillian A. Whalley PhD , Peter S. Morris MBBS, PhD , Dianne Bruce BSc , Michael Cursaro BMS , Ari Horton MBBS , Robert Justo MBBS , Catherine H. Mylrea GradDipCardiacUltrasound , Suzanne Davy-Snow BSc , Sela Takau BASc , Gavin R. Wheaton MBBS , Amy N. Zanker BSc , Zhiqiang Wang PhD , Bo Remenyi MBBS, PhD","doi":"10.1016/j.hlc.2025.03.001","DOIUrl":"10.1016/j.hlc.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Rheumatic heart disease (RHD) rates remain high in many socially disadvantaged populations. Early detection through active case finding is resource intensive and task-sharing with cardiac sonographers may improve access to screening. The accuracy of cardiac sonographers in the echocardiographic evaluation of RHD has not previously been assessed. The 2012 World Heart Federation guidelines were used to compare agreement, inter-rater reliability, and accuracy between cardiac sonographers and cardiologists in the echocardiographic evaluation of RHD.</div></div><div><h3>Method</h3><div>Four paediatric cardiologists and seven cardiac sonographers underwent structured training before independently reporting the same 210 echocardiograms (a total of 2,310 individual studies). Participants were blind to the results of other assessors and blind to the original diagnoses by a three-person expert panel consensus. Median results from each group of professionals were compared to each other and the original diagnosis. Individual results were also analysed to determine agreement with the original panel diagnosis using Cohen’s kappa. Inter-rater agreement for multiple assessors in each group was determined using Fleiss’ kappa. Sensitivity, specificity, and likelihood ratios were estimated using the original panel diagnosis as the reference standard.</div></div><div><h3>Results</h3><div>The agreement was substantial between median cardiac sonographer and median cardiologist results for the detection of any abnormality (<em>k</em>=0.74, 95% CI 0.61–0.88); any RHD (<em>k</em>=0.79, 95% CI 0.65–0.92); and definite RHD (<em>k</em>=0.78, 95% CI 0.64–0.91). Accuracy for the detection of any RHD was high with sensitivity of median cardiologist results of 79% (95% CI 71%–86%) and specificity of 97% (95% CI 87%–99%) and median sonographer sensitivity was 83% (95% CI 75%–89%) with specificity of 93% (95% CI 85%–98%).</div></div><div><h3>Conclusions</h3><div>Expert cardiac sonographers achieved a similar level of agreement, inter-rater reliability, and accuracy to expert cardiologists in the reporting of RHD. These findings support the use of task-sharing for the echocardiographic detection of RHD.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 900-907"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reduction in Age Threshold for Half-Dose Thrombolytic Therapy for STEMI in Australian Clinical Guideline for Diagnosing and Managing Acute Coronary Syndromes 2025","authors":"Arunav Thakur MBBS , Harry C. Lowe PhD, FRACP","doi":"10.1016/j.hlc.2025.04.092","DOIUrl":"10.1016/j.hlc.2025.04.092","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Page e142"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tyson A. Fricke MBBS, PhD, FRACS , Melissa G.Y. Lee MBBS, PhD, FRACP , Edward Buratto MBBS, PhD, FRACS
{"title":"Rapid Progression in the Management of Repaired Tetralogy","authors":"Tyson A. Fricke MBBS, PhD, FRACS , Melissa G.Y. Lee MBBS, PhD, FRACP , Edward Buratto MBBS, PhD, FRACS","doi":"10.1016/j.hlc.2025.08.006","DOIUrl":"10.1016/j.hlc.2025.08.006","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 875-876"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yantong Wang BMedSc(Hons) , Michael Bailey PhD , Silvana F. Marasco PhD, FRACS
{"title":"Radial Artery Conduit Use After Transradial Catheterisation","authors":"Yantong Wang BMedSc(Hons) , Michael Bailey PhD , Silvana F. Marasco PhD, FRACS","doi":"10.1016/j.hlc.2025.03.008","DOIUrl":"10.1016/j.hlc.2025.03.008","url":null,"abstract":"<div><h3>Background</h3><div><span>Transradial catheterisation<span> (TRC) via the radial artery (RA) is now the default approach for </span></span>coronary angiography<span>, but TRC is known to be associated with endothelial damage and vasodilatory dysfunction of the RA. To date, there is insufficient evidence regarding the impact of TRC on RA graft patency.</span></div></div><div><h3>Method</h3><div><span>This retrospective cohort study of patients who underwent </span>coronary artery bypass grafting<span> with previously catheterised RA grafts was conducted at two major hospitals in Victoria, Australia. Graft patency was assessed with either invasive or computed tomography coronary angiography.</span></div></div><div><h3>Results</h3><div><span>Overall, 68 patients were studied, all of whom had bilateral RAs harvested, of which all right RAs had been previously catheterised for angiography<span><span>. Grafts included sequential and Y grafts leading to 90 left RA (LRA) grafts and 76 right RA (RRA) grafts studied. Previously catheterised RRA grafts had significantly lower patency (72%) than non-catheterised LRA grafts (87%; p=0.02). Female sex, peripheral vascular disease, and a history of myocardial infarction were associated with RRA </span>graft occlusion. Severe right </span></span>coronary artery stenosis<span> was associated with RRA graft patency.</span></div></div><div><h3>Conclusions</h3><div>Previously catheterised RRA grafts may have a lower patency rate than non-catheterised LRA grafts. However, previously catheterised RAs remain a useful conduit option especially when other conduit choices are limited.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 926-934"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tom Ford MBChB, PhD , Christopher Zeitz MBBS, PhD , Jon Spiro MBBS, BSc, MD , Andy Yong MBBS, PhD , Jamie Layland MBChB, MD, PhD , Monique Watts MBBS, BMedSci , William Chan MBBS, PhD , Olivia Girolamo BMedSc , Jessica A. Marathe BMedSc, MBBS, PhD , Kazuaki Negishi MD, PhD, MSc , Samuel Sidharta MBBS, BMedSc, PhD , Kuljit Singh MBBS, PhD , Rosanna Tavella BSc, PhD , Omar Farouque MBBS, PhD , Lynn Khor MBBS , Eng Lee Ooi MBBS, PhD , Sarena La BMedSc , Jerrett K. Lau BSc(Med), MBBS, PhD , Nicholas J. Montarello MBBS , Martin Ng BSc (Med), MBBS, PhD , John F. Beltrame BSc, BMBS, PhD
{"title":"Functional Coronary Angiography for the Diagnosis of Coronary Vasomotor Disorders","authors":"Tom Ford MBChB, PhD , Christopher Zeitz MBBS, PhD , Jon Spiro MBBS, BSc, MD , Andy Yong MBBS, PhD , Jamie Layland MBChB, MD, PhD , Monique Watts MBBS, BMedSci , William Chan MBBS, PhD , Olivia Girolamo BMedSc , Jessica A. Marathe BMedSc, MBBS, PhD , Kazuaki Negishi MD, PhD, MSc , Samuel Sidharta MBBS, BMedSc, PhD , Kuljit Singh MBBS, PhD , Rosanna Tavella BSc, PhD , Omar Farouque MBBS, PhD , Lynn Khor MBBS , Eng Lee Ooi MBBS, PhD , Sarena La BMedSc , Jerrett K. Lau BSc(Med), MBBS, PhD , Nicholas J. Montarello MBBS , Martin Ng BSc (Med), MBBS, PhD , John F. Beltrame BSc, BMBS, PhD","doi":"10.1016/j.hlc.2024.09.012","DOIUrl":"10.1016/j.hlc.2024.09.012","url":null,"abstract":"<div><div>Microvascular and/or vasospastic angina are two common forms of coronary vasomotor disorders that may occur in patients with ischaemia and non-obstructed coronary arteries (INOCA) or myocardial infarction with non-obstructive coronary arteries (MINOCA). Functional coronary angiography involves invasive guidewire-based assessment of the coronary circulation using pharmacological vasoactive agents to assess small and large vasomotor dysfunction. Typically, responses to adenosine (microvascular vasodilator) and acetylcholine (large and small vessel vasospastic agent) are sequentially assessed. Currently, the assessment and treatment of INOCA and MINOCA patients varies widely. We therefore provide a standard protocol for ‘functional coronary angiography’ for use in Australia and New Zealand. Ischaemic heart disease (IHD) due to disorders of coronary vasomotion causes angina and impairs quality of life and prognosis. INOCA is prevalent in both men and women, however relative to obstructive CAD, INOCA is over-represented in women. This may also be a relevant contributor to sex differences which persist in IHD outcomes (notably in young women).</div><div>Recent European Society of Cardiology guidelines make a class I recommendation in support of the use of functional coronary angiography in INOCA. Despite this, testing for disorders of coronary vasomotion is performed in very few centres in Australia and New Zealand. Barriers to more widespread clinical adoption include the lack of a standard protocol for testing, additional time and training required, lack of funding, concerns over safety and physician knowledge pertaining to over diagnosis and treatment options. Taken together, it is not surprising that local prevalence and outcome data are lacking. We summarise indications for functional assessment of coronary vasomotor disorders with a simple standardised operating protocol for use in cardiac catheter laboratories throughout Australia and New Zealand. We provide guidance on training recommendations for clinical proficiency in undertaking and interpreting functional coronary angiography. Clinical performance and research will be enhanced with the establishment of a national clinical quality registry for functional coronary angiography. By unifying the clinical approach, we hope to facilitate better care for this frequently overlooked heterogenous group of patients.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages e89-e103"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Simple Prognostic Index Based on Heart Rate, Age, and Systolic Blood Pressure for the Risk Stratification of Heart Failure With Preserved Ejection Fraction","authors":"Kenichi Matsushita MD , Kazumasa Harada MD , Takashi Kohno MD , Hiroki Nakano MD , Daisuke Kitano MD , Makoto Takei MD , Shun Kohsaka MD , Tetsuro Miyazaki MD , Hideaki Yoshino MD , Takeshi Yamamoto MD , Ken Nagao MD , Morimasa Takayama MD","doi":"10.1016/j.hlc.2025.03.007","DOIUrl":"10.1016/j.hlc.2025.03.007","url":null,"abstract":"<div><h3>Aim</h3><div>A rapid and effective risk stratification method is highly important for the emergency care of patients with acute heart failure with preserved ejection fraction (HFpEF). Previous studies, including our own, have suggested that heart rate, age, and systolic blood pressure contribute to the pathophysiology of HFpEF. This study aimed to examine the predictive utility of the thrombolysis in myocardial infarction risk index (TRI)—consisting of heart rate, age, and systolic blood pressure—for determining the in-hospital mortality in patients with acute HFpEF.</div></div><div><h3>Methods</h3><div>This multicentre retrospective study included 7,040 consecutive patients with acute HFpEF. The TRI was calculated as TRI=(heart rate × [age/10]<sup>2</sup>)/systolic blood pressure. Univariable and multivariable Cox regression analyses were used to identify the prognostic factors for in-hospital mortality. Receiver operating characteristic curve analysis was performed to evaluate the predictive ability of the TRI for in-hospital mortality.</div></div><div><h3>Results</h3><div>In-hospital mortality significantly increased from the low to the high quartile groups according to the TRIs. Univariable and multivariable Cox regression analyses identified the TRI as an independent prognostic factor for in-hospital mortality. The best cut-off TRI value was 35 and a TRI ≥35 had a sensitivity of 82%, specificity of 42%, positive predictive value of 66%, and negative predictive value of 98% for predicting in-hospital mortality.</div></div><div><h3>Conclusion</h3><div>The simple TRI tool is a significant predictor of in-hospital mortality of patients with acute HFpEF, suggesting that this rapid and straightforward risk stratification tool can be useful in daily clinical practice.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 883-890"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fang Shawn Foo MBChB, FRACP , Mildred Lee BTech, MSc , Wil Harrison MBChB, FRACP , Geoffrey C. Clare MBChB, FRACP , Martin K. Stiles MBChB, PhD, FRACP , Andrew Gavin MBChB, FRACP , Matthew Webber MBChB, FRACP , Andrew Martin MBChB, FRACP , Rod Jackson MBChB, PhD, FNZCPH, FRSNZ , Andrew J. Kerr MBChB, MD, FRACP
{"title":"Long-Term Clinical Outcomes and Predictors of Mortality in Implantable Cardioverter-Defibrillator Recipients in New Zealand (ANZACS-QI 83)","authors":"Fang Shawn Foo MBChB, FRACP , Mildred Lee BTech, MSc , Wil Harrison MBChB, FRACP , Geoffrey C. Clare MBChB, FRACP , Martin K. Stiles MBChB, PhD, FRACP , Andrew Gavin MBChB, FRACP , Matthew Webber MBChB, FRACP , Andrew Martin MBChB, FRACP , Rod Jackson MBChB, PhD, FNZCPH, FRSNZ , Andrew J. Kerr MBChB, MD, FRACP","doi":"10.1016/j.hlc.2025.03.015","DOIUrl":"10.1016/j.hlc.2025.03.015","url":null,"abstract":"<div><h3>Background</h3><div>The long-term clinical outcomes of implantable cardioverter-defibrillator (ICD) recipients across New Zealand are unknown. This study aims to compare the all-cause mortality of primary and secondary prevention ICD recipients in New Zealand and identify predictors of mortality.</div></div><div><h3>Method</h3><div>Patients who received a primary or secondary prevention ICD in New Zealand between 2016 and 2020 were identified using the Aotearoa NZ All Cardiology Services Quality Improvement Cardiac Implanted Device Registry [ANZACS-QI DEVICE], a national registry for cardiac implantable electronic devices. Patients with infiltrative cardiomyopathies, congenital heart disease, and channelopathies were excluded. The primary outcome was all-cause mortality. Secondary outcomes were cardiovascular (CVD) mortality, non-CVD mortality, heart failure hospitalisation, and ventricular arrhythmia hospitalisation. Log-rank tests on Kaplan–Meier curves and 4-year Kaplan–Meier event rates were reported. Cox regression multivariate analysis was performed to identify predictors of all-cause mortality.</div></div><div><h3>Results</h3><div>There were 1,990 patients, including 1,067 (53.6%) primary prevention and 923 (46.4%) secondary prevention ICD recipients, with a mean follow-up of 4.0±1.5 years. The median age was 62 years, 29.6% were Māori or Pacific Islanders.</div><div>At 4 years, the all-cause mortality was higher in the primary prevention group than in the secondary prevention group (17.1% vs 11.8%; p=0.002). This was due to a higher rate of CVD mortality (11.9% vs 7.3%; p=0.008), with no significant difference in non-CVD mortality (5.9% vs 4.8%; p=0.093). Compared with the secondary prevention group, the primary prevention group had more heart failure hospitalisations (30.2% vs 17.9%; p<0.001) but fewer ventricular arrhythmia hospitalisations (14.8% vs 29.0%; p<0.001).</div><div>Significant predictors of mortality in multivariate regression analyses were Māori or Pacific Islander ethnicity (primary prevention hazard ratio [HR] 2.12; p<0.001; secondary prevention HR 1.71; p=0.018); older age (per 10-year increase in age: primary prevention HR 1.33; p=0.003; secondary prevention HR 1.72; p<0.001), and poorer renal function (per 10 mL/min/1.73m<sup>2</sup> decrease: primary prevention HR 1.21; p<0.001; secondary prevention HR 1.25; p<0.001). Previous myocardial infarction was not a significant predictor of mortality in either cohort.</div></div><div><h3>Conclusions</h3><div>In New Zealand ICD recipients, long-term all-cause mortality and CVD mortality rates were higher in primary prevention than secondary prevention ICD implants. Non-CVD mortality was low and similar in both cohorts, consistent with appropriate patient selection. The higher mortality observed for Māori and Pacific Islander patients require further investigation.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 891-899"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Hidden Congenital Secret: Unmasking a Rare Right Upper Lobe PAPVR Draining into the IVC","authors":"Furkan Ufuk MD, Andrew Williams MD","doi":"10.1016/j.hlc.2025.04.091","DOIUrl":"10.1016/j.hlc.2025.04.091","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages e140-e141"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}