HautarztPub Date : 2021-12-01Epub Date: 2021-11-18DOI: 10.1007/s00105-021-04909-y
Stephan Traidl, Thomas Werfel
{"title":"[Allergen immunotherapy for atopic dermatitis].","authors":"Stephan Traidl, Thomas Werfel","doi":"10.1007/s00105-021-04909-y","DOIUrl":"https://doi.org/10.1007/s00105-021-04909-y","url":null,"abstract":"<p><p>Since the first report of allergen-specific immunotherapy (AIT) by Noon et al. 110 years ago, a multitude of clinical and in vitro studies have been performed to identify the effects of the only curative treatment for allergies. However, in atopic dermatitis (AD), one of the most prevalent skin diseases, it is rarely used, despite evidence showing that aeroallergens can contribute to disease exacerbation. This review gives an overview about the studies, meta-analyses, and current guideline recommendations regarding AIT in AD patients. There is a distinct heterogeneity in the study designs, different allergens and application forms, endpoints and patient cohorts, which hinders the comparability of studies. Several trials depict a beneficial effect of AIT in AD patients suggesting that at least a subgroup of patients can benefit from treatment. Further developments in the field of AIT may advocate broader use in AD patients.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1103-1112"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39902458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-01-01DOI: 10.1007/s00105-020-04706-z
E Rabe, E Földi, H Gerlach, M Jünger, G Lulay, A Miller, K Protz, S Reich-Schupke, T Schwarz, M Stücker, E Valesky, F Pannier
{"title":"Medical compression therapy of the extremities with medical compression stockings (MCS), phlebological compression bandages (PCB), and medical adaptive compression systems (MAC) : S2k guideline of the German Phlebology Society (DGP) in cooperation with the following professional associations: DDG, DGA, DGG, GDL, DGL, BVP.","authors":"E Rabe, E Földi, H Gerlach, M Jünger, G Lulay, A Miller, K Protz, S Reich-Schupke, T Schwarz, M Stücker, E Valesky, F Pannier","doi":"10.1007/s00105-020-04706-z","DOIUrl":"https://doi.org/10.1007/s00105-020-04706-z","url":null,"abstract":"","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 Suppl 2","pages":"37-50"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00105-020-04706-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38772071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-04-14DOI: 10.1007/s00105-021-04811-7
Daniela Jäger, Narges Soltanpour, Maximillian Gassenmaier, Sebastian Volc, Stephan Forchhammer
{"title":"[Intertriginous plaques with pustules in a patient with systemic lupus erythematosus].","authors":"Daniela Jäger, Narges Soltanpour, Maximillian Gassenmaier, Sebastian Volc, Stephan Forchhammer","doi":"10.1007/s00105-021-04811-7","DOIUrl":"https://doi.org/10.1007/s00105-021-04811-7","url":null,"abstract":"","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1113-1115"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00105-021-04811-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-10-20DOI: 10.1007/s00105-021-04900-7
Sandra Schuh, C Ruini, E Sattler, J Welzel
{"title":"[Confocal line-field OCT].","authors":"Sandra Schuh, C Ruini, E Sattler, J Welzel","doi":"10.1007/s00105-021-04900-7","DOIUrl":"https://doi.org/10.1007/s00105-021-04900-7","url":null,"abstract":"<p><p>Optical coherence tomography (OCT) and confocal laser microscopy (CLSM) are established non-invasive methods in clinical dermatological routine diagnosis. Whereas CLSM is especially useful to distinguish between nevi and melanoma, OCT is suitable for the diagnosis and differentiation of non-melanoma skin cancer. Line-field confocal optical coherence tomography (LC-OCT) is a new innovative device, which has better cellular resolution than OCT and a higher penetration depth than CLSM. Similar to CLSM, LC-OCT also allows 3D images in real time to be taken. Therefore LC-OCT is very useful for the examination of skin lesions of all kinds, since it unites the features of CLSM and OCT.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1039-1047"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39536293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-10-27DOI: 10.1007/s00105-021-04906-1
D Hartmann
{"title":"[Ex vivo confocal laser scanning microscopy for melanocytic lesions and autoimmune diseases].","authors":"D Hartmann","doi":"10.1007/s00105-021-04906-1","DOIUrl":"https://doi.org/10.1007/s00105-021-04906-1","url":null,"abstract":"<p><strong>Background: </strong>Ex vivo confocal laser scanning microscopy (CLSM) enables bedside histology and offers the surgeon a direct intraoperative tissue examination.</p><p><strong>Objectives: </strong>To determine whether this innovative, ultra-fast diagnostic tool can be expanded beyond nonmelanoma skin cancer, particularly basal cell carcinoma, to other indications including melanocytic lesions and autoimmune diseases.</p><p><strong>Materials and methods: </strong>Review of literature and summary of the current knowledge and experience of the use of ex vivo CLSM in melanocytic lesions and in autoimmune diseases.</p><p><strong>Results: </strong>Up to date experience of the use of ex vivo CLSM in melanocytic lesions and in autoimmune diseases is limited but promising. Current knowledge on melanocytic lesions in ex vivo CLSM and their examples together with classic ex vivo CLSM features are presented. Previous results on the use of ex vivo CLSM in autoimmune dermatoses are presented, and future application possibilities of ex vivo CLSM are discussed.</p><p><strong>Conclusions: </strong>The method is particularly suitable for the rapid examination of basal cell carcinomas during Mohs surgery but could also be used in the future for the intraoperative examination of melanocytic and autoimmune skin lesions.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1058-1065"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-07-30DOI: 10.1007/s00105-021-04868-4
Sigbert Jahn, Julia Föhr, Evangelia Diamanti, Matthias Herbst
{"title":"[Treatment of atopic dermatitis with dupilumab : A retrospective cohort analysis from dermatological practice].","authors":"Sigbert Jahn, Julia Föhr, Evangelia Diamanti, Matthias Herbst","doi":"10.1007/s00105-021-04868-4","DOIUrl":"https://doi.org/10.1007/s00105-021-04868-4","url":null,"abstract":"<p><p>We present the results of a retrospective data analysis of a practice cohort of 44 patients with atopic dermatitis treated with the IL-4/13 receptor antibody dupilumab for up to 3 years. Patients were followed up over a period of 21 months during specialized consultation hours named Immunodermatology, which was established to guarantee comprehensive documentation. The patient's characteristics regarding age and sex distribution, severity and duration of disease were comparable with the patient collectives in large, pivotal studies. The therapeutic efficiency however was high (percentage of patients with EASI50, -75, -90 after 16 weeks: 94, 84, 60%, respectively) and long lasting (86% EASI90 after 52 weeks on therapy) under everyday conditions in the clinical setting. Approximately half of the patients had facial skin or eye involvement either in their history or at the start of treatment. This group of patients proved to need more and intense care because facial dermatitis and periocular dermatitis, which often involved conjunctivitis, took longer to heal, relapses occurred, and an additional topical treatment was often required. We did not observe any severe side effects during the 48 patient-years analyzed in this study. Dupilumab proved to be a safe and efficient treatment for atopic dermatitis in dermatological practice.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1071-1078"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00105-021-04868-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39259424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-03-24DOI: 10.1007/s00105-021-04799-0
Katja Dicke, Vasileios Dervenis, Axel Hauschild, Thomas Dirschka
{"title":"[Local tumor control of metastatic Merkel cell carcinoma in a 90-year-old woman].","authors":"Katja Dicke, Vasileios Dervenis, Axel Hauschild, Thomas Dirschka","doi":"10.1007/s00105-021-04799-0","DOIUrl":"https://doi.org/10.1007/s00105-021-04799-0","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer. Many people suffer early local recurrences and distant metastases. The anti-PDL1 (PDL1: programmed death ligand 1) antibody avelumab has been approved as first-line treatment for advanced MCC in Europe. It is also an alternative treatment for old and multimorbid patients.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1090-1093"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00105-021-04799-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25512108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-10-26DOI: 10.1007/s00105-021-04905-2
Cristel Ruini, Fabia Daxenberger, Charlotte Gust, Sandra Schuh, Lars E French, Julia Welzel, Elke C Sattler
{"title":"[Advances in optical coherence tomography].","authors":"Cristel Ruini, Fabia Daxenberger, Charlotte Gust, Sandra Schuh, Lars E French, Julia Welzel, Elke C Sattler","doi":"10.1007/s00105-021-04905-2","DOIUrl":"https://doi.org/10.1007/s00105-021-04905-2","url":null,"abstract":"<p><p>Optical coherence tomography (OCT) has been able to establish itself in recent years not only in academic-scientific, but also in everyday dermatological practice. Its focus lies on epithelial tumors of the skin, which can be diagnosed intuitively and within a few seconds. Thus, basal cell carcinomas, actinic keratoses, and different stages of field cancerization can be diagnosed and monitored for response to therapy or possible recurrence. This often helps to avoid invasive sample extraction. Recently, the field of OCT and its latest advancement, dynamic OCT (D-OCT), has been expanded to include non-oncologic dermatological diseases. This encompasses inflammatory dermatoses and the analysis of physiological skin parameters such as hydration. Thanks to automated vascular imaging and the measurement of objective parameters such as epidermal thickness, blood flow at depth, optical attenuation coefficient, and skin roughness, more and more characteristics of the skin can be studied in a noninvasive and standardized way. New potential areas of application are eczema, contact allergic dermatitis, psoriasis, rosacea, telangiectasia, acute and chronic wounds, melasma and nevus flammeus but also melanocytic lesions.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1048-1057"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39560008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01DOI: 10.1007/s00105-020-04705-0
E Rabe, F X Breu, I Flessenkämper, H Gerlach, S Guggenbichler, B Kahle, R Murena, S Reich-Schupke, T Schwarz, M Stücker, E Valesky, S Werth, F Pannier
{"title":"Sclerotherapy in the treatment of varicose veins : S2k guideline of the Deutsche Gesellschaft für Phlebologie (DGP) in cooperation with the following societies: DDG, DGA, DGG, BVP.","authors":"E Rabe, F X Breu, I Flessenkämper, H Gerlach, S Guggenbichler, B Kahle, R Murena, S Reich-Schupke, T Schwarz, M Stücker, E Valesky, S Werth, F Pannier","doi":"10.1007/s00105-020-04705-0","DOIUrl":"10.1007/s00105-020-04705-0","url":null,"abstract":"","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 Suppl 2","pages":"23-36"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38657391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HautarztPub Date : 2021-12-01Epub Date: 2021-03-15DOI: 10.1007/s00105-021-04795-4
Lukas Wellkamp, Niklas-Chris Dellmann, Sebastian Bushart, Mutaz Al-Shakhanbeh, Pascal Kirchhoff, Andrej Ring
{"title":"[Fluorescence lymphangiography in the diagnosis and navigated microsurgical treatment of iatrogenic lymph vessel lesion].","authors":"Lukas Wellkamp, Niklas-Chris Dellmann, Sebastian Bushart, Mutaz Al-Shakhanbeh, Pascal Kirchhoff, Andrej Ring","doi":"10.1007/s00105-021-04795-4","DOIUrl":"https://doi.org/10.1007/s00105-021-04795-4","url":null,"abstract":"<p><p>Injuries of lymph vessels can occur due to trauma or surgery and may result in significant difficulties for patients. Wound healing is often severely impaired and patients may need extensive surgical treatment. A case of iatrogenic lymph vessel injury after excision of a skin tumor in the axillary region is reported, as is the reconstructive procedure by lymphaticovenous anastomosis.</p>","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"72 12","pages":"1094-1097"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00105-021-04795-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25479909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}