[Ex vivo confocal laser scanning microscopy for melanocytic lesions and autoimmune diseases].

4区医学 Q3 Medicine

Hautarzt Pub Date : 2021-12-01 Epub Date: 2021-10-27 DOI:10.1007/s00105-021-04906-1

D Hartmann

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引用次数: 0

Abstract

Background: Ex vivo confocal laser scanning microscopy (CLSM) enables bedside histology and offers the surgeon a direct intraoperative tissue examination.

Objectives: To determine whether this innovative, ultra-fast diagnostic tool can be expanded beyond nonmelanoma skin cancer, particularly basal cell carcinoma, to other indications including melanocytic lesions and autoimmune diseases.

Materials and methods: Review of literature and summary of the current knowledge and experience of the use of ex vivo CLSM in melanocytic lesions and in autoimmune diseases.

Results: Up to date experience of the use of ex vivo CLSM in melanocytic lesions and in autoimmune diseases is limited but promising. Current knowledge on melanocytic lesions in ex vivo CLSM and their examples together with classic ex vivo CLSM features are presented. Previous results on the use of ex vivo CLSM in autoimmune dermatoses are presented, and future application possibilities of ex vivo CLSM are discussed.

Conclusions: The method is particularly suitable for the rapid examination of basal cell carcinomas during Mohs surgery but could also be used in the future for the intraoperative examination of melanocytic and autoimmune skin lesions.

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[黑色素细胞病变和自身免疫性疾病的体外共聚焦激光扫描显微镜]。

背景:体外共聚焦激光扫描显微镜(CLSM)可以进行床边组织学检查，并为外科医生提供直接的术中组织检查。目的:确定这种创新的超快速诊断工具是否可以扩展到非黑色素瘤皮肤癌，特别是基底细胞癌以外的其他适应症，包括黑色素细胞病变和自身免疫性疾病。材料和方法:回顾文献，总结目前体外CLSM治疗黑色素细胞病变和自身免疫性疾病的知识和经验。结果:迄今为止，体外CLSM在黑色素细胞病变和自身免疫性疾病中的应用经验有限，但前景广阔。本文介绍了目前关于体外CLSM中黑色素细胞病变的知识，以及它们的例子和经典的体外CLSM特征。本文介绍了体外CLSM在自身免疫性皮肤病中的应用的既往结果，并讨论了体外CLSM未来的应用可能性。结论:该方法特别适用于Mohs手术中基底细胞癌的快速检查，但也可用于术中黑素细胞和自身免疫性皮肤病变的检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hautarzt 医学-皮肤病学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Der Hautarzt is an internationally recognized journal informing all dermatologists working in practical or clinical environments about important developments in the field of dermatology including allergology, venereology and related areas. Comprehensive reviews on a specific topical issue focus on providing evidenced based information on diagnostics and therapy. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice.