Heart rhythm最新文献

{"title":"A dedicated radiofrequency microcatheter assembly for trans-right atrial appendage pericardial carbon dioxide insufflation to facilitate epicardial access.","authors":"Ioan Liuba, Arwa Younis, Paresh Vasandani, Jakub Sroubek, Koji Higuchi, Justin Lee, Walid Saliba, Alison Krywanczyk, Shady Nakhla, Mandeep Bhargava, Ayman Hussein, Mohamed Kanj, Samir Kapadia, Oussama Wazni, Pasquale Santangeli","doi":"10.1016/j.hrthm.2025.03.1977","DOIUrl":"10.1016/j.hrthm.2025.03.1977","url":null,"abstract":"<p><strong>Background: </strong>Trans-right atrial appendage (RAA) pericardial insufflation of carbon dioxide can improve safety of percutaneous epicardial access. Dedicated device solutions for safe, effective, and standardized microperforation are needed.</p><p><strong>Objective: </strong>We evaluated the efficacy and safety of a novel radiofrequency (RF)-powered microcatheter specifically designed to facilitate trans-RAA exit to the pericardial space.</p><p><strong>Methods: </strong>Four healthy swine underwent repeated RAA and left atrial appendage (LAA) perforations to access the pericardial space by a dedicated 1.8F microcatheter with an RF tip. Perforations were obtained by delivering short bursts of RF energy (20-25 W, <1 second, \"cut\" mode). Animals were sacrificed immediately after the experiment, and the hearts were assessed by gross pathologic and histologic examination.</p><p><strong>Results: </strong>A median number of 7 microperforations/animal (interquartile range, 7-9) were performed in the RAA and 3/animal (interquartile range, 2-3) in the LAA. In 1 animal, a posterolateral right atrial perforation was also performed. All perforations and microcatheter advancements in the pericardial space were successful (<5 seconds). There was no evidence of pericardial effusion by intracardiac echocardiography and no hemodynamic changes with any of the perforations. On pathologic examination, no pericardial effusion was noted, and the atrial perforations could be identified as punctate red areas (0.5-1 mm) in 28 of 31 targeted RAA sites and 5 of 8 targeted LAA sites. Histologic evaluation showed central full-thickness defects with associated acute thrombus formation and surrounded by a small rim of contraction band necrosis.</p><p><strong>Conclusion: </strong>In this preclinical study, repeated trans-RAA/LAA perforations with pericardial space access were successfully obtained with a dedicated RF-tip 1.8F microcatheter with no evidence of significant pericardial bleeding.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Left Atrial Thrombus in Patients with Atrial Flutter in Comparison to Atrial Fibrillation.","authors":"Maciej T Wybraniec, Fabian Wesołek, Przemysław Szyszka, Małgorzata Cichoń, Michał Orszulak, Magdalena Mizia-Szubryt, Michał Wita, Monika Gawałko, Monika Budnik, Beata Uziębło-Życzkowska, Paweł Krzesiński, Katarzyna Starzyk, Beata Wożakowska-Kapłon, Ludmiła Daniłowicz-Szymanowicz, Damian Kaufmann, Maciej Wójcik, Robert Błaszczyk, Jarosław Hiczkiewicz, Jan Budzianowski, Katarzyna Łojewska, Katarzyna Kosmalska, Marcin Fijałkowski, Anna Szymańska, Anna Wiktorska, Maciej Haberka, Michał Kucio, Błażej Michalski, Karolina Kupczyńska, Anna Tomaszuk-Kazberuk, Katarzyna Wilk-Śledziewska, Renata Wachnicka-Truty, Marek Koziński, Paweł Burchardt, Katarzyna Mizia-Stec, Agnieszka Kapłon-Cieślicka","doi":"10.1016/j.hrthm.2025.03.1980","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1980","url":null,"abstract":"<p><strong>Background: </strong>Atrial flutter (AFL) and atrial fibrillation (AF) are believed to carry the same risk of systemic thromboembolism however there is paucity of data concerning such risk in patients with AFL in comparison to AF.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the prevalence of left atrial thrombus (LAT) on transesophageal echocardiography (TEE) in patients with AFL in comparison to AF depending on anticoagulation status.</p><p><strong>Methods: </strong>The study is the sub-analysis of a multicenter, prospective Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) registry, which enrolled AF and AFL patients referred for ablation or electrical cardioversion regardless of oral anticoagulation (OAC) use. All patients underwent pre-procedural TEE to assess the primary endpoint of the LAT presence.</p><p><strong>Results: </strong>A total of 3109 patients (AF n=2577; AFL n=532) were included in the study. Therapeutic OAC, defined as anticoagulation lasting at least three weeks, was used by 89.8% of patients in the AF subgroup and 82.5% in the AFL subgroup (p<0.001). LAT was present in 8.3% of patients with AF and 6.8% with AFL, regardless of therapeutic OAC use (p=0.235). In patients on therapeutic OAC, LAT was present in 7.6% in AF group and 5.7% in AFL subgroup (p=0.167), while in patients without therapeutic OAC in 14.9% in AF subgroup and 11.8% in AFL subgroup (p=0.459).</p><p><strong>Conclusion: </strong>The risk of thrombus formation in AFL seems to be similar to AF, supporting similar recommendations concerning OAC use.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvenous extraction of quadripolar coronary sinus pacing leads.","authors":"Ethan S Wagner, Robert K Lewis, Sean D Pokorney, Donald D Hegland, Jonathan P Piccini","doi":"10.1016/j.hrthm.2025.03.1979","DOIUrl":"10.1016/j.hrthm.2025.03.1979","url":null,"abstract":"<p><strong>Background: </strong>Quadripolar coronary sinus (CS) leads are commonly employed to achieve left ventricular pacing. There are limited data on extraction of these leads relative to traditional unipolar or bipolar CS pacing leads.</p><p><strong>Objective: </strong>The purpose of this study was to examine the safety and efficacy of quadripolar CS lead extraction and CS lead reimplantation and to compare outcomes with extraction of non-quadripolar CS leads.</p><p><strong>Methods: </strong>Patients who underwent extraction of CS leads between 2013 and 2024 were included. Outcomes of interest were rates of complete CS lead removal, complete procedural success, major adverse events, and successful reimplantation in the CS.</p><p><strong>Results: </strong>A total of 182 patients were included (102 quadripolar leads and 80 non-quadripolar leads). The mean age of the patients was 68.0 ± 11.6 years, and 22% were female. The mean CS lead age was significantly lower in the quadripolar group (3.0 ± 2.7 years vs 8.2 ± 4.3 years; P < .001). The complete procedural success rate was significantly higher in the quadripolar group (99% vs 90%; P = .01); there was no difference between groups after accounting for lead age. There was no significant difference in complete CS lead removal rates between groups (99% vs 95%; P = .17). Two major adverse events occurred in the non-quadripolar group and were directly related to lead extraction. In the quadripolar group, manual traction alone was successful in 59%, laser sheaths were used in 39%, and rotational cutting tools were used in 9%. In the non-quadripolar group, manual traction alone was successful in 19%, laser sheaths were used in 79%, and rotational cutting tools were used in 26%. There was no significant difference in reimplantation success rates between groups (82% vs 90%; P = .30).</p><p><strong>Conclusion: </strong>Quadripolar CS lead extraction had a high success rate and low rate of major adverse events. Reimplantation in the CS was possible with a good success rate but was often limited by CS branch stenosis or occlusion.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse right coronary artery spasm occurring 45 minutes after pulsed field ablation for atrial fibrillation.","authors":"Vishal Luther, Justin Chiong, Catherine James, Simon Modi, Dhiraj Gupta, John Hung","doi":"10.1016/j.hrthm.2025.03.1978","DOIUrl":"10.1016/j.hrthm.2025.03.1978","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of septal vascular injury and perforation in left bundle branch area pacing: Evaluating septal integrity using an institutional protocol.","authors":"Emine Özpak, Tijs Tournoy, Thomas Van Overmeiren, Frederic Van Heuverswyn, Frank Timmermans, Jan De Pooter","doi":"10.1016/j.hrthm.2025.03.1982","DOIUrl":"10.1016/j.hrthm.2025.03.1982","url":null,"abstract":"<p><strong>Background: </strong>Left bundle branch area pacing (LBBAP) involves deep septal lead deployment to capture the left bundle branch or adjacent myocardium, which could compromise the septum's structural integrity or pose injury to the septal vasculature. The potential long-term effects of these complications remain unclear.</p><p><strong>Objective: </strong>This study aimed to evaluate acute and long-term outcomes of septal injury during LBBAP using a structured institutional protocol.</p><p><strong>Methods: </strong>Adult patients receiving LBBAP between March 2019 and October 2024 were assessed for septal complications, including septal perforation, septal venous channel perforation (SVCP), septal coronary artery fistula (SCAF), and septal hematomas. The protocol included intraprocedural septography and postprocedural echocardiography, including visual assessment and strain imaging, to assess global and septal kinetics.</p><p><strong>Results: </strong>Of 636 patients, 32 (5%) experienced septal complications: 26 septal perforations (4%), 3 SVCPs (0.5%), and 3 SCAFs (0.5%). All perforations and SVCPs were identified during implantation, whereas SCAFs were diagnosed postprocedurally. All complications were asymptomatic with no adverse clinical outcomes. Septal kinetics remained unaffected as peak septal strain values showed no significant differences before and after implantation (from 20.4% ± 3.6% to 21.3% ± 3.3%; P = .16). No late perforations or ventricular septal defects were observed. Two SCAFs healed spontaneously, and 1 persisted asymptomatically. Key pacing characteristics and left ventricular ejection fraction remained stable throughout follow-up.</p><p><strong>Conclusion: </strong>Septal perforations are the most frequent septal complication and are easily detected. Septal vascular injuries can be detected by dedicated protocols but occur rarely. None of these complications compromised septal integrity or function.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and anticoagulant management for new-onset atrial fibrillation in patients with ST-elevation myocardial infarction following primary percutaneous coronary intervention: Findings from a national multicenter registry and meta-analysis.","authors":"Can Zhou, Minghui Zhang, Zixu Zhao, Enze Li, Yichen Zhao, Hong Wang, Wei Luo, Keyang Zheng, Yu Liu, Chengqian Yin, Xinyong Zhang, Hai Gao, Xiaotong Hou, Dong Zhao, Changsheng Ma","doi":"10.1016/j.hrthm.2025.02.036","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.02.036","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the risk factors and prognosis of new-onset atrial fibrillation (NOAF) in patients with primary percutaneous coronary intervention (PCI).</p><p><strong>Objective: </strong>The purpose of this study was to assess the prevalence and prognosis of NOAF after PCI and the effects of anticoagulation on clinical outcomes.</p><p><strong>Method: </strong>Using data from the CCC-ACS (Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome) project, ST-elevation myocardial infarction (STEMI) patients undergoing PCI were stratified into 2 groups: with NOAF or without any atrial fibrillation. Multivariable logistic regression was used to identify NOAF predictors, and propensity-score matching estimated associations between NOAF and in-hospital outcomes. A meta-analysis was also performed by pooling our results with literature data.</p><p><strong>Results: </strong>Of 19,288 STEMI patients undergoing PCI, 1.3% (n = 253) experienced NOAF. Independent risk factors were age ≥65 years, history of hypertension, stroke, heart failure, Killip class IV, and right coronary artery as the culprit artery. NOAF was associated with a higher risk of all-cause mortality (hazard ratio [HR] 2.26, 95% confidence interval [CI] 1.08-4.71), heart failure (HR 4.29, 95% CI 2.81-6.55), cardiogenic shock (HR 4.30, 95% CI 2.28-8.13), in-stent thrombosis (HR 6.04, 95% CI 1.71-21.45), and major bleeding (HR 2.86, 95% CI 1.44-5.66) during hospitalization. Meta-analysis found that NOAF had a higher risk of in-hospital stroke (odds ratio 3.33, 95% CI 1.73-6.43). In-hospital use of anticoagulants was associated with lower rates of all-cause mortality but similar rates of major bleeding in NOAF patients.</p><p><strong>Conclusion: </strong>Our study suggests NOAF following PCI is uncommon but associated with poor in-hospital prognosis. Findings support the use of anticoagulants in these patients during hospitalization.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Impact of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery in Sinus Rhythm Patients: A Meta-Analysis.","authors":"Samuel Burton, Rayyan Ahmed, Nicola King, Alexander Reynolds, Amit Modi, Sanjay Asopa","doi":"10.1016/j.hrthm.2025.03.1975","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1975","url":null,"abstract":"<p><strong>Background: </strong>The clinical efficacy of surgical occlusion of the left atrial appendage in sinus rhythm patients receiving cardiac surgery remains controversial.</p><p><strong>Objective: </strong>This meta-analysis attempts to demonstrate the impact of left atrial appendage occlusion (LAAO) on early and late outcomes in patients with sinus rhythm undergoing cardiac surgery.</p><p><strong>Methods: </strong>Screened and selected studies were sourced from PubMed, Embase, and Web of Science databases, following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Early clinical outcomes were pooled by odds ratio, and long-term outcomes were extracted from Kaplan-Meier curves to reconstruct individual time-to-event patient data and allow for proportional hazard regression. Bias-treated data was selected when available.</p><p><strong>Results: </strong>Six studies, comprising 2742 patients, were included from an initial 1431 reports. Pooling demonstrated no significant association between LAAO and the development of postoperative atrial fibrillation (odds ratio (OR) 1.157, 95% confidence interval (CI) 0.904-1.481, I² = 46%, p = 0.246). Reconstruction of Kaplan Meier data revealed a higher freedom from cerebrovascular events in the LAAO group than in no-LAAO (hazards ratio (HR) 0.482, 95%CI 0.361-0.643, p <0.001). The LAAO study group also demonstrated improved mid-term survival (HR 0.701, 95%CI 0.554-0.886, p=0.003).</p><p><strong>Conclusions: </strong>Analysis of patients in sinus rhythm undergoing cardiac surgery and receiving surgical LAAO has demonstrated improved freedom from cerebrovascular events and a mid-term survival benefit. This meta-analysis did not demonstrate an increased occurrence of postoperative atrial fibrillation in the LAAO study group. Larger randomised controlled trials stratified by cardiac pathology are required to validate these findings.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Atrial Reverse Remodeling After Pulmonary Vein Isolation: Analyzing Changes in Volume and Function Using Cardiac Magnetic Resonance Imaging.","authors":"Nikki van Pouderoijen, Luuk H G A Hopman, Leontine E Wentrup, Joris R de Groot, Michiel J B Kemme, Cornelis P Allaart, Marco J W Götte","doi":"10.1016/j.hrthm.2025.03.1976","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1976","url":null,"abstract":"<p><strong>Background: </strong>Successful pulmonary vein isolation (PVI) promotes left atrial (LA) reverse remodeling, but its effect on right atrial (RA) remodeling remains unclear.</p><p><strong>Objective: </strong>To study the impact of radiofrequency (RF) PVI on RA volumes and function in atrial fibrillation (AF) patients, assessed by cardiac MRI (CMR).</p><p><strong>Methods: </strong>Forty-three AF patients (74.4% male, 61±7 years) undergoing first RF PVI, without atrial flutter ablation, underwent three CMR scans: pre-PVI, early (<72 hours), and 3 months post-PVI. Indexed atrial volumes (RAVImin/max, LAVImin/max) and function were derived from two- and four chamber cine images, with longitudinal atrial strain analyzed using feature tracking.</p><p><strong>Results: </strong>Early post-PVI, RAVImin significantly decreased (28.7±10.3mL/m² to 26.0±9.9mL/m²,p=0.03), while RA EF significantly increased (37.3±11.5% to 41.7±10.1%,p=0.03). At 3 months, both RAVImin and RAVImax showed significant further reductions compared to baseline (28.7±10.3mL/m² to 24.8±8.8mL/m²,p=0.002; 45.2±11.8mL/m² to 40.3±11.9mL/m²,p<0.001, respectively). During this period, RA functional improvement persisted, as evidenced by RA reservoir and contractile strain (16.2±4.1% to 18.9±3.6%,p=0.003; 6.6±2.6% to 8.3±2.8%,p=0.005, respectively). LA volumes remained unchanged early post-PVI, but at 3 months, LAVImax significantly decreased compared to baseline (46.1±13.0mL/m² to 39.1±11.3mL/m²,p<0.001). LA function, demonstrated by reservoir and contractile strain, was significantly diminished early post-PVI, which persisted at 3 months compared with baseline (18.6±4.0% to 17.0±3.4%,p=0.04; 8.5±3.0% to 6.9±2.4%,p<0.01, respectively).</p><p><strong>Conclusion: </strong>This study demonstrates that RF PVI results in reverse bi-atrial remodeling, with significant reductions observed in RA and LA volumes. RA function showed a significant improvement post-PVI, while LA function demonstrated a persistent impaired function at 3 months, possibly due to LA ablation scarring.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference of genetic risk in the prevalence of atrial fibrillation.","authors":"Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa","doi":"10.1016/j.hrthm.2025.03.1974","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.03.1974","url":null,"abstract":"<p><strong>Background: </strong>Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied.</p><p><strong>Objective: </strong>To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan.</p><p><strong>Methods: </strong>Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated.</p><p><strong>Results: </strong>Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733).</p><p><strong>Conclusion: </strong>Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-onset atrial fibrillation in acute coronary syndrome: To anticoagulate or not?","authors":"Hani Essa, Joel P Giblett, Gregory Y H Lip","doi":"10.1016/j.hrthm.2025.02.047","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.02.047","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}