Heredity最新文献_第8页

Ecological genetics of isolated loach populations indicate compromised adaptive potential 与世隔绝的泥鳅种群的生态遗传学表明其适应潜力受到损害。

IF 3.1 2区生物学

Heredity Pub Date : 2024-07-03 DOI: 10.1038/s41437-024-00695-0

Xi Wang, Kerry Reid, Ying Chen, David Dudgeon, Juha Merilä

{"title":"Ecological genetics of isolated loach populations indicate compromised adaptive potential","authors":"Xi Wang, Kerry Reid, Ying Chen, David Dudgeon, Juha Merilä","doi":"10.1038/s41437-024-00695-0","DOIUrl":"10.1038/s41437-024-00695-0","url":null,"abstract":"Many endangered species live in fragmented and isolated populations with low genetic variability, signs of inbreeding, and small effective population sizes - all features elevating their extinction risk. The flat-headed loach (Oreonectes platycephalus), a small noemacheilid fish, is widely across southern China, but only in the headwaters of hillstreams; as a result, they are spatially isolated from conspecific populations. We surveyed single nucleotide polymorphisms in 16 Hong Kong populations of O. platycephalus to determine whether loach populations from different streams were genetically isolated from each other, showed low levels of genetic diversity, signs of inbreeding, and had small contemporary effective population sizes. Estimates of average observed heterozygosity (HO = 0.0473), average weighted nucleotide diversity (πw = 0.0546) and contemporary effective population sizes (Ne = 10.2 ~ 129.8) were very low, and several populations showed clear signs of inbreeding as judged from relatedness estimates. The degree of genetic differentiation among populations was very high (average FST = 0.668), even over short geographic distances (<1.5 km), with clear patterns of isolation by distance. These results suggest that Hong Kong populations of O. platycephalus have experienced strong genetic drift and loss of genetic variability because sea-level rise after the last glaciation reduced connectedness among paleodrainages, isolating populations in headwaters. All this, together with the fact that the levels of genetic diversity and contemporary effective population sizes within O. platycephalus populations are lower than most other freshwater fishes, suggests that they face high local extinction risk and have limited capacity for future adaptation.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"88-98"},"PeriodicalIF":3.1,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and optimization of expected cross value for mate selection problems 开发和优化择偶问题的预期交叉值。

IF 3.1 2区生物学

Heredity Pub Date : 2024-07-02 DOI: 10.1038/s41437-024-00697-y

Pouya Ahadi, Balabhaskar Balasundaram, Juan S. Borrero, Charles Chen

{"title":"Development and optimization of expected cross value for mate selection problems","authors":"Pouya Ahadi, Balabhaskar Balasundaram, Juan S. Borrero, Charles Chen","doi":"10.1038/s41437-024-00697-y","DOIUrl":"10.1038/s41437-024-00697-y","url":null,"abstract":"In this study, we address the mate selection problem in the hybridization stage of a breeding pipeline, which constitutes the multi-objective breeding goal key to the performance of a variety development program. The solution framework we formulate seeks to ensure that individuals with the most desirable genomic characteristics are selected to cross in order to maximize the likelihood of the inheritance of desirable genetic materials to the progeny. Unlike approaches that use phenotypic values for parental selection and evaluate individuals separately, we use a criterion that relies on the genetic architecture of traits and evaluates combinations of genomic information of the pairs of individuals. We introduce the expected cross value (ECV) criterion that measures the expected number of desirable alleles for gametes produced by pairs of individuals sampled from a population of potential parents. We use the ECV criterion to develop an integer linear programming formulation for the parental selection problem. The formulation is capable of controlling the inbreeding level between selected mates. We evaluate the approach or two applications: (i) improving multiple target traits simultaneously, and (ii) finding a multi-parental solution to design crossing blocks. We evaluate the performance of the ECV criterion using a simulation study. Finally, we discuss how the ECV criterion and the proposed integer linear programming techniques can be applied to improve breeding efficiency while maintaining genetic diversity in a breeding program.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"113-125"},"PeriodicalIF":3.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating environmental gradients into breeding: application of genomic reactions norms in a perennial species 将环境梯度纳入育种：基因组反应规范在多年生物种中的应用。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-28 DOI: 10.1038/s41437-024-00702-4

Victor Papin, Alexandre Bosc, Leopoldo Sanchez, Laurent Bouffier

{"title":"Integrating environmental gradients into breeding: application of genomic reactions norms in a perennial species","authors":"Victor Papin, Alexandre Bosc, Leopoldo Sanchez, Laurent Bouffier","doi":"10.1038/s41437-024-00702-4","DOIUrl":"10.1038/s41437-024-00702-4","url":null,"abstract":"Global warming threatens the productivity of forest plantations. We propose here the integration of environmental information into a genomic evaluation scheme using individual reaction norms, to enable the quantification of resilience in forest tree improvement and conservation strategies in the coming decades. Random regression models were used to fit wood ring series, reflecting the longitudinal phenotypic plasticity of tree growth, according to various environmental gradients. The predictive ability of the models was considered to select the most relevant environmental gradient, namely a gradient derived from an ecophysiological model and combining trunk water potential and temperature. Even if the individual ranking was preserved over most of the environmental gradient, strong genotype x environment interactions were detected in the extreme unfavorable part of the gradient, which includes environmental conditions that are very likely to be more frequent in the future. Combining genomic information and longitudinal data allowed to predict the growth of individuals in environments where they have not been observed. Phenotyping of 50% of the individuals in all the environments studied allowed to predict the growth of the remaining 50% of individuals in all these environments with a predictive ability of 0.25. Without changing the total number of observations, adding observations in a reduced number of environments for the individuals to be predicted, while decreasing the number of individuals phenotyped in all environments, increased the predictive ability to 0.59, highlighting the importance of phenotypic data allocation. We found that genomic reaction norms are useful for the characterization and prediction of the function of genetic parameters and facilitate breeding in a climate change context.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 3","pages":"160-172"},"PeriodicalIF":3.1,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptic diversity of shallow and mesophotic Stephanocoenia intersepta corals across Florida Keys National Marine Sanctuary 佛罗里达礁岛群国家海洋保护区浅海和中海 Stephanocoenia intersepta 珊瑚的隐秘多样性。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-27 DOI: 10.1038/s41437-024-00698-x

Ryan J. Eckert, Alexis B. Sturm, Ashley M. Carreiro, Allison M. Klein, Joshua D. Voss

{"title":"Cryptic diversity of shallow and mesophotic Stephanocoenia intersepta corals across Florida Keys National Marine Sanctuary","authors":"Ryan J. Eckert, Alexis B. Sturm, Ashley M. Carreiro, Allison M. Klein, Joshua D. Voss","doi":"10.1038/s41437-024-00698-x","DOIUrl":"10.1038/s41437-024-00698-x","url":null,"abstract":"Population genetic analyses can provide useful data on species’ regional connectivity and diversity which can inform conservation and restoration efforts. In this study, we quantified the genetic connectivity and diversity of Stephanocoenia intersepta corals from shallow (<30 m) to mesophotic (30–45 m) depths across Florida Keys National Marine Sanctuary. We generated single nucleotide polymorphism (SNP) markers to identify genetic structuring of shallow and mesophotic S. intersepta corals. We uncovered four distinct, cryptic genetic lineages with varying levels of depth-specificity. Shallow-specific lineages exhibited lower heterozygosity and higher inbreeding relative to depth-generalist lineages found across both shallow and mesophotic reefs. Estimation of recent genetic migration rates demonstrated that mesophotic sites are more prolific sources than shallow sites, particularly in the Lower Keys and Upper Keys. Additionally, we compared endosymbiotic Symbiodiniaceae among sampled S. intersepta using the ITS2 region and SymPortal analysis framework, identifying symbionts from the genera Symbiodinium, Breviolum, and Cladocopium. Symbiodiniaceae varied significantly across depth and location and exhibited significant, but weak correlation with host lineage and genotype. Together, these data demonstrate that despite population genetic structuring across depth, some mesophotic populations may provide refuge for shallow populations moving forward and remain important contributors to the overall genetic diversity of this species throughout the region. This study highlights the importance of including mesophotic as well as shallow corals in population genetic assessments and informs future science-based management, conservation, and restoration efforts within Florida Keys National Marine Sanctuary.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 3","pages":"137-148"},"PeriodicalIF":3.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term climatic stability drives accumulation and maintenance of divergent freshwater fish lineages in a temperate biodiversity hotspot 长期的气候稳定性推动了温带生物多样性热点地区淡水鱼系分化的积累和维持。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-25 DOI: 10.1038/s41437-024-00700-6

Sean James Buckley, Chris J. Brauer, Peter J. Unmack, Michael P. Hammer, Mark Adams, Stephen J. Beatty, David L. Morgan, Luciano B. Beheregaray

{"title":"Long-term climatic stability drives accumulation and maintenance of divergent freshwater fish lineages in a temperate biodiversity hotspot","authors":"Sean James Buckley, Chris J. Brauer, Peter J. Unmack, Michael P. Hammer, Mark Adams, Stephen J. Beatty, David L. Morgan, Luciano B. Beheregaray","doi":"10.1038/s41437-024-00700-6","DOIUrl":"10.1038/s41437-024-00700-6","url":null,"abstract":"Anthropogenic climate change is forecast to drive regional climate disruption and instability across the globe. These impacts are likely to be exacerbated within biodiversity hotspots, both due to the greater potential for species loss but also to the possibility that endemic lineages might not have experienced significant climatic variation in the past, limiting their evolutionary potential to respond to rapid climate change. We assessed the role of climatic stability on the accumulation and persistence of lineages in an obligate freshwater fish group endemic to the southwest Western Australia (SWWA) biodiversity hotspot. Using 19,426 genomic (ddRAD-seq) markers and species distribution modelling, we explored the phylogeographic history of western (Nannoperca vittata) and little (Nannoperca pygmaea) pygmy perches, assessing population divergence and phylogenetic relationships, delimiting species and estimating changes in species distributions from the Pliocene to 2100. We identified two deep phylogroups comprising three divergent clusters, which showed no historical connectivity since the Pliocene. We conservatively suggest these represent three isolated species with additional intraspecific structure within one widespread species. All lineages showed long-term patterns of isolation and persistence owing to climatic stability but with significant range contractions likely under future climate change. Our results highlighted the role of climatic stability in allowing the persistence of isolated lineages in the SWWA. This biodiversity hotspot is under compounding threat from ongoing climate change and habitat modification, which may further threaten previously undetected cryptic diversity across the region.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 3","pages":"149-159"},"PeriodicalIF":3.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41437-024-00700-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and environmental effects on morphological traits of social phenotypes in wasps 遗传和环境对黄蜂社会表型形态特征的影响。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-25 DOI: 10.1038/s41437-024-00701-5

Sarah E. Orr, Nicole A. Hedrick, Kayla A. Murray, Abhinav K. Pasupuleti, Jennifer L. Kovacs, Michael A. D. Goodisman

{"title":"Genetic and environmental effects on morphological traits of social phenotypes in wasps","authors":"Sarah E. Orr, Nicole A. Hedrick, Kayla A. Murray, Abhinav K. Pasupuleti, Jennifer L. Kovacs, Michael A. D. Goodisman","doi":"10.1038/s41437-024-00701-5","DOIUrl":"10.1038/s41437-024-00701-5","url":null,"abstract":"Many species exhibit distinct phenotypic classes, such as sexes in dioecious species or castes in social species. The evolution of these classes is affected by the genetic architecture governing traits shared between phenotypes. However, estimates of the genetic and environmental factors contributing to phenotypic variation in distinct classes have rarely been examined. We studied the genetic architecture underlying morphological traits in phenotypic classes in the social wasp Vespula maculifrons. Our data revealed patriline effects on a few traits, indicating weak genetic influences on caste phenotypic variation. Interestingly, traits exhibited higher heritability in queens than workers. This result suggests that genetic variation has a stronger influence on trait variation in the queen caste than the worker caste, which is unexpected because queens typically experience direct selection. Moreover, estimates of heritability for traits were correlated between the castes, indicating that variability in trait size was governed by similar genetic architecture in the two castes. However, we failed to find evidence for a significant relationship between caste dimorphism and caste correlation, as would be expected if trait evolution was constrained by intralocus genetic conflict. Our analyses also uncovered variation in the allometric relationships for traits. These analyses suggested that worker traits were proportionally smaller than queen traits for most traits examined. Overall, our data provide evidence for a strong environmental and moderate genetic basis of trait variation among castes. Moreover, our results suggest that selection previously operated on caste phenotype in this species, and phenotypic variation is now governed primarily by environmental differences.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"126-136"},"PeriodicalIF":3.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rolling down that mountain: microgeographical adaptive divergence during a fast population expansion along a steep environmental gradient in European beech 滚下那座山：欧洲山毛榉沿陡峭环境梯度快速种群扩张过程中的微地理适应性分化。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-18 DOI: 10.1038/s41437-024-00696-z

Andrea Modica, Hadrien Lalagüe, Sylvie Muratorio, Ivan Scotti

{"title":"Rolling down that mountain: microgeographical adaptive divergence during a fast population expansion along a steep environmental gradient in European beech","authors":"Andrea Modica, Hadrien Lalagüe, Sylvie Muratorio, Ivan Scotti","doi":"10.1038/s41437-024-00696-z","DOIUrl":"10.1038/s41437-024-00696-z","url":null,"abstract":"Forest tree populations harbour high genetic diversity thanks to large effective population sizes and strong gene flow, allowing them to diversify through adaptation to local environmental pressures within dispersal distance. Many tree populations also experienced historical demographic fluctuations, including spatial population contraction or expansions at various temporal scales, which may constrain their ability to adapt to environmental variations. Our aim is to investigate how recent contraction and expansion events interfere with local adaptation, by studying patterns of adaptive divergence between closely related stands undergoing environmentally contrasted conditions, and having or not recently expanded. To investigate genome-wide signatures of local adaptation while accounting for demography, we analysed divergence in a European beech population by testing pairwise differentiation among four tree stands at ~35k Single Nucleotide Polymorphisms from ~9k genomic regions. We applied three divergence outlier search methods resting on different assumptions and targeting either single SNPs or contiguous genomic regions, while accounting for the effect of population size variations on genetic divergence. We found 27 signals of selective signatures in 19 target regions. Putatively adaptive divergence involved all stand pairs. We retrieved signals both when comparing old-growth stands and recently colonised areas and when comparing stands within the old-growth area. Therefore, adaptive divergence processes have taken place both over short time spans, under strong environmental contrasts, and over short ecological gradients, in populations that have been stable in the long term. This suggests that standing genetic variation supports local, microgeographic divergence processes, which can maintain genetic diversity at the landscape level.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"99-112"},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence for gene flow and trait reversal during radiation of Mexican Goodeid fish 墨西哥古德鱼辐射过程中基因流动和性状逆转的证据。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-10 DOI: 10.1038/s41437-024-00694-1

Leeban H. Yusuf, Yolitzi Saldívar Lemus, Peter Thorpe, Constantino Macías Garcia, Michael G. Ritchie

{"title":"Evidence for gene flow and trait reversal during radiation of Mexican Goodeid fish","authors":"Leeban H. Yusuf, Yolitzi Saldívar Lemus, Peter Thorpe, Constantino Macías Garcia, Michael G. Ritchie","doi":"10.1038/s41437-024-00694-1","DOIUrl":"10.1038/s41437-024-00694-1","url":null,"abstract":"Understanding the phylogeographic history of a group and identifying the factors contributing to speciation is an important challenge in evolutionary biology. The Goodeinae are a group of live-bearing fishes endemic to Mexico. Here, we develop genomic resources for species within the Goodeinae and use phylogenomic approaches to characterise their evolutionary history. We sequenced, assembled and annotated the genomes of four Goodeinae species, including Ataeniobius toweri, the only matrotrophic live-bearing fish without a trophotaenia in the group. We estimated timings of species divergence and examined the extent and timing of introgression between the species to assess if this may have occurred during an early radiation, or in more recent episodes of secondary contact. We used branch-site models to detect genome-wide positive selection across Goodeinae, and we specifically asked whether this differs in A. toweri, where loss of placental viviparity has recently occurred. We found evidence of gene flow between geographically isolated species, suggesting vicariant speciation was supplemented by limited post-speciation gene flow, and gene flow may explain previous uncertainties about Goodeid phylogeny. Genes under positive selection in the group are likely to be associated with the switch to live-bearing. Overall, our studies suggest that both volcanism-driven vicariance and changes in reproductive mode influenced radiation in the Goodeinae.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"78-87"},"PeriodicalIF":3.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why we thrive beneath a northern sky – genomic signals of selection in apple for adaptation to northern Sweden 我们为何在北方的天空下茁壮成长--苹果适应瑞典北部的基因组选择信号。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-04 DOI: 10.1038/s41437-024-00693-2

J. Skytte af Sätra, L. Garkava-Gustavsson, P. K. Ingvarsson

{"title":"Why we thrive beneath a northern sky – genomic signals of selection in apple for adaptation to northern Sweden","authors":"J. Skytte af Sätra, L. Garkava-Gustavsson, P. K. Ingvarsson","doi":"10.1038/s41437-024-00693-2","DOIUrl":"10.1038/s41437-024-00693-2","url":null,"abstract":"Good understanding of the genomic regions underlying adaptation of apple to boreal climates is needed to facilitate efficient breeding of locally adapted apple cultivars. Proper infrastructure for phenotyping and evaluation is essential for identification of traits responsible for adaptation, and dissection of their genetic composition. However, such infrastructure is costly and currently not available for the boreal zone of northern Sweden. Therefore, we used historical pomological data on climate adaptation of 59 apple cultivars and whole genome sequencing to identify genomic regions that have undergone historical selection among apple cultivars recommended for cultivation in northern Sweden. We found the apple collection to be composed of two ancestral groups that are largely concordant with the grouping into ‘hardy’ and ‘not hardy’ cultivars based on the pomological literature. Using a number of genome-wide scans for signals of selection, we obtained strong evidence of positive selection at a genomic region around 29 MbHFTH1 of chromosome 1 among apple cultivars in the ‘hardy’ group. Using phased genotypic data from the 20 K apple Infinium® SNP array, we identified haplotypes associated with the two cultivar groups and traced transmission of these haplotypes through the pedigrees of some apple cultivars. This demonstrates that historical data from pomological literature can be analyzed by population genomic approaches as a step towards revealing the genomic control of a key property for a horticultural niche market. Such knowledge is needed to facilitate efficient breeding strategies for development of locally adapted apple cultivars in the future. The current study illustrates the response to a very strong selective pressure imposed on tree crops by climatic factors, and the importance of genetic research on this topic and feasibility of breeding efforts in the light of the ongoing climate change.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 2","pages":"67-77"},"PeriodicalIF":3.1,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The structure of the TH/INS locus and the parental allele expressed are not conserved between mammals TH/INS基因座的结构和表达的亲本等位基因在哺乳动物之间并不一致。

IF 3.1 2区生物学

Heredity Pub Date : 2024-06-04 DOI: 10.1038/s41437-024-00689-y

Trent Newman, Teruhito Ishihara, Geoff Shaw, Marilyn B. Renfree

{"title":"The structure of the TH/INS locus and the parental allele expressed are not conserved between mammals","authors":"Trent Newman, Teruhito Ishihara, Geoff Shaw, Marilyn B. Renfree","doi":"10.1038/s41437-024-00689-y","DOIUrl":"10.1038/s41437-024-00689-y","url":null,"abstract":"Parent-of-origin-specific expression of imprinted genes is critical for successful mammalian growth and development. Insulin, coded by the INS gene, is an important growth factor expressed from the paternal allele in the yolk sac placenta of therian mammals. The tyrosine hydroxylase gene TH encodes an enzyme involved in dopamine synthesis. TH and INS are closely associated in most vertebrates, but the mouse orthologues, Th and Ins2, are separated by repeated DNA. In mice, Th is expressed from the maternal allele, but the parental origin of expression is not known for any other mammal so it is unclear whether the maternal expression observed in the mouse represents an evolutionary divergence or an ancestral condition. We compared the length of the DNA segment between TH and INS across species and show that separation of these genes occurred in the rodent lineage with an accumulation of repeated DNA. We found that the region containing TH and INS in the tammar wallaby produces at least five distinct RNA transcripts: TH, TH-INS1, TH-INS2, lncINS and INS. Using allele-specific expression analysis, we show that the TH/INS locus is expressed from the paternal allele in pre- and postnatal tammar wallaby tissues. Determining the imprinting pattern of TH/INS in other mammals might clarify if paternal expression is the ancestral condition which has been flipped to maternal expression in rodents by the accumulation of repeat sequences.","PeriodicalId":12991,"journal":{"name":"Heredity","volume":"133 1","pages":"21-32"},"PeriodicalIF":3.1,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41437-024-00689-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0