Heliyon最新文献

{"title":"Factors influencing sustainable E-participation in public service delivery: A case of rail infrastructure project.","authors":"Rajesh R Pai, Sreejith Alathur","doi":"10.1016/j.heliyon.2025.e42715","DOIUrl":"10.1016/j.heliyon.2025.e42715","url":null,"abstract":"<p><p>This research aims to analysis factors influencing sustainable e-participation in development projects. The case of a semi-high-speed rail infrastructure project in a south Indian state is examined in this paper. The analysis considers e-participation-related social media content and news items from 2017 to 2022. Results reveal development themes and campaign strategies influence long-term e-participation. The findings demonstrate that government social media initiatives significantly influence knowledge generation in development projects and thus better-informed e-participation. The growing information-seeking culture among e-participants, on the other hand, compels for knowledge resources and the readiness of the initiators to divulge suitable decisions to meet citizens' requirements. Current research is limited by its concentration on a rail project. The moderators are expected to construct campaign event plans and involve rail initiatives to enable sustainable e-participation. Unlike previous studies that focused on the delays due to e-participation, the current research portrays the improvement of public service delivery.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42715"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clay-based magnetite nano carriers for breast cancer treatment: Apoptosis induction and physicochemical properties.","authors":"Masoud Pourrahim, Leila Zolghadr","doi":"10.1016/j.heliyon.2025.e42569","DOIUrl":"10.1016/j.heliyon.2025.e42569","url":null,"abstract":"<p><p>Breast cancer was the most common cancer in women in 157 countries out of 185 in 2022. Therefore, its prognosis and treatment are the concern of many researchers. On the other hand, the synthesis of nanocomposite based on clay and its ability to be used in the field of cancer treatment and drug delivery has always been attractive and is being developed. In this study, the effect of inducing apoptosis based on synthesized magnetite clay-based for introducing a high-potential nano carrier for breast cancer was investigated. Synthesis of nano-carriers was based on three types of modified clay nano colloids) CbNC), magnetite (MNC) and clay-based magnetite nano carriers (MCbNC). The physicochemical properties of the synthesized samples were investigated by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), thermal analysis (TGA) and energy X-ray analysis (EDX). Also, flow cytometry and MTT were used to investigate the induction of apoptosis and toxicity, respectively. In this study, the physicochemical properties of the compounds after surface modification were improved compared to other studies, and the MCbNC compound showed anticancer and apoptosis-inducing properties (96 %) at a lower concentration (IC50,500 μM) than the other two compounds.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42569"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of antimicrobial resistance, biofilm formation and virulence factors of staphylococci isolated from bovine mastitis.","authors":"Juan Moreno, Leticia Diana, Melisa Martínez, Victoria Iribarnegaray, Rodrigo Puentes","doi":"10.1016/j.heliyon.2025.e42749","DOIUrl":"10.1016/j.heliyon.2025.e42749","url":null,"abstract":"<p><p>Bovine mastitis, a prevalent disease, is often attributed to staphylococci species. These microorganisms can express a diverse array of virulence genes and have the capability to form biofilms, establishing a robust defense against antimicrobials and host immune responses. In this study, we analyzed 191 <i>Staphylococcus</i> spp.<i>,</i> of which 81 % were identified as <i>Staphylococcus aureus</i>, and 19 % as non-aureus staphylococci (NAS), including species such as <i>S. borealis, S. chromogenes, S. haemolyticus, S. saprophyticus, S. capitis, S. ratti,</i> and <i>S. pasteuri</i>. Our analysis involved determining antimicrobial susceptibility profiles, assessing biofilm-forming capacities, and identifying genes associated with virulence, biofilm formation, adhesion, and antimicrobial resistance. Notably, 17.2 % of the strains exhibited resistance to penicillin, with 97 % carrying the <i>blaZ</i> gene, while 9.4 % demonstrated resistance to erythromycin. All strains were sensitive to gentamicin and cefoxitin. Additionally, resistance was observed for clindamycin (8.4 %) and tetracycline (1.0 %). Concerning biofilm development, 2.6 % displayed no formation, 24.6 % were categorized as weak producers, 47.1 % as moderate, and 25.7 % as strong formers. Our investigation also unveiled the presence of virulence genes, such as superantigens like <i>sea</i> (4.7 %), <i>seb</i> (3.7 %), sec (8.4 %), <i>sed</i> (0.5 %), and <i>tst</i> (6.8 %); Panton-Valentine leukocidin (<i>pvl</i>) (59.7 %); haemolysins <i>hla</i> (88.5 %) and <i>hlb</i> (91.1 %); genes responsible for biofilm production <i>icaA</i> (87.9 %), <i>icaD</i> (78.5 %), and <i>bap</i> (4.2 %); and adhesion genes <i>fnbpA</i> (89.5 %), <i>fnbpB</i> (20.4 %), and <i>clfA</i> (89.0 %). Additionally, the strains were categorized into four groups based on their virulence attributes, revealing differences between <i>S</i>. <i>aureus</i> and NAS, with the latter showing a lower presence of the studied genes compared to <i>S. aureus</i> strains. This research sheds light on the resistance and virulence profiles of staphylococci strains associated with bovine mastitis, providing valuable insights for potential treatment approaches.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42749"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical applications of halophilic enzymes.","authors":"Maryam Yavari-Bafghi, Mohammad Ali Amoozegar","doi":"10.1016/j.heliyon.2025.e42754","DOIUrl":"10.1016/j.heliyon.2025.e42754","url":null,"abstract":"<p><p>Halophiles produce extraordinarily stable enzymes under conditions where conventional enzymes cease to function, denature, and precipitate. Halophilic enzymes have adapted to function optimally at high salt concentrations besides tolerance of organic solvents and thermal stability. These special features offer potential advantages of cost-effectiveness and improved treatment outcomes that make them valuable for pharmaceutical purposes including the synthesis, design, and discovery of new drugs. The article highlights the unique characteristics and adaptation strategies of halophiles towards salinity. It provides an overview of halophilic enzymes' pharmaceutical applications and examines different challenges, opportunities, and recent advances in applying these enzymes in this field.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42754"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the performance of recycled aggregate concrete incorporating 3D-Printed concrete waste as aggregate using the rebound hammer test.","authors":"Girum Mindaye Mengistu, Rita Nemes","doi":"10.1016/j.heliyon.2025.e42745","DOIUrl":"10.1016/j.heliyon.2025.e42745","url":null,"abstract":"<p><p>This study investigates the strength of recycled aggregate concrete (RAC) incorporating 3D-printed concrete (3DPC) waste as recycled aggregates over a year. With the growing adoption of 3DPC, recycling its waste presents a sustainable solution to mitigate environmental impact and conserve resources. The 3DPC waste was processed into recycled aggregates through a single stage crushing method using a jaw crusher, producing a mix of fine and coarse aggregates. These recycled aggregates were blended with the river sand at 50 %, and 67 % of the total aggregate content to produce C30/37 and C40/50 strength classes. The experimental program involved performing a rebound hammer test, a nondestructive testing (NDT) method, to estimate compressive strength while considering the effects of replacement ratio, aggregate type, specimen age, and surface temperature. The results were then validated with a standard compression test, a destructive testing (DT) method, to evaluate the reliability of the NDT approach. Findings reveal that density significantly influences RAC compressive strength, with strength increasing progressively over time. Surface temperatures above 30 °C moderately reduced estimated compressive strength, causing deviations of up to 11.5 %. RAC mixes with 50 % and 67 % recycled aggregates exhibited higher compressive strength, except for the C30-RA50 mix, which deviated from this trend. An empirical formula was developed using rebound hammer and standard compression results to predict RAC strength and was compared with existing curve equations. These findings provide a robust basis for improving NDT-based strength assessments of RAC and highlight the potential of utilizing 3DPC waste in sustainable construction practices.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42745"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of miR-16 and miR-34a family in the regulation of cancers: A review.","authors":"Zahra Sadeghi, Mehrnoush Malekzadeh, Mohammadreza Sharifi, Batool Hashemibeni","doi":"10.1016/j.heliyon.2025.e42733","DOIUrl":"10.1016/j.heliyon.2025.e42733","url":null,"abstract":"<p><p>microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease. Their regulatory functions include biological processes such as improvement, differentiation, cell death, survival, and cell metabolism. The use of miR-16 and miR-34a families as biomarkers for cancer treatment is likely to improve patients with cancer. In this review, we update on recent advances in understanding the mechanism of miR-16 and miR-34 families function in cancer. Knowing about these mechanisms is effective for improving drugs and treatment methods. We also evaluated the reviewed studies and by introducing their weaknesses, we made suggestions for improving future research.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42733"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.","authors":"Woo-Jin Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Sang Kun Lee","doi":"10.1016/j.heliyon.2025.e42536","DOIUrl":"10.1016/j.heliyon.2025.e42536","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the domain-specific patterns of the association of segmental brain volume and white matter signal abnormality (WMSA) volume with longitudinal changes in cognitive function.</p><p><strong>Methods: </strong>Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder and underwent baseline and follow-up evaluations for cognitive function and brain MRI with an interval of at least 1 year were included. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K) assessment battery. Performance changes in each cognitive domain were analyzed for associations with serial data of segmental brain volume and WMSA volume.</p><p><strong>Results: </strong>A total of 190 subjects were included (115 [60.1 %] females, mean age 68.2 ± 8.2 years [range 50-82 years]). Declines in global cognition were associated with lower baseline (<i>P=</i>0.001) and decreasing volumes (<i>P=</i>0.001) of the hippocampus and amygdala and with increasing total WMSA volumes (<i>P=</i>0.008). Declines in the executive function domain were associated with lower baseline volumes of the hippocampus and amygdala (<i>P</i> = 0.018) and with increasing total WMSA volumes (<i>P=</i>0.015). Declines in the language function and the verbal learning domains were associated with lower baseline (<i>P=</i>0.009 and <i>P=</i>0.002, respectively) and decreasing volumes (<i>P=</i>0.008 and <i>P=</i>0.001, respectively) of the hippocampus and amygdala. Decline in the memory recall was associated with higher total WMSA volumes at baseline (<i>P=</i>0.014). Declines in the recognition memory domains were associated with lower baseline hippocampus and amygdala volume (<i>P</i> = 0.020) and with increases in total WMSA volumes (<i>P=</i>0.012).</p><p><strong>Conclusions: </strong>The segmental brain volume and the WMSA volume parameters have domain-specific associations with longitudinal cognitive changes, which might reflect the different dependence on the brain reserve according to the cognitive domains.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42536"},"PeriodicalIF":3.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferrocenyl Lawesson's reagent-based porous organic polymers for efficient adsorption-assisted photocatalysis degradation of organic dyes.","authors":"Shadi Asgari, Ghodsi Mohammadi Ziarani, Aylar Naderahmadian, Elaheh Rajabinejad, Ahmad Amiri, Alireza Badiei","doi":"10.1016/j.heliyon.2025.e42717","DOIUrl":"10.1016/j.heliyon.2025.e42717","url":null,"abstract":"<p><p>The adsorption process followed by photodegradation, adsorption-assisted photocatalysis, is an efficient way to achieve an enhanced overall removal of pollutants from wastewater. This aim can be achieved by a new type of metallocene-based porous organic polymers, denoted as Ferrocenyl Lawesson's reagent-metal-organic porous polymers (FcLR-MOPPs), including FcLR-P1 and FcLR-P2, synthesized through 1) synthesis of ferrocene-MOPPs (ferrocene-P1 and ferrocene-P2) through a Friedel-Crafts reaction between dimethoxymethane and ferrocene at two different ratios of 3:1 and 5:1 and 2) reaction of the ferrocene-MOPPs with phosphonium pentasulfide (P₂S₅). The photodegradation efficiencies of methylene blue (MB) and methyl orange (MO) toward FcLR-MOPPs were higher than those of the ferrocene-MOPPs. In contrast, the adsorption efficiencies of the dyes declined after the reaction of ferrocene-MOPPs with P₂S₅. In both cases, a higher photocatalytic activity and adsorption affinity were observed towards MB dye. When combined degradation/adsorption of dyes was investigated, a boosted dye elimination was observed for both the MOPP-based catalysts. FcLR-P1, as the optimal catalyst with the MB degradation/adsorption efficiency of 87.0 % ± 3.0, indicated a pseudo-first-order kinetic model for degradation of MB with a degradation rate constant of 0.074 min^-1, a pseudo-second-order kinetic model and Langmuir isotherm for adsorption of MB, and high reusing after three cycles of use. A band gap energy (E_g) value of +2.3 eV was determined for FcLR-P1 via Tauc plots, consistent with the E_g value obtained from the cyclic voltammetry curves (+1.98 eV). Mott-Schottky plots consistent with radical trapping experiments indicated ^•OH species as the critical species in the MB photodegradation.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42717"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing NADPH to restore redox homeostasis and lysosomal function in G6PD-deficient microglia.","authors":"Abir Mondal, Soumyadeep Mukherjee, Prince Upadhyay, Isha Saxena, Soumya Pati, Shailja Singh","doi":"10.1016/j.heliyon.2025.e42735","DOIUrl":"10.1016/j.heliyon.2025.e42735","url":null,"abstract":"<p><p>Microglia, the immune cells of the central nervous system (CNS), play key roles in neurogenesis, myelination, synaptic transmission, immune surveillance, and neuroinflammation. Inflammatory responses in microglia can lead to oxidative stress and neurodegeneration, contributing to diseases like Parkinson's and Alzheimer's. The enzyme glucose-6-phosphate dehydrogenase (G6PD) is essential for producing nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which neutralizes oxidative stress. G6PD deficiency has been linked to several disorders, including neurological conditions. Our study shows that G6PD deficiency in microglia reduces NADPH levels, disrupting redox balance and lysosomal function. To address this, we explored alternative metabolic pathways by targeting enzymes like isocitrate dehydrogenase 1 (IDH1) and malic enzyme 1 (ME1), both crucial for NADPH production. Supplementing metabolites such as citric and malic acid improved NADPH levels, while small molecules like dieckol and resveratrol enhanced IDH1 and ME1 expression. The combination of these approaches restored redox homeostasis and lysosomal function, offering potential therapeutic strategies for G6PD deficiency.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42735"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of FANCI suppresses hepatocellular carcinoma development via the PI3K/Akt/GSK-3β pathway.","authors":"Ziwei Yin, Minqiang Lu, Rongdang Fu","doi":"10.1016/j.heliyon.2025.e42731","DOIUrl":"10.1016/j.heliyon.2025.e42731","url":null,"abstract":"<p><strong>Background: </strong>Abnormal expression of Fanconi anaemia complementation group I (FANCI) has been implicated in carcinogenesis. However, the precise role of FANCI in the development of hepatocellular carcinoma (HCC) remains unclear.</p><p><strong>Materials & methods: </strong>We conducted a comprehensive bioinformatics analysis of FANCI's role based on HCC patient sequencing data in the TCGA and GEO databases. Then, we performed qPCR, Western blotting (WB), and immunohistochemistry (IHC) assays. SiRNA-mediated knockdown of FANCI was conducted, followed by CCK-8, EdU staining, and colony formation experiments to evaluate the impact of FANCI knockdown on HCC cell behaviour. Flow cytometry was employed to explore alterations in the cell cycle after FANCI knockdown in HCC cell lines. Furthermore, RNA sequencing was performed to investigate potential mechanisms following FANCI knockdown, and WB analysis was used to validate the corresponding pathway.</p><p><strong>Results: </strong>Our bioinformatics analysis revealed elevated expression of FANCI in HCC, which was subsequently validated through qPCR, WB, and IHC assays. High expression of FANCI was significantly associated with a poor prognosis in HCC patients. Univariate and multivariate Cox regression analyses identified FANCI as an independent prognostic risk factor for HCC patients. Additionally, the coexpressed genes of FANCI were found to be associated with multiple cancer pathways. Knockdown of FANCI expression significantly inhibited HCC cell proliferation and colony formation by inducing cell cycle arrest. Further WB analysis revealed that FANCI knockdown suppressed the expression of Cyclin D1 and p-AKT while increasing the expression of GSK-3β in HCC cells. However, no significant differences were observed in the expression levels of AKT and PI3K.</p><p><strong>Conclusion: </strong>Overall, our research provides substantial proof of FANCI's crucial function as an oncogene in HCC. It could serve as a potential prognostic marker, therapeutic target, and tumorigenic factor in HCC.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42731"},"PeriodicalIF":3.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}