一类新型噻二唑衍生物的合成与表征

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2020-01-01 DOI:10.1515/hc-2020-0002

U. A. Çevik, Derya Osmaniye, Serkan Levent, B. Sağlık, B. Çavușoğlu, Y. Özkay, Zafer Asım Kaplancikl

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引用次数: 13

摘要

摘要癌症是世界上最常见的死亡原因之一。尽管抗击癌症在医疗保健系统和研究中心很重要，但正常组织的毒性和抗癌药物的低效率是化疗中的主要问题。如今，许多医学研究项目的目的是发现新的更安全、更有效的抗癌药物。1,3,4-噻二唑化合物具有广泛的生物活性，包括抗癌活性，是药物化学中的重要片段。本研究的目的是测定新合成的1，3，4-噻二唑化合物作为化疗药物的能力。利用1H-NMR、13C-NMR和质谱对所获得的化合物的结构进行了鉴定。尽管噻二唑衍生物未被证明对肿瘤组织培养物具有显著的细胞毒性，但化合物4i在测试浓度下显示出对C6大鼠脑癌症细胞系（IC50 0.097mM）的活性。

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Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

Abstract Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.