Heart rhythm最新文献

{"title":"Feasibility of Unipolar Signal Guided Ablation in Creating Contiguous Lines of Conduction Block: A Proof-of-Concept Study.","authors":"Hagai D Yavin, Arwa Younis, Arsalan Derakhshan, Zachary Koch, Alison Krywanczyk, Hayley Bryce, Alexander Sean Esposito, Liad Naveh, Mohamed Kanj, Jakub Sroubek, Oussama Wazni, Pasquale Santangeli, Christine Tanaka-Esposito","doi":"10.1016/j.hrthm.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.010","url":null,"abstract":"<p><strong>Background: </strong>Modification of the atrial unipolar electrogram (Uni-<sub>EGM</sub>) with loss of the near-field negative component in response to radiofrequency ablation reflects transmural loss of tissue conductivity.</p><p><strong>Objective: </strong>The present study sought to investigate feasibility of Uni-<sub>EGM</sub> morphology guided radiofrequency ablation (RFA) in generating contiguous, transmural lesions that result in conduction block. This method was compared with ablation guided by standard Ablation Index parameters.</p><p><strong>Methods: </strong>In a beating heart swine model, linear transcaval ablation was performed using an irrigated ablation catheter with standard and high power RFA. First, an optimal Uni-<sub>EGM</sub> endpoint for predicting a transmural lesion was determined by single RF applications in the smooth and trabeculated portions of the right atrium. We compared termination of RF energy immediately upon observing consistent loss of the negative component (s-wave) on the local unipolar electrogram (U<sub>+0</sub>) versus extending RF delivery for an additional 3 seconds beyond (U<sub>+3</sub>). Next, linear ablation was achieved with either target Ablation Index (AI<sub>400</sub>) or unipolar electrogram (U<sub>+3</sub>) based techniques. The latter method relied upon Uni-<sub>EGM</sub> morphology to both direct catheter positioning at sites of contiguous and viable tissue and to titrate RF delivery. Bidirectional block was demonstrated with standard EP pacing maneuvers, high density activation mapping and pathology.</p><p><strong>Results: </strong>Extending RF delivery for 3 additional seconds (U<sub>+3</sub>) after consistent loss of the negative component on the Uni-<sub>EGM</sub> proved an optimal endpoint, predicting a transmural lesion with 94% sensitivity and 100% specificity. It was observed that with increasing distance from site of radiofrequency application, the near field s-wave on the Uni-<sub>EGM</sub> grows in magnitude while an acute current of injury pattern diminishes. Uni-<sub>EGM</sub> based technique resulted in equal efficacy in producing ablation lines with complete bidirectional block, compared with target AI guided ablation. With standard power, Uni-<sub>EGM</sub> guided ablation resulted in significantly less energy delivered per RF application.</p><p><strong>Conclusions: </strong>We demonstrate that Uni-<sub>EGM</sub> can successfully guide ablation yielding conduction lines of block. Uni-<sub>EGM</sub> morphology reflects local tissue activation and its modification in response to thermal injury can serve as an endpoint to ensure adequate yet avoid excess RF delivery. The near-field s-wave on the Uni-<sub>EGM</sub> indicates viable tissue, and in conjunction with an acute current of injury identified contiguous, conductive tissue for targeting. Characterization of unipolar electrogram morphology with respect to myocardial electrical properties and understanding its modi","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARTIFICIAL INTELLIGENCE ELECTROCARDIOGRAM-PREDICTED BIOLOGICAL AGE GAP AND MORTALITY: CAPTURING DYNAMIC RISK WITH MULTIPLE ELECTROCARDIOGRAMS.","authors":"Shaun Evans, Sarah A Howson, Andrew E C Booth, Elnaz Shahmohamadi, Matthew Lim, Stephen Bacchi, Mohanaraj Jayakumar, Suraya Kamsani, John Fitzgerald, Anand Thiyagarajah, Mehrdad Emami, Adrian D Elliott, Melissa E Middeldorp, Prashanthan Sanders","doi":"10.1016/j.hrthm.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.009","url":null,"abstract":"<p><strong>Background: </strong>Artificial Intelligence (AI) can predict biological age from electrocardiograms (ECGs), which is prognostic for mortality. Widely available and inexpensive, serial ECG measurements may enhance individual risk profiles.</p><p><strong>Objective: </strong>We investigated whether repeated measurement of AI-derived biological age identifies divergent biological and chronological ageing, and whether it significantly improves all-cause mortality hazard estimates.</p><p><strong>Methods: </strong>This single-center, retrospective cohort study included cardiology patients aged 20-90 years with ≥2 ECGs recorded. An AI model estimated the biological age from each ECG, and the biological age gap (difference from chronological age) was calculated. Survival was analyzed using Cox Proportional Hazards models: a fixed-hazard model with a single ECG per-patient, and a time-varying hazards model for multiple ECGs. Models were evaluated with the log-likelihood ratio test and overall mortality risk predictions were compared with the C-index.</p><p><strong>Results: </strong>Among 46,960 patients (337,415 ECGs, median follow-up 4.5 years), the mean biological ageing rate was 0.7±4.1 years/year. Increasing biological age gap was associated with a non-linear mortality hazard increase, while negative gaps had a small protective effect. The multiple-ECG model outperformed the single-ECG model with a higher log-likelihood ratio test value (6280 vs 5225) and improved C-index estimates (0.763 vs 0.747, P=0.002). The improvement in predictive accuracy increased with more ECGs per-patient, plateauing at ≥10 ECGs.</p><p><strong>Conclusion: </strong>Many patients demonstrate biological ageing which diverges from chronological ageing. AI-derived biological age from a single ECG predicted all-cause mortality, but multiple ECGs significantly increased predictive accuracy. Serial biological age estimates may enhance risk assessment and inform personalized care.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional prognostic index domain phenotypes identified using latent class analysis and mortality in the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF).","authors":"Huah Shin Ng, Richard Woodman, Nicola Veronese, Alberto Pilotto, Arduino A Mangoni","doi":"10.1016/j.hrthm.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.012","url":null,"abstract":"<p><strong>Background: </strong>The Multidimensional Prognostic Index (MPI), an established tool to predict adverse outcomes, classifies frailty using an aggregate-weighted tripartite scoring system based on eight domains (low-, moderate-, or severe-risk). However, this approach may fail to capture specific patient phenotypes that can be characterised by separate MPI domains and for whom health outcome risk also differs.</p><p><strong>Objective: </strong>We sought to identify latent patient phenotypes based on MPI domain data and to determine their association with mortality in older patients with atrial fibrillation (AF).</p><p><strong>Methods: </strong>Using data from the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF), we used latent class analysis (LCA) to identify phenotypes using individual MPI domains and Cox regression models to examine their association with 12-month mortality.</p><p><strong>Results: </strong>Four MPI domain phenotypes were identified in N=2,019 AF patients (mean (SD) age=82.9 (7.5) years; 57% females): phenotype 1 (relatively fit, few comorbidities; n=672, 33%), phenotype 2 (functionally impaired, polypharmacy, comorbidities; n=685, 34%), phenotype 3 (multidimensional frailty, comorbidities; n=161, 8%), and phenotype 4 (relatively fit, polypharmacy, comorbidities; n=501, 25%). Compared to phenotype 1, 12-month mortality was higher in phenotype 3 (adjusted hazard ratio (aHR):4.68, 95%CI=3.41-6.43), phenotype 2 (aHR:1.98, 95%CI=1.53-2.57), and phenotype 4 (aHR:1.44, 95%CI=1.07-1.94).</p><p><strong>Conclusion: </strong>In a cohort of older AF patients, LCA identified four MPI domain phenotypes with different risk of mortality. Pending confirmatory studies, the identified sub-groups might allow more targeted interventions to improve outcomes in this population.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal hematopoiesis of indeterminate potential and atrial fibrillation.","authors":"Jie Liu, Nan Zhang, Guangshuai Teng, Gary Tse, Jie Bai, Gregory Y H Lip, Tong Liu","doi":"10.1016/j.hrthm.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.011","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the most common sustained arrhythmia. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the clonal expansion of hematopoietic stem cells due to acquired mutations without hematologic malignancies, has emerged as a potential risk factor for AF. This narrative review summarizes the shared risk factors between CHIP and AF, including age, lifestyle behaviors and cardiometabolic conditions. It then explores the underlying mechanisms including inflammation, atrial fibrosis and abnormal red cell distribution width. Among these, inflammation is a central driver that promotes abnormal calcium handling, which further accelerates atrial remodeling. For specific mutations, TET2 mutations correlate strongest with AF, with other mutations in genes such as ASXL1, JAK2, TP53, PPM1D and spliceosomes, may also modulate AF susceptibility, though their precise roles require further investigation.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed ventricular stimulation for risk stratification in patients with myocardial scarring and mildly reduced or preserved ejection fraction.","authors":"Auriane Soris, Claudia Herrera-Siklody, Adrian Luca, Mathieu Le Bloa, Giulia Domenichini, Cheryl Teres, Alessandra Pia Porretta, Christelle Haddad, Grégoire Girod, Etienne Pruvot, Patrizio Pascale","doi":"10.1016/j.hrthm.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.014","url":null,"abstract":"<p><strong>Background: </strong>Implantable cardioverter defibrillators (ICD) are recommended in patients with left ventricular ejection fraction (LVEF) below or equal to 35%. However, no recommendation exists to guide the use of prophylactic ICD in patients with less altered LVEF and myocardial scarring, even though they represent the majority of sudden cardiac deaths (SCD).</p><p><strong>Objective: </strong>To evaluate the prognostic value of programmed ventricular stimulation (PVS) in patients with mildly reduced or preserved LVEF.</p><p><strong>Methods: </strong>Patients who underwent PVS with myocardial scarring and LVEF ≥ 40% were included. The primary endpoint was the occurrence of a major arrhythmic event (MAE), namely SCD, ventricular tachycardia (VT)/fibrillation, and appropriate ICD therapy.</p><p><strong>Results: </strong>168 patients were included (mean age 62 ± 13 years, LVEF 54 ± 9 %). Indication for PVS was mostly non-sustained VT and/or syncope (83%). Post-myocardial infarction patients represented about half of the cases (52%). Inducibility during PVS was observed in 21 patients (13%). Over a mean follow-up of 46 ± 38 months, a MAE occurred in 9 patients with positive PVS (43%), versus 4 patients (2.7%) with negative PVS. Inducibility during PVS provided high rule-out performance with a 97% negative predictive value for the prediction of MAE and a fair rule-in performance with a 43% positive predictive value (sensitivity 69%, specificity 92%).</p><p><strong>Conclusion: </strong>PVS is a useful tool to discriminate patients with myocardial scar and LVEF ≥ 40% at increased arrhythmic risk. Effective utilization of ICD may be anticipated in case of positive PVS, while non-inducible patients are at lower MAE risk.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and functional characterization of DENND3 as a novel regulator of ion channel trafficking.","authors":"Shan Gao, Dan Ye, Raquel Neves, Cs John Kim, David J Tester, Wei Zhou, John R Giudicessi, Michael J Ackerman","doi":"10.1016/j.hrthm.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.04.016","url":null,"abstract":"<p><strong>Background: </strong>Genome sequencing of a pedigree with familial ventricular fibrillation identified an ultrarare missense variant, p.R534S, in the DENND3 gene. DENND3 is a guanine nucleotide exchange factor for Rab guanosine triphosphatases (GTPases), which regulate intracellular membrane trafficking, including cardiac ion channels.</p><p><strong>Objective: </strong>The purpose of this study was to assess the impact of DENND3 as a potential genetic modifier contributing to lethal arrhythmia syndromes including familial ventricular fibrillation.</p><p><strong>Methods: </strong>The variant's impact was assessed using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and TSA201 cells. Super-resolution Airyscan imaging (LSM980 Zeiss, Jena, Germany) and the GTPase-Glo assay (Promega, Madison, WI) were used to investigate the distribution and activity of Rab proteins. Electrophysiological analyses measured ion channel currents and cellular arrhythmogenicity.</p><p><strong>Results: </strong>The DENND3-p.R534S variant increased the membrane localization of KCNQ1-, KCNH2-, SCN5A-, and CACNA1C-encoded ion channels in both TSA201 cells and iPSC-CMs. Electrophysiological studies revealed an increase in KCNH2-encoded rapid delayed rectifying K⁺ channel and CACNA1C-encoded L-type calcium channel. iPSC-CMs expressing DENND3-p.R534S exhibited erratic electrical activity, including irregular beating patterns, early afterdepolarizations, and delayed afterdepolarizations. Rab5 showed ectopic distribution in cells expressing DENND3-p.R534S, while other Rab proteins did not display such changes. The GTPase activity of Rab5 increased, while Rab12 activity decreased in the presence of the variant.</p><p><strong>Conclusion: </strong>Our findings unveiled a mechanism whereby the DENND3-p.R534S variant disrupts Rab-mediated trafficking pathways critical for ion channel distribution and cellular function. This study reveals for the first time a potential association of DENND3 and Rab GTPases in cardiac physiology and arrhythmogenic risk.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adeno-associated Virus-mediated PKP2 gene therapy confers robust exercise tolerance in a murine model of arrhythmogenic cardiomyopathy.","authors":"Marina Cerrone, Sarah Boyce, Mingliang Zhang, Manuela Gencarelli, Mario Delmar","doi":"10.1016/j.hrthm.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.05.007","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic, electrical, and hemodynamic characterization of Bachmann bundle in the swine heart.","authors":"Neal C Duong, Zhongping Yang, Paul A Iaizzo","doi":"10.1016/j.hrthm.2025.04.022","DOIUrl":"https://doi.org/10.1016/j.hrthm.2025.04.022","url":null,"abstract":"<p><strong>Background: </strong>Bachmann bundle area (BBA) pacing is an attractive alternative to traditional right atrial appendage (RAA) pacing, but its hemodynamic benefits are poorly understood.</p><p><strong>Objective: </strong>The purpose of this study was to evaluate hemodynamic effects of BBA pacing and structural characteristics of the aligned myocytes within BBA.</p><p><strong>Methods: </strong>Five swine were subjected to volume overload by intravenous infusion of 3 L of 0.9% saline solution during 30 minutes. Medtronic 3830 pacing leads were placed in the RAA and BBA. Rates were alternated between the 2 sites at 110, 120, and 130 beats/min, with the acquisition of left ventricular pressure-volume loops. Anatomies were formalin-fixed and treated with a 7.5% iodine solution to delineate contractile myocardium. The specimens underwent a perfused contrast-enhanced micro-computed tomography protocol with iodine to identify soft tissue differences in the tissue.</p><p><strong>Results: </strong>Our findings revealed atrial synchrony with BBA pacing compared with RAA pacing. BBA pacing reduced average P-wave duration by 27 ms, accompanied by increased left ventricular stroke volume across pacing speeds (23%, 17%, and 15% at 110, 120, and 130 beats/min, respectively). Micro-computed tomography scans depicted orientations of the Bachmann bundle.</p><p><strong>Conclusion: </strong>Through this study, we have achieved a comprehensive hemodynamic characterization and anatomic reconstruction of Bachmann bundle in a swine model subjected to volume overload. The hemodynamic improvements of BBA pacing relative to RAA pacing underscore the potential of BBA pacing as an alternative site for atrial pacing. This understanding of atrial physiology may inform clinical interventions to optimize pacing strategies.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific performance of electrocardiographic criteria for left ventricular hypertrophy in elite athletes.","authors":"Maarten A Van Diepen, Joelle J N Daems, Sjoerd M Verwijs, Juliette C Van Hattum, S Matthijs Boekholdt, Adrienne Van Randen, R Nils Planken, Maarten H Moen, Stephan Van der Zwaard, Nick Bijsterveld, Jan A Kors, Pieter G Postema, Arthur A M Wilde, Folkert W Asselbergs, Harald T Jørstad","doi":"10.1016/j.hrthm.2025.05.004","DOIUrl":"10.1016/j.hrthm.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>In athletes, left ventricular hypertrophy (LVH) criteria based on electrocardiograms (ECGs) have been validated almost exclusively in men using echocardiography. Sex-specific cardiac magnetic resonance (CMR) validation is lacking.</p><p><strong>Objective: </strong>To evaluate ECG-LVH criteria against contrast-enhanced CMR in male and female elite athletes.</p><p><strong>Methods: </strong>Cross-sectional study in healthy elite athletes. Eight ECG-LVH criteria of voltages and products and QRS duration were quantified using automated ECG analysis, and compared to CMR-derived LVH indicators (indexed left ventricular mass (LVM) and maximum left ventricular wall thickness (maxLVWT). Primary metrics of interest were sex-specific correlations (ρ) between ECG-LVH criteria and LVM/maxLVWT. Secondary metrics included discriminative performance (AUROC) and sensitivity at a 95%-specificity level for detecting increased LVM or maxLVWT.</p><p><strong>Results: </strong>Among 209 elite athletes (median age 25, 45% women), men more frequently met one or more voltage criteria than women (64% vs 45%, P = .010). In men, no ECG-LVH criteria showed meaningful correlations or discriminative performance for LVM or maxLVWT. Only QRS duration demonstrated discriminative performance (AUROC: LVM 0.67; maxLVWT 0.74). In women, all voltage and product criteria correlated with LVM (ρ = 0.25-0.45) with acceptable discrimination (AUROC: 0.63-0.73). Peguero-Lo Presti, Cornell-, and Modified Sum of 12-Lead Product showed moderate performance (sensitivities: 24%-29%) at 95% specificity in female athletes. Increased precordial QRS voltages were independently correlated with lower extracellular volume (β = -0.3 mV per %ECV, P < .001).</p><p><strong>Conclusion: </strong>In elite athletes, ECG-LVH criteria, except for QRS duration, lack diagnostic value for LVH in men. Voltage criteria may have diagnostic potential in women.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bachmann's bundle: How anatomists and electrophysiologists see it.","authors":"Robert H Anderson, Richard Sutton, Damián Sánchez-Quintana","doi":"10.1016/j.hrthm.2025.04.064","DOIUrl":"10.1016/j.hrthm.2025.04.064","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}