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Bilateral drusenoid deposits with subretinal fluid and cystoid macular edema in a serum anti-phospholipase A2 receptor antibody positive patient: A case report.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42764
Hailiang Wu, Lanjing Liu, Li Yan, Na Zhao, Wei Yan
{"title":"Bilateral drusenoid deposits with subretinal fluid and cystoid macular edema in a serum anti-phospholipase A2 receptor antibody positive patient: A case report.","authors":"Hailiang Wu, Lanjing Liu, Li Yan, Na Zhao, Wei Yan","doi":"10.1016/j.heliyon.2025.e42764","DOIUrl":"10.1016/j.heliyon.2025.e42764","url":null,"abstract":"<p><strong>Introduction: </strong>Phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic membranous nephropathy (IMN). IMN was often reported to have retinal vascular abnormalities secondary to hypercoagculability or hypertension. We describe a case of a serum anti-PLA2R antibody positive patient with bilateral drusenoid deposits and subretinal fluid (SRF) and cystoid macular edema (CME) to stress the necessity of fundus examination in anti-PLA2R antibody positive or IMN patients.</p><p><strong>Objective: </strong>To report a case of unique fundus manifestations in a serum anti-phospholipase A2 receptor (anti-PLA2R) antibody positive patient.</p><p><strong>Design: </strong>Interventional case report.</p><p><strong>Participant: </strong>A patient diagnosed with nephrotic syndrome who was positive for serum anti-PLA2R antibody.</p><p><strong>Main symptoms and/or important clinical findings: </strong>Main symptoms: bilateral blurred vision for half a year.</p><p><strong>Important clinical findings: </strong>There were numerous large drusenoid lesions throughout the posterior pole of the patient's fundus symmetrically. These lesions were more obvious on autofluorescence (AF) and near-infrared reflectance imaging (NIR) with a \"starry-sky' pattern. They presented hyper-reflective deposits beneath the retinal pigment epithelium on optical coherence tomography (OCT). The lesions showed hypofluorescent through all phases on FA and ICGA. Several pinpoint areas of hyperfluorescence gradually expanded in an \"inkblot leak\" fashion bilaterally on FA.</p><p><strong>Main diagnoses: </strong>Bilateral drusenoid deposits and subretinal fluid (SRF) and cystoid macular edema (CME).</p><p><strong>Intervention: </strong>The patient was examined with ultrawide-field imaging, autofluorescence (AF), near-infrared reflectance imaging (NIR), optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), fluorescein angiography (FA) and indocyanine green angiography (ICGA). The patient received medical treatment including ultrafiltration, anticoagulation and intravenous Obinutuzumab.</p><p><strong>Results: </strong>5 days after medical treatment, the patient perceived improvement in vision with the best corrected visual acuity (BCVA) improved from 4/20 OD and 5/20 OS to 8/20 OU. Follow-up OCT showed absorption of CME and SRF, while the drusenoid lesions persisted.</p><p><strong>Conclusions: </strong>This is the first report of bilateral drusenoid deposits and subretinal fluid (SRF) and cystoid macular edema (CME) in a serum anti-PLA2R antibody positive patient and probably the first report in an idiopathic membranous nephropathy (IMN) patient. The importance of ophthalmological assessment in identifying ocular complications in serum anti-PLA2R antibody positive or IMN patients should be emphasized.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42764"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the Chinese capital culture perception based on Weibo big data.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42758
Zihang Qin, Dan He, Qimeng Li, Bin Meng, Jing Zhou, Siyu Chen, Zixuan Chen, Jing Chen
{"title":"Research on the Chinese capital culture perception based on Weibo big data.","authors":"Zihang Qin, Dan He, Qimeng Li, Bin Meng, Jing Zhou, Siyu Chen, Zixuan Chen, Jing Chen","doi":"10.1016/j.heliyon.2025.e42758","DOIUrl":"10.1016/j.heliyon.2025.e42758","url":null,"abstract":"<p><p>Ancient capital culture, red culture, Beijing-style culture, and innovation culture together constitute the capital's cultural system of China and support Beijing's position as the Chinese cultural center. In order to better help the cultural construction of the capital, Beijing, and to find some common and reasonable ways to reconcile the complex urban cultural system, this paper is based on the Weibo data of Beijing in 2019, takes the BERT pre-training model and the newer topic model \"BERTopic\" as the tools, combines the text content, spatial layout, and sentiment analysis methods, and explores the public perception of four types of capital culture in Beijing. The results reveal that: (1) Although the perception level of Dongcheng, Xicheng, Haidian and Chaoyang core areas is much higher than that of remote areas, the sentiment feedback of remote areas is better than that of the former; (2) A type of culture actively introduces other cultural types or even foreign cultural elements in the system, which helps it form a unique cultural attraction. The typical cases are Shichahai Bar Street, the perception place of Beijing culture, and the corner cafe in the Imperial Palace, which is the perception place of ancient capital culture. (3) Traditional and popular elements are not independent and incompatible in the cultural system. In the capital culture construction, combining pop song art forms in innovation culture and classic stories of ancient capital culture, red culture, and Beijing-style culture is a road worth exploring and practicing in the future.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42758"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42768
Anita Borsati, Christian Ciurnelli, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Linda Toniolo, Ilaria Trestini, Daniela Tregnago, Michele Milella, Federico Schena, Sara Pilotto, Alice Avancini
{"title":"Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report.","authors":"Anita Borsati, Christian Ciurnelli, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Linda Toniolo, Ilaria Trestini, Daniela Tregnago, Michele Milella, Federico Schena, Sara Pilotto, Alice Avancini","doi":"10.1016/j.heliyon.2025.e42768","DOIUrl":"10.1016/j.heliyon.2025.e42768","url":null,"abstract":"<p><p>A 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consisted of aerobic and strength training. Aerobic training was composed of moderate-intensity continuous training for the first 3 months and then high-intensity interval training. Strength training was performed through body-weight/elastic band exercises for the first 6 months and isotonic machines from months 6-9. Assessments, performed every 3 months, included physical fitness parameters, such as functional capacity, muscle strength, anthropometric measures, body composition, and quality of life. Functional capacity progressively improved by 80 m at month 6 and slightly decreased by 22 m at month 9. At the end of the intervention, grip strength increased in both arms, whereas the body composition showed a progressive decrease in fat mass (-3.39 kg) and an increase in muscle mass (+3.89 kg) until month 6 and then stabilization. Quality of life exhibits a great improvement in the first 3 months, especially in the physical role, emotional functioning, fatigue, pain, dyspnoea, insomnia, appetite loss, constipation, and diarrhea, and then maintained with little variations. This case suggests that a highly structured physical exercise program may be feasible, safe, and effective in patients with lung cancer and bone metastases if performed under the supervision of trained experts.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42768"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and poly-fluoroalkyl substances as forever chemicals in drinking water: Unraveling the nexus with obesity and endocrine disruption - A mini review.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42782
Hoda Pezeshki, Saeed Rajabi, Majid Hashemi, Saeideh Moradalizadeh, Habibeh Nasab
{"title":"Per- and poly-fluoroalkyl substances as forever chemicals in drinking water: Unraveling the nexus with obesity and endocrine disruption - A mini review.","authors":"Hoda Pezeshki, Saeed Rajabi, Majid Hashemi, Saeideh Moradalizadeh, Habibeh Nasab","doi":"10.1016/j.heliyon.2025.e42782","DOIUrl":"10.1016/j.heliyon.2025.e42782","url":null,"abstract":"<p><p>Per- and Poly-fluoroalkyl substances (PFASs) are among the substances that have been widely employed across the world due to their distinct features. These chemicals' great stability in the environment and capacity to be released from consumer goods have demonstrated their existence in all matrices. Additionally, the world's attention has been drawn to these substances' direct relation to human health in recent years. This research aimed to unravel the nexus of PFASs with obesity and endocrine disruption as a comprehensive review. Studies have shown that drinking water is the primary way in which humans are exposed to PFASs. As a result, it has become difficult to determine how drinking water is contaminated with these compounds and how their impacts affect human health. Through various routes, disruption of metabolic processes, and possible effects on the hypothalamus-pituitary-thyroid axis, these chemicals increase the incidence of obesity, particularly during crucial growth phases. Another negative health impact of PFASs is the disruption of the endocrine glands' function, which is crucial for controlling the body's physiological functions. This leads to alterations in hormone production. The effects of exposure to these substances include secondary hyperparathyroidism, non-alcoholic fatty liver, diabetes, cardiovascular illnesses, reproductive abnormalities, and infertility. Because of their characteristics, including the propensity to propagate through the food chain, accumulate and biomagnify, and ultimately pose a threat to human life, it is crucial to replace and remove these chemicals.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42782"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rural multidimensional poverty and livelihood mix: A micro level study in Bihar, India.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42772
Ogbonna Amarachi Onyeyirichi, M G Deepika
{"title":"Rural multidimensional poverty and livelihood mix: A micro level study in Bihar, India.","authors":"Ogbonna Amarachi Onyeyirichi, M G Deepika","doi":"10.1016/j.heliyon.2025.e42772","DOIUrl":"10.1016/j.heliyon.2025.e42772","url":null,"abstract":"<p><p>Understanding the livelihood dynamics of rural households is crucial for formulating rural, pro-poor policies. Quite a few studies in the past have explored the impact of several aspects of livelihoods on rural poverty using unidimensional or multidimensional poverty measures, which fail to capture the nuances of rural poverty sufficiently. Identifying the gap in the literature, we explore the dynamics of rural poverty in relation to access to livelihood capitals and livelihood diversification of the rural households in India. We measure the rural poverty using the Rural multidimensional poverty index (RMPI) developed by FAO and OPHI (Oxford Poverty and Human Development Initiative) in 2022, access to livelihood capitals using the Alkire-Foster method and livelihood diversification using the Simpson's Diversification Index (SDI). We examine whether livelihood diversification mediates the relationship between access to livelihood capitals and rural multidimensional poverty, as suggested by the Sustainable Livelihood Framework. Our results show that there is low livelihood diversification and lack of access to livelihood capitals in our study area. We also find that livelihood diversification does not mediate the relationship between access to livelihood capitals and rural multidimensional poverty, but access to livelihood capitals is instrumental for poverty reduction in rural communities.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42772"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ergonomic risk assessment in construction: Case study Ecuador.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42751
Oswaldo Tandazo, Victoria Jaramillo-Carrión, Eduardo Valarezo, Mercedes Sanchís-Almenara, Laura Montalbán-Domingo, Joaquín Catalá-Alís
{"title":"Ergonomic risk assessment in construction: Case study Ecuador.","authors":"Oswaldo Tandazo, Victoria Jaramillo-Carrión, Eduardo Valarezo, Mercedes Sanchís-Almenara, Laura Montalbán-Domingo, Joaquín Catalá-Alís","doi":"10.1016/j.heliyon.2025.e42751","DOIUrl":"10.1016/j.heliyon.2025.e42751","url":null,"abstract":"<p><p>Ergonomic risks are a global problem in construction, with health effects that have an impact on the economy. Risk assessment allows companies to identify the risks and the exposure levels to which the workers are subjected and allows to define management plans to address them. However, studies to assess risk levels through new techniques are very scarce in construction. This study aims to evaluate ergonomic risks in construction workers using Ergo/IBV (software for the assessment of ergonomic risks and design recommendations) by the observational REBA (Rapid Entire Body Assessment) method. Data were collected from 14 public sector building projects from May to November 2023. Thirty-two construction finishing activities were identified. Through the stratified method, the five most frequently executed activities were selected: interior and exterior painting, floor ceramics, wall plastering, ceiling and wall plastering. This made it possible to evaluate the ergonomic risk in 94 workers. The evaluation shows that 40 % of the workers were exposed to a high-risk level in the trunk, 2 % in the legs, 20 % in the right arm, and 22 % in the left arm. In short, the five activities adopt forced postures, with REBA scores: medium, high and very high, with high risk level being the most relevant.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42751"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Domain decomposition and mortar mixed approach for nonlinear elliptic equations modeling flow in porous media. 多孔介质流动模型非线性椭圆方程的域分解和砂浆混合方法。
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42724
Muhammad Arshad, Adil Mehmood, Zabidin Salleh, Sumaira Saleem Akhtar, Suliman Khan, Mustafa Inc
{"title":"Domain decomposition and mortar mixed approach for nonlinear elliptic equations modeling flow in porous media.","authors":"Muhammad Arshad, Adil Mehmood, Zabidin Salleh, Sumaira Saleem Akhtar, Suliman Khan, Mustafa Inc","doi":"10.1016/j.heliyon.2025.e42724","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42724","url":null,"abstract":"<p><p>The equations describe the behavior of steady state flow in porous medium generally results in elliptic partial differential equations with coefficient represents the permeability of the medium. This article presents the extension of mortar mixed method for second order nonlinear elliptic equations that describes flow in porous media. The domain is decomposed into non-overlapping regions with each partitioned independently. The grids on subdomains are allowed to be non-matching across the subdomains internal boundaries. The fixed point argument (FPA) is employed to establish the existence and uniqueness of discrete problem, and optimal order error estimates are provided for approximations. The computational results are given to validate the theory.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42724"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D DC geoelectric resistivity modeling with the singularity removal technique using finite element method based on orthosceme element.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42759
Supriyadi, I G P F Soerya Djaja, Elfitra Desifatma, Harry Mahardika, Wahyu Srigutomo
{"title":"3D DC geoelectric resistivity modeling with the singularity removal technique using finite element method based on orthosceme element.","authors":"Supriyadi, I G P F Soerya Djaja, Elfitra Desifatma, Harry Mahardika, Wahyu Srigutomo","doi":"10.1016/j.heliyon.2025.e42759","DOIUrl":"https://doi.org/10.1016/j.heliyon.2025.e42759","url":null,"abstract":"<p><p>As a commonly used method for near-surface surveys, there is a demand for lightweight, fast, and accurate 3D DC geoelectric resistivity modeling that can be execute on portable computers. This study employed a singularity removal technique, solving the primary potential equation analytically and the secondary potential equation numerically using the finite element method. The modeling domain was discretized using orthosceme elements derived from dividing a hexahedron into six elements. The modeling domain (area of interest [AOI] + padding) covered [-300, 300] m × [-250, 250] m × [0, 250] m, divided into 59 × 39 × 20 nodes. The global matrix equation of the secondary potential is solved using the preconditioned conjugate gradients (PCG) with incomplete Cholesky factorization (ICF) as a preconditioner, making it 6.7 times faster than the direct solver. The combination of the singularity removal, orthosceme discretization, and the PCG solver enabled lightweight, fast, and accurate 3D resistivity modeling on a portable computer. Benchmarking this modeling against a layered Earth model showed that the Wenner and Schlumberger arrays achieved apparent resistivity with a relative error of mostly <5 %. Applying this modeling to the vertical contact and buried block 3D anomaly Earth models demonstrated that the apparent resistivity profiles from Wenner, Schlumberger, and dipole-dipole arrays effectively captured resistivity changes at the anomaly boundaries, aligning with previous studies.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42759"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophages in Bacteroides fragilis: Distribution and genetic diversity. 脆弱拟杆菌中的噬菌体:分布和遗传多样性。
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42755
Paolo Gaibani, Rocco Latorre
{"title":"Prophages in <i>Bacteroides fragilis</i>: Distribution and genetic diversity.","authors":"Paolo Gaibani, Rocco Latorre","doi":"10.1016/j.heliyon.2025.e42755","DOIUrl":"10.1016/j.heliyon.2025.e42755","url":null,"abstract":"<p><strong>Objectives: </strong>We evaluated the distribution, epidemiology, and relationships of prophage regions among 500 <i>Bacteroides fragilis</i> group genomes.</p><p><strong>Methods: </strong>Average nucleotide identity (ANI) analysis was carried out to characterize the genome at the species level and phylogenetic analysis was performed to identify the genomic relationship among <i>B. fragilis</i> genomes<i>.</i> Prophages in B. fragilis genomes were performed with PHASTEST and pairwise comparison of prophage regions was performed by using Jspecies.</p><p><strong>Results: </strong>Prophages were found in 67.6 % (338/500) of <i>B. fragilis</i> genomes with a degree of nucleotide identity >80 % in 54.2 % of these regions. Comparison in the total number of prophages demonstrated that strains belonging to division I showed a higher number of these regions than strains of division II (<i>p</i> < 0.01). Characterization of prophage sequences revealed that strains belonging to division I exhibited a lower conservation degree (<i>i.e.</i> nucleotide identity ≥90 %) of the nucleotide regions than strains belonging to division II (71.88 % vs 90.0 %; <i>p</i> < 0.0001) and strains harbouring toxin-gene showed a lower conservation degree (<i>i.e.</i> nucleotide identity ≥70 %) than toxin-negative strains (70.0 % vs 95.4 %; <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>We demonstrated a wide distribution and high conservation degree of the prophages among <i>B. fragilis</i> genomes. Diversity observed within prophages could reflect the major adaptability of pathogenic strains and that low pressure exerted in the gut of healthy individuals could be related to the high conservation degree of prophage regions in human commensal strains.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42755"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological equivalent temperature and hospitalized due to respiratory and cardiovascular diseases in Dezful, Iran.
IF 3.4 3区 综合性期刊
Heliyon Pub Date : 2025-02-18 eCollection Date: 2025-02-28 DOI: 10.1016/j.heliyon.2025.e42763
Hamidreza Aghababaeian, Rahim Sharafkhani, Maryam Mazaheri, Masoumeh Gharaee, Mohsen Nouri, Nasim Hamidipour
{"title":"Physiological equivalent temperature and hospitalized due to respiratory and cardiovascular diseases in Dezful, Iran.","authors":"Hamidreza Aghababaeian, Rahim Sharafkhani, Maryam Mazaheri, Masoumeh Gharaee, Mohsen Nouri, Nasim Hamidipour","doi":"10.1016/j.heliyon.2025.e42763","DOIUrl":"10.1016/j.heliyon.2025.e42763","url":null,"abstract":"<p><strong>Background: </strong>The Physiological Equivalent Temperature (PET) index providing a standardized reference point, PET enables non-experts to better understand and assess the physiological implications of varying environmental temperatures and thermal comfort levels across different settings. We aimed to evaluate the relationships between the PET Index and Hospitalized due to Respiratory Diseases (RD) and Cardiovascular Diseases (CVD) in Dezful city.</p><p><strong>Method: </strong>Hospital admissions, climate variables and environmental pollution data (PM<sub>2.5</sub>, PM<sub>10</sub>) of Dezful city were collected from 2014 to 2019. The relationships were assessed using Distributed Lag Non-linear Models (DLNM) in conjunction with quasi-Poisson regression methods. The effect of Confounding variables was adjusted.</p><p><strong>Result: </strong>In high PET, the risk of respiratory diseases has been significantly reduced (Lag <sub>0-7</sub> and Lag <sub>0-14</sub>). Additionally, in the group of females and individuals <65 years old admitted to the hospital, the risk of respiratory admissions, as well as the risk of cardiovascular admissions among females, has also been significantly reduced. Additionally, in low PET, the risk of cardiovascular disease hospitalization (especially in male) increased significantly (Lag<sub>0-14</sub>).</p><p><strong>Discussion: </strong>It seems that in Dezful, low levels of PET increase the risk of hospitalization for cardiovascular patients, while due to certain factors, including the potential adaptive effect of the people of Dezful to heat on health, high levels of PET reduce the risk of hospitalization for all respiratory diseases and the risk of cardiovascular hospitalization in women.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42763"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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