Heart and VesselsPub Date : 2026-08-19DOI: 10.1007/s00380-026-02747-3
Dae-Young Kim, Ki Jeung Lee, Sung Kee Ryu, Ji-Hun Jang, Seong-Huan Choi, Yong-Soo Baek, Sang-Don Park, Seong-Ill Woo, Dae-Hyeok Kim, Sung-Hee Shin
{"title":"Right atrial functional remodeling for early risk stratification of tricuspid regurgitation progression in atrial fibrillation.","authors":"Dae-Young Kim, Ki Jeung Lee, Sung Kee Ryu, Ji-Hun Jang, Seong-Huan Choi, Yong-Soo Baek, Sang-Don Park, Seong-Ill Woo, Dae-Hyeok Kim, Sung-Hee Shin","doi":"10.1007/s00380-026-02747-3","DOIUrl":"https://doi.org/10.1007/s00380-026-02747-3","url":null,"abstract":"<p><p>Tricuspid regurgitation (TR) is related to a poor prognosis in atrial fibrillation (AF). Although right atrial (RA) structural remodeling contributes to TR progression, the impact of RA functional remodeling on the progression of TR remains unclear. We investigated whether RA function influences TR progression in AF. Among 664 AF patients with baseline and follow-up echocardiography, 484 (mean 68 ± 12 years, 38% female) with insignificant (mild or less) TR at baseline were included. Patients with prior cardiac surgery, cardiac implantable electronic devices, significant (at least moderate) valvular diseases, LVEF < 50%, suboptimal images for strain analysis, or follow-up echocardiography < 6 months were excluded. A cut-off value for RA reservoir strain was 12.6%, as determined by ROC analysis. Over a mean 3.6 ± 2.7 years, 46 (9.5%) patients developed significant TR. Patients with RA reservoir strain < 12.6% were older, had more persistent AF, higher E/e' and pulmonary artery systolic pressure (PASP), larger left atrium (LA) and RA, and lower LA strain. On multivariable regression, RA reservoir strain < 12.6% was independently associated with TR progression after adjustment for age, sex, and RA volume (p = 0.027), and remained significant after further adjustment for E/e' or PASP. Impaired RA reservoir strain was independently associated with TR progression in AF patients with initially insignificant TR, suggesting that RA functional assessment may provide additional information complementary to RA structural remodeling and help identify patients at higher risk of TR progression.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to \"Interleukin-6 in acute heart failure: a marker of phenotype-specific biology or multimorbidity?\"","authors":"Makoto Kishihara, Yuichiro Minami, Hidetoshi Hattori, Shintaro Haruki, Junichi Yamaguchi","doi":"10.1007/s00380-026-02742-8","DOIUrl":"https://doi.org/10.1007/s00380-026-02742-8","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-10DOI: 10.1007/s00380-026-02753-5
Mustafa Tunahan Öz, Umut Şahin, Adnan Kaya
{"title":"Post-dialysis weight loss and cardiac recovery in hemodialysis: volume signal or causal determinant?","authors":"Mustafa Tunahan Öz, Umut Şahin, Adnan Kaya","doi":"10.1007/s00380-026-02753-5","DOIUrl":"10.1007/s00380-026-02753-5","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-05DOI: 10.1007/s00380-026-02741-9
Güney Sarıoğlu, Ertuğrul Kurtoğlu
{"title":"Interleukin-6 in acute heart failure: A marker of phenotype-specific biology or multimorbidity?","authors":"Güney Sarıoğlu, Ertuğrul Kurtoğlu","doi":"10.1007/s00380-026-02741-9","DOIUrl":"10.1007/s00380-026-02741-9","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-05DOI: 10.1007/s00380-026-02737-5
Jin Li, Kesen Tang
{"title":"Fibrosis-5 in patients with chronic heart failure: a participant or a bystander?","authors":"Jin Li, Kesen Tang","doi":"10.1007/s00380-026-02737-5","DOIUrl":"https://doi.org/10.1007/s00380-026-02737-5","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The utility of the T wave peak to T wave end interval to Q-T end interval ratio as a dynamic indicator of cardiac sympathetic activity: a preliminary study.","authors":"Shota Saito, Taro Temma, Masaya Watanabe, Takahide Kadosaka, Motoki Nakao, Taro Koya, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai","doi":"10.1007/s00380-026-02739-3","DOIUrl":"https://doi.org/10.1007/s00380-026-02739-3","url":null,"abstract":"<p><p>Excessive cardiac sympathetic nerve activity significantly contributes to chronic heart failure (CHF) and lethal arrhythmias. However, reliable dynamic markers to assess sympathetic modulation are lacking in clinical practice. The T wave peak to T wave end interval (TpTe) to Q-T end interval ratio (TpTe/QTe) has been suggested as a surrogate marker for transmural dispersion of repolarization (TDR). We hypothesized that the TpTe/QTe reflects cardiac sympathetic nerve activity based on anatomical differences in the distribution and activation of cardiac sympathetic nerves. 12-lead Electrocardiograms (ECGs) were analyzed retrospectively in two cohorts without structural heart disease: (1) Exercise study; ECGs from patients who underwent treadmill or cardiopulmonary exercise testing between 2013 and 2023 were analyzed at baseline and 1-min post-maximal exercise. (2) β-stimulator infusion study; ECGs from patients who underwent catheter ablation (CA) of premature ventricular contractions (PVCs) or paroxysmal supraventricular tachycardias (PSVT) between 2017 and 2022 were analyzed at baseline and post-isoproterenol (ISO) infusion. In the exercise study, 45 patients (35.6% female, median age: 51) showed significant changes in the TpTe/QTe (interquartile range [IQR]: 0.20-0.30) from baseline to 1-min post-maximal exercise. In the β-Stimulator infusion study, 55 patients (63.6% female, median age: 55) had significant TpTe/QTe changes (0.19-0.33) from baseline to post-ISO infusion. The TpTe/QTe exhibited the largest change among the ECG parameters in both groups, regardless of sex, with no correlation to the left ventricular wall thickness. The TpTe/QTe may serve as a valuable dynamic indicator of cardiac sympathoexcitaion in patients without organic heart disease.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to \"Fibrosis-5 in patients with chronic heart failure: a participant or a bystander?\"","authors":"Saori Uchiyama, Yoshiaki Kubota, Takuya Nishino, Yukihiro Watanabe, Shuhei Tara, Katsuhito Kato, Kuniya Asai","doi":"10.1007/s00380-026-02736-6","DOIUrl":"https://doi.org/10.1007/s00380-026-02736-6","url":null,"abstract":"","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-01Epub Date: 2026-01-21DOI: 10.1007/s00380-025-02651-2
Hidetomi Takahashi, Masahiko Ando, Minoru Ono
{"title":"Incidence of right heart failure and its impact on survival outcomes after implantable left ventricular assist device implantation.","authors":"Hidetomi Takahashi, Masahiko Ando, Minoru Ono","doi":"10.1007/s00380-025-02651-2","DOIUrl":"10.1007/s00380-025-02651-2","url":null,"abstract":"<p><p>In Japan, median waiting time of heart transplantation (HT) is estimated as more than 5 years. Internationally, they report relatively high incidence of right heart failure (RHF) during left ventricular assist device (LVAD) support. However, the analysis based on nationwide survey in Japan is still limited. Therefore, we aimed to clarify the predictor and incidence of RHF after LVAD implantation in contemporary cohort, and its impact on their survival outcomes. Adult patients who underwent LVAD implantation at our institution from 2007 to 2023 were retrospectively reviewed. Those eventually weaned off and those bridged from paracorporeal VAD were excluded, and finally 178 patients were enrolled. We evaluated the incidence of RHF, post-LVAD survival, and predictors of RHF or on-device mortality. Five-year on-device survival was 78.5%. The incidence of early RHF was 3.4% and its cumulative incidence at 5 year was 22.1%. While 91.5% of the cohort underwent LVAD as BTT, post-LVAD survival was not significantly worse with RHF (p = 0.107). Cox regression analyses demonstrated preoperative severe TR and dilated phase of hypertrophic cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy were the independent predictors of RHF and on-device death (hazard ratio (HR) 8.59, 95% confidence interval (CI) 3.68-20.0, HR 2.62, 95% CI 1.08-6.34, respectively). The incidence of early RHF was 3.4% and its cumulative incidence at 5 year was 22.1%, which was relatively low. Although RHF was not significantly associated with worse 5-year survival after LVAD implantation, we would need a large, nation-wide study to further address this issue.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"513-523"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart and VesselsPub Date : 2026-08-01Epub Date: 2025-11-11DOI: 10.1007/s00380-025-02626-3
Brijesh Sathian, Farah Rahat, Reham Kamal Aboshdi, Hanadi Al Hamad
{"title":"Bridging the health literacy gap in cardiac rehabilitation through intervention and program design.","authors":"Brijesh Sathian, Farah Rahat, Reham Kamal Aboshdi, Hanadi Al Hamad","doi":"10.1007/s00380-025-02626-3","DOIUrl":"10.1007/s00380-025-02626-3","url":null,"abstract":"<p><p>This Letter to the Editor responds to the recent study by Kanejima et al. on the association between health literacy (HL) and behavioral changes during phase I cardiac rehabilitation (CR). While acknowledging the study's valuable contribution, we contest the conclusion that low HL is an inherent barrier to behavioral change. Drawing on recent evidence, we highlight that HL is a modifiable factor that can be improved through targeted interventions, program designs, and the rehabilitation process itself. We present six key arguments: (1) digital health technologies and structured education can enhance HL and foster behavioral adaptation in low-HL populations; (2) non-literacy barriers such as logistical constraints often play a larger role; (3) comparable cardiovascular interventions have shown sustained benefits despite low baseline HL; (4) CR programs themselves can directly improve HL; (5) modern CR designs employ adaptive, individualized approaches effective across HL levels; and (6) nurse-led and home-based strategies can successfully overcome HL limitations. Collectively, these points suggest that low HL should be viewed as a dynamic and addressable factor rather than a fixed constraint. We urge future research to incorporate HL-enhancing interventions and longitudinal follow-up to better understand HL's evolving role in CR outcomes.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":"574-575"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}