{"title":"Authors' reply: bridging the health literacy gap in cardiac rehabilitation through intervention and program design.","authors":"Yuji Kanejima, Kazuhiro P Izawa, Masahiro Kitamura, Kodai Ishihara, Asami Ogura, Ikko Kubo, Hitomi Nagashima, Hideto Tawa, Daisuke Matsumoto, Ikki Shimizu","doi":"10.1007/s00380-025-02621-8","DOIUrl":"10.1007/s00380-025-02621-8","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"576-577"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk of cardiac dysfunction in patients receiving anthracyclines across breast cancer and hematologic malignancies: a single-center retrospective cohort study in Japan.","authors":"Yujiro Homma, Kazuyoshi Kimura, Kenta Sasaki, Yuji Okura, Takeshi Kashimura, Takayuki Inomata, Yasuo Saijo, Qiliang Zhou","doi":"10.1007/s00380-026-02654-7","DOIUrl":"10.1007/s00380-026-02654-7","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"531-540"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-01Epub Date: 2025-11-29DOI: 10.1007/s00380-025-02615-6
Xiaoyan Chen, Youai Xie, Meiqing Zhou
{"title":"TAPSE/PASP ratio as a prognostic marker in HFmrEF: a missed opportunity?","authors":"Xiaoyan Chen, Youai Xie, Meiqing Zhou","doi":"10.1007/s00380-025-02615-6","DOIUrl":"10.1007/s00380-025-02615-6","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"571"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145632467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combined prognostic value of elevated lipoprotein(a) and severe calcification for limb outcomes after endovascular therapy.","authors":"Takeo Horikoshi, Takamitsu Nakamura, Toshiki Takei, Toru Yoshizaki, Manabu Uematsu, Tsuyoshi Kobayashi, Akira Sato","doi":"10.1007/s00380-026-02738-4","DOIUrl":"https://doi.org/10.1007/s00380-026-02738-4","url":null,"abstract":"<p><p>Lipoprotein(a) [Lp(a)] and vascular calcification have each been associated with poor outcomes in lower extremity arterial disease (LEAD). This study investigated whether elevated Lp(a) levels and severe calcification have combined prognostic value for major adverse limb events (MALE) after endovascular therapy (EVT). We retrospectively analyzed 145 patients who underwent EVT. Patients were classified according to the number of Lp(a)/ Peripheral Arterial Calcium Scoring System (PACSS) risk markers: elevated Lp(a) (≥ 30 mg/dL) and PACSS grade 4. The primary endpoint was 1-year MALE incidence. MALE occurred in 17 patients during follow-up. Patients were classified into three groups according to the number of Lp(a)/PACSS risk markers. The cumulative incidence of MALE differed significantly among the three groups (overall P = 0.032). Compared with the 0 risk-marker group, the 1 risk-marker group and the 2 risk-marker group had significantly higher risks of MALE (hazard ratio [HR], 3.175; 95% confidence interval [CI], 1.064-9.475; P = 0.038; and HR, 4.803; 95% CI 1.146-20.128; P = 0.032, respectively). A significant trend toward higher MALE risk was observed with an increasing number of risk markers (P for trend = 0.012). Elevated Lp(a) and severe calcification may identify a subgroup at higher risk of MALE after EVT. Integrating Lp(a) measurement with anatomical assessment by PACSS may provide exploratory insights into risk stratification.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aortic calcification and contrast-associated acute kidney injury in patients undergoing urgent coronary angiography.","authors":"Masatsugu Miyagawa, Riku Arai, Yoshikuni Shoji, Ayame Saito, Tatsuya Otake, Yusuke Sasa, Shonosuke Sugai, Kazuki Iso, Wataru Atsumi, Eizo Tachibana, Satoshi Kunimoto, Keisuke Kojima, Yasuo Okumura","doi":"10.1007/s00380-026-02740-w","DOIUrl":"10.1007/s00380-026-02740-w","url":null,"abstract":"<p><p>Aortic calcification detected on computed tomography (CT) is a marker of systemic atherosclerosis. Its clinical significance in predicting contrast-associated acute kidney injury (CA-AKI) after urgent coronary angiography remains unclear. A total of 140 patients (median age, 73 years [interquartile range 58-81]; female, 24.3%) were included. Calcification was assessed in the ascending aorta, aortic arch/descending aorta, abdominal aorta, coronary arteries, and renal arteries. The primary endpoint was CA-AKI, and the secondary endpoint was serial change in estimated glomerular filtration rate (eGFR) within 3 days after the procedure. CA-AKI occurred in 12.9% of patients. In univariate analysis, calcification of the aortic arch/descending aorta and abdominal aorta was associated with CA-AKI. Calcification of the ascending aorta was not associated with CA-AKI. After multivariable adjustment, calcification of the aortic arch/descending aorta remained associated with CA-AKI. Patients with calcification in these segments showed significantly attenuated improvement in eGFR over time. Among patients undergoing urgent coronary angiography, calcification of the aortic arch/descending aorta and abdominal aorta on CT was associated with CA-AKI and impaired short-term renal recovery. Aortic calcification may provide rapid preprocedural risk stratification.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-07-19DOI: 10.1007/s00380-026-02728-6
Yuncong Ma, Suxia Fang
{"title":"Relationship between serum circulating Syndecan-1 levels and myocardial fibrosis and major adverse cardiovascular events in elderly patients with atrial fibrillation.","authors":"Yuncong Ma, Suxia Fang","doi":"10.1007/s00380-026-02728-6","DOIUrl":"https://doi.org/10.1007/s00380-026-02728-6","url":null,"abstract":"<p><p>This research investigated the relationship between serum Syndecan-1 levels and myocardial fibrosis (MF) and major adverse cardiovascular events (MACEs) in elderly patients with atrial fibrillation (AF). Elderly patients with AF were divided into MF (n = 162) and N-MF (n = 89) groups. During 5-year follow-up, 78 patients with MACEs formed the MACEs group, and 173 without MACEs formed the N-MACEs group. Spearman correlation analysis was performed. Multivariate Cox regression and Kaplan-Meier curves were conducted, and ROC curves were plotted. Serum Syndecan-1 was elevated in the MF group versus the N-MF group. Serum Syndecan-1 levels in AF patients showed moderate positive correlations with both sST2 (r = 0.569) and PINP (r = 0.446). Serum Syndecan-1 showed diagnostic value for MF in patients with AF, with an AUC of 0.810. Moreover, combined detection with sST2 and PINP further achieved an AUC of 0.872. Serum Syndecan-1 levels were elevated in the MACE group compared to the N-MACEs group, and serum Syndecan-1 demonstrated discriminatory value for 5-year MACEs (AUC = 0.832). Serum Syndecan-1 (HR = 1.049) was independently associated with 5-year MACEs in AF patients. The risk associated with Syndecan-1 was more pronounced in patients with paroxysmalAF. After adjusting for sST2, NT-proBNP, LVEF, and MF, Syndecan-1 was independently associated with MACEs in patients with heart failure (P = 0.021). Elevated serum Syndecan-1 levels are associated with MF and MACEs in AF patients, suggesting its potential value as a biomarker for discriminating MF and MACEs in AF patients.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}