Heart and Vessels最新文献_第10页

Clinical features, future cardiac events, and prognostic factors following percutaneous coronary intervention in young female patients. 年轻女性患者经皮冠状动脉介入治疗后的临床特征、未来心脏事件和预后因素。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-27 DOI: 10.1007/s00380-024-02369-7

Yosuke Tatami, Akihito Tanaka, Taiki Ohashi, Ryuji Kubota, Shinji Kaneko, Masanori Shinoda, Yusuke Uemura, Kensuke Takagi, Miho Tanaka, Norio Umemoto, Hiroshi Tashiro, Naoki Shibata, Naoki Yoshioka, Masato Watarai, Itsuro Morishima, Yasunobu Takada, Kiyokazu Shimizu, Hideki Ishii, Toyoaki Murohara

{"title":"Clinical features, future cardiac events, and prognostic factors following percutaneous coronary intervention in young female patients.","authors":"Yosuke Tatami, Akihito Tanaka, Taiki Ohashi, Ryuji Kubota, Shinji Kaneko, Masanori Shinoda, Yusuke Uemura, Kensuke Takagi, Miho Tanaka, Norio Umemoto, Hiroshi Tashiro, Naoki Shibata, Naoki Yoshioka, Masato Watarai, Itsuro Morishima, Yasunobu Takada, Kiyokazu Shimizu, Hideki Ishii, Toyoaki Murohara","doi":"10.1007/s00380-024-02369-7","DOIUrl":"10.1007/s00380-024-02369-7","url":null,"abstract":"Background: The proportion of young females among the patients who undergo percutaneous coronary intervention (PCI) is relatively small, and information on their clinical characteristics is limited. This study investigated the clinical characteristics and prognostic factors for future cardiac events in young females who underwent PCI.Methods: This multicenter observational study included 187 consecutive female patients aged < 60 years who underwent PCI in seven hospitals. The primary composite endpoint was the incidence of cardiac death, nonfatal myocardial infarction, and target vessel revascularization.Results: The mean patient age was 52.1 ± 6.1 years and 89 (47.6%) had diabetes, and renal dysfunction (an estimated glomerular filtration rate < 60 mL/min/1.73 m2) was observed in 38 (20.3%). During a median follow-up of 3.3 years, the primary endpoint occurred in 28 patients. The Cox proportional hazards models showed that renal dysfunction was an independent predictor for the primary endpoint (hazard ratio 3.04, 95% confidence interval 1.25-7.40, p = 0.01), as well as multivessel disease (hazard ratio 2.79, 95% confidence interval 1.12-6.93, p = 0.03). Patients with renal dysfunction had a significantly higher risk for the primary endpoint than those without renal dysfunction.Conclusions: Renal dysfunction was strongly associated with future cardiac events in young females who underwent PCI.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome. 培马贝特对患有冠心病和代谢综合征的高甘油三酯血症患者血脂状况和胰岛素抵抗的影响

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI: 10.1007/s00380-024-02363-z

Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo

{"title":"Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome.","authors":"Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo","doi":"10.1007/s00380-024-02363-z","DOIUrl":"10.1007/s00380-024-02363-z","url":null,"abstract":"This study examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α agonist, on the serum biochemical parameters of male patients with coronary artery disease and metabolic syndrome (MetS). This was a post hoc analysis of a randomized, crossover study that treated hypertriglyceridemia with pemafibrate or bezafibrate for 24 weeks, followed by a crossover of another 24 weeks. Of the 60 patients enrolled in the study, 55 were male. Forty-one of 55 male patients were found to have MetS. In this sub-analysis, male patients with MetS (MetS group, n = 41) and those without MetS (non-MetS group, n = 14) were compared. The primary endpoint was a change in fasting serum triglyceride (TG) levels during pemafibrate therapy, and the secondary endpoints were changes in insulin resistance-related markers and liver function parameters. Serum TG levels significantly decreased (MetS group, from 266.6 to 148.0 mg/dL, p < 0.001; non-MetS group, from 203.9 to 97.6 mg/dL, p < 0.001); however, a percent change (%Change) was not significantly different between the groups (- 44.1% vs. - 51.6%, p = 0.084). Serum insulin levels and homeostasis model assessment of insulin resistance significantly decreased in the MetS group but not in the non-MetS group. %Change in liver enzyme levels was markedly decreased in the MetS group compared with that in the non-MetS group (alanine aminotransferase, - 25.1% vs. - 11.3%, p = 0.027; gamma-glutamyl transferase, - 45.8% vs. - 36.2%, p = 0.020). In conclusion, pemafibrate can effectively decrease TG levels in patients with MetS, and it may be a more efficient drug for improving insulin resistance and liver function in such patients.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow pattern analysis of right ventricular outflow tract in repaired tetralogy of Fallot through 4D flow MRI. 通过四维血流磁共振成像分析法洛四联症修复后右室流出道的血流模式。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-18 DOI: 10.1007/s00380-024-02361-1

Noriyuki Iwashita, Shigeo Okuda, Jun Maeda, Hiroyuki Yamagishi

{"title":"Flow pattern analysis of right ventricular outflow tract in repaired tetralogy of Fallot through 4D flow MRI.","authors":"Noriyuki Iwashita, Shigeo Okuda, Jun Maeda, Hiroyuki Yamagishi","doi":"10.1007/s00380-024-02361-1","DOIUrl":"10.1007/s00380-024-02361-1","url":null,"abstract":"Cardiac magnetic resonance imaging (CMR) often shows discrepancies between right ventricular outflow tract (RVOT) flow and left ventricular outflow tract flow in patients with late-stage repaired tetralogy of Fallot (rTOF), leading to potential errors in pulmonary regurgitation fraction (PRF) assessment. This study aimed to identify the conditions under which RVOT flow can be acutely evaluated using four-dimensional (4D) flow CMR. Twenty-seven consecutive patients with rTOF underwent both two-dimensional phase-contrast (2D PC) and 4D flow CMR between 2016 and 2018, excluding those with peripheral pulmonary artery stenosis, RVOT conduit replacement, unknown surgical method, and an aortic valve regurgitation greater than 20%. Seven healthy controls also underwent only 4D Flow CMR. All healthy controls and fifteen patients with rTOF showed laminar RVOT flow, while seven patients exhibited helical, and four patients exhibited vortical RVOT flow in 4D flow CMR visualization. Flow-volume concordance between the pulmonary artery and aortic flow was significantly lower in patients with rTOF and PRF > 40% in 2D PC CMR. This concordance rate in the suprapulmonary valve was high in both the TOF and control groups, comparing at five RVOT locations in 4D flow CMR. Regarding RVOT flow regurgitation in 4D flow, the whole bulk evaluation exhibited greater variation depending on the flow type compared to the whole pixel-wise evaluation. The study confirmed the flow volume at the upper section of the pulmonary valve as the most accurate correlate of aortic flow volume. Furthermore, the 4D flow CMR using the pixel-wise method demonstrated superior accuracy compared to the traditional bulk flow method.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirty-year outcomes of low-intensity anticoagulation for mechanical aortic valve. 机械主动脉瓣低强度抗凝治疗的 30 年疗效。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI: 10.1007/s00380-024-02365-x

Shintaro Sawa, Satoshi Saito, Kozo Morita, Shinka Miyamoto, Masashi Hattori, Atomu Hino, Yasuhito Okuzono, Yuji Shiozaki, Yuki Echie, Hiroshi Niinami

{"title":"Thirty-year outcomes of low-intensity anticoagulation for mechanical aortic valve.","authors":"Shintaro Sawa, Satoshi Saito, Kozo Morita, Shinka Miyamoto, Masashi Hattori, Atomu Hino, Yasuhito Okuzono, Yuji Shiozaki, Yuki Echie, Hiroshi Niinami","doi":"10.1007/s00380-024-02365-x","DOIUrl":"10.1007/s00380-024-02365-x","url":null,"abstract":"The long-term safety, efficacy, and outcomes of low-intensity anticoagulation for mechanical heart valves remain unclear. This study aimed to evaluate the long-term outcomes of low-intensity anticoagulation therapy after aortic valve replacement (AVR) with a mechanical prosthesis. This retrospective cohort study consulted medical records and conducted a questionnaire to investigate 519 patients who underwent single AVR with the St. Jude Medical bileaflet valve and were in sinus rhythm. All patients were followed up with an international normalized ratio (INR) target of 1.6-2.5, and their INR values were checked throughout the follow-up period. The survival rate, incidence of major adverse cardiac and cerebrovascular events (MACCE), and risk factors for cardiac death and MACCE were investigated. The total follow-up was 9793 patient-years, and the follow-up periods were 19.9 (standard deviation [SD]: 7.9) years. The mean INR was 2.03 (SD: 0.54). Survival rates from cardiac death were 93.6% in 20 years and 85.2% in 30 years. Advanced age ≥ 70 years was the only significant risk factor for cardiac death and MACCE, and the INR < 2.0 was not significant risk factor for MACCE including thromboembolism or bleeding events. Low-intensity anticoagulation with an INR of 1.6-2.5 for patients with sinus rhythm after AVR with a bileaflet mechanical valve is safe and effective, even over 30 years.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of polypharmacy and discharge medications in octogenarians and nonagenarian patients with acute heart failure. 八旬老人和非八旬老人急性心力衰竭患者多药治疗和出院用药对预后的影响。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-22 DOI: 10.1007/s00380-024-02366-w

Yusuke Uemura, Rei Shibata, Kazuhisa Sawada, Shinji Ishikawa, Kenji Takemoto, Toyoaki Murohara, Masato Watarai

{"title":"Prognostic impact of polypharmacy and discharge medications in octogenarians and nonagenarian patients with acute heart failure.","authors":"Yusuke Uemura, Rei Shibata, Kazuhisa Sawada, Shinji Ishikawa, Kenji Takemoto, Toyoaki Murohara, Masato Watarai","doi":"10.1007/s00380-024-02366-w","DOIUrl":"10.1007/s00380-024-02366-w","url":null,"abstract":"With the increasing frequency of heart failure (HF) in elderly patients, polypharmacy has become a major concern owing to its adverse outcomes. However, reports on the clinical impact of polypharmacy and discharge medications in hospitalized super-aged patients with acute HF are rare. Data from 682 patients aged 80 years or older, hospitalized for treating acute HF, were analyzed. We recorded the number of medications at discharge and classified them into three groups: HF, non-HF cardiovascular, and non-cardiovascular medications. We investigated the correlation of polypharmacy, defined as daily administration of 10 or more medications at discharge, and the use of discharge medications with post-discharge prognosis. Polypharmacy was recorded in 24.3% of enrolled patients. Polypharmacy was not an independent predictor of all-cause mortality, the incidence of cardiac-related death, or HF-associated rehospitalization; however, the number of non-cardiovascular medications, multiple usage of potentially inappropriate medications, use of mineralocorticoid receptor antagonists, and doses of loop diuretics were associated with poor prognosis. Polypharmacy was significantly associated with higher mortality in patients with Barthel index ≥ 60 at discharge; hence, physical function at discharge was useful for the stratification of prognostic impacts of polypharmacy. The current study demonstrated that polypharmacy was not essentially associated with poor prognosis in super-aged patients with acute HF. Appropriate medications that consider the patient's physical function, rather than polypharmacy itself, are important for the management of HF.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of left atrial appendage measurements between conventional transesophageal echocardiography and "Virtual TEE" reconstructed from computed tomography for pre-procedural planning of device closure. 传统经食道超声心动图与计算机断层扫描重建的 "虚拟经食道超声心动图 "对左心房阑尾测量结果的比较，用于装置闭合术前规划。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-08 DOI: 10.1007/s00380-024-02360-2

Natsuki Cho, Yoshifumi Nakajima, Shunsuke Kubo, Hidehiko Hara, Mamoru Nanasato, Maiko Hozawa, Akio Doi, Yoshihiro Morino

{"title":"Comparison of left atrial appendage measurements between conventional transesophageal echocardiography and \"Virtual TEE\" reconstructed from computed tomography for pre-procedural planning of device closure.","authors":"Natsuki Cho, Yoshifumi Nakajima, Shunsuke Kubo, Hidehiko Hara, Mamoru Nanasato, Maiko Hozawa, Akio Doi, Yoshihiro Morino","doi":"10.1007/s00380-024-02360-2","DOIUrl":"10.1007/s00380-024-02360-2","url":null,"abstract":"For pre-procedural planning of left atrial appendage (LAA) closure, sizing is crucial. Although transesophageal echocardiography (TEE) is a standard modality, cardiac computed tomography (CT) is also widely used. The virtual TEE (V-TEE) that our group developed enables us to reconstruct images similar to TEE images from CT images. The software should be helpful to understand and plan the procedure strategy. Accordingly, we investigated the utility of V-TEE. Sixty-six patients at 4 participating sites who completed both CT and TEE prior to LAA closure were included. The LAA diameter at the landing zone (LZ) for WATCHMAN™ device implantation was statistically compared at 0°, 45°, 90°, and 135° between V-TEE and TEE. Among 66 cases, only 3 cases were excluded due to poor imaging quality, and 63 cases were analyzed. The device LZ diameters based on V-TEE were strongly correlated with those based on TEE, despite the significantly greater diameter based on V-TEE with mean differences of 2.4 to 3.0 mm (all of them: P < 0.001). The discordances (V-TEE/TEE ratio) at most angles were significantly larger in the elliptical LAAs. V-TEE provides a valuable method for the evaluation of the LAA diameters. V-TEE-based measurements were larger than conventional TEE-based measurements, especially in cases of elliptical LAAs. The assessment by V-TEE has the potential benefit of ensuring proper device sizing regardless of the LAA morphology.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of statins treatments for plaque characteristics in stable angina pectoris patients with very low and high low-density lipoprotein cholesterol levels: an intracoronary optical coherence tomography study. 他汀类药物治疗对低密度脂蛋白胆固醇水平极低和极高的稳定性心绞痛患者斑块特征的影响：冠状动脉内光学相干断层扫描研究。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI: 10.1007/s00380-024-02359-9

Hideo Amano, Yoshimasa Kojima, Shojiro Hirano, Yosuke Oka, Hiroto Aikawa, Ryota Noike, Takayuki Yabe, Ryo Okubo, Takanori Ikeda

{"title":"The impact of statins treatments for plaque characteristics in stable angina pectoris patients with very low and high low-density lipoprotein cholesterol levels: an intracoronary optical coherence tomography study.","authors":"Hideo Amano, Yoshimasa Kojima, Shojiro Hirano, Yosuke Oka, Hiroto Aikawa, Ryota Noike, Takayuki Yabe, Ryo Okubo, Takanori Ikeda","doi":"10.1007/s00380-024-02359-9","DOIUrl":"10.1007/s00380-024-02359-9","url":null,"abstract":"Low-density lipoprotein cholesterol (LDL-C) levels are recommended according to the patient's risk factors based on guidelines. In patients achieving low LDL-C levels, the need for statins is uncertain, and the plaque characteristics of patients not treated with statins are unclear. In addition, the difference in plaque characteristics with and without statins is unclear in similarly high LDL levels. We evaluate the impact of statins on plaque characteristics on optical coherence tomography (OCT) in patients with very low LDL-C levels and high LDL-C levels. A total of 173 stable angina pectoris patients with 173 lesions undergoing OCT before percutaneous coronary intervention were evaluated. We divided the LDL-C levels into three groups: < 70 mg/dL (n = 48), 70 mg/dL ≤ LDL-C < 100 mg/dL (n = 71), and ≥ 100 mg/dL (n = 54). Among patients with LDL-C < 70 mg/dL, patients not treated with statins showed a significantly higher C-reactive protein level (0.27 ± 0.22 mg/dL vs. 0.15 ± 0.19 mg/dL, p = 0.049), and higher incidence of thin-cap fibroatheromas (TCFAs; 44% [7/16] vs. 13% [4/32], p = 0.021) than those treated with statins. Among patients with LDL-C level ≥ 100 mg/dL, patients treated with statins showed a significantly higher prevalence of familial hypercholesterolemia (FH) (38% [6/16] vs. 5% [2/38], p = 0.004), lower incidence of TCFAs (6% [1/16] vs. 39% [15/38], p = 0.013), healed plaques (13% [2/16] vs. 47% [18/38], p = 0.015), and higher incidence of fibrous plaques (75% [12/16] vs. 42% [16/38], p = 0.027) than patients not treated with statins. While patients achieved a low LDL-C, patients not treated with statins had high plaque vulnerability and high systemic inflammation. While patients had a high LDL-C level with a high prevalence of FH, patients treated with statins had stable plaque characteristics.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of left pulmonary vein trunk and subclinical atrial fibrillation in patients with cardiac implantable electronic device. 心脏植入式电子装置患者左肺静脉干与亚临床心房颤动的关系

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 DOI: 10.1007/s00380-024-02423-4

Manabu Kashiwagi, Akio Kuroi, Natsuki Higashimoto, Kazuya Mori, Kosei Terada, Yosuke Katayama, Kazushi Takemoto, Akira Taruya, Yasutsugu Shiono, Takashi Tanimoto, Hironori Kitabata, Atsushi Tanaka

{"title":"Association of left pulmonary vein trunk and subclinical atrial fibrillation in patients with cardiac implantable electronic device.","authors":"Manabu Kashiwagi, Akio Kuroi, Natsuki Higashimoto, Kazuya Mori, Kosei Terada, Yosuke Katayama, Kazushi Takemoto, Akira Taruya, Yasutsugu Shiono, Takashi Tanimoto, Hironori Kitabata, Atsushi Tanaka","doi":"10.1007/s00380-024-02423-4","DOIUrl":"https://doi.org/10.1007/s00380-024-02423-4","url":null,"abstract":"The relationship between subclinical atrial fibrillation (SCAF) and left pulmonary vein anatomy is unknown. This study sought to investigate whether left pulmonary vein trunk predict the development of SCAF in patients with cardiac implantable electronic device (CIED). We also examined the relationship between the duration of SCAF and left pulmonary vein trunk. We retrospectively enrolled 162 patients who underwent implantation of dual-chamber CIEDs and follow-up by remote monitoring system. Computed tomography was used to measure the length of the left pulmonary vein. During median follow up of 2.7 years, the episodes of > 6 min and > 24 h SCAF were observed in 61 (37.7%) and 24 (14.8%) patients, respectively. The diagnosis of sinus node disease (HR: 3.66 [2.06-6.52], P < 0.01 and HR: 2.68 [1.09-6.62], P = 0.04) and left atrial diameter (HR: 1.04 [1.00-1.07], P = 0.04 and HR: 1.05 [1.00-1.10], P = 0.04) were independent predictors for > 6 min and > 24 h SCAF, respectively. Length of the left pulmonary vein trunk was an independent predictor for > 6 min SCAF (HR: 1.06 [1.02-1.10], P < 0.01), but not for > 24 h SCAF (P = 0.06). Sinus node disease, size of the left atrium and length of the left pulmonary vein trunk were related to SCAF. The left pulmonary vein trunk might especially contribute as a trigger rather than as a driver of development of atrial fibrillation.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating convolutional neural network-enhanced electrocardiography for hypertrophic cardiomyopathy detection in a specialized cardiovascular setting. 评估卷积神经网络增强型心电图在专业心血管环境中用于肥厚型心肌病检测的效果。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-03-30 DOI: 10.1007/s00380-024-02367-9

Naomi Hirota, Shinya Suzuki, Jun Motogi, Takuya Umemoto, Hiroshi Nakai, Wataru Matsuzawa, Tsuneo Takayanagi, Akira Hyodo, Keiichi Satoh, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroaki Semba, Hiroto Kano, Shunsuke Matsuno, Yuko Kato, Takayuki Otsuka, Tokuhisa Uejima, Yuji Oikawa, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Junji Yajima, Takeshi Yamashita

{"title":"Evaluating convolutional neural network-enhanced electrocardiography for hypertrophic cardiomyopathy detection in a specialized cardiovascular setting.","authors":"Naomi Hirota, Shinya Suzuki, Jun Motogi, Takuya Umemoto, Hiroshi Nakai, Wataru Matsuzawa, Tsuneo Takayanagi, Akira Hyodo, Keiichi Satoh, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroaki Semba, Hiroto Kano, Shunsuke Matsuno, Yuko Kato, Takayuki Otsuka, Tokuhisa Uejima, Yuji Oikawa, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Junji Yajima, Takeshi Yamashita","doi":"10.1007/s00380-024-02367-9","DOIUrl":"10.1007/s00380-024-02367-9","url":null,"abstract":"The efficacy of convolutional neural network (CNN)-enhanced electrocardiography (ECG) in detecting hypertrophic cardiomyopathy (HCM) and dilated HCM (dHCM) remains uncertain in real-world applications. This retrospective study analyzed data from 19,170 patients (including 140 HCM or dHCM) in the Shinken Database (2010-2017). We evaluated the sensitivity, positive predictive rate (PPR), and F1 score of CNN-enhanced ECG in a ''basic diagnosis'' model (total disease label) and a ''comprehensive diagnosis'' model (including disease subtypes). Using all-lead ECG in the \"basic diagnosis\" model, we observed a sensitivity of 76%, PPR of 2.9%, and F1 score of 0.056. These metrics improved in cases with a diagnostic probability of ≥ 0.9 and left ventricular hypertrophy (LVH) on ECG: 100% sensitivity, 8.6% PPR, and 0.158 F1 score. The ''comprehensive diagnosis'' model further enhanced these figures to 100%, 13.0%, and 0.230, respectively. Performance was broadly consistent across CNN models using different lead configurations, particularly when including leads viewing the lateral walls. While the precision of CNN models in detecting HCM or dHCM in real-world settings is initially low, it improves by targeting specific patient groups and integrating disease subtype models. The use of ECGs with fewer leads, especially those involving the lateral walls, appears comparably effective.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follistatin-like 1 (FSTL1) levels as potential early biomarker of cardiovascular disease in a Mexican population. 墨西哥人群中作为心血管疾病潜在早期生物标志物的类花粉素 1（FSTL1）水平。

IF 1.5 4区医学

Heart and Vessels Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI: 10.1007/s00380-024-02364-y

N Ponce-Ruíz, J F Herrera-Moreno, A E Rojas-García, B S Barrón-Vivanco, C A González-Arias, Y Y Bernal-Hernández, L Ortega-Cervantes, J Ponce-Gallegos, J A Hernández-Nolasco, I M Medina-Díaz

{"title":"Follistatin-like 1 (FSTL1) levels as potential early biomarker of cardiovascular disease in a Mexican population.","authors":"N Ponce-Ruíz, J F Herrera-Moreno, A E Rojas-García, B S Barrón-Vivanco, C A González-Arias, Y Y Bernal-Hernández, L Ortega-Cervantes, J Ponce-Gallegos, J A Hernández-Nolasco, I M Medina-Díaz","doi":"10.1007/s00380-024-02364-y","DOIUrl":"10.1007/s00380-024-02364-y","url":null,"abstract":"Cardiovascular diseases (CVD) are the leading cause of death globally. In recent years, follistatin-like protein 1 (FSTL1) has been proposed as an emerging potential clinical biomarker of CVD, since its concentration is upregulated in heart failure. The aim of the present study was to evaluate the association of FSTL1 levels and classic biomarkers with the risk of CVD in Mexican population. A case-control study was carried out in patients with cardiovascular diseases (CVD), arterial hypertension, but not CVD (cardiovascular risk factor-CRF), and healthy controls (control group) from the Mexican Institute of Social Security. Lipid profile, homocysteine (Hcys), serum amyloid A (SAA), FSTL1 concentration, PON1 concentration and activities [Arylesterase (ARE), and Lactonase (LAC)] were evaluated. High levels of FSTL1 were found in the CRF group and a positive association of FSTL1 (OR = 4.55; 95% CI 1.29-16.04, p = 0.02) with the presence of arterial hypertension, as well as Hcys (OR, 3.09; 95% CI 1.23-7.76, p = 0.02) and SAA (OR, 1.03; 95% CI 1.01-1.05, p < 0.01) with the presence of CVD. LAC activity (OR, 0.26; 95% CI 0.07-0.94, p = 0.04) and PON1 concentration (OR, 0.17; 95% CI 0.05-0.62, p = 0.01) were associated with a decrease in OR belonging to the group with CVD. Our results suggest that FSTL1 may be a useful biomarker for monitoring cardiovascular risk in clinical settings. However, longitudinal studies are needed to evaluate how FSTL1 could influence the association of PON1 activity and Hcys with CVD.","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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