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Heterocyclic Communications最新文献

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Fluorescence properties in different solvents and synthesis of axially substituted silicon phthalocyanine bearing bis-4-tritylphenoxy units 不同溶剂中的荧光性质及含双-4-三苯氧基轴向取代硅酞菁的合成
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0113
M. Ağırtaş
{"title":"Fluorescence properties in different solvents and synthesis of axially substituted silicon phthalocyanine bearing bis-4-tritylphenoxy units","authors":"M. Ağırtaş","doi":"10.1515/hc-2020-0113","DOIUrl":"https://doi.org/10.1515/hc-2020-0113","url":null,"abstract":"Abstract In this present study, a new axially bis-4-tritylphenoxy substituted silicon phthalocyanine compound was synthesized and characterized using infrared, mass, electronic absorption and nuclear magnetic resonance spectroscopy. Fluorescence and absorption spectra studies of the disubstituted silicon phthalocyanine complex were conducted on the chloroform, dimethyl formamide, dimethyl sulfoxide and tetrahydrofuran solutions. The findings of the fluorescence studies demonstrated that the compound has fluorescence spectra in the different solvents. The effects of the substitution with axially bis-4-tritylphenoxy functionalized groups on these parameters were also compared with the previously synthesized axially disubstituted silicon phthalocyanines. These results proved that the compound has different fluorescence properties in the different solvents.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"130 - 136"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49661552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Synthesis and optical characterization of bipod carbazole derivatives 两足类咔唑衍生物的合成及光学表征
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0111
B. Çiçek, Merve Çağlı, R. Tülek, A. Teke
{"title":"Synthesis and optical characterization of bipod carbazole derivatives","authors":"B. Çiçek, Merve Çağlı, R. Tülek, A. Teke","doi":"10.1515/hc-2020-0111","DOIUrl":"https://doi.org/10.1515/hc-2020-0111","url":null,"abstract":"Abstract In this study, some new biscarbazole derivatives were synthesized for the purpose of being used in OLED technologies and related areas. The following compounds: {1,2-bis(2-(3,6-diphenyl-9H-carbazole-9-yl) ethoxy)ethane (C-1), bis[2-(2-(3,6- diphenyl-9H-carbazole-9-yl) ethoxy)etyl]ether (C-2), bis[2-(2-(3,6-di(naphthalene-1-yl)-9H-carbazol-9-yl)ethoxy)etyl]ether (C-3) and bis [2-(2-(3,6-di(naphthalene-2-yl)-9H-carbazol-9-yl)ethoxy) ethyl]ether (C-4) were synthesized by Suzuki-Miyaura Cross Coupling reactions. The structural properties of the synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and LC-MS. The maximum product yields of 81.6% were obtained for C-4 biscarbazole derivatives. The optical properties were studied using UV-visible and temperature/excitation power density dependent photoluminescence (PL) techniques. The emissions were observed at green and yellow-red color spectral bands. By applying Gaussian fitting to the measured spectra, the superposition of the broad peaks was deconvoluted into two peaks. The origin of emissions was attributed to π- π* transition in aromatic compounds caused by intramolecular charge transfer from host carbazole to these compounds.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"148 - 156"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45979248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors 新型4-氧-5-氰基硫脲嘧啶类SecA抑制剂的合成及生物学评价
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0100
Fante Bamba, Jinshan Jin, P. Tai, B. Wang
{"title":"Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors","authors":"Fante Bamba, Jinshan Jin, P. Tai, B. Wang","doi":"10.1515/hc-2020-0100","DOIUrl":"https://doi.org/10.1515/hc-2020-0100","url":null,"abstract":"Abstract The continuous emergence of drug-resistant strains of bacteria poses an urgent risk to human health and dictates the need for new antimicrobials. Along this line, we have been working on developing inhibitors of SecA, a key component of the bacterial Sec-dependent secretion machinery. Herein, we describe the synthesis and antimicrobial evaluation of 6-oxo-1,6-dihydropyrimidine-5-carbonitrile derivatives as potential SecA inhibitors.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"76 - 83"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44527536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Reactivity of 1-allylsilatrane in ruthenium-catalyzed silylative coupling with olefins – mechanistic considerations 1-烯丙基硅烷川在钌催化的硅烷基化与烯烃偶联中的反应性——机理考虑
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0006
B. Sztorch, D. Fra̧ckowiak, B. Marciniec
{"title":"Reactivity of 1-allylsilatrane in ruthenium-catalyzed silylative coupling with olefins – mechanistic considerations","authors":"B. Sztorch, D. Fra̧ckowiak, B. Marciniec","doi":"10.1515/hc-2020-0006","DOIUrl":"https://doi.org/10.1515/hc-2020-0006","url":null,"abstract":"Abstract We have developed a new effective route for obtaining (E)-vinyl-substituted silatranes via ruthenium-catalyzed silylative coupling of 1-allylsilatrane with olefins. Experimental research allowed us also to propose the mechanism of the process based on stoichiometric reactions.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"33 - 36"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44958677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anticancer activity of novel Schiff bases and azo dyes derived from 3-amino-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione 由3-氨基-4-羟基- 2h -吡喃[3,2-c]喹啉-2,5(6H)-二酮衍生的新型希夫碱和偶氮染料的抗癌活性
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/HC-2020-0116
Abdeltawab M. Saeed, Shaikha S. Alneyadi, I. Abdou
{"title":"Anticancer activity of novel Schiff bases and azo dyes derived from 3-amino-4-hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione","authors":"Abdeltawab M. Saeed, Shaikha S. Alneyadi, I. Abdou","doi":"10.1515/HC-2020-0116","DOIUrl":"https://doi.org/10.1515/HC-2020-0116","url":null,"abstract":"\u0000 New Schiff bases and azo dyes derivatives have been synthesized via appropriate conventional methods using pyranoquinolinone as a starting material. The compounds obtained were characterized by spectral analysis and evaluated for anticancer activity in several human tumor cell lines: MCF-7 breast cancer, HepG2 liver cancer and HCT-116 colon carcinoma. 5-fluorouracil was used as a reference drug. The in vitro cytotoxicity screening results revealed that all tested compounds showed promising activity against MCF-7 cells. In particular, compounds 6a, 6b, and 7b showed excellent activity against the three human tumor cell lines. Structure-activity relationship studies indicated that the azo derivative with a trifluoromethoxy group (compound 7b) was the most potent candidate against the three human tumor cell lines (IC50, 1.82-8.06 μg/mL). Our findings highlight pyranoquinolinone analogues as a promising class of compounds for new anticancer therapies.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/HC-2020-0116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46326682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents 一类新型噻二唑衍生物的合成与表征
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0002
U. A. Çevik, Derya Osmaniye, Serkan Levent, B. Sağlık, B. Çavușoğlu, Y. Özkay, Zafer Asım Kaplancikl
{"title":"Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents","authors":"U. A. Çevik, Derya Osmaniye, Serkan Levent, B. Sağlık, B. Çavușoğlu, Y. Özkay, Zafer Asım Kaplancikl","doi":"10.1515/hc-2020-0002","DOIUrl":"https://doi.org/10.1515/hc-2020-0002","url":null,"abstract":"Abstract Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"6 - 13"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48087639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Design, Synthesis and Biological Evaluation of N-((2-phenyloxazol-4-yl)methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents N-((2-苯氧恶唑-4-基)甲基)嘧啶类羧胺衍生物的设计、合成及生物学评价
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/HC-2020-0117
Danling Huang, Shumin Zheng, Yong‐Xian Cheng
{"title":"Design, Synthesis and Biological Evaluation of N-((2-phenyloxazol-4-yl)methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents","authors":"Danling Huang, Shumin Zheng, Yong‐Xian Cheng","doi":"10.1515/HC-2020-0117","DOIUrl":"https://doi.org/10.1515/HC-2020-0117","url":null,"abstract":"\u0000 Twelve N-((2-phenyloxazol-4-yl)methyl) pyrimidine carboxamide derivatives were designed, synthesized, and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these new compounds against Sclerotinia sclerotiorum, Botrytis cinereal, and Colletotrichum fragariae were evaluated. The results indicated that compounds 5b, 5f, and 5g displayed potential fungicidal activities against tested fungi, especially 5f exhibited IC50 value of 28.9 mg/L against S. sclerotiorum. Moreover, the compounds 5f and 5g showed IC50 values of 54.8 mg/L and 62.2 mg/L against C. fragariae respectively, which shows that they were more active than the commercial fungicide hymexazol. The superficial structure-activity relationships were discussed, which may be of benefit for the development of fungicides and discovery of novel fungicides.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/HC-2020-0117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44404355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties 新型含醚基生物丁香豆素衍生物的合成与表征
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0009
S. Behzadi, E. Sheikhhosseini, S. A. Ahmadi, D. Ghazanfari, M. Akhgar
{"title":"Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties","authors":"S. Behzadi, E. Sheikhhosseini, S. A. Ahmadi, D. Ghazanfari, M. Akhgar","doi":"10.1515/hc-2020-0009","DOIUrl":"https://doi.org/10.1515/hc-2020-0009","url":null,"abstract":"Abstract A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"60 - 67"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45949050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Some topological indices of dendrimers determined by their Banhatti polynomials 由Banhatti多项式确定树枝状大分子的一些拓扑指数
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0102
Zheng-Qing Chu, M. Salman, Asia Munir, Imran Khalid, M. U. Rehman, Jia-bao Liu, Faisal Ali
{"title":"Some topological indices of dendrimers determined by their Banhatti polynomials","authors":"Zheng-Qing Chu, M. Salman, Asia Munir, Imran Khalid, M. U. Rehman, Jia-bao Liu, Faisal Ali","doi":"10.1515/hc-2020-0102","DOIUrl":"https://doi.org/10.1515/hc-2020-0102","url":null,"abstract":"Abstract Several properties of chemical compounds in a molecular structure can be determined with the aid of mathematical languages provided by various types of topological indices. In this paper, we consider eight dendrimer structures in the context of valency based topological indices. We define four Banhatti polynomials for general (molecular) graphs, and compute them for underline dendrimers. We use these polynomials to determine four Banhatti indices. We also determine Zagreb (first, second and hyper) and forgotten indices by developing their relationships with Banhatti indices.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"99 - 111"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45930206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Facile Synthesis of Spiro[cyclohexane-1,3’-indoline]-2,2’-diones 螺旋[环己烷-1,3 ' -吲哚]-2,2 ' -二酮的简易合成
IF 2.3 3区 化学
Heterocyclic Communications Pub Date : 2019-12-31 DOI: 10.1515/hc-2019-0022
Shin-taro Katayama, Hiroshi Nishino
{"title":"Facile Synthesis of Spiro[cyclohexane-1,3’-indoline]-2,2’-diones","authors":"Shin-taro Katayama, Hiroshi Nishino","doi":"10.1515/hc-2019-0022","DOIUrl":"https://doi.org/10.1515/hc-2019-0022","url":null,"abstract":"Abstract Spiro[cyclohexane-1,3’-indoline]-2,2’-diones were easily prepared in good to high yields by the oxidation of N-aryl-N-methyl-2-oxocyclohexane-1-carboxamides in one pot with a short reaction time. The spiroindolinediones could be important for the total synthesis of natural products.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"109 1-2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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